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1دورية أكاديمية
المؤلفون: Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn
المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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2دورية أكاديمية
المؤلفون: Francesca G. Tomasi, Jessica T. P. Schweber, Satoshi Kimura, Junhao Zhu, Laura A. T. Cleghorn, Susan H. Davis, Simon R. Green, Matthew K. Waldor, Eric J. Rubin
المصدر: mBio, Vol 14, Iss 1 (2023)
مصطلحات موضوعية: Mycobacterium tuberculosis, antibiotic resistance, bacterial genetics, ribosomes, tRNA, tRNA sequencing, Microbiology, QR1-502
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2150-7511
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3دورية أكاديمية
المؤلفون: Peter C. Ray, Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie Early, Anuradha Kumar, Shilah A. Bonnett, Lindsay Flint, Douglas Joerss, James Johnson, Aaron Korkegian, Steven Mullen, Abraham L. Moure, Susan H. Davis, Dinakaran Murugesan, Michael Mathieson, Nicola Caldwell, Curtis A. Engelhart, Dirk Schnappinger, Ola Epemolu, Fabio Zuccotto, Jennifer Riley, Paul Scullion, Laste Stojanovski, Lisa Massoudi, Gregory T. Robertson, Anne J. Lenaerts, Gail Freiberg, Dale J. Kempf, Thierry Masquelin, Philip A. Hipskind, Joshua Odingo, Kevin D. Read, Simon R. Green, Paul G. Wyatt, Tanya Parish
المصدر: ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2470-1343
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المؤلفون: Francesca G. Tomasi, Jessica T. P. Schweber, Satoshi Kimura, Junhao Zhu, Laura A. T. Cleghorn, Susan H. Davis, Simon R. Green, Matthew K. Waldor, Eric J. Rubin
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e5d8e62bb213164804cd2ce5be445ba6
https://doi.org/10.1101/2022.11.15.516451 -
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المؤلفون: Tanya Parish, Lindsay Flint, Anuradha Kumar, Lisa M. Massoudi, Paul Scullion, Gregory T. Robertson, Shilah A. Bonnett, Simon Green, Nicola Caldwell, Jennifer Riley, Gail M. Freiberg, Philip Arthur Hipskind, Michael Mathieson, Thierry Masquelin, Laste Stojanovski, Curtis A. Engelhart, Margaret Huggett, Dinakaran Murugesan, Abraham Lopez Moure, Fabio Zuccotto, Julie V. Early, Ola Epemolu, Paul G. Wyatt, Dale J. Kempf, Kevin D. Read, Susan Davis, Laura A. T. Cleghorn, James Johnson, Steven Mullen, Malcolm Taylor, Anne J. Lenaerts, Penelope A. Turner, Peter C. Ray, Joshua Odingo, Dirk Schnappinger, Aaron Korkegian, Douglas Joerss
المصدر: ACS Omega
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)مصطلحات موضوعية: 0303 health sciences, Tuberculosis, biology, 030306 microbiology, Chemistry, General Chemical Engineering, Phenotypic screening, hERG, General Chemistry, Pharmacology, medicine.disease, biology.organism_classification, In vitro, Article, 3. Good health, Mycobacterium tuberculosis, 03 medical and health sciences, Minimum inhibitory concentration, In vivo, biology.protein, medicine, Cytotoxicity, QD1-999, 030304 developmental biology
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المؤلفون: Lucy Ellis, Yumi Park, Ola Epemolu, Paul G. Wyatt, Stefano Donini, Laura E. Via, Carolyn Selenski, Matthew Axtman, Thomas R. Ioerger, Menico Rizzi, Tom L. Blundell, Nian Zhou, Simon Green, Olalla Sanz, Maria Osuna-Cabello, David B. Ascher, Helena I. Boshoff, Laste Stojanovski, Travis Hartman, Dale J. Kempf, Clifton E. Barry, Joël Lelièvre, Tracy Bayliss, Zhe Wang, Fred Simeons, Claire J. MacKenzie, Hannah Pflaumer, Valerie Mizrahi, Fabio Zuccotto, James C. Sacchettini, Gracia Santos Diaz, Véronique Dartois, Angela Pacitto, Susan Davis, Kyu Y. Rhee, Laura A. T. Cleghorn, Margaret Huggett, Matthew D. Kurnick, Dinakaran Murugesan, Penelope A. Turner, Kriti Arora, Gerard Drewes, Lluis Ballell, Markus Bösche, Gail M. Freiberg, Kevin D. Read, Surendranadha Reddy Jonnala, Kirsteen I. Buchanan, Maria Jose Lafuente-Monasterio, María José Rebollo-López, Sonja Ghidelli-Disse, Peter C. Ray, Alasdair Smith, Myron Srikumaran, Ardala Breda
المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madridمصطلحات موضوعية: 0301 basic medicine, Protein Conformation, 030106 microbiology, Antitubercular Agents, Gene Expression Regulation, Enzymologic, Article, Green fluorescent protein, IMPDH, Mycobacterium tuberculosis, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, IMP Dehydrogenase, Biosynthesis, IMP dehydrogenase, Drug Discovery, Drug Resistance, Bacterial, Animals, Humans, Tuberculosis, guanine, Nucleotide salvage, Sulfonamides, Indazole, Molecular Structure, biology, Gene Expression Regulation, Bacterial, biology.organism_classification, Molecular biology, 3. Good health, Mice, Inbred C57BL, 030104 developmental biology, Infectious Diseases, target validation, chemistry, Biochemistry, Drug Design, Mutation, purine salvage, Rabbits, Growth inhibition, indazole sulfonamide, Intracellular
