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1E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis
المؤلفون: Danny T. Huang, David Sumpton, Sergio Lilla, Lori Buetow, Syed Feroj Ahmed, William C. Clark, Gary J. Sibbet, Ann Hedley, Sara Zanivan, Mads Gabrielsen
المصدر: Oncogene
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Lymphoma, B-Cell, Ubiquitylation, Endosome, Receptor Protein-Tyrosine Kinases, Mutant, Breast Neoplasms, macromolecular substances, Biology, medicine.disease_cause, environment and public health, Interactome, Article, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, hemic and lymphatic diseases, Genetics, medicine, Humans, Proto-Oncogene Proteins c-cbl, Molecular Biology, Adaptor Proteins, Signal Transducing, Cell Proliferation, Myeloproliferative Disorders, Ubiquitin, fungi, Cancer, Oncogenes, medicine.disease, Ubiquitin ligase, ErbB Receptors, Gene Expression Regulation, Neoplastic, enzymes and coenzymes (carbohydrates), 030104 developmental biology, Tissue Array Analysis, 030220 oncology & carcinogenesis, Mutation, Proteolysis, biology.protein, Cancer research, Female, Carcinogenesis, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Sara Zanivan, Lori Buetow, Chatrin Chatrin, Danny T. Huang, Sergio Lilla, Syed Feroj Ahmed, Gary J. Sibbet, Mads Gabrielsen
المصدر: Science Advances
مصطلحات موضوعية: Poly Adenosine Diphosphate Ribose, Ubiquitin-Protein Ligases, Interactome, Biochemistry, Domain (software engineering), 03 medical and health sciences, 0302 clinical medicine, PARP1, Ubiquitin, Structural Biology, Humans, Ring domain, Research Articles, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, Chemistry, C-terminus, Ubiquitination, SciAdv r-articles, 3. Good health, Cell biology, Adenosine Diphosphate, biology.protein, Signal transduction, 030217 neurology & neurosurgery, Function (biology), Research Article
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af33917f9c6abc0821c6c526665cea28
https://eprints.gla.ac.uk/222684/1/222684.pdf -
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المؤلفون: Brian O. Smith, Gary J. Sibbet, Chatrin Chatrin, David Sumpton, Mads Gabrielsen, Syed Feroj Ahmed, Danny T. Huang, Mark A. Nakasone, Lori Buetow
المصدر: Science Advances
مصطلحات موضوعية: Future studies, Ubiquitin-Protein Ligases, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, ADP-Ribosylation, Ubiquitin, Structural Biology, Humans, Ring domain, Research Articles, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, Chemistry, Ubiquitination, SciAdv r-articles, NAD, 3. Good health, Cell biology, ADP-ribosylation, biology.protein, NAD+ kinase, 030217 neurology & neurosurgery, Function (biology), Research Article
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f05735803f347e349100b8c131a59d
https://pubmed.ncbi.nlm.nih.gov/32948590 -
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المؤلفون: Dmitri I. Svergun, Lori Buetow, Hao Dou, Gary J. Sibbet, Syed Feroj Ahmed, Giancarlo Tria, Danny T. Huang, Andreas K. Hock
المساهمون: Institute of Nanoscopy (IoN), RS: M4I - Nanoscopy
المصدر: BMC Biology
Bmc Biology, 14:76. BioMed Central
BMC biology 14(1), 76 (2016). doi:10.1186/s12915-016-0298-6مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Physiology, Mutant, Plant Science, environment and public health, Myeloproliferative neoplasms, Mice, 0302 clinical medicine, Ubiquitin, Structural Biology, Neoplasms, hemic and lymphatic diseases, Native state, Phosphorylation, chemistry.chemical_classification, Agricultural and Biological Sciences(all), biology, 3T3 Cells, SAXS, Oncogene Protein v-cbl, 3. Good health, Ubiquitin ligase, 030220 oncology & carcinogenesis, General Agricultural and Biological Sciences, Tyrosine kinase, hormones, hormone substitutes, and hormone antagonists, Research Article, Biotechnology, Cbl, Transformation potential, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, ddc:570, Animals, Point Mutation, Ecology, Evolution, Behavior and Systematics, Cell Proliferation, DNA ligase, Myeloproliferative Disorders, Biochemistry, Genetics and Molecular Biology(all), Point mutation, fungi, Cell Biology, Molecular biology, enzymes and coenzymes (carbohydrates), 030104 developmental biology, chemistry, biology.protein, Developmental Biology
