المؤلفون: Brunella Felicetti, Paul Frewer, Juanita Lopez, Anthony El-Khouiery, Glen Clack, Christine Stephens, Simon J. Hollingsworth, Matthew G Krebs, Alan Lau, Andrew Goldwin, Alienor Berges, Jean-Charles Soria, Gemma N Jones, Sophie Postel-Vinay, Itziar Irurzun-Arana, Emma Dean, Sy Amy Cheung, Timothy A. Yap, Andrew J. Pierce, Simon Smith

المصدر: Yap, T, Krebs, M, Postel-Vinay, S, El-Khouiery, A, Soria, J-C, Lopez, J, Berges, A, Cheung, S Y A, Irurzan-Arana, I, Goldwin, A, Felicetti, B, Jones, G, Lau, A, Frewer, P, Pierce, A, Clack, G, Stephens, C, Smith, S, Dean, E J & Hollingsworth, S J 2021, ' Ceralasertib (AZD6738), an oral ATR kinase inhibitor, in combination with carboplatin in patients with advanced solid tumors: a Phase I study ', Clinical Cancer Research . https://doi.org/10.1158/1078-0432.CCR-21-1032

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Indoles, Neutropenia, Maximum Tolerated Dose, Anemia, Morpholines, Ataxia Telangiectasia Mutated Proteins, Gastroenterology, Carboplatin, chemistry.chemical_compound, Pharmacokinetics, Internal medicine, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Adverse effect, Protein Kinase Inhibitors, Sulfonamides, Manchester Cancer Research Centre, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Nuclear Proteins, Common Terminology Criteria for Adverse Events, medicine.disease, Thrombocytopenia, Pyrimidines, Oncology, Tolerability, chemistry, Pharmacodynamics, Sulfoxides, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5158d7388a6bd09605d2ca9977160f12
https://pubmed.ncbi.nlm.nih.gov/34301752

المؤلفون: Andrea Zivi, Andrew Hastie, Peter Lawrence, Christine Stephens, Paul Elvin, Malcolm R Ranson, Ruud van der Noll, Jan H.M. Schellens, Sy Amy Cheung, Taito Esaki, Kenji Tamura, Marcelo Marotti, Michelle D. Garrett, Paul K. Stockman, Udai Banerji, Barry R. Davies, Emma Dean

المصدر: Cancer Research. 73:LB-66

مصطلحات موضوعية: Oncology, Gerontology, Cancer Research, medicine.medical_specialty, business.industry, Cmax, Cancer, medicine.disease, Pharmacokinetics, Internal medicine, Pharmacodynamics, Toxicity, medicine, Dosing, Adverse effect, Off Treatment, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6bc44bfee88b25df32004292703dc1d8
https://doi.org/10.1158/1538-7445.am2013-lb-66

المؤلفون: Robertson JFR, Coleman RE, Cheung KL, Evans A, Holcombe C, Skene A, Rea D, Ahmed S, Jahan A, Horgan K, Rauchhaus P, Littleford R, Amy Cheung SY, Cullberg M, de Bruin EC, Koulai L, Lindemann JPO, Pass M, Rugman P, Schiavon G, Deb R, Finlay P, Foxley A, Gee JMW

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Dec 15; Vol. 28 (24), pp. 5469.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Barrett JS; Quantitative Sciences, Bill & Melinda Gates Medical Research Institute, Cambridge, Massachusetts, USA., Bucci-Rechtweg C; Pediatric & Maternal Health Policy, Regulatory Affairs, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA., Amy Cheung SY; Certara, Princeton, New Jersey, USA., Gamalo-Siebers M; Global Statistical Sciences, Eli Lilly & Co., Indianapolis, Indiana, USA., Haertter S; Translational Med & Clinical Pharmacology, Boehringer Ingelheim, Biberach, Germany., Karres J; Paediatric Medicines Office, European Medicines Agency, Amsterdam, The Netherlands., Marquard J; Global Clinical Development CardioMetabolism, Boehringer Ingelheim, Ingelheim, Germany., Mulugeta Y; Division of Pediatric and Maternal Health, Office of New Drugs, Center for Drug Evaluation and Research, Washington, DC, USA., Ollivier C; Aparito, Leiden, The Netherlands., Strougo A; Translational Medicine, Pharmacokinetics, Dynamics and Metabolism, Sanofi, Frankfurt, Germany., Yanoff L; Division of Metabolism and Endocrinology Products, Office of New Drugs, Center for Drug Evaluation and Research, Washington, DC, USA., Yao L; Division of Pediatric and Maternal Health, Office of New Drugs, Center for Drug Evaluation and Research, Washington, DC, USA., Zeitler P; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 Jul; Vol. 108 (1), pp. 29-39. Date of Electronic Publication: 2020 Mar 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2/*drug therapy , Hypoglycemic Agents/*pharmacology, Adolescent ; Adult ; Age Factors ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/physiopathology ; Disease Progression ; Education/methods ; Humans

المؤلفون: Cucurull-Sanchez L; GlaxoSmithKline Medicines Research Centre, Stevenage, UK., Chappell MJ; School of Engineering, University of Warwick, Coventry, UK., Chelliah V; Certara QSP, Canterbury, UK., Amy Cheung SY; Quantitative Clinical Pharmacology, Early Clinical Development, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, UK.; Certara, Princeton, New Jersey, USA., Derks G; Department of Mathematics, University of Surrey, Guildford, UK., Penney M; Union Chimique Belge-Celltech, Slough, Berkshire, UK., Phipps A; Pharmaceutical Sciences, Roche Pharmaceutical Research & Early Development, Roche Innovation Center, Welwyn Garden City, UK., Malik-Sheriff RS; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK., Timmis J; Department of Electronic Engineering, University of York, York, UK., Tindall MJ; Department of Mathematics and Statistics, University of Reading, Reading, UK.; The Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, UK., van der Graaf PH; Certara QSP, Canterbury, UK.; Leiden Academic Centre for Drug Research, Leiden, The Netherlands., Vicini P; Clinical Pharmacology, Pharmacometrics and Drug Metabolism and Pharmaco-Kinetics, MedImmune, Cambridge, UK.; Development Sciences, Kymab Ltd, Cambridge, UK., Yates JWT; Drug Metabolism and Pharmaco-Kinetics, Oncology, Innovative Medicines and Early Development, AstraZeneca, Chesterford Research Park, Cambridge, UK.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2019 May; Vol. 8 (5), pp. 259-272. Date of Electronic Publication: 2019 Mar 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Parathyroid Hormone/*pharmacology , Systems Biology/*standards, Humans ; Models, Biological ; Parathyroid Hormone/adverse effects ; Practice Guidelines as Topic ; Reproducibility of Results ; United Kingdom