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1
المؤلفون: Sébastien Gagné, Amandine Chefson, Sylvie Toulmond, Patrick Lacombe, Mélissa Arbour, Austin Chen, Dan McKay, Elizabeth Cauchon, Erich L. Grimm, Yeeman K. Ramtohul, M. David Percival, Jean-François Lévesque, Yves Ducharme, Dwight Macdonald, Yongxin Han, René St-Jacques, Robert Houle, Bruce Mackay, Jean-Pierre Falgueyret, Pierre-André Fournier
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2670-2674
مصطلحات موضوعية: Dependent manner, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Renin inhibitor, Structure-Activity Relationship, Enzyme activator, chemistry.chemical_compound, Catalytic Domain, Renin, Drug Discovery, Renin–angiotensin system, medicine, Animals, Humans, Structure–activity relationship, Isoxazole, Molecular Biology, Antihypertensive Agents, Molecular Structure, CYP3A4, Chemistry, Organic Chemistry, Isoxazoles, Rats, Enzyme Activation, Drug Design, Molecular Medicine, Linker
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2
المؤلفون: W. Cameron Black, Karine Khougaz, Sonia Lamontagne, Denis Riendeau, Jean-Pierre Falgueyret, Renata Oballa, Frédéric Massé, M. David Percival, Wanda Cromlish, Sylvie Desmarais, Sylvie Toulmond
المصدر: Journal of Medicinal Chemistry. 48:7535-7543
مصطلحات موضوعية: Cathepsin L, Morpholines, Cathepsin K, Cathepsin A, Piperazines, Cathepsin B, Cell Line, Cathepsin C, Mice, Structure-Activity Relationship, Cathepsin O, Cathepsin H, Cathepsin L1, Drug Discovery, Animals, Humans, Tissue Distribution, Antigen Presentation, Bone Density Conservation Agents, biology, Chemistry, Cathepsins, Rats, Mice, Inbred C57BL, Cysteine Endopeptidases, Thiazoles, Biochemistry, Benzamides, biology.protein, Autoradiography, Molecular Medicine, Female, Rabbits, Lysosomes
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3
المؤلفون: John Tam, George S. Robertson, Sophie Roy, John Colucci, Helen Ashdown, Yves Bureau, Sarah Degen, Donald W. Nicholson, Jean-Pierre Flückiger, Keith Tang, Andre Giroux, Yongxin Han, Robert Zamboni, Steven Xanthoudakis, Michael Rigby, Yanxia Zhu, Sylvie Toulmond, Ruth O'Donnell, Gordon Y.K. Ng, Bill Pikounis, Mathieu Boucher
المصدر: British Journal of Pharmacology. 141:689-697
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, biology, Caspase 3, Striatum, Neuroprotection, chemistry.chemical_compound, Malonate, Endocrinology, chemistry, Apoptosis, In vivo, Internal medicine, medicine, biology.protein, NMDA receptor, Caspase
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المؤلفون: Steven Xanthoudakis, Sophie Roy, Yongxin Han, John Colucci, Sylvie Toulmond, Nathalie Coulombe, Nathalie Méthot, Donald W. Nicholson, Robert Zamboni, JingQi Huang, John P. Vaillancourt, Dita M. Rasper, John Tam
المصدر: The Journal of Experimental Medicine
مصطلحات موضوعية: Programmed cell death, caspase-3, Proteolysis, T-Lymphocytes, Immunology, Caspase 3, Apoptosis, Mice, Transgenic, DNA Fragmentation, Cysteine Proteinase Inhibitors, Article, Rats, Sprague-Dawley, Mice, Sepsis, medicine, Immunology and Allergy, Animals, Spectrin, peritonitis, Caspase, Oxadiazoles, biology, medicine.diagnostic_test, Caspase Inhibitors, Cell biology, Genes, bcl-2, Rats, Mice, Inbred C57BL, Thymocyte, ICAD, thymocytes, Pyrazines, biology.protein, DNA fragmentation, Female, Biomarkers
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac87d1bba6920acb8025aeb38cc0881
http://europepmc.org/articles/PMC2211770 -
5
المؤلفون: Sylvie Toulmond, Nancy J. Rothwell, Francisco Molina-Holgado
المصدر: Journal of Neuroimmunology. 111:1-9
مصطلحات موضوعية: Lipopolysaccharides, medicine.medical_specialty, Lipopolysaccharide, Sialoglycoproteins, Immunology, Mice, Inbred Strains, Endogeny, Biology, Nitric Oxide, Dinoprostone, Nitric oxide, Mice, chemistry.chemical_compound, Internal medicine, medicine, Animals, Immunology and Allergy, Interleukin 6, Incubation, Cells, Cultured, Neuroinflammation, Interleukin-6, Neurodegeneration, Interleukin, medicine.disease, Specific Pathogen-Free Organisms, Interleukin 1 Receptor Antagonist Protein, Endocrinology, Neurology, chemistry, biology.protein, lipids (amino acids, peptides, and proteins), Neurology (clinical), Inflammation Mediators, Neuroglia, Interleukin-1
