المؤلفون: L Megret, B Gris, S Sasidharan Nai, J Cevost, M Wertz, J Aaronson, J Rosinski, TF Vogt, H Wilkinson, M Heiman, C Neri

المصدر: A: Pathogenic mechanisms.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e20be618a1ea14aadbcb646da472cd2d
https://doi.org/10.1136/jnnp-2022-ehdn.39

المؤلفون: Bragg RM; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA., Coffey SR; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA., Cantle JP; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA., Hu S; School of Medicine, Tsinghua University, Beijing, China.; Division of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Singh S; Division of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Legg SR; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA., McHugh CA; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA., Toor A; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA., Zeitlin SO; https://ror.org/0153tk833 Department of Neuroscience, University of Virginia, Charlottesville, VA, USA., Kwak S; CHDI Foundation, Princeton, NJ, USA., Howland D; CHDI Foundation, Princeton, NJ, USA., Vogt TF; CHDI Foundation, Princeton, NJ, USA., Monga SP; Division of Experimental Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh Medical Center and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Carroll JB; Behavioral Neuroscience Program, Department of Psychology, Western Washington University, Bellingham, WA, USA jeffcarr@uw.edu.; https://ror.org/00cvxb145 Department of Neurology, University of Washington, Seattle, WA, USA.

المصدر: Life science alliance [Life Sci Alliance] 2023 Sep 08; Vol. 6 (11). Date of Electronic Publication: 2023 Sep 08 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

مواضيع طبية MeSH: Liver* , Hepatocytes*, Animals ; Mice ; Acetaminophen ; Phenotype

المؤلفون: Wang N; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Langfelder P; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Stricos M; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Ramanathan L; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Richman JB; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Vaca R; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Plascencia M; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Gu X; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Zhang S; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Tamai TK; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Zhang L; Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Gao F; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Ouk K; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Lu X; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Ivanov LV; Rancho Biosciences LLC, San Diego, CA, USA., Vogt TF; CHDI Management /CHDI Foundation, Princeton, NJ, USA., Lu QR; Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Morton AJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Colwell CS; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; UCLA Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA., Aaronson JS; CHDI Management /CHDI Foundation, Princeton, NJ, USA., Rosinski J; CHDI Management /CHDI Foundation, Princeton, NJ, USA., Horvath S; Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA., Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: xwyang@mednet.ucla.edu.

المصدر: Neuron [Neuron] 2022 Oct 19; Vol. 110 (20), pp. 3318-3338.e9.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE

مواضيع طبية MeSH: Transcriptome* , Huntington Disease*/genetics, Animals ; Mice ; Protein Kinase C-theta/genetics ; Gene Regulatory Networks ; Brain

المؤلفون: Macabuag N; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Esmieu W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Breccia P; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Jarvis R; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Blackaby W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Lazari O; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Urbonas L; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Eznarriaga M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Williams R; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Strijbosch A; Charles River, Darwinweg 24, Leiden 2333 CR, The Netherlands., Van de Bospoort R; Charles River, Darwinweg 24, Leiden 2333 CR, The Netherlands., Matthews K; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clissold C; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Ladduwahetty T; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Vater H; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Heaphy P; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States., Stafford DG; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States., Wang HJ; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States., Mangette JE; Curia, The Conventus Building, 1001 Main Street, Buffalo, New York 14203, United States., McAllister G; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Beaumont V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Vogt TF; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Wilkinson HA; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Doherty EM; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Sep 22; Vol. 65 (18), pp. 12445-12459. Date of Electronic Publication: 2022 Sep 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylases*/metabolism , Huntington Disease*/genetics, Animals ; Disease Models, Animal ; Drug Development ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism ; Mice ; Neurons/metabolism ; Proteolysis ; Ubiquitins

