المؤلفون: Nelson AT; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States., Jones PM; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States; Children's Health System, Dallas, TX, United States., Cao J; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States; Children's Health System, Dallas, TX, United States. Electronic address: Jing.Cao2@UTSouthwestern.edu.

المصدر: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2024 Jun 15; Vol. 560, pp. 119747. Date of Electronic Publication: 2024 May 22.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1302422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3492 (Electronic) Linking ISSN: 00098981 NLM ISO Abbreviation: Clin Chim Acta Subsets: MEDLINE

مواضيع طبية MeSH: Carnitine*/analogs & derivatives , Carnitine*/blood , Carnitine*/urine , Holocarboxylase Synthetase Deficiency*/diagnosis , Holocarboxylase Synthetase Deficiency*/genetics, Humans ; Female ; Infant, Newborn ; Infant

المؤلفون: Taylor JL, Ayres-Galhardo PH, Brown BL

المصدر: Biochemistry [Biochemistry] 2024 Jul 02; Vol. 63 (13), pp. 1636-1646. Date of Electronic Publication: 2024 Jun 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: 5-Aminolevulinate Synthetase*/genetics , 5-Aminolevulinate Synthetase*/metabolism , 5-Aminolevulinate Synthetase*/chemistry , 5-Aminolevulinate Synthetase*/deficiency , Anemia, Sideroblastic*/genetics , Anemia, Sideroblastic*/metabolism, Humans ; Genetic Diseases, X-Linked/genetics ; Genetic Diseases, X-Linked/metabolism ; Loss of Function Mutation ; Enzyme Stability ; Heme/metabolism ; Heme/chemistry ; Porphyrias/genetics ; Porphyrias/metabolism ; Models, Molecular ; Mutation ; Protoporphyria, Erythropoietic

SCR Disease Name: X-linked sideroblastic anemia; Protoporphyria, Erythropoietic, X-Linked Dominant

المؤلفون: Zeng Q; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China., Ren Y; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China., Wang Y; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China., Yang J; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China., Qin Y; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China., Yang L; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China., Zheng X; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China., Huang A; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China., Fan H; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China.

المصدر: Journal of medical virology [J Med Virol] 2024 Jul; Vol. 96 (7), pp. e29805.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Innate* , Hepatitis B virus*/immunology , Hepatitis B virus*/genetics , 2',5'-Oligoadenylate Synthetase*/genetics , 2',5'-Oligoadenylate Synthetase*/metabolism , Transcription, Genetic*, Humans ; Host-Pathogen Interactions/immunology ; Host-Pathogen Interactions/genetics ; Hep G2 Cells ; Hepatitis B/immunology ; Hepatitis B/virology ; Hepatitis B/genetics ; Viral Regulatory and Accessory Proteins/genetics ; Viral Regulatory and Accessory Proteins/metabolism ; Viral Regulatory and Accessory Proteins/immunology ; Trans-Activators

المؤلفون: Cusic R; Department of Molecular Medicine, Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA.; Department of Immunology and Microbiology, Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA., Burke JM; Department of Molecular Medicine, Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA.; Department of Immunology and Microbiology, Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA.

المصدر: Science signaling [Sci Signal] 2024 May 21; Vol. 17 (837), pp. eadi9844. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

مواضيع طبية MeSH: Endoribonucleases*/metabolism , Endoribonucleases*/genetics , Endoribonucleases*/chemistry , 2',5'-Oligoadenylate Synthetase*/metabolism , 2',5'-Oligoadenylate Synthetase*/genetics , 2',5'-Oligoadenylate Synthetase*/chemistry , RNA, Double-Stranded*/metabolism , RNA, Double-Stranded*/chemistry , RNA, Double-Stranded*/genetics , Zika Virus*/metabolism, Humans ; Animals ; Dengue Virus/metabolism ; RNA, Viral/metabolism ; RNA, Viral/genetics ; RNA Stability ; West Nile virus/metabolism ; West Nile virus/genetics ; Zika Virus Infection/metabolism ; Zika Virus Infection/virology ; Enzyme Activation ; HeLa Cells ; HEK293 Cells

المؤلفون: Wang S; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Xu Z; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Liu Y; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Yu M; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Zhang T; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Liu P; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Qi X; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Chen Y; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Meng L; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Guo R; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Zhang L; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Fan W; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Gao L; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Duan Y; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Zhang Y; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Cui H; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Gao Y; Avian Immunosuppressive Diseases Division, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.; WOAH Reference Laboratory for Infectious Bursal Disease, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, Yangzhou University, Yangzhou, China.; National Poultry Laboratory Animal Resource Center, Harbin, China.

المصدر: Journal of virology [J Virol] 2024 May 14; Vol. 98 (5), pp. e0018124. Date of Electronic Publication: 2024 Apr 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

مواضيع طبية MeSH: Infectious bursal disease virus*/physiology , Virus Replication* , Autophagy* , Birnaviridae Infections*/virology , Birnaviridae Infections*/metabolism , Viral Structural Proteins*/metabolism , Viral Structural Proteins*/genetics , Chickens* , 2',5'-Oligoadenylate Synthetase*/metabolism , 2',5'-Oligoadenylate Synthetase*/genetics, Animals ; Poultry Diseases/virology ; Poultry Diseases/metabolism ; Host-Pathogen Interactions ; HEK293 Cells ; Humans ; Cell Line

المؤلفون: Chen Q; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Jiang LY; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Cao C; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Liu FY; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Li DR; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Wu PF; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Jiang KR; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

المصدر: Molecular carcinogenesis [Mol Carcinog] 2024 May; Vol. 63 (5), pp. 938-950. Date of Electronic Publication: 2024 Feb 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

مواضيع طبية MeSH: Adenine Nucleotides* , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Glycoproteins*/metabolism , 2',5'-Oligoadenylate Synthetase*/metabolism, Humans ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Carrier Proteins/metabolism

المؤلفون: To-Figueras J; Biochemistry and Molecular Genetics Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain., Erwin AL; Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care, Cleveland Clinic, Cleveland, Ohio, USA., Aguilera P; Dermatology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain., Millet O; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bilbao, Spain., Desnick RJ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

المصدر: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2024 Aug; Vol. 44 (8), pp. 1842-1855. Date of Electronic Publication: 2024 May 08.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-3231 (Electronic) Linking ISSN: 14783223 NLM ISO Abbreviation: Liver Int Subsets: MEDLINE

مواضيع طبية MeSH: Porphyria, Erythropoietic*/genetics , Porphyria, Erythropoietic*/diagnosis , Porphyria, Erythropoietic*/therapy , Uroporphyrinogen III Synthetase*/genetics , Uroporphyrinogen III Synthetase*/metabolism, Humans ; Uroporphyrins/genetics

المؤلفون: Yousfi FZE; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Haroun AE; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Nebhani C; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Belayachi J; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Acute Medical Unit, Ibn Sina University Hospital, Rabat, Morocco., Askander O; Faculty of Medical Science, Mohammed VI Polytechnic University, Benguerir, Morocco., Fahime EE; Molecular Biology and Functional Genomics Platform, National Center for Scientific and Technical Research, Rabat, Morocco., Fares H; Intensive Care Department, Cheikh Zaid International Universitary Hospital, Rabat, Morocco., Ennibi K; Virology, Infectious and Tropical Diseases Center, Hopital Militaire d'Instruction Mohammed V, Rabat, Morocco., Abouqal R; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Razine R; Laboratory of Biostatistics, Clinical and Epidemiological Research, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco.; Laboratory of Community Health, Department of Public Health, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco., Bouhouche A; Laboratory of Human Genetics, Medical School and Pharmacy, University Mohammed V in Rabat, Rabat, Morocco. a.bouhouche@um5r.ac.ma.; Genomic Center of the Cheikh Zaid Foundation, Abulcasis International University of Health Sciences, Rabat, Morocco. a.bouhouche@um5r.ac.ma.

