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المؤلفون: Kathleen Hoyt, Kim Fletcher, Christian Harcken, Steven Richard Brunette, T. Gregg Davis, Delphine Collin, Ryan M. Fryer, Robert Sibley, Thomas Wieckowski, Jörg P Hehn, Dustin Smith, Yin-Chao Tseng, Stanley Kugler, Csengery Johanna, Donald Souza, Liang Shuang, Michael Robert Turner, Mark E. Labadia, Donna Terenzio, Anita L. Wayne, Mark Panzenbeck, Wu Lifen, Robert Hughes
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, Organic Chemistry, Retinoic acid, Interleukin, Metabolic stability, Scaffold hopping, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Nuclear receptor, RAR-related orphan receptor gamma, Drug Discovery, Aqueous solubility, Cancer research, Transcription factor
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المؤلفون: Paul Bryan Wren, Roberto Arban, Frank A Gray, Ceri H. Davies, Dino Montanari, Jessica L. Schneck, T. Gregg Davis, A. Richard Rutter, Michele Negri, Palmina Cavallini, Alessandro Poffe, Elena Vicentini
المصدر: Journal of Pharmacology and Experimental Therapeutics. 350:153-163
مصطلحات موضوعية: Cyclopropanes, Male, medicine.drug_class, Central nervous system, Drug Evaluation, Preclinical, Aminopyridines, Pharmacology, Anxiolytic, PDE4B, Therapeutic index, medicine, Animals, Adverse effect, Nootropic Agents, Rolipram, Roflumilast, Cerebral Cortex, Inflammation, Oxadiazoles, Behavior, Animal, business.industry, Ferrets, Phosphodiesterase, Callithrix, Cyclic Nucleotide Phosphodiesterases, Type 4, Rats, Isoenzymes, Macaca fascicularis, Thiazoles, medicine.anatomical_structure, Anti-Anxiety Agents, Benzamides, Pica, Molecular Medicine, Phosphodiesterase 4 Inhibitors, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec1494680d1840df35a21a219888b5f
https://doi.org/10.1124/jpet.114.214155 -
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المؤلفون: T. Gregg Davis
المصدر: Current Protocols in Neuroscience
مصطلحات موضوعية: 0301 basic medicine, Vomiting, Drug Evaluation, Preclinical, Pharmacology, Bioinformatics, 03 medical and health sciences, Eating, 0302 clinical medicine, Therapeutic index, Test article, medicine, Animals, Pica (disorder), Adverse effect, Behavior, Animal, business.industry, General Medicine, Feeding Behavior, Gastrointestinal Contents, Rats, 030104 developmental biology, Models, Animal, Pica, medicine.symptom, Vomiting reflex, business, 030217 neurology & neurosurgery
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المؤلفون: A. Dale Wright, Laura L. Carter, Mark C. Munson, Robinson John E, Shelley Allen, Leila J. Jackson, T. Gregg Davis, Tracy Pheneger, Pheneger Jed
المصدر: Cellular Immunology. 272:200-213
مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Cell Survival, T cell, Immunology, Apoptosis, Cell Growth Processes, Mice, SCID, Lymphocyte Activation, Resting Phase, Cell Cycle, p38 Mitogen-Activated Protein Kinases, Serine, Mice, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, medicine, Animals, Humans, Cytotoxic T cell, Kinase activity, Protein Kinase Inhibitors, Janus Kinases, Mice, Inbred BALB C, biology, Effector, Kinase, G1 Phase, Cell Differentiation, Cell Cycle Checkpoints, Inflammatory Bowel Diseases, MAP Kinase Kinase Kinases, Mice, Inbred C57BL, medicine.anatomical_structure, Mitogen-activated protein kinase, Cancer research, biology.protein, Cytokines, G1 phase, Signal Transduction
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المؤلفون: Joanne O. Wiseman, Richard G. Knowles, Patricia L. Podolin, Doug Ball, Jen-Pyng Kou, Fiona S. Lucas, Paul Bryan Wren, John J. Peterson, Mary S. Barnette, Livia Ferrari, T. Gregg Davis, Richard A. Williamson, Anthony T. Nials, Elizabeth A. Capper-Spudich, Yemisi E. Solanke