المؤلفون: Iennaco R; Department of Biosciences, University of Milan, 20122, Milan, Italy.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Formenti G; Department of Biosciences, University of Milan, 20122, Milan, Italy.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Trovesi C; Department of Biosciences, University of Milan, 20122, Milan, Italy.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Rossi RL; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Zuccato C; Department of Biosciences, University of Milan, 20122, Milan, Italy.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Lischetti T; Department of Biosciences, University of Milan, 20122, Milan, Italy.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Bocchi VD; Department of Biosciences, University of Milan, 20122, Milan, Italy.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Scolz A; Department of Biosciences, University of Milan, 20122, Milan, Italy.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Martínez-Labarga C; Department of Biology, University of Roma Tor Vergata, 00173, Rome, Italy., Rickards O; Department of Biology, University of Roma Tor Vergata, 00173, Rome, Italy., Pacifico M; Department of Biosciences, University of Milan, 20122, Milan, Italy.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy., Crottini A; CIBIO, Research Centre in Biodiversity and Genetic Resources, InBIO, Universidade do Porto, 4485-661, Vairão, Portugal., Møller AP; Ecologie Systématique Evolution, Université Paris-Sud, CNRS, Agro ParisTech, Université Paris-Saclay, 91405, Orsay, CEDEX, France., Chen RZ; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Vogt TF; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Pavesi G; Department of Biosciences, University of Milan, 20122, Milan, Italy., Horner DS; Department of Biosciences, University of Milan, 20122, Milan, Italy., Saino N; Department of Environmental Science and Policy, University of Milan, 20133, Milan, Italy., Cattaneo E; Department of Biosciences, University of Milan, 20122, Milan, Italy. elena.cattaneo@unimi.it.; Istituto Nazionale Genetica Molecolare, Romeo ed Enrica Invernizzi, 20122, Milan, Italy. elena.cattaneo@unimi.it.

المصدر: Cell death and differentiation [Cell Death Differ] 2022 Feb; Vol. 29 (2), pp. 293-305. Date of Electronic Publication: 2022 Jan 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/pathology , Peptides*/genetics , Peptides*/metabolism, Animals ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism ; Mice ; Neurons/metabolism

المؤلفون: Megret L; Sorbonne Université, Centre National de la Recherche Scientifique UMR 8256, INSERM ERL U1164, Paris, France., Gris B; Sorbonne Université, Centre National de la Recherche Scientifique, Laboratoire Jacques-Louis Lyons (LJLL), Paris, France., Sasidharan Nair S; Sorbonne Université, Centre National de la Recherche Scientifique UMR 8256, INSERM ERL U1164, Paris, France., Cevost J; Sorbonne Université, Centre National de la Recherche Scientifique UMR 8256, INSERM ERL U1164, Paris, France., Wertz M; MIT, Broad Institute, MIT, Picower Institute for Learning and Memory, Cambridge, United States., Aaronson J; CHDI Foundation, Princeton, United States., Rosinski J; CHDI Foundation, Princeton, United States., Vogt TF; CHDI Foundation, Princeton, United States., Wilkinson H; CHDI Foundation, Princeton, United States., Heiman M; MIT, Broad Institute, MIT, Picower Institute for Learning and Memory, Cambridge, United States., Neri C; Sorbonne Université, Centre National de la Recherche Scientifique UMR 8256, INSERM ERL U1164, Paris, France.

المصدر: ELife [Elife] 2021 Feb 23; Vol. 10. Date of Electronic Publication: 2021 Feb 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Mutation* , Proteostasis*, Huntingtin Protein/*genetics , Huntington Disease/*genetics, Animals ; Disease Models, Animal ; Female ; Huntingtin Protein/metabolism ; Male ; Mice

المؤلفون: Aaronson J; CHDI Management/CHDI Foundation, Princeton, NJ, USA., Beaumont V; CHDI Management/CHDI Foundation, Princeton, NJ, USA., Blevins RA; Bridlewood Consulting LLC, Flower Mound, TX, USA., Andreeva V; Rancho Biosciences LLC, San Diego, CA, USA., Murasheva I; Rancho Biosciences LLC, San Diego, CA, USA., Shneyderman A; Rancho Biosciences LLC, San Diego, CA, USA., Armah K; Rancho Biosciences LLC, San Diego, CA, USA., Gill R; Rancho Biosciences LLC, San Diego, CA, USA., Chen J; CHDI Management/CHDI Foundation, Princeton, NJ, USA., Rosinski J; CHDI Management/CHDI Foundation, Princeton, NJ, USA., Park LC; CHDI Management/CHDI Foundation, Princeton, NJ, USA., Coppola G; Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA., Munoz-Sanjuan I; CHDI Management/CHDI Foundation, Princeton, NJ, USA., Vogt TF; CHDI Management/CHDI Foundation, Princeton, NJ, USA.

