المؤلفون: Yilin Wang, Chunmei Wang, Meiyan Liu, Wuhen Xu, Simei Wang, Fang Yuan, Xiaona Luo, Quanmei Xu, Rongrong Yin, Anqi Wang, Miao Guo, Longlong Lin, Chao Wang, Hongyi Cheng, Zhiping Liu, Yuanfeng Zhang, Fanyi Zeng, Jingbin Yan, Yucai Chen

المصدر: Frontiers in Genetics, Vol 13 (2022)

مصطلحات موضوعية: TH tyrosine hydroxylase deficiency, dopa-responsive dystonia, tyrosine hydroxylase gene, high-throughput sequencing, guanosine triphosphate cyclic hydrolase, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.1004307/full; https://doaj.org/toc/1664-8021

URL الوصول: https://doaj.org/article/b4c72c20fa7b4310acb4c5086f031a5c

المؤلفون: Chergui, Ning Yao, Olga Skiteva, Karima

المصدر: Biomolecules; Volume 13; Issue 1; Pages: 51

مصطلحات موضوعية: BAC: bacterial artificial chromosome, DA: dopaminergic, DAT: dopamine transporter, KI: knock-in, LRRK2: leucine-rich repeat kinase 2, PD: Parkinson’s disease, SNc: substantia nigra pars compacta, TH: tyrosine hydroxylase

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=multidiscipl::48087f6f72c7023e4de51552e88c65b3

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المؤلفون: Sarah R. Evans, Judith Klein-Seetharaman, Colista West

المصدر: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5348-5359 (2021)
Computational and Structural Biotechnology Journal

مصطلحات موضوعية: SIP, shared interaction partner, Amyloid, Structural similarity, pHSPB6, phosphorylated Heat Shock Protein beta-6, YWHAE, 14-3-3 protein epsilon isoform gene name, Protein domain, Biophysics, Sequence alignment, SNCA, alpha-synuclein gene name, Biochemistry, Homology (biology), Alpha-synuclein, chemistry.chemical_compound, Protein structure, Structural Biology, IDP, Intrinsically disorder protein(s), Genetics, PPI, Protein-Protein interactions, ComputingMethodologies_COMPUTERGRAPHICS, biology, BAD, BCL2 associated agonist of cell death gene name, 14-3-3 proteins, Homology, Computer Science Applications, TH, tyrosine hydroxylase gene name, chemistry, YWHAH, 14-3-3 protein eta isoform gene name, Chaperone (protein), biology.protein, Prediction, sHSP, small heat shock protein, αSyn, alpha-synuclein, MAPT, microtubule-associated protein tau gene name, Tetramer, TP248.13-248.65, Research Article, YWHAB, 14-3-3 protein beta isoform gene name, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3815ae5a59c507002487ccf613576d
https://doi.org/10.1016/j.csbj.2021.09.011

المؤلفون: A. Cota-Coronado, O.R. Hernández-Pérez, Néstor F. Díaz, Pavel H. Lugo-Fabres, N. Emmanuel Díaz-Martínez, Valeria Valadez-Barba, Eduardo Padilla-Camberos

المصدر: Regenerative Therapy, Vol 15, Iss, Pp 332-339 (2020)
Regenerative Therapy

مصطلحات موضوعية: 0301 basic medicine, Neurodegenerative diseasaes, MHC, Mayor Histocompatibility Complex, Review, Disease, BBB, Blood Brain Barrier, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Human health, 0302 clinical medicine, B-III-TUB, β–III–Tubulin, TH, Tyrosine Hydroxylase, Medicine, PCR, Polymerase Chain Reaction, Parkinson, Induced pluripotent stem cell, lcsh:R5-920, hESC, Human Embryonic Stem Cells, lcsh:Cytology, iPSCs, Induced Pluripotent Stem Cells, EBs, Embryoid Bodies, PD, Parkinson's Disease, gRNA, guide RNA, nsSNVs, nonsynonymous single nucleotide variants, DOPAL, 3,4-Dihydroxyphenylacetaldehyde, FLASH, Fast Length Adjustment of Short Reads, AD, Alzheimer's disease, lcsh:Medicine (General), Biomedical Engineering, iPSCs, WGS, Whole Genome Sequencing, Cell fate determination, AFP, Alpha-Fetoprotein, Biomaterials, 03 medical and health sciences, lcsh:QH573-671, Aβ, β-Amyloid, pTau, Phosphorylated Tau, PD - Parkinson's disease, business.industry, SCs, Stem Cells, SNPc, Substantia Nigra Pars Compacta, Disease modelling, 030104 developmental biology, LUHMES, Lund Human Mesencephalic Cell Line, Alzheimer, Personalized medicine, AFP - Alpha-fetoprotein, SMA, Smooth-Muscle Antibody, business, Neuroscience, 030217 neurology & neurosurgery, ROS, Reactive Oxygen Species, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5533df458e5d5b5603371b246a30631c
http://www.sciencedirect.com/science/article/pii/S2352320420300894

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المؤلفون: Alfredo Rodríguez-Cruz, Guadalupe García-Alcocer, Antonio Romo-Mancillas, Jesus Mendiola-Precoma, Laura C. Berumen, Jesica Escobar-Cabrera

المصدر: IBRO Reports, Vol 8, Iss, Pp 28-35 (2020)
IBRO Reports

مصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, TH, tyrosine hydroxylase, Substantia nigra, PBS, phosphate buffered solution, Pharmacology, Screen test, Neuroprotection, Article, lcsh:RC321-571, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, MPTP, 1-methyl-4-phenyl-12,3,6-tetrahidropyridine, C57BL/6J mice, medicine, LSD, lysergic acid diethylamide, GFAP, glial fibrillary acid protein, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, MPTP, Tyrosine hydroxylase, Pars compacta, General Neuroscience, PD, Parkinson´s disease, CD-1 mice, Valerenic acid, medicine.disease, Parkinson´s disease, 030104 developmental biology, chemistry, V.A., valerenic acid, Molecular docking, 5-HT5A, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b09491839f0fbe941359d445d0490d1
http://www.sciencedirect.com/science/article/pii/S2451830119319405

المؤلفون: Yingying Sun, Xiaoqing Jin, Lihong Li, Jun Lu

المصدر: Saudi Journal of Biological Sciences, Vol 26, Iss 8, Pp 1948-1955 (2019)
Saudi Journal of Biological Sciences

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, medicine.medical_specialty, Parkinson's disease, TH, tyrosine hydroxylase, GI, Gastrointestinal, IHC, immunohistochemical, Substantia nigra, SNc, substantia nigra pars compacta, Striatum, 01 natural sciences, Fpn1, ferritin 1, Article, 03 medical and health sciences, Iron accumulation, Dopamine, Internal medicine, medicine, Acupuncture, lcsh:QH301-705.5, chemistry.chemical_classification, Tyrosine hydroxylase, business.industry, SN, substantia nigral, Gut-brain, medicine.disease, Parkinson’s disease (PD), 030104 developmental biology, medicine.anatomical_structure, Endocrinology, chemistry, DMT1, divalent metalloion transporter 1, lcsh:Biology (General), Transferrin, Duodenum, DA, dopamine, General Agricultural and Biological