وصف الملف: application/pdf
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المؤلفون: Patricia S. Tsang, Tracy Bayliss, Clifton E. Barry, Peter C. Ray, Claire J. MacKenzie, Valerie Mizrahi, Jinwoo Lee, Helena I. Boshoff, Eugene Uh, Bernardo Ochoa-Montaño, Stephanie S. Dawes, Kriti Arora, Paul G. Wyatt, Laura A. T. Cleghorn, Tom L. Blundell
المصدر: Antimicrobial Agents and Chemotherapy. 58:6962-6965
مصطلحات موضوعية: Cytochrome, Pyridines, Mutant, Antitubercular Agents, Microbial Sensitivity Tests, Drug resistance, medicine.disease_cause, Microbiology, Electron Transport, Electron Transport Complex IV, Mycobacterium tuberculosis, Gene Knockout Techniques, Drug Resistance, Multiple, Bacterial, Oxazines, medicine, Tuberculosis, Cytochrome c oxidase, Pharmacology (medical), Author Correction, Pharmacology, Mutation, Oxidase test, Binding Sites, biology, biology.organism_classification, Protein Structure, Tertiary, Infectious Diseases, Xanthenes, biology.protein, Energy Metabolism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8873ff9a62be7411ce9549af65eda550
https://doi.org/10.1128/aac.03486-14 -
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المؤلفون: Kriti Arora, Clifton E. Barry, Jinwoo Lee, Patricia S. Tsang, Claire J. MacKenzie, Stephanie S. Dawes, Paul G. Wyatt, Tracy Bayliss, Laura A. T. Cleghorn, Eugene Uh, Bernardo Ochoa-Montaño, Peter C. Ray, Tom L. Blundell, Helena I. Boshoff, Valerie Mizrahi
المصدر: Antimicrobial Agents and Chemotherapy. 61
مصطلحات موضوعية: Pharmacology, Oxidase test, biology, Chemistry, Operon, biology.organism_classification, Molecular biology, Mycobacterium tuberculosis, Infectious Diseases, biology.protein, Cytochrome c oxidase, Pharmacology (medical), Respiratory system, Gene
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::83f8d3d47d145fa69f69d374a7347223
https://doi.org/10.1128/aac.01429-17 -
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المؤلفون: Andrew Woodland, Torsten Luksch, Julie A. Frearson, Kayode K. Ojo, Paul G. Wyatt, Ian H. Gilbert, Ruth Brenk, Laura A. T. Cleghorn, Wesley C. Van Voorhis, Raffaella Grimaldi
المصدر: Chemmedchem
مصطلحات موضوعية: Models, Molecular, Trypanosoma brucei brucei, Biology, Trypanosoma brucei, Biochemistry, GSK3, Cell Line, Glycogen Synthase Kinase 3, Structure-Activity Relationship, 03 medical and health sciences, Parasitic Sensitivity Tests, medicinal chemistry, parasitic diseases, Drug Discovery, medicine, Humans, Structure–activity relationship, African trypanosomiasis, General Pharmacology, Toxicology and Pharmaceutics, Protein kinase A, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, Pharmacology, protein kinases, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, 030306 microbiology, Drug discovery, Kinase, Organic Chemistry, Full Papers, medicine.disease, biology.organism_classification, Trypanocidal Agents, In vitro, 3. Good health, Molecular Medicine, Pharmacophore, antiprotozoal agents
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المؤلفون: Iain T. Collie, Julie A. Frearson, Paul G. Wyatt, Laura A. T. Cleghorn, Ruth Brenk, Chidochangu P. Mpamhanga, Roderick G. Walker, Torsten Luksch, Jeremy C. Mottram, Andrew Woodland, Neil R. Norcross, Ian H. Gilbert, Leah S. Torrie
المصدر: Chemmedchem
مصطلحات موضوعية: Drug Evaluation, Preclinical, Protozoan Proteins, cyclin-dependent cdc2-related kinases, Trypanosoma brucei, Biochemistry, Structure-Activity Relationship, Cyclin-dependent kinase, CDC2 Protein Kinase, Drug Discovery, Humans, Urea, Computer Simulation, General Pharmacology, Toxicology and Pharmaceutics, Protein kinase A, Protein Kinase Inhibitors, leishmaniasis, Leishmania, Pharmacology, Cyclin-dependent kinase 1, Binding Sites, biology, Kinase, ureas, Organic Chemistry, Cyclin-dependent kinase 2, Full Papers, biology.organism_classification, Protein Structure, Tertiary, CRK3, Pyrimidines, triazolopyridines, biology.protein, Pyrazoles, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2202f6601d8578d3a2bae1b2198e8018
https://doi.org/10.1002/cmdc.201100344
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