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المؤلفون: Sylvie M. Sur, Xun Shen, Andrea M. Peier, Yi Pei, William T. McElroy, Serena Xu, Andy Liaw, Jing Li, Edward Hudak, Tony Kreamer, Meiping Chang, Kristine Devito, Xi Ai, Elizabeth Smith
المصدر: SLAS discovery : advancing life sciences RD. 24(10)
مصطلحات موضوعية: 0301 basic medicine, DNA, Complementary, Recombinant Fusion Proteins, CHO Cells, Ligands, Biochemistry, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Cricetulus, Cell surface receptor, Complementary DNA, Drug Discovery, Animals, Humans, Biotinylation, Receptor, Alexa Fluor, Gene Library, Chemistry, Ligand binding assay, Membrane Proteins, Flow Cytometry, Fusion protein, Cell biology, High-Throughput Screening Assays, 030104 developmental biology, Membrane protein, 030220 oncology & carcinogenesis, Molecular Medicine, Biological Assay, Biotechnology, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752bff8a39d8a65edc36193b576a1550
https://pubmed.ncbi.nlm.nih.gov/31491347 -
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المؤلفون: Joel M. Harris, Xiaoping Zhou, John A. Morrow, Sue-Ing Lin, Marco A. S. Baptista, John M. Sanders, Xiaoping Zhang, Hong Mei, Mark W. Embrey, Sylvie M. Sur, Duane E. DeMong, Ravi P. Nargund, Alan Hruza, Heather E. Tiscia, Matthew J. Fell, Zhizhang Yin, Gautam Agnihotri, Honglu Zhang, Thomas J. Greshock, Jack D. Scott, Yinghui Lin, Zhi-Cai Shi, John A. Mccauley, Sarah W. Li, Ronald K. Chang, Mark T. Bilodeau, Michael W. Miller, Reshma Kuvelkar, Andrew Stamford, Marc Poirier, Hong Liu, Megan K. Macala, Kallol Basu, Li Xiao, Lynn A. Hyde, Jonathan T. Kern, Xing Dai, Christian Mirescu, Paul L. Walsh, Matthew E. Kennedy, John J. Renger, Zhiyong Hu, John Columbus, Robert E. Drolet, Eric M. Parker
المصدر: Journal of medicinal chemistry. 60(7)
مصطلحات موضوعية: 0301 basic medicine, Male, Indazoles, Leucine-rich repeat, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Enzyme Inhibitors, Rats, Wistar, biology, Cyclin-dependent kinase 4, Kinase, Chemistry, Cyclin-dependent kinase 2, Brain, Parkinson Disease, LRRK2, nervous system diseases, Rats, Molecular Docking Simulation, 030104 developmental biology, Protein kinase domain, Biochemistry, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery
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المؤلفون: John A. McCauley, Ronald K. Chang, Thomas J. Greshock, Ming-Tain Lai, John M. Sanders, Hemaka A. Rajapakse, Hua Su, Robert E. Drolet, Rosa I. Sanchez, Sylvie M. Sur, John J. Renger, Jonathan T. Kern, Heather E. Tiscia, Rada Vanessa L, Mark T. Bilodeau, Boyoung Kim
المصدر: Bioorganicmedicinal chemistry letters. 26(11)
مصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Thiophenes, Leucine-rich repeat, Pharmacology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, medicine, Structure–activity relationship, Humans, Molecular Biology, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Kinase, Organic Chemistry, medicine.disease, LRRK2, Small molecule, nervous system diseases, Molecular Docking Simulation, 030104 developmental biology, Lactam, Molecular Medicine, Sample collection, 030217 neurology & neurosurgery
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المؤلفون: Owen B. McManus, William A. Schmalhofer, Dong-Ming Shen, Sylvie M. Sur, Gregory J. Kaczorowski, Min Shu, Andra Stevenson, Tarak Shah, Maria L. Garcia, James B. Doherty, Ge Dai, Ravi P. Nargund, Guilherme Suarez-Kurtz, Cristiano G Ponte, Laszlo Kiss
المصدر: Molecular Pharmacology. 81:567-577
مصطلحات موضوعية: BK channel, Magnetic Resonance Spectroscopy, Muscle Relaxation, Potassium, chemistry.chemical_element, CHO Cells, Pharmacology, Mass Spectrometry, SK channel, Cricetulus, Cricetinae, Animals, Large-Conductance Calcium-Activated Potassium Channels, Voltage-dependent calcium channel, biology, Activator (genetics), Chemistry, T-type calcium channel, Muscle, Smooth, Hyperpolarization (biology), Calcium-activated potassium channel, biology.protein, Biophysics, Molecular Medicine, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129f1135576eb00877ce08849c2655a7
https://doi.org/10.1124/mol.111.075853 -
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المؤلفون: Cuyue Tang, Kerry L. Fillgrove, Marlene A. Jacobson, Pete H. Hutson, Chris Culberson, Sylvie M. Sur, Yuhsin Kuo, John M. Sanders, Mark E. Layton, Mark E. Fraley, George D. Hartman, Robert M. Garbaccio, Brian C. Magliaro, Sarah L. Huszar, Jason M. Uslaner, Edward J. Brnardic, Julie A. O'Brien
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3129-3133
مصطلحات موضوعية: Agonist, Allosteric modulator, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Receptors, Metabotropic Glutamate, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, medicine, Animals, Molecular Biology, Oxazolidinones, Organic Chemistry, Hit to lead, Rats, chemistry, Metabotropic glutamate receptor, Schizophrenia, Molecular Medicine, Ketamine, Metabotropic glutamate receptor 2, Penetrant (biochemical), Lead compound, Antipsychotic Agents
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