المصدر: Journal of Huntington's disease [J Huntingtons Dis] 2021; Vol. 10 (3), pp. 405-412.

نوع المنشور: Letter; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101589965 Publication Model: Print Cited Medium: Internet ISSN: 1879-6400 (Electronic) Linking ISSN: 18796397 NLM ISO Abbreviation: J Huntingtons Dis Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/genetics, Humans

المؤلفون: Lu AT; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA., Narayan P; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, 1010, New Zealand., Grant MJ; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, 1010, New Zealand., Langfelder P; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA., Wang N; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA., Kwak S; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Wilkinson H; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Chen RZ; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Chen J; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Simon Bawden C; Livestock and Farming Systems, South Australian Research and Development Institute, Roseworthy, SA, 5371, Australia., Rudiger SR; Livestock and Farming Systems, South Australian Research and Development Institute, Roseworthy, SA, 5371, Australia., Ciosi M; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Chatzi A; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Maxwell A; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Hore TA; Department of Anatomy, University of Otago, Dunedin, 9016, New Zealand., Aaronson J; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Rosinski J; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Preiss A; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Vogt TF; CHDI Management/CHDI Foundation, Princeton, NJ, 08540, USA., Coppola G; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA., Monckton D; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK., Snell RG; Applied Translational Genetics Group, School of Biological Sciences, Centre for Brain Research, The University of Auckland, Auckland, 1010, New Zealand., William Yang X; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA., Horvath S; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. shorvath@mednet.ucla.edu.; Department of Biostatistics, School of Public Health, University of California, Los Angeles, Los Angeles, CA, 90095, USA. shorvath@mednet.ucla.edu.

المصدر: Nature communications [Nat Commun] 2020 Sep 10; Vol. 11 (1), pp. 4529. Date of Electronic Publication: 2020 Sep 10.

نوع المنشور: Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation* , Epigenesis, Genetic*, Huntingtin Protein/*genetics , Huntington Disease/*genetics, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Animals, Genetically Modified ; Behavior, Animal ; CpG Islands/genetics ; Cross-Sectional Studies ; Disease Models, Animal ; Disease Progression ; Female ; Follow-Up Studies ; Gene Knock-In Techniques ; Genetic Loci ; Genome-Wide Association Study ; Global Burden of Disease ; Humans ; Huntington Disease/blood ; Huntington Disease/diagnosis ; Huntington Disease/epidemiology ; Longitudinal Studies ; Male ; Mice ; Middle Aged ; Mutation ; Prospective Studies ; Recombinant Proteins/genetics ; Registries/statistics & numerical data ; Severity of Illness Index ; Sheep ; Young Adult

المؤلفون: Cariulo C; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy., Verani M; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy., Martufi P; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy., Ingenito R; Peptide Chemistry Unit, IRBM S.p.A., Via Pontina Km 30 600, 00071, Pomezia, Rome, Italy., Finotto M; Peptide Chemistry Unit, IRBM S.p.A., Via Pontina Km 30 600, 00071, Pomezia, Rome, Italy., Deguire SM; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Station 19, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Lavery DJ; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Toledo-Sherman L; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Lee R; CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA. Electronic address: ramee.lee@chdifoundation.org., Doherty EM; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Vogt TF; CHDI Management/CHDI Foundation, Princeton, NJ 08540, USA., Dominguez C; CHDI Management/CHDI Foundation, Los Angeles, CA, 90045, USA., Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Station 19, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland., Petricca L; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy., Caricasole A; Department of Neuroscience, IRBM S.p.A, Via Pontina Km 30.600, 00071, Pomezia, Rome, Italy.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jan 15; Vol. 521 (3), pp. 549-554. Date of Electronic Publication: 2019 Oct 31.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Huntingtin Protein/*analysis, Animals ; Cells, Cultured ; Gene Knock-In Techniques ; HEK293 Cells ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/genetics ; Mice ; Mutation ; Neurons/chemistry ; Neurons/metabolism ; Phosphorylation ; Protein Aggregates ; Protein Processing, Post-Translational

