المؤلفون: Rasmus P. Clausen, Claus H. Jensen, Sara Björk Sigurdardóttir, Kenneth T. Kongstad, David E. Gloriam, Petrine Wellendorph, Mia Nittegaard-Nielsen, Christina Birkedahl Falk-Petersen, Francesco Bavo, Yongsong Tian, Jan Kehler, Kasper Harpsøe, Jacob Krall, Stine B. Vogensen, Bente Frølund, Anne S. Haugaard

المصدر: Journal of Medicinal Chemistry. 60:9022-9039

مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Carboxylic Acids, Molecular Conformation, Hydroxybutyrates, Cyclopentanes, Ligands, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, γ-Hydroxybutyric acid, Drug Discovery, T-HCA, Binding site, Binding Sites, 010405 organic chemistry, Chemistry, Ligand, 0104 chemical sciences, Molecular hybridization, Design synthesis, Crotonates, Drug Design, Molecular Medicine, Pharmacophore, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371f91bb7a8a910a778dba45c5ffc706
https://doi.org/10.1021/acs.jmedchem.7b01351

المؤلفون: Anders B. Klein, Tina Bay, Petrine Wellendorph, Laura F. Eghorn

المصدر: Biochemical pharmacology. 87(2)

مصطلحات موضوعية: Central Nervous System, NCS-382, GABAB receptor, Pharmacology, Biochemistry, chemistry.chemical_compound, Drug Delivery Systems, T-HCA, medicine, Animals, Humans, Receptor, G protein-coupled receptor, Brain Chemistry, Binding Sites, GABAA receptor, GHB receptor, Receptors, GABA-A, nervous system, chemistry, Receptors, GABA-B, 4-Hydroxy-4-methylpentanoic acid, Sodium Oxybate, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565ed28fb1b6886caf0aef4e18f2c5a5
https://pubmed.ncbi.nlm.nih.gov/24269284

المؤلفون: Jean-Jacques Bourguignon, Dominique Schott, Martine Schmitt, Camille-Georges Wermuth, J. P. Beaucourt, Bernard Rousseau

المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 27:23-33

مصطلحات موضوعية: chemistry.chemical_classification, High affinity binding, Stereochemistry, Organic Chemistry, Central nervous system, Endogeny, Metabolism, Biochemistry, Analytical Chemistry, 4-hydroxycrotonic acid, chemistry.chemical_compound, Enzyme, medicine.anatomical_structure, chemistry, Drug Discovery, T-HCA, medicine, Radiology, Nuclear Medicine and imaging, Spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a26bd73fa765668def1275ba57d9204
https://doi.org/10.1002/jlcr.2580270105

المؤلفون: Camille G. Wermuth, Jean-Jacques Bourguignon, J. P. Beaucourt, Martine Schmitt, Dominique Schott, A. Vanhove, Bernard Rousseau

المصدر: International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes. 39:570

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Biochemistry, T-HCA, General Engineering, Endogeny

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c326c93e696a845a3fb2d7f7104cfe0a
https://doi.org/10.1016/0883-2889(88)90307-3

المؤلفون: Bay T; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Fruebjergvej 3, 2100 Copenhagen, Denmark., Eghorn LF; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Fruebjergvej 3, 2100 Copenhagen, Denmark., Klein AB; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Fruebjergvej 3, 2100 Copenhagen, Denmark., Wellendorph P; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Fruebjergvej 3, 2100 Copenhagen, Denmark. Electronic address: pw@sund.ku.dk.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2014 Jan 15; Vol. 87 (2), pp. 220-8. Date of Electronic Publication: 2013 Nov 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Brain Chemistry/*drug effects , Central Nervous System/*drug effects , Drug Delivery Systems/*methods , Receptors, GABA-A/*metabolism , Receptors, GABA-B/*metabolism , Sodium Oxybate/*administration & dosage, Animals ; Binding Sites/drug effects ; Binding Sites/physiology ; Brain Chemistry/physiology ; Central Nervous System/chemistry ; Central Nervous System/metabolism ; Humans ; Protein Binding/drug effects ; Protein Binding/physiology ; Receptors, GABA-A/physiology ; Receptors, GABA-B/physiology ; Sodium Oxybate/metabolism