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المؤلفون: Ning Liu, Mika Kosaka, Utkarsh Doshi, Jane R. Kenny, Albert P. Li, Peter Vuong, Suzanne Tay, Hoa Le, Susan Wong, Zhengyin Yan
المصدر: Drug Metabolism Letters. 12:3-13
مصطلحات موضوعية: Male, 0301 basic medicine, Loperamide, Metabolic Clearance Rate, CYP3A, Metabolite, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Pharmacokinetics, Pharmacology (medical), Intestinal Mucosa, Cells, Cultured, Cryopreservation, CYP3A4, Chemistry, Biochemistry (medical), Transporter, Metabolism, In vitro, Enterocytes, 030104 developmental biology, Hepatocytes, Female, Efflux, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19a9d3d789b2df64d293be5faba52dc
https://doi.org/10.2174/1872312812666171213114422 -
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المؤلفون: Mingcui Liu, Aijun Lu, Shun Zhang, Heidi J.A. Wallweber, Matthew Volgraf, Bianca M. Liederer, David H. Hackos, Jacob Schwarz, Yuen Po-Wai, Elisia Villemure, Gauri Deshmukh, Xifeng Luo, Benjamin D. Sellers, Jesse E. Hanson, Tzu-Ming Wang, Jiang Yu, Kimberly Scearce-Levie, Cuong Ly, Guosheng Wu, Emile Plise, Suzanne Tay, Patrick J. Lupardus
المصدر: ACS Medicinal Chemistry Letters. 8:84-89
مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, Chemistry, musculoskeletal, neural, and ocular physiology, Organic Chemistry, Allosteric regulation, Glutamate receptor, AMPA receptor, Pharmacology, Potentiator, Biochemistry, 03 medical and health sciences, 030104 developmental biology, nervous system, mental disorders, Drug Discovery, Ionotropic glutamate receptor, NMDA receptor, Receptor
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المؤلفون: Lisa Almond, M Jamei, K Rowland-Yeo, Suzanne Tay, Oliver Hatley, Sophie Mukadam, Krystle Okialda, Jane R. Kenny, Susan Wong, Iain Gardner, Amin Rostami-Hodjegan
المصدر: Drug Metabolism and Disposition. 44:821-832
مصطلحات موضوعية: Phenytoin, CYP3A, Administration, Oral, Pharmaceutical Science, Pharmacology, Models, Biological, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, Cytochrome P-450 CYP3A, Humans, Drug Interactions, RNA, Messenger, CYP3A4, Chemistry, Carbamazepine, In vitro, Gastrointestinal Tract, Liver, Enzyme Induction, Phenobarbital, 030220 oncology & carcinogenesis, Hepatocytes, Rifampin, Erratum, Rifampicin, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5960bcec5ce78454d5159e90fbadccd4
https://doi.org/10.1124/dmd.115.066845 -
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المؤلفون: Rebecca M. Reese, Desiree Amm, Justin Ly, Aleksandr Kolesnikov, Christine E. Brotherton-Pleiss, Steven Do, Daniel G. Shore, David H. Hackos, Vishal Verma, Matthew Volgraf, Lesley J. Murray, Xiaofeng Xu, Guosheng Wu, Aijun Lu, Jun Chen, Baihua Hu, Martin E. Dahl, Huifen Chen, Yuen Po-Wai, Elisia Villemure, Yamin Zhang, Joseph P. Lyssikatos, Yong Chen, Brian Safina, Lan Wang, Anthony Estrada, Wienke Lange, Shawn David Erickson, Shannon D. Shields, Suzanne Tay
المصدر: Journal of medicinal chemistry. 61(8)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Molecular model, Proline, Molecular Conformation, Pharmacology, Ligands, 01 natural sciences, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Transient receptor potential channel, Structure-Activity Relationship, Dogs, Drug Stability, In vivo, Drug Discovery, Structure–activity relationship, Ankyrin, Animals, Humans, Prodrugs, TRPA1 Cation Channel, chemistry.chemical_classification, Sulfonamides, 010405 organic chemistry, Drug discovery, Chemistry, Prodrug, 0104 chemical sciences, Sulfonamide, Rats, 030104 developmental biology, Solubility, Microsomes, Liver, Molecular Medicine
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المؤلفون: Daniel F. Ortwine, Rebecca Erickson, Jonathan Hau, Binqing Wei, Charles Eigenbrot, Arna Katewa, James J. Crawford, Regina Choy, Dinah Misner, Georgette Castanedo, Pawan Bir Kohli, Suzanne Tay, Liming Dong, Lisa D. Belmont, Joseph W. Lubach, Wendy B. Young, Adam R. Johnson, Lichuan Liu, Harvey Wong, Leah Schutt, Karin Reif, Brent S. McKenzie, Melis Coraggio, Nico Ghilardi, Wendy Lee
المصدر: Journal of medicinal chemistry. 61(6)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Pyridones, Inflammatory arthritis, Anti-Inflammatory Agents, Arthritis, Piperazines, Madin Darby Canine Kidney Cells, Arthritis, Rheumatoid, Rats, Sprague-Dawley, 03 medical and health sciences, Dogs, immune system diseases, Drug Discovery, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Humans, Lupus Erythematosus, Systemic, Protein Kinase Inhibitors, B cell, Systemic lupus erythematosus, Lupus erythematosus, biology, Molecular Structure, Chemistry, medicine.disease, Arthritis, Experimental, Rats, 030104 developmental biology, medicine.anatomical_structure, Rats, Inbred Lew, Rheumatoid arthritis, biology.protein, Cancer research, Molecular Medicine, Tyrosine kinase