المؤلفون: Turcot V; Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada., Lu Y; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Highland HM; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.; Human Genetics Center, University of Texas School of Public Health, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA., Schurmann C; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Justice AE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Fine RS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA., Bradfield JP; Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Quantinuum Research, LLC, San Diego, CA, USA., Esko T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Giri A; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Guo X; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Hendricks AE; Wellcome Trust Sanger Institute, Hinxton, UK.; Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA., Karaderi T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus., Lempradl A; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Locke AE; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Sivapalaratnam S; Department of Vascular Medicine, AMC, Amsterdam, the Netherlands.; Massachusetts General Hospital, Boston, MA, USA.; Department of Haematology, University of Cambridge, Cambridge, UK., Young KL; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Alfred T; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Masca NGD; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK., Manning AK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA., Medina-Gomez C; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Mudgal P; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA., Ng MCY; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Vedantam S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA., Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Aben KK; Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands.; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Alam DS; School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada., Alharthi SE; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Allison M; Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA., Amouyel P; INSERM U1167, Lille, France.; Institut Pasteur de Lille, U1167, Lille, France.; Université de Lille, U1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France., Asselbergs FW; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK., Auer PL; Zilber School of Public Health, University of Wisconsin- Milwaukee, Milwaukee, WI, USA., Balkau B; INSERM U1018, Centre de Recherche en Épidémiologie et Santé des Populations (CESP), Villejuif, France., Bang LE; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Barroso I; Wellcome Trust Sanger Institute, Hinxton, UK.; Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Bastarache L; Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA., Benn M; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Blüher M; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Department of Medicine, University of Leipzig, Leipzig, Germany., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Boeing H; Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany., Boerwinkle E; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Bottinger EP; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bowden DW; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Breen G; MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Hospital, London, UK., Brilliant MH; Marshfield Clinic Research Institute, Marshfield, WI, USA., Broer L; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Brumat M; Department of Medical Sciences, University of Trieste, Trieste, Italy., Burt AA; Department of Medicine, University of Washington, Seattle, WA, USA., Butterworth AS; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Campbell PT; Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA., Cappellani S; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Carey DJ; Weis Center for Research, Geisinger Health System, Danville, PA, USA., Catamo E; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Chambers JC; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UK.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Chasman DI; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chen YI; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Chowdhury R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Christensen C; Medical Department, Lillebaelt Hospital, Vejle, Denmark., Chu AY; NHLBI Framingham Heart Study, Framingham, MA, USA.; Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA., Cocca M; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK., Corley J; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Galbany JC; Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands., Cox AJ; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia., Crosslin DS; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA., Cuellar-Partida G; Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., D'Eustacchio A; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Danesh J; Wellcome Trust Sanger Institute, Hinxton, UK.; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Bakker PIW; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands., Groot MCH; Department of Clinical Chemistry and Haematology, Division of Laboratory and Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands.; Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, the Netherlands., Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Demerath EW; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Heijer M; Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands., Hollander AI; Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands., Ruijter HM; Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Dennis JG; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Denny JC; Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA., Di Angelantonio E; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Drenos F; Institute of Cardiovascular Science, University College London, London, UK.; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Du M; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dubé MP; Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Edwards TL; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA., Ellinghaus D; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany., Ellinor PT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA., Elliott P; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.; Department of Health Sciences, University of Leicester, Leicester, UK., Farooqi IS; Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fauser S; Department of Ophthalmology, University of Cologne, Cologne, Germany., Feng S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Ferrannini E; CNR Institute of Clinical Physiology, Pisa, Italy.; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Ferrieres J; Toulouse University School of Medicine, Toulouse, France., Florez JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA., Ford I; University of Glasgow, Glasgow, UK., Fornage M; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Franco OH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Franke A; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden., Friedrich N; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Frikke-Schmidt R; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Galesloot TE; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Gan W; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Gandin I; Research Unit, AREA Science Park, Trieste, Italy., Gasparini P; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Gibson J; Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK., Giedraitis V; Geriatrics, Department of Public Health, Uppsala University, Uppsala, Sweden., Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gordon-Larsen P; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany., Grant