المصدر: Archives of virology [Arch Virol] 2024 Apr 25; Vol. 169 (5), pp. 109. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-8798 (Electronic) Linking ISSN: 03048608 NLM ISO Abbreviation: Arch Virol Subsets: MEDLINE

مواضيع طبية MeSH: 2',5'-Oligoadenylate Synthetase*/genetics , COVID-19*/genetics , COVID-19*/virology , COVID-19*/epidemiology , Polymorphism, Single Nucleotide*, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Africa, Northern ; Alleles ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; North African People ; Prevalence

المؤلفون: Gajate-Arenas M; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna, 38029 San Cristóbal de La Laguna, Spain., Fricke-Galindo I; HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico., García-Pérez O; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna, 38029 San Cristóbal de La Laguna, Spain., Domínguez-de-Barros A; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna, 38029 San Cristóbal de La Laguna, Spain., Pérez-Rubio G; HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico., Dorta-Guerra R; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna, 38029 San Cristóbal de La Laguna, Spain.; Department of Mathematics, Statistics and Operations Research, Faculty of Sciences, Mathematics Section, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain., Buendía-Roldán I; Translational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico., Chávez-Galán L; Laboratory of Integrative Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City 14080, Mexico., Lorenzo-Morales J; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna, 38029 San Cristóbal de La Laguna, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Department of Obstetrics and Gynecology, Pediatrics, Preventive Medicine and Public Health, Toxicology, Legal and Forensic Medicine and Parasitology, Faculty of Health Sciences, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain., Falfán-Valencia R; HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico., Córdoba-Lanús E; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), Universidad de La Laguna, 38029 San Cristóbal de La Laguna, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 24; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: 2',5'-Oligoadenylate Synthetase*/genetics , COVID-19*/genetics , COVID-19*/immunology , COVID-19*/virology , SARS-CoV-2* , Interferon-Stimulated Gene Factor 3, gamma Subunit*/genetics , Interferon-Stimulated Gene Factor 3, gamma Subunit*/metabolism, Humans ; Male ; Female ; Middle Aged ; Nuclear Proteins/genetics ; Adult ; Aged ; Mitochondrial Proteins

المؤلفون: Chávez-Vélez E; Carrera de Biología, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Quito, Ecuador., Álvarez-Nava F; Carrera de Biología, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Quito, Ecuador., Torres-Vinueza A; Carrera de Biología, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Quito, Ecuador., Balarezo-Díaz T; Carrera de Biología, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Quito, Ecuador., Pilataxi K; Carrera de Biología, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Quito, Ecuador., Acosta-López C; Carrera de Biología, Facultad de Ciencias Biológicas, Universidad Central del Ecuador, Quito, Ecuador., Peña IZ; Unidad de Cuidados Críticos de Adultos, Hospital Quito Sur del Instituto Ecuatoriano de Securidad Social, Quito, Ecuador., Narváez K; Unidad de Cuidados Críticos de Adultos, Hospital Quito Sur del Instituto Ecuatoriano de Securidad Social, Quito, Ecuador.

المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Apr 17; Vol. 14, pp. 1322882. Date of Electronic Publication: 2024 Apr 17 (Print Publication: 2024).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Observational Study

بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Single Nucleotide* , 2',5'-Oligoadenylate Synthetase*/genetics , COVID-19*/genetics , Chemokine CCL2*/genetics , Severity of Illness Index* , SARS-CoV-2*/genetics, Humans ; Ecuador/epidemiology ; Female ; Male ; Case-Control Studies ; Adult ; Middle Aged ; Genetic Predisposition to Disease ; Genotype ; Gene Frequency ; Aged ; Young Adult