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المؤلفون: Grace Ka Yan Chan, Jae H. Chang, Vickie Tsui, Heidi J.A. Wallweber, Jeremy Murray, John Moffat, Huiyong Hu, Steven Do, Suzanne Tay, Veerendra Munugalavadla, Justin Ly, Eric Harstad, Dionysos Slaga, Jason Drummond, Allen J. Ebens, Ning Liu, Qi Chao, Aleksandr Kolesnikov, Matthew Volgraf, Xiaojing Wang
المصدر: Journal of medicinal chemistry. 60(10)
مصطلحات موضوعية: 0301 basic medicine, Indazoles, Biological Availability, Pharmacology, Crystallography, X-Ray, 03 medical and health sciences, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Potency, Animals, Humans, Protein Isoforms, Intestinal Metabolism, Intestinal Mucosa, Protein Kinase Inhibitors, Kinase, Chemistry, Bioavailability, Rats, Molecular Docking Simulation, Inhibitory potency, 030104 developmental biology, Pim kinases, Molecular Medicine, Transferase inhibitor, Biological availability
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المؤلفون: Elisia, Villemure, Matthew, Volgraf, Yu, Jiang, Guosheng, Wu, Cuong Q, Ly, Po-Wai, Yuen, Aijun, Lu, Xifeng, Luo, Mingcui, Liu, Shun, Zhang, Patrick J, Lupardus, Heidi J A, Wallweber, Bianca M, Liederer, Gauri, Deshmukh, Emile, Plise, Suzanne, Tay, Tzu-Ming, Wang, Jesse E, Hanson, David H, Hackos, Kimberly, Scearce-Levie, Jacob B, Schwarz, Benjamin D, Sellers
المصدر: ACS medicinal chemistry letters. 8(1)
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المؤلفون: Wendy Lee, Lionel Rouge, Joachim Rudolph, Sreemathy Ramaswamy, Klaus P. Hoeflich, Suzanne Tay, Lesley J. Murray, Ignacio Aliagas, Christopher E. Heise, Hank La, Weiru Wang, Robert Mintzer, James J. Crawford, Simon Mathieu
المصدر: Bioorganicmedicinal chemistry letters. 26(15)
مصطلحات موضوعية: Models, Molecular, Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Mice, Nude, 01 natural sciences, Biochemistry, Madin Darby Canine Kidney Cells, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Potency, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Indole test, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, 0104 chemical sciences, Diaminopyrimidine, p21-Activated Kinases, 030220 oncology & carcinogenesis, Lipophilicity, P21 Activated Kinase 1, Molecular Medicine
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المؤلفون: Paul Reynen, Matthew Volgraf, Gauri Deshmukh, James B Herrington, Shun Zhang, Richard Pastor, Guosheng Wu, Liang Sun, David H. Hackos, Aijun Lu, Mingcui Liu, Bianca M. Liederer, Yanzhou Liu, Heidi J.A. Wallweber, Yuen Po-Wai, Elisia Villemure, Jacob Bradley Schwarz, Xifeng Luo, Akim Dirksen, Matthias G. A. Dietz, Yichin Liu, Benjamin D. Sellers, Amy Gustafson, Patrick J. Lupardus, Tzu-Ming Wang, Cuong Ly, Yuhong Fu, Jiang Yu, Jesse E. Hanson, Suzanne Tay, Kimberly Scearce-Levie, Emile Plise
المصدر: Journal of medicinal chemistry. 59(6)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Patch-Clamp Techniques, Allosteric regulation, CHO Cells, Pharmacology, Crystallography, X-Ray, Receptors, N-Methyl-D-Aspartate, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Cricetulus, Cricetinae, Drug Discovery, Animals, Humans, Receptors, AMPA, Receptor, Chemistry, Glutamate receptor, High-Throughput Screening Assays, Electrophysiology, Kinetics, 030104 developmental biology, HEK293 Cells, nervous system, Glycine, Molecular Medicine, NMDA receptor, Ionotropic glutamate receptor, Calcium, Synaptic signaling, Neuroscience, Excitatory Amino Acid Antagonists, 030217 neurology & neurosurgery
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المؤلفون: Erlie Marie Delarosa, Suzanne Tay, Leslie Wang, S. Cyrus Khojasteh, Jane R. Kenny, Sophie Mukadam, Jason Halladay, Daniel Tran
المصدر: Drug Metabolism Letters. 6:43-53
مصطلحات موضوعية: Time Factors, Clinical Biochemistry, Analytical chemistry, Pharmaceutical Science, Tandem mass spectrometry, Automation, Inhibitory Concentration 50, Tandem Mass Spectrometry, High-Throughput Screening Assays, Ic50 values, Cytochrome P-450 Enzyme Inhibitors, Humans, Pharmacology (medical), Enzyme Inhibitors, Throughput (business), Chromatography, Human liver, biology, Chemistry, Biochemistry (medical), Area under the curve, Cytochrome P450, Area Under Curve, Microsomes, Liver, biology.protein, NADP, Chromatography, Liquid, Automated method
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87977a598b71aaf619bd8278d416ac34
https://doi.org/10.2174/187231212800229309
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