SFA; Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Endocrinology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Griffiths HL; Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK., Grove ML; School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kopavogur, Iceland., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hakonarson H; Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hammerschlag AR; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Harris KM; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Sociology, University of North Carolina, Chapel Hill, NC, USA., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Have CT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., He L; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.; Department of Public Health, University of Helsinki, Helsinki, Finland., Heard-Costa NL; NHLBI Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Heath AC; Department of Psychiatry, Washington University, St. Louis, MO, USA., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Helgeland Ø; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway., Hernesniemi J; Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Hewitt AW; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia.; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia., Holmen OL; KG Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Hovingh GK; Department of Vascular Medicine, AMC, Amsterdam, the Netherlands., Howson JMM; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Hu Y; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Huang PL; Massachusetts General Hospital, Boston, MA, USA., Huffman JE; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Jansson JH; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.; Research Unit Skellefteå, Skellefteå, Sweden., Jarvik GP; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Jensen GB; Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, Denmark., Jia Y; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Johansson S; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway., Jørgensen ME; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Jørgensen T; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark.; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands., Kahali B; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.; Centre for Brain Research, Indian Institute of Science, Bangalore, India., Kahn RS; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., Kähönen M; Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Kamstrup PR; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kaprio J; Department of Public Health, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland., Karaleftheri M; Echinos Medical Centre, Echinos, Greece., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Kathiresan S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kee F; UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast, UK., Kiemeney LA; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Kim E; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Kitajima H; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Kooner JS; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UK.; Imperial College Healthcare NHS Trust, London, UK.; National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Korhonen T; Department of Public Health, University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Kovacs P; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany., Kuivaniemi H; Weis Center for Research, Geisinger Health System, Danville, PA, USA.; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland., Kuulasmaa K; National Institute for Health and Welfare, Helsinki, Finland., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lakka TA; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Lamparter D; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Lange EM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Lange LA; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK., Larson EB; Department of Medicine, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA., Lee NR; Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines.; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Lewis CE; Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Li H; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Li J; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Lin H; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Lin KH; Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan., Lin LA; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Lin X; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden., Lindström J; National Institute for Health and Welfare, Helsinki, Finland., Linneberg A; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu DJ; Department of Public Health Sciences, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA., Liu Y; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Lo KS; Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada., Lophatananon A; Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK., Lotery AJ; Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK., Loukola A; Department of Public Health, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK., Lubitz SA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Männistö S; National Institute for Health and Welfare, Helsinki, Finland., Marenne G; Wellcome Trust Sanger Institute, Hinxton, UK., Mazul AL, McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., McKean-Cowdin R; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mistry V; Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Mitchell P; Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Moilanen L; Department of Medicine, Kuopio University Hospital, Kuopio, Finland., Moitry M; Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France.; Department of Public Health, University Hospital of Strasbourg, Strasbourg, France., Montgomery GW; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Moore C; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Mori TA; School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia., Morris AD; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Großhadern, Ludwig-Maximilians-Universitat, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK., Neville M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland., Njølstad PR; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nyholt DR; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia., O'Connel JR; Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., O'Donoghue ML; Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Loohuis LMO; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Ophoff RA; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Packard CJ; University of Glasgow, Glasgow, UK., Padmanabhan S; University of Glasgow, Glasgow, UK., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Pasterkamp G; Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; Laboratory of Clinical Chemistry and Hematology, Division of Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, the Netherlands., Patel AP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Pattie A; Department of Psychology, University of Edinburgh, Edinburgh, UK., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Peissig PL; Marshfield Clinic Research Institute, Marshfield, WI, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Pennell CE; School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia., Perola M; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; National Institute for Health and Welfare, Helsinki, Finland.; Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland., Perry JA; Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Person TN; Marshfield Clinic Research Institute, Marshfield, WI, USA., Peters A; German Center for Diabetes Research, Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Petersen ERB; Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Pirie A; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Polasek O; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; School of Medicine, University of Split, Split, Croatia., Polderman TJ; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands., Puolijoki H; Central Hospital of Southern Ostrobothnia, Seinäjoki, Finland., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Rasheed A; Centre for Non-Communicable Diseases, Karachi, Pakistan., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland., Reilly DF; Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden.; Department of Biobank Research, Umeå University, Umeå, Sweden., Rheinberger M; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Rioux JD; Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Rivas MA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Roberts DJ; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant-Oxford Centre, Oxford, UK.; BRC Haematology Theme and Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Robertson NR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Robino A; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, Sweden., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Ruth KS; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Saleheen D; Centre for Non-Communicable Diseases, Karachi, Pakistan.; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK., Sapkota Y; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Sattar N; University of Glasgow, Glasgow, UK., Schoen RE; Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Schreiner PJ; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK., Segura-Lepe MP; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Shah SH; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore., Slater AJ; Genetics, Target Sciences, GlaxoSmithKline, Research Triangle Park, NC, USA.; OmicSoft at Qiagen Company, Cary, NC, USA., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Smith AV; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Icelandic Heart Association, Kopavogur, Iceland., Southam L; Wellcome Trust Sanger Institute, Hinxton, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Speliotes EK; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK., Stefansson K; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Steinthorsdottir V; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Stirrups KE; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Stumvoll M; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Department of Medicine, University of Leipzig, Leipzig, Germany., Sun L; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA.; Department of Public Health, University of Helsinki, Helsinki, Finland., Surendran P; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA., Tada H; Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Kanazawa University, Kanazawa, Japan., Tansey KE; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.; College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK., Tardif JC; Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada., Taylor KD; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Thorleifsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Thorsteinsdottir U; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Thuesen BH; Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark., Tönjes A; Center for Pediatric Research, Department for Women's and Child Health, University of Leipzig, Leipzig, Germany., Tromp G; Weis Center for Research, Geisinger Health System, Danville, PA, USA.; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Tsafantakis E; Anogia Medical Centre, Anogia, Greece., Tuomilehto J; National Institute for Health and Welfare, Helsinki, Finland.; Centre for Vascular Prevention, Danube University Krems, Krems, Austria.; Dasman Diabetes Institute, Dasman, Kuwait.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Tybjaerg-Hansen A; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Tyrer JP; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Uher R; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Laan SW; Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Leeuwen N; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands.; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands., van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands., Vanhala M; Primary Health Care Unit, Central Hospital of Central Finland, Jyväskylä, Finland.; Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland., Varbo A; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden., Varma R; USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA., Edwards DRV; Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA., Vermeulen SH; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands., Veronesi G; Research Center on Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Vogt TF; Cardiometabolic Disease, Merck, Sharp & Dohme, Kenilworth, NJ, USA., Völker U; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Vuckovic D; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Wagenknecht LE; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Walker M; Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle, UK., Wallentin L; Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden., Wang F; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Wang CA; School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Wang Y; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Ware EB; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Waterworth DM; Genetics, Target Sciences, GlaxoSmithKline, King of Prussia, PA, USA., Wessel J; Departments of Epidemiology and Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health and School of Medicine, Indiana University, Indianapolis, IN, USA., White HD; Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand., Willer CJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Witte DR; Danish Diabetes Academy, Odense, Denmark.; Department of Public Health, Aarhus University, Aarhus, Denmark., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Yao J; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Yao P; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China., Yerges-Armstrong LM; Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; GlaxoSmithKline, King of Prussia, PA, USA., Young R; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; University of Glasgow, Glasgow, UK., Zeggini E; Wellcome Trust Sanger Institute, Hinxton, UK., Zhan X; Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA., Zhang W; Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UK.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK., Zhao W; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Zondervan KT; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Endometriosis CaRe Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK., Rotter JI; Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA., Pospisilik JA; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Borecki IB; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Lettre G; Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., North KE; Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, NC, USA., Lindgren CM; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK., Hirschhorn JN; Broad Institute of MIT and Harvard, Cambridge, MA, USA. joelh@broadinstitute.org.; Department of Genetics, Harvard Medical School, Boston, MA, USA. joelh@broadinstitute.org.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA. joelh@broadinstitute.org.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. joelh@broadinstitute.org., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@mssm.edu.; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@mssm.edu.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@mssm.edu.

مؤلفون مشاركون: CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Understanding Society Scientific Group

المصدر: Nature genetics [Nat Genet] 2019 Jul; Vol. 51 (7), pp. 1191-1192.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: PubMed not MEDLINE