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المؤلفون: Sylvie Toulmond, Victoria Louise Pearson, Nancy J. Rothwell
المصدر: Glia. 25:311-323
مصطلحات موضوعية: Microglia, Neurodegeneration, Glutamate receptor, Excitotoxicity, Striatum, Biology, medicine.disease, medicine.disease_cause, Cell biology, Cellular and Molecular Neuroscience, medicine.anatomical_structure, nervous system, Neurology, Gliosis, medicine, Neuroglia, medicine.symptom, Neuroscience, Astrocyte
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::14309deea39ec160aa551e7315bcff1a
https://doi.org/10.1002/(sici)1098-1136(19990215)25:4<311::aid-glia1>3.0.co;2-e -
7Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology
المؤلفون: Nancy J. Rothwell, Giamal N. Luheshi, Sylvie Toulmond
المصدر: Pharmacology & Therapeutics. 69:85-95
مصطلحات موضوعية: Brain Chemistry, Pharmacology, Necrosis, medicine.medical_treatment, Neurodegeneration, Central nervous system, Brain, Receptors, Interleukin, Biology, medicine.disease, Neuroimmunology, Immune system, medicine.anatomical_structure, Cytokine, Immunology, medicine, Cytokines, Pharmacology (medical), medicine.symptom, Receptor, Function (biology)
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8
المؤلفون: Denis Riendeau, Jie Lan, Wanda Cromlish, Christoph Binkert, Patrick Hess, Anick Auger, Walter Fischli, Susana Liu, Beat Steiner, M. David Percival, René St-Jacques, Jennifer Harris, Sylvie Toulmond
المصدر: Journal of the Renin-Angiotensin-Aldosterone System, Vol 12 (2011)
مصطلحات موضوعية: Mean arterial pressure, medicine.medical_specialty, Medicine (General), Rat model, Angiotensinogen, Blood Pressure, Human renin, Rats, Sprague-Dawley, Endocrinology, R5-920, Enalapril, Fumarates, Heart Rate, Internal medicine, Renin–angiotensin system, Heart rate, Renin, Internal Medicine, medicine, Animals, Humans, Tissue Distribution, RNA, Messenger, Messenger RNA, business.industry, Amides, Macaca mulatta, Rats, Disease Models, Animal, Blood pressure, Gene Expression Regulation, Hypertension, Female, Rats, Transgenic, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug, circulatory and respiratory physiology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beab646a7377bffe0e829d1926e833b3
https://doaj.org/article/90ef8e6e178544eeae4cb4918a5e8df2 -
9
المؤلفون: Christopher P. Regan, Elizabeth Cauchon, Bruce Mackay, Yves Ducharme, Sylvie Toulmond, Sebastien Laliberte, Patrick Lacombe, Sébastien Gagné, M. David Percival, Daniel Dube, Jean-Pierre Falgueyret, JingQi Huang, Jean-François Lévesque, Dan McKay, Yongxin Han, René St-Jacques, Louis-Charles Campeau, Austin Chen, Hillary K. Regan, Pierre-André Fournier, Amandine Chefson, Erich L. Grimm, Robert Houle, Dwight Macdonald, Susana Liu
المصدر: Bioorganicmedicinal chemistry letters. 21(13)
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Renin inhibitor, Chemical synthesis, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Piperidines, In vivo, Drug Discovery, Renin–angiotensin system, Renin, medicine, Structure–activity relationship, Animals, Enzyme Inhibitors, Molecular Biology, biology, Molecular Structure, Organic Chemistry, Rats, chemistry, Enzyme inhibitor, Drug Design, Lipophilicity, Hypertension, Lactam, biology.protein, Molecular Medicine
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10
المؤلفون: Flora Zavala, Sylvie Toulmond, André Serrano, Jesus Benavides, Véronique Taupin
المصدر: Journal of Neuroimmunology. 42:177-185
مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.medical_treatment, Immunology, Interleukin, Hippocampus, Ro5-4864, Lesion, Basal (phylogenetics), medicine.anatomical_structure, Cytokine, Endocrinology, Neurology, Internal medicine, Cortex (anatomy), medicine, Immunology and Allergy, Tumor necrosis factor alpha, Neurology (clinical), medicine.symptom, business