المصدر: Journal of Pharmacology and Experimental Therapeutics. 330:922-931
مصطلحات موضوعية: Pharmacology, Chemistry, Cilomilast, Peripheral blood mononuclear cell, Neutrophilia, Therapeutic index, In vivo, medicine, Molecular Medicine, Potency, medicine.symptom, Roflumilast, Rolipram, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ab5d6de430cda26fe55b15cd754bffd6
https://doi.org/10.1124/jpet.109.152454 -
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المؤلفون: Michael S. McQueney, Roy A. Johanson, Elizabeth A. Capper-Spudich, Josephine H. Fox, Patricia L. Podolin, John J. Peterson, Robert W. Marquis, Edit Kurali, T. Gregg Davis, Dennis S. Yamashita, Stephen M. LoCastro, Gerald J. Terfloth, Brian R. Smith, Donald C. Carpenter, Edward Long, Xiaoyang Dong, Brian Bolognese
المصدر: The Journal of Immunology. 180:7989-8003
مصطلحات موضوعية: Male, Encephalomyelitis, Autoimmune, Experimental, Pyridines, Encephalomyelitis, T cell, Immunology, Cysteine Proteinase Inhibitors, Lymphocyte Activation, Mice, Antigen, Leucine, Cell Line, Tumor, MHC class I, medicine, Splenocyte, Animals, Humans, Immunology and Allergy, Collagen Type II, Cells, Cultured, Benzofurans, Mice, Knockout, biology, Chemistry, Experimental autoimmune encephalomyelitis, Histocompatibility Antigens Class II, Azepines, medicine.disease, Arthritis, Experimental, Cathepsins, Molecular biology, Raji cell, Antigens, Differentiation, B-Lymphocyte, Mice, Inbred C57BL, medicine.anatomical_structure, Mice, Inbred DBA, Cell culture, biology.protein, Cattle, Female, Protein Processing, Post-Translational, Spleen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88df259ac244132f833d3d9196e414fd
https://doi.org/10.4049/jimmunol.180.12.7989 -
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المؤلفون: James F. Callahan, Yue H. Li, T. Gregg Davis, Amy K. Roshak, Karey Carlson, Geoff W. Mellor, Brian Bolognese, Patricia L. Podolin, Christopher J. Evans
المصدر: Journal of Pharmacology and Experimental Therapeutics. 312:373-381
مصطلحات موضوعية: Lipopolysaccharides, Male, T-Lymphocytes, T cell, Arthritis, Thiophenes, IκB kinase, Protein Serine-Threonine Kinases, Pharmacology, Binding, Competitive, Monocytes, Proinflammatory cytokine, Etanercept, Mice, Adenosine Triphosphate, In vivo, Animals, Humans, Medicine, Anti-Asthmatic Agents, Cell Proliferation, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Interleukin-8, NF-kappa B, Transcription Factor RelA, medicine.disease, Amides, Arthritis, Experimental, I-kappa B Kinase, Disease Models, Animal, medicine.anatomical_structure, Mice, Inbred DBA, Immunology, Cytokines, Molecular Medicine, Tumor necrosis factor alpha, Collagen, Chemokines, business, Ex vivo, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2360a1ec8f54029b9ca7466b697e43
https://doi.org/10.1124/jpet.104.074484 -
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المؤلفون: T Gregg, Davis, John J, Peterson, Jen-Pyng, Kou, Elizabeth A, Capper-Spudich, Doug, Ball, Anthony T, Nials, Joanne, Wiseman, Yemisi E, Solanke, Fiona S, Lucas, Richard A, Williamson, Livia, Ferrari, Paul, Wren, Richard G, Knowles, Mary S, Barnette, Patricia L, Podolin
المصدر: The Journal of pharmacology and experimental therapeutics. 330(3)
مصطلحات موضوعية: Cyclopropanes, Lipopolysaccharides, Cyclohexanecarboxylic Acids, Neutrophils, Phosphodiesterase Inhibitors, Pyridines, Tumor Necrosis Factor-alpha, Vomiting, Carboxylic Acids, Ferrets, Aminopyridines, Piperazines, Rats, Mice, Inbred C57BL, Mice, Rats, Inbred Lew, Receptors, Adrenergic, alpha-2, Benzamides, Nitriles, Pica, Animals, Humans, Phosphodiesterase 4 Inhibitors, Rolipram
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1a0c09708dbb0eab1b245cd28dcd32ed
https://pubmed.ncbi.nlm.nih.gov/19498103