المؤلفون: Ryan MB; Nested Therapeutics, Cambridge, Massachusetts., Quade B; Nested Therapeutics, Cambridge, Massachusetts., Schenk N; Nested Therapeutics, Cambridge, Massachusetts., Fang Z; Nested Therapeutics, Cambridge, Massachusetts., Zingg M; Nested Therapeutics, Cambridge, Massachusetts., Cohen SE; Nested Therapeutics, Cambridge, Massachusetts., Swalm BM; Nested Therapeutics, Cambridge, Massachusetts., Li C; Nested Therapeutics, Cambridge, Massachusetts., Özen A; Nested Therapeutics, Cambridge, Massachusetts., Ye C; Nested Therapeutics, Cambridge, Massachusetts., Ritorto MS; Nested Therapeutics, Cambridge, Massachusetts., Huang X; Nested Therapeutics, Cambridge, Massachusetts., Dar AC; Program in Chemical Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York., Han Y; Nested Therapeutics, Cambridge, Massachusetts., Hoeflich KP; Nested Therapeutics, Cambridge, Massachusetts., Hale M; Nested Therapeutics, Cambridge, Massachusetts., Hagel M; Nested Therapeutics, Cambridge, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2024 Jul 01; Vol. 14 (7), pp. 1190-1205.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/therapeutic use , MAP Kinase Signaling System*/drug effects , Neoplasms*/drug therapy , Neoplasms*/metabolism, Humans ; Animals ; Mice ; raf Kinases/metabolism ; raf Kinases/antagonists & inhibitors ; Cell Line, Tumor ; ras Proteins/metabolism ; Xenograft Model Antitumor Assays ; Brain/metabolism ; Brain/drug effects ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinase Kinases/metabolism

المؤلفون: Canarelli SE; Department of Chemistry, Boston College Chestnut Hill Massachusetts 02467 USA eranthie@bc.edu., Swalm BM; Rheos Medicines, Inc Cambridge Massachusetts 02142 USA elarson@rheosrx.com mmorrison57@gmail.com., Larson ET; Rheos Medicines, Inc Cambridge Massachusetts 02142 USA elarson@rheosrx.com mmorrison57@gmail.com., Morrison MJ; Rheos Medicines, Inc Cambridge Massachusetts 02142 USA elarson@rheosrx.com mmorrison57@gmail.com., Weerapana E; Department of Chemistry, Boston College Chestnut Hill Massachusetts 02467 USA eranthie@bc.edu.

المصدر: RSC chemical biology [RSC Chem Biol] 2022 Jun 09; Vol. 3 (7), pp. 972-982. Date of Electronic Publication: 2022 Jun 09 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101768727 Publication Model: eCollection Cited Medium: Internet ISSN: 2633-0679 (Electronic) Linking ISSN: 26330679 NLM ISO Abbreviation: RSC Chem Biol Subsets: PubMed not MEDLINE

المؤلفون: Quiroz RV; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Reutershan MH; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Schneider SE; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Sloman D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Lacey BM; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Swalm BM; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Yeung CS; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Gibeau C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Spellman DS; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Rankic DA; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Chen D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Witter D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Linn D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Munsell E; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Feng G; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Xu H; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hughes JME; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Lim J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Saurí J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Geddes K; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Wan M; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Mansueto MS; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Follmer NE; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Fier PS; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Siliphaivanh P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Daublain P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Palte RL; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hayes RP; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Lee S; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Kawamura S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Silverman S; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States., Sanyal S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Henderson TJ; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Ye Y; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Gao Y; Merck & Co., Inc., 770 Sumneytown Pike, Lansdale, Pennsylvania 19446, United States., Nicholson B; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Machacek MR; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3911-3939. Date of Electronic Publication: 2021 Mar 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aminoquinolines/*therapeutic use , Antineoplastic Agents/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Neoplasms/*drug therapy , Nucleosides/*therapeutic use , Protein-Arginine N-Methyltransferases/*antagonists & inhibitors, Aminoquinolines/chemical synthesis ; Aminoquinolines/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Cell Proliferation/drug effects ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/metabolism ; Female ; Humans ; Mice, SCID ; Molecular Docking Simulation ; Molecular Structure ; Nucleosides/chemical synthesis ; Nucleosides/metabolism ; Protein Binding ; Protein-Arginine N-Methyltransferases/metabolism ; Structure-Activity Relationship ; Mice

المؤلفون: Swalm BM; Epizyme, Inc. 400 Technology Square, Fourth Floor, Cambridge, Massachusetts 02139, United States., Knutson SK, Warholic NM, Jin L, Kuntz KW, Keilhack H, Smith JJ, Pollock RM, Moyer MP, Scott MP, Copeland RA, Wigle TJ

المصدر: ACS chemical biology [ACS Chem Biol] 2014 Nov 21; Vol. 9 (11), pp. 2459-64. Date of Electronic Publication: 2014 Aug 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Neoplasms/*genetics , Polycomb Repressive Complex 2/*chemistry, Enhancer of Zeste Homolog 2 Protein ; Humans ; Polycomb Repressive Complex 2/genetics

المؤلفون: Swalm BM; Epizyme Inc., 400 Technology Square, Cambridge, MA 02139, USA., Hallenbeck KK, Majer CR, Jin L, Scott MP, Moyer MP, Copeland RA, Wigle TJ

المصدر: The Biochemical journal [Biochem J] 2013 Jul 15; Vol. 453 (2), pp. 241-7.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin/*metabolism , Histones/*metabolism , Lysine/*metabolism , Polycomb Repressive Complex 2/*metabolism, Amino Acid Sequence ; Biocatalysis ; Humans ; Methylation ; Methyltransferases/chemistry ; Methyltransferases/metabolism ; Molecular Sequence Data ; Polycomb Repressive Complex 2/chemistry ; Protein Conformation ; Sequence Homology, Amino Acid