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1
المؤلفون: Hidehiko Fukahori, Kaoru Yamagami, Satoshi Kubo, Yukihito Sugano, Fumie Takahashi, Ayako Moritomo, Koji Kato, Susumu Yamaki, Koji Nakamura, Koji Yokoo, Toshihiro Hamajima, Suzuki Daisuke
المصدر: Bioorganic & Medicinal Chemistry. 27:1056-1064
مصطلحات موضوعية: Gene isoform, Scaffold, Pyrrolidines, Pyrimidine, Class I Phosphatidylinositol 3-Kinases, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Potency, Molecular Biology, Cells, Cultured, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, 010405 organic chemistry, Chemistry, Organic Chemistry, Highly selective, 0104 chemical sciences, Molecular Docking Simulation, Antibody production, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Female
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2
المؤلفون: Koichiro Mukoyoshi, Kaoru Yamagami, Kousei Yoshihara, Koji Yokoo, Susumu Yamaki, Fumie Takahashi, Toshihiro Hamajima, Yukihito Sugano, Koji Kato, Hidehiko Fukahori, Ayako Moritomo
المصدر: Bioorganic & Medicinal Chemistry. 26:2410-2419
مصطلحات موضوعية: 0301 basic medicine, Class I Phosphatidylinositol 3-Kinases, Pyridines, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Amide, Drug Discovery, Pyrazolopyridine, Animals, Humans, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Biological evaluation, Mice, Inbred BALB C, Molecular Structure, Chemistry, Organic Chemistry, Nuclear Proteins, Stereoisomerism, Molecular Docking Simulation, 030104 developmental biology, Pyrazoles, Molecular Medicine, Female, Selectivity, Transcription Factors
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3
المؤلفون: Hiroyoshi Yamada, Yoshiaki Shimada, Keitaro Kadono, Susumu Yamaki, Akira Nagashima, Mitsuhiro Kondo, Kosei Yoshihara
المصدر: Bioorganic & Medicinal Chemistry. 25:6024-6038
مصطلحات موضوعية: Male, 0301 basic medicine, Pyrimidine, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, 030209 endocrinology & metabolism, Inhibitory postsynaptic potential, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Pharmacokinetics, Oral administration, Drug Discovery, Animals, Enzyme Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Chemical modification, Adhesion, Rats, Bioavailability, Macaca fascicularis, 030104 developmental biology, Injections, Intravenous, Molecular Medicine, Amine Oxidase (Copper-Containing), Carbamates, Cell Adhesion Molecules, Ex vivo
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4
المؤلفون: Ayako Moritomo, Kosei Yoshihara, Susumu Yamaki, Mitsuhiro Kondo, Yuji Koga, Yoshiaki Shimada, Keitaro Kadono, Akira Nagashima
المصدر: Bioorganic & Medicinal Chemistry. 25:4110-4122
مصطلحات موضوعية: 0301 basic medicine, Spectrometry, Mass, Electrospray Ionization, Proton Magnetic Resonance Spectroscopy, Clinical Biochemistry, Glycine, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Diabetic nephropathy, 03 medical and health sciences, chemistry.chemical_compound, Oral administration, Drug Discovery, medicine, Animals, Humans, Diabetic Nephropathies, Molecular Biology, Benzoic acid, Proteinuria, CYP3A4, 010405 organic chemistry, Organic Chemistry, Adhesion, bacterial infections and mycoses, Streptozotocin, medicine.disease, Rats, respiratory tract diseases, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, chemistry, Cytochrome P-450 CYP2C19 Inhibitors, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Amine Oxidase (Copper-Containing), medicine.symptom, Cell Adhesion Molecules, Lead compound, medicine.drug
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5
المؤلفون: Toshihiro Hamajima, Fumie Takahashi, Yukihito Sugano, Susumu Yamaki, Satoshi Kubo, Kaoru Yamagami, Koji Kato, Koji Nakamura, Nozomu Hamakawa, Koji Yokoo, Hidehiko Fukahori, Ayako Moritomo
المصدر: Bioorganicmedicinal chemistry. 26(14)
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Models, Molecular, Class I Phosphatidylinositol 3-Kinases, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, 03 medical and health sciences, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, 0302 clinical medicine, Pharmacokinetics, In vivo, Drug Discovery, Pyrazolopyridine, Potency, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Computational Biology, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Microsome, Molecular Medicine, Pyrazoles, Female, Antibody, Selectivity
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6
المؤلفون: Takafumi Akabane, Akira Nagashima, Ayako Moritomo, Jiro Fujiyasu, Susumu Yamaki, Kosei Yoshihara, Keitaro Kadono, Masahiro Neya, Suzuki Daisuke, Mitsuhiro Kondo
المصدر: Bioorganicmedicinal chemistry. 25(1)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Glycine, Pharmaceutical Science, CHO Cells, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, 03 medical and health sciences, Glycine amide, chemistry.chemical_compound, Structure-Activity Relationship, Cricetulus, Drug Stability, Oral administration, Amide, Drug Discovery, Acetamides, Moiety, Animals, Humans, Molecular Biology, Enzyme Assays, Chemistry, Organic Chemistry, Adhesion, bacterial infections and mycoses, respiratory tract diseases, 0104 chemical sciences, Rats, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine, Amine Oxidase (Copper-Containing), Cell Adhesion Molecules, Ex vivo, VASCULAR ADHESION PROTEIN 1