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1
المؤلفون: Yuanjin Zhang, Yuanqing Guo, Yeye Xu, Jie Liu, Jian Lu, Xin Wang
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2973-2982 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NCBI, National Center for Biotechnology Information, TALEN, transcriptional activators like effector nucleases, RNP, ribonucleoprotein, Review, Gene editing, SREBP-2, sterol regulatory element-binding protein 2, 0302 clinical medicine, AAV, adeno-associated virus, Genome editing, DDI, drug–drug interaction, CRISPR, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, HDR, homology directed repair, tracRNA, trans-activating crRNA, ADMET, absorption, distribution, metabolism, excretion and toxicity, HIV, human immunodeficiency virus, 030220 oncology & carcinogenesis, CRISPR-Cas9, OATP1B, organic anion transporting polypeptides 1B, Rat model, CRISPR-Cas, clustered regularly interspaced short palindromic repeats-CRISPR-associated, pre-crRNA, pre-CRISPR RNA, Computational biology, RM1-950, 03 medical and health sciences, Animal model, Pharmacokinetics, TALE, transcriptional activator-like effector, ZFN, zinc finger nucleases, DSB, double-strand break, PAM, protospacer-associated motif, Gene knockout, BSEP, bile salt export pump, 030304 developmental biology, Drug metabolism, KO, knockout, Mechanism (biology), sgRNA, single guide RNA, crRNAs, CRISPR RNAs, WT, wild-type, HBV, hepatitis B virus, T7E I, T7 endonuclease I, NHEJ, non-homologous end joining, SD, Sprague–Dawley, OTS, off-target site, DMPK, drug metabolism and pharmacokinetics, Therapeutics. Pharmacology, HPV, human papillomaviruses
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2
المؤلفون: Jian Lu, Xinrun Ma, Xin Wang, Xuan Qin, Mingyao Liu, Xuyang Shang
المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 850-860 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: WT, wild type, Knockout rat, SLC, solute carrier, BUN, blood urea nitrogen, HMG, hydroxymethylglutaryl, PMSG, pregnant mare serum gonadotropin, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Endogeny, GLB, globulin, AST, aspartate aminotransferase, DMSO, dimethyl sulfoxide, Rotor syndrome, IS, internal standard solution, HDL-C, high density lipoprotein cholesterol, chemistry.chemical_compound, 0302 clinical medicine, MC, methylcellulose, DDI, drug–drug interaction, HCG, human chorionic gonadotropin, TBL, total bilirubin, General Pharmacology, Toxicology and Pharmaceutics, AUC, the area under the time–plasma concentration curve, OATP1B1/3, organic anion transporting polypeptide 1B1 and 1B3, Chr, chromosome, p.o., peroral, TBA, total bile acid, 0303 health sciences, CL/F, clearance/bioavailability, ADRs, adverse drug reactions, A/G, albumin/globulin ratio, ZFN, zinc-finger nucleases, biology, TG, triglyceride, OATP1B2, OATPs, organic anion transporting polypeptides, GLU, glucose, HRP, horseradish peroxidase, TP, total protein, CR, reatinine, DBL, direct bilirubin, UA, uric acid, Organic anion-transporting polypeptide, Biochemistry, Cmax, peak concentration, CRISPR, clustered regularly interspaced short palindromic repeats, 030220 oncology & carcinogenesis, SNPs, single nucleotide polymorphisms, Rat model, R-GT, γ-glutamyltranspeptidase, MRT, mean residence time, NC, nitrocellulose, LDL-C, low density lipoprotein cholesterol, Vd/F, the apparent volume of distribution/bioavailability, medicine.drug, Original article, IBIL, indirect bilirubin, Bilirubin, crRNA, mature CRISPR RNA, Transporter, FDA, the U.S. Food and Drug Administration, TBST, Tris-buffered saline Tween 20, 03 medical and health sciences, Pharmacokinetics, OATP1B1/3, ALT, alanine aminotransferase, TALEN, transcription activator-like effector nuclease, medicine, PAM, protospacer adjacent motif, Tmax, peak time, Pitavastatin, ALB, albumin, CRISPR/Cas9, 030304 developmental biology, HE, haemotoxylin and eosin, KO, knockout, ALP, alkaline phosphatase, DAB, 3,3′-diaminobenzidine, lcsh:RM1-950, sgRNA, single guide RNA, T-CH, total cholesterol, medicine.disease, HZ, heterozygous, lcsh:Therapeutics. Pharmacology, chemistry, T7E I, T7 endonuclease I, SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, biology.protein, SD, Sprague–Dawley, Ugt1a1, UDP glucuronosyltransferase family 1 member A1
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3دورية أكاديمية
المؤلفون: Lu J; Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China., Liu J; Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China., Guo Y; Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China., Zhang Y; Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China., Xu Y; Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China., Wang X; Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Oct; Vol. 11 (10), pp. 2973-2982. Date of Electronic Publication: 2021 Jan 07.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE
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4دورية أكاديمية
المؤلفون: Ma X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China., Shang X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China., Qin X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China., Lu J; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China., Liu M; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China., Wang X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 May; Vol. 10 (5), pp. 850-860. Date of Electronic Publication: 2019 Nov 14.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE