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المؤلفون: Po Hu, Hongzheng Wang, Xiaoxuan Yu, Wenzhuo Sun, Hui Hui, Hui Li, Mengyuan Zhu, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Yingjie Qing
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3178-3192 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NPC, Niemann-Pick type disease C, Cathepsin D, ATG, autophagy related, NH4Cl, ammonium chloride, Lysosomal damage, Calcium in biology, Hematological malignancies, 0302 clinical medicine, RAB7A, RAS-related protein RAB-7a, K48, lysine 48, LC3, microtubule-associated protein 1 light chain 3, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, RT-qPCR, real time quantitative PCR, Chemistry, LCD, lysosome-dependent cell death, CaN, calcineurin, P62/SQSTM1, sequestosome 1, Cell biology, TRPML1, transient receptor potential mucolipin 1, medicine.anatomical_structure, Cholesterol, 030220 oncology & carcinogenesis, shRNA, short hairpin RNA, Original Article, CsA, cyclosporine A, DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride, Programmed cell death, AO, acridine orange, CTSD, cathepsin D, LW-218, PBS, phosphate-buffered saline, CTSB, cathepsin B, LMP, lysosome membrane permeabilization, EGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid, RM1-950, Lysosome-dependent cell death, 03 medical and health sciences, Dex, dexamethasone, ROS, reactive oxygen species, FBS, fetal bovine serum, Lysosome, NPC1, NPC intracellular cholesterol transporter 1, medicine, BAF A1, bafilomycin A1, 030304 developmental biology, Cathepsin, PBMCs, peripheral blood mononuclear cells, Lysosomal membrane permeabilization, K63, lysine 63, Cell growth, DCFH-DA, 2,7-dichlorodi-hydrofluorescein diacetate, Autophagy, BID, BH3-interacting domain death agonist, Lysophagy, OD, optical density, TFEB, CCK8, Cell Counting Kit, Therapeutics. Pharmacology, LAMPs, lysosomal-associated membrane proteins
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المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2
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المؤلفون: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)مصطلحات موضوعية: LOX1, lectin-like oxidized LDL receptor 1, BUN, blood urea nitrogen, TGBM, thickness of glomerular basement membrane, NQO1, NAD(P)H:quinone oxidoreductase 1, STAT, signal transducers and activators of transcription, N/O, not observed, p62, sequestosome 1 protein, p-IRS1, phospho-IRS1, Review, NOX-4, nicotinamide adenine dinucleotide phosphate-oxidase-4, OCP, oxidative carbonyl protein, Traditional Chinese medicine, AGEs, advanced glycation end-products, N/A, not applicable, TRAF5, tumor-necrosis factor receptor-associated factor 5, Health problems, 0302 clinical medicine, ESRD, end-stage renal disease, LDL, low-density lipoprotein, BMP-7, bone morphogenetic protein-7, TGFβR-I/II, TGF-β receptor I/II, Medicine, P70S6K, 70-kDa ribosomal protein S6 kinase, General Pharmacology, Toxicology and Pharmaceutics, SOCS, suppressor of cytokine signaling proteins, HO-1, heme oxygenase-1, 0303 health sciences, TG, triglyceride, BW, body weight, HDL-C, high density lipoprotein-cholesterol, RASI, renin-angiotensin system inhibitor, ATK, protein kinase B, TBARS, thiobarbituric acid-reactive substance, BCL-XL, B-cell lymphoma-extra large, Gαq, Gq protein alpha subunit, GCK, glucokinase, PI3K, phosphatidylinositol 3 kinases, Systematic review, TLR-2/4, toll-like receptor 2/4, IR, insulin receptor, PERK, protein kinase RNA-like eukaryotic initiation factor 2A kinase, 030220 oncology & carcinogenesis, CRP, C-reactive protein, IRS, insulin receptor substrate, AM, mesangial area, JAK, Janus kinase, FBG, fasting blood glucose, ETAR, endothelium A receptor, LDL-C, low density lipoprotein-cholesterol, CD2AP, CD2-associated protein, eIF2α, eukaryotic initiation factor 2α, RM1-950, mTOR, mammalian target of rapamycin, CHOP, C/EBP homologous protein, STZ, streptozotocin, 03 medical and health sciences, ADE, adverse event, PKC, protein kinase C, LC3, microtubule-associated protein light chain 3, ORP150, 150-kDa oxygen-regulated protein, PGE2, prostaglandin E2, IL-1β/6, interleukin 1β/6, Diabetic kidney disease, IGF-1, insulin-like growth factor 1, EP, E-prostanoid receptor, FN, fibronectin, eGFR, estimated GFR, MDA, malondialdehyde, Chinese medicine, MMP-2, matrix metallopeptidase 2, XBP-1, spliced X box-binding protein 1, TGF-β, tumor growth factor β, GRB 10, growth factor receptor-bound protein 10, medicine.disease, Clinical trial, GRP78, glucose-regulated protein 78, UP, urinary protein, IGF-1R, insulin-like growth factor 1 receptor, ACEI, angiotensin-converting enzyme inhibitor, BCL-2, B-cell lymphoma 2, EMT, epithelial-to-mesenchymal transition, MAPK, mitogen-activated protein kinase, MYD88, myeloid differentiation primary response 88, PBG, postprandial blood glucose, RCT, randomized clinical trial, N/R, not reported, COL-I/IV, collagen I/IV, PINK1, PTEN-induced putative kinase 1, UACR, urinary albumin to creatinine ratio, C, control group, Diabetic nephropathy, GPX, glutathione peroxidase, ICAM-1, intercellular adhesion molecule-1, Bioinformatics, VCAM-1, vascular cell adhesion molecule-1, AMPKα, adenosine monophosphate-activated protein kinase α, DM, diabetes mellitus, TFEB, transcription factor EB, TNF-α, tumor necrosis factor α, Molecular target, IKK-β, IκB kinase β, Signaling pathway, GLUT4, glucose transporter type 4, BAX, BCL-2-associated X protein, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, PARP, poly(ADP-Ribose) polymerase, SMURF-2, SMAD ubiquitination regulatory factor 2, AREs, antioxidant response elements, MD, mean difference, SMAD, small mothers against decapentaplegic, MCP-1, monocyte chemotactic protein-1, VEGF, vascular endothelial growth factor, cAMP, cyclic adenosine monophosphate, ARB, angiotensin receptor blocker, PAI-1, plasminogen activator inhibitor-1, SMD, standard mean difference, JNK, c-Jun N-terminal kinase, NRF2, nuclear factor erythroid 2-related factor 2, IκB-α, inhibitory protein α, Herbal medicine, TCM, traditional Chinese medicine, DG, glomerular diameter, GSK-3, glycogen synthase kinase 3, SIRT1, sirtuin 1, D, duration, HbA1c, glycosylated hemoglobin, WMD, weight mean difference, CTGF, connective tissue growth factor, ER, endoplasmic reticulum, DN, diabetic nephropathy, ROS, reactive oxygen species, CCR, creatinine clearance rate, SOD, superoxide dismutase, Diabetes mellitus, PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α, ET-1, endothelin-1, UMA, urinary microalbumin, SCr, serum creatinine, IRE-1α, inositol-requiring enzyme-1α, 030304 developmental biology, TII, tubulointerstitial injury index, RAGE, receptors of AGE, business.industry, GFR, glomerular filtration rate, PTEN, phosphatase and tensin homolog, CI, confidence interval, TC, total cholesterol, SD-rat, Sprague–Dawley rat, UAER, urinary albumin excretion rate, DKD, diabetic kidney disease, T, treatment group, Molecular targets, Therapeutics. Pharmacology, α-SMA, α smooth muscle actin, SD, standard deviation, business, DAG, diacylglycerol, GCLC, glutamate-cysteine ligase catalytic subunit, Kidney disease
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4كتاب إلكتروني
المساهمون: Choi, Sangdun, editorAff1
المصدر: Encyclopedia of Signaling Molecules. :5373-5373
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5
المؤلفون: Dianwen Ju, Yang Hu, Wei Chen
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1347-1359 (2020)مصطلحات موضوعية: CHOP, CCAAT/enhancer binding homologous protein, Genetic enhancement, AAVs, adeno-associated viruses, BCSFB, blood–cerebrospinal fluid barrier, SMN, survival motor neuron, Review, Disease, Bioinformatics, CSF, cerebrospinal fluid, PD, Parkinson's disease, IDS, iduronate 2-sulfatase, ASOs, antisense oligonucleotides, Bip, glucose regulated protein 78, UPR, unfolded protein response, 0302 clinical medicine, Medicine, HD, Huntington's disease, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, Therapeutic strategy, GAD, glutamic acid decarboxylase, TPP1, tripeptidyl peptidase 1, 0303 health sciences, RNAi, RNA interference, SUMF, sulfatase-modifying factor, RPE, retinal pigmented epithelial, 030220 oncology & carcinogenesis, AADC, aromatic-l-amino-acid, AD, Alzheimer's disease, LVs, retrovirus/lentivirus, AD - Alzheimer's disease, GDNF, glial derived neurotrophic factor, NGF, nerve growth factor, GAA, lysosomal acid α-glucosidase, HTT, mutant huntingtin, mTOR, mammalian target of rapamycin, ARSA, arylsulfatase A, CNS, central nervous system, ER, endoplasmic reticulum, 03 medical and health sciences, Gene therapy, SOD, superoxide dismutase, TREM2, triggering receptor expressed on myeloid cells 2, ASPA, aspartoacylase, Adeno-associated viruses, 030304 developmental biology, Lamp2a, lysosomal-associated membrane protein 2a, PGRN, Progranulin, Adv, adenovirus, BRB, blood–retina barrier, PD - Parkinson's disease, CLN6, ceroidlipofuscinosis neuronal protein 6, business.industry, lcsh:RM1-950, Delivery routes, PINK1, putative kinase 1, PTEN, phosphatase and tensin homolog, RGCs, retinal ganglion cells, Clinical trial, FDA, U.S. Food and Drug Administration, SGSH, lysosomal heparan-N-sulfamidase gene, lcsh:Therapeutics. Pharmacology, Central nervous system, HSPGs, heparin sulfate proteoglycans, siRNA, small interfering RNA, Neurodegenerative disorders, business, ZFPs, zinc finger proteins, CSF - Cerebrospinal fluid
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المؤلفون: Jifa Zhang, Bo Liu, Liang Ouyang, Honggang Xiang, Congcong Lin, Lan Zhang
المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 569-581 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PINK1, PTEN-induced putative kinase 1, Review, PROTAC, proteolysis targeting chimeras, PTMs, post-translational modifications, Protein aggregation, PKCα, protein kinase C alpha type, AKT1, AKT serine/threonine kinase 1, PD, Parkinson's disease, Autophagy-related kinase, DAPK, death associated protein kinase, PKD1, polycystin-1, GAP, GTPase-activating protein, PKACα, a protein kinase cAMP-activated catalytic subunit alpha, 0302 clinical medicine, Human disease, TNBC - Triple-negative breast cancer, Protein kinases, LC3, microtubule-associated protein 1 light chain 3, UVRAG, ultraviolet resistance-associated gene, TFEB, transcription factor EB, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Rheb, the RAS homolog enriched in brain, TAK1, transforming growth factor activated kinase-1, 0303 health sciences, Kinase, mTORC1, mammalian target of rapamycin complex 1, PI3 kinase, phosphoinositide 3-kinase, Cell biology, GSK3α, glycogen synthase kinase 3 alpha, HMGB1, high mobility group protein B1, AMBRA1, autophagy/beclin-1 regulator 1, ULK complex, ULK1–mATG13–FIP200–ATG101 complex, ARF, auxin response factor gene, 030220 oncology & carcinogenesis, TSC1/2, tuberous sclerosis complex proteins 1/2, PIM2, proviral insertion in murine lymphomas 2, LPS, lipopolysaccharide, PI3P, phosphatidylinositol triphosphate, Small-molecule kinase inhibitors/activators, JNK1, C-Jun N-terminal kinase, mTOR, mammalian target of rapamycin, ULK1, unc-51-like kinase 1, Biology, PPIs, protein–protein interactions, PI, phosphatidylinositol, TNBC, triple-negative breast cancer, FIP200, FAK family kinase-interacting protein of 200 kDa, 03 medical and health sciences, 4E-BP1, eukaryotic translation initiation factor 4E-binding protein, Organelle, Autophagy, LRRK2, leucine rich repeat kinase 2, ATG, autophagy-related protein, GO, gene ontology, 030304 developmental biology, PD - Parkinson's disease, lcsh:RM1-950, CaMKK2, calcium/calmodulin-dependent protein kinase kinase 2, Human disease therapy, AMPK, AMP-activated protein kinase, lcsh:Therapeutics. Pharmacology, PIP2, phosphatidylinositol-4,5-bisphosphate, LKB1, serine/threonine-protein kinase stk11
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المؤلفون: David Hood, Jonathan Memme, Ashley Oliveira
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: p53, muscle atrophy, mitochondrial biogenesis, ATF4, activating transcription factor 4, log2FC, log2 fold change, Biochemistry, mKO, muscle-specific KO, Mice, transcriptomics, 0302 clinical medicine, GSEA, gene set enrichment analysis, PINK1, phosphatase and tensin homolog–induced kinase 1, ClpP, caseinolytic mitochondrial matrix peptidase proteolytic subunit, SirT3, sirtuin 3, TFEB, transcription factor EB, UPRmt, mitochondrial unfolded protein response, PGC-1α, peroxisome proliferator–activated receptor gamma coactivator 1 alpha, 0303 health sciences, mitochondrial quality control, EDL, extensor digitorum longus, Mitophagy, unfolded protein response, LC3, microtubule-associated proteins 1a/1b light chain 3, CtsD, cathepsin D, Denervation, MQC, mitochondrial quality control, mitochondria, Muscular Atrophy, LonP, lon protease homolog, mitochondrial, CON, control, COX, cytochrome c oxidase, SDH, succinate dehydrogenase, lysosome, HSP, heat shock protein, Research Article, DEN, denervated, REVIGO, reduce and visualize Gene Ontology, CHOP, C/EBP homologous protein, 03 medical and health sciences, cDNA, complementary DNA, ROS, reactive oxygen species, GO, Gene Ontology, Animals, skeletal muscle, Muscle, Skeletal, Molecular Biology, 030304 developmental biology, Atg, autophagy-related protein, TA, tibialis anterior, ATF5, activating transcription factor 5, Prkn, Parkin, TFE3, transcription factor E3, Cell Biology, p62, sequestosome-1, Mitochondria, Muscle, mtDNA, mitochondrial DNA, Tumor Suppressor Protein p53, qPCR, quantitative PCR, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb3a97e49a86a03392f94c39be1c648
https://pubmed.ncbi.nlm.nih.gov/34958797 -
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المؤلفون: Milana Fraiberg, Boris Macek, Zvulun Elazar, Philipp J. Kahle, Anna Lechado Terradas, Katharina Zittlau
المصدر: The Journal of Biological Chemistry
The journal of biological chemistry 297(5), 101339 (2021). doi:10.1016/j.jbc.2021.101339مصطلحات موضوعية: Mitochondrial fission factor, PTM, post-translational modification, Mitochondrial Turnover, MIM, mitochondrial inner membrane, NGLY1, N-glycanase 1, LIR, LC3-interacting region, BNIP, Bcl-2 19 kDa protein-interacting protein, Biochemistry, PD, Parkinson's disease, Mitochondrial Dynamics, DNM1L, FUNDC1, FUN14 domain-containing protein 1, USP, ubiquitin-specific protease, VPS, vacuolar sorting protein, Mitophagy, MFF, mitochondrial fission factor, TFEB, transcription factor EB, MFN, mitofusin, PARL, presenilin-associated rhomboid-like protease, HK2, hexokinase 2, OMA1, overlapping with the mitochondrial matrix ATPase associated with diverse cellular activities (m-AAA) protease 1, Chemistry, phosphorylation, SUMO, small ubiquitin-related modifier, DFCP1, double FYVE domain-containing protein 1, NBR1, next to breast cancer type 1 susceptibility gene 1 protein, DRP1, dynamin-related protein 1, Far, factor arrest, RAB, Ras-associated binding protein, MIRO, mitochondrial Rho GTPase, GCN5L1, general control of amino acid synthesis protein 5-like 1, Cell biology, BAK, Bcl-2 homologous antagonist/killer, Mitochondria, mitochondria, OPA1, optic atrophy protein 1, ddc:540, ARIH1, ariadne-1 homolog in humans, SIRT, sirtuin, Mitochondrial fission, genetics [Mitochondrial Proteins], Signal Transduction, FIS1, autophagy, WIPI, WD40 repeat protein interacting with phosphoinositides, Bcl, B cell lymphoma, TBK1, tumor necrosis factor receptor-associated factor family member associated NF-κB activator-binding kinase 1, NF-κB, nuclear factor-κB, PINK1, PINK1, phosphatase and tensin homolog (PTEN)-induced kinase 1, mTOR, mammalian target of rapamycin, metabolism [Mitochondrial Proteins], CCCP, carbonyl cyanide m-chlorophenyl hydrazone, RING, really interesting new gene, Mitochondrial Proteins, SNARE, soluble N-ethylmaleimide-sensitive factor-attachment protein receptor, ΔΨm, mitochondrial membrane potential, LC3, microtubule-associated protein light chain 3, FKBP8, FK506-binding protein 8, GABARAP, γ-amino-butyric acid receptor-associated protein, MOM, mitochondrial outer membrane, Animals, HOPS, homotypic fusion and protein sorting, ubiquitylation, ATG, autophagy-related protein, FIS1, mitochondrial fission 1 protein, Molecular Biology, gp78, glycoprotein 78, CLEAR, coordinated lysosomal expression and regulation, MGRN1, mahogunin RING finger protein 1, ULK1, uncoordinated protein 51-like kinase 1, protein kinase PINK1, JBC Reviews, BH3, Bcl-2 homology 3 domain, Ubiquitination, AMBRA1, activating molecule in beclin-1 regulated autophagy protein 1, VDAC, voltage-dependent anion selective channel, Cell Biology, metabolism [Mitochondria], HUWE1, homologous to the E6-AP carboxyl terminus (HECT), ubiquitin-associated and WWE domain-containing protein 1, FIP200, focal adhesion kinase-interacting protein of 200 kDa, BAD, Bcl-2 associated agonist of cell death, DUB, deubiquitylating enzyme, Mcl-1, induced myeloid leukemia cell differentiation protein, AMPK, AMP-activated protein kinase, PI3P, phosphatidylinositol 3-phosphate, MUL1, genetics [Mitochondria], TOM, translocase of the outer membrane, mTORC1, mTOR complex 1, Ubl, ubiquitin-like domain, MTS, mitochondrial targeting sequence, MITOL, mitochondrial ubiquitin ligase, ubiquitin ligase parkin, MUL1, mitochondrial ubiquitin ligase 1, NDP52, nuclear dot protein of 52 kDa
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbec8d603702bfc18179f4f97b4c81b
http://europepmc.org/articles/PMC8591368 -
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المؤلفون: Bin Sun, Huanmin Niu, Hong-Xiang Lou, Fang Wang, Huiqing Yuan, Qian Wang, Xiao-Tian Ji, Effat Un Nesa, Wenjian Liu, Lilin Qian, Yanhai Luo
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 923-936 (2019)مصطلحات موضوعية: BUN, blood urea nitrogen, medicine.medical_treatment, DMSO, dimethyl sulfoxide, SASP, AST, transaminase, NF-κB, Doc, docetaxel, Doxo, doxorubicin, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, chemistry.chemical_compound, 0302 clinical medicine, CI, combinatory index, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, CM, conditioned media, PGPH, peptidylglutamyl hydrolyzing, Chemistry, CDDP, cisplatin, ALT, glutamic-pyruvic transaminase, EdU, 5-ethynyl-2′-deoxyuridine, Phenotype, Sv, starvation, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Toxicity, LPS, lipopolysaccharide, medicine.drug, Original article, TCGA, the Cancer Genome Atlas, NF-κB, nuclear factor-κB, SASP, senescence-associated secretory phenotype, PI, propidium iodide, Mar-M, Marchantin M, 03 medical and health sciences, ROS, reactive oxygen species, medicine, Doxorubicin, Secretion, Fibroblast, 030304 developmental biology, TFEB, Chemotherapy, lcsh:RM1-950, fungi, Marchantin M, CREA, creatinine, lcsh:Therapeutics. Pharmacology, CT-like, both chymotrypsin-like, Drug resistance, Tg, thapsigargin, Cancer research, SA-β-gal, senescence-associated β-galactosidase
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المؤلفون: Mengru Liu, Shijia Ma, Yue Li, Anil Ahsan, Wenping Yan, Yanrong Zheng, Zhong Chen, Zhanxun Wu, Ming Cao, Xingxian Zhang, Weiwei Hu, Ling Pan, Xiangnan Zhang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1708-1720 (2021)مصطلحات موضوعية: Review, Mitochondrion, PD, Parkinson's disease, 0302 clinical medicine, FOXO, forkhead box O, Mitophagy, HD, Huntington's disease, TFEB, transcription factor EB, SQSTM1, sequestosome 1, General Pharmacology, Toxicology and Pharmaceutics, TIGAR, TP53-induced glycolysis and apoptosis regulator, Stroke, 0303 health sciences, AMPK, 5′-adenosine monophosphate-activated protein kinase, mTOR, mechanistic target of rapamycin, eIF2a, eukaryotic translation-initiation factor 2, PI3K, phosphatidylinositol 3-kinase, OGD/R, oxygen and glucose deprivation-reperfusion, Cerebral ischemia, ALS, amyotrophic lateral sclerosis, PERK, protein kinase R (PKR)-like endoplasmic reticulum kinase, Neuroprotection, Mitochondria, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, ULK, Unc-51- like kinase, AD, Alzheimer's disease, Intracellular, Programmed cell death, ATF6, activating transcription factor 6, IRE1, inositol-requiring enzyme 1, RM1-950, Natural compounds, IPC, ischemic preconditioning, ER, endoplasmic reticulum, 03 medical and health sciences, COPII, coat protein complex II, LKB1, liver kinase B1, ROS, reactive oxygen species, ΔΨm, mitochondrial membrane potential, medicine, Autophagy, Lysosomal activation, ATG, autophagy related genes, 030304 developmental biology, Uro-A, urolithin A, business.industry, FUNDC1, FUN14 domain containing 1, medicine.disease, LC3, light chain 3, GPCR, G-protein coupled receptor, BNIP3L, BCL2/adenovirus, Therapeutics. Pharmacology, LAMP, lysosomal-associated membrane protein, business, Neuroscience, Homeostasis, Neurological disorders, BCL-2, B-cell lymphoma 2