وصف الملف: application/pdf
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المؤلفون: Anirban Chatterjee, Indranil Paul, Satamita Deb, Syed Feroj Ahmed, Tapashi Mandal, Uttara Chatterjee, Mrinal K. Ghosh
المصدر: Journal of Biological Chemistry. 287:15996-16006
مصطلحات موضوعية: Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Green Fluorescent Proteins, WWP2, Transfection, Biochemistry, law.invention, Ubiquitin, law, Cell Line, Tumor, Humans, Immunoprecipitation, PTEN, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Molecular Biology, biology, PTEN Phosphohydrolase, Ubiquitination, Cell Biology, Ubiquitin ligase, Cell biology, XIAP, HEK293 Cells, Microscopy, Fluorescence, Proteasome, Protein Synthesis and Degradation, Chaperone (protein), Mutation, Proteolysis, biology.protein, Cancer research, Suppressor, RNA Interference, HeLa Cells, Molecular Chaperones, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7008622f8f9396dead5689c8dde4e7
https://doi.org/10.1074/jbc.m111.321083 -
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المؤلفون: Lori Buetow, Sachdev S. Sidhu, Wei Zhang, Syed Feroj Ahmed, Danny T. Huang, Mark A. Nakasone, Gary J. Sibbet, Mads Gabrielsen, Brian O. Smith
المصدر: Molecular Cell
مصطلحات موضوعية: 0301 basic medicine, Ubiquitin-Protein Ligases, Enzyme Activators, X-Linked Inhibitor of Apoptosis Protein, Plasma protein binding, Article, 03 medical and health sciences, Ubiquitin, Drug Discovery, Humans, ubiquitin variant, RING E3 ligase, Enzyme Inhibitors, Binding site, Molecular Biology, chemistry.chemical_classification, DNA ligase, 030102 biochemistry & molecular biology, biology, Tumor Suppressor Proteins, Ubiquitin-Protein Ligase Complexes, Cell Biology, inhibition, 3. Good health, Ubiquitin ligase, XIAP, HEK293 Cells, 030104 developmental biology, Enzyme, Biochemistry, chemistry, U-box E3 ligase, biology.protein, Phosphorylation, activation, Protein Multimerization, HeLa Cells
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bf97682abc728823a0513984759175
https://doi.org/10.1016/j.molcel.2017.09.027 -
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المؤلفون: Satamita Deb, Indranil Paul, Mrinal K. Ghosh, Arijit Bhowmik, Syed Feroj Ahmed
المصدر: Oncogene. 32(10)
مصطلحات موضوعية: Transcriptional Activation, Cancer Research, Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Cellular homeostasis, Transfection, Proto-Oncogene Proteins c-myc, Rats, Sprague-Dawley, Ubiquitin, RNA interference, Cell Line, Tumor, Genetics, Animals, Humans, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, RNA, Small Interfering, Molecular Biology, Transcription factor, biology, Ubiquitination, Glioma, HCT116 Cells, Molecular biology, Hsp90, Hsp70, Ubiquitin ligase, Rats, Tetratricopeptide, HEK293 Cells, Gene Knockdown Techniques, biology.protein, MCF-7 Cells
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المؤلفون: M. Basu, Syed Feroj Ahmed, Satamita Deb
المصدر: Bulletin of environmental contamination and toxicology. 90(3)
مصطلحات موضوعية: Scanning electron microscope, Health, Toxicology and Mutagenesis, Analytical chemistry, chemistry.chemical_element, Microbial Sensitivity Tests, Toxicology, law.invention, Metal, Cell wall, Microscopy, Electron, Transmission, law, Cell Wall, Drug Resistance, Bacterial, Pseudomonas stutzeri, Cadmium, biology, Dose-Response Relationship, Drug, Spectrophotometry, Atomic, General Medicine, biology.organism_classification, Pollution, Anti-Bacterial Agents, Biodegradation, Environmental, chemistry, Transmission electron microscopy, visual_art, visual_art.visual_art_medium, Environmental Pollutants, Atomic absorption spectroscopy, Bacteria, Nuclear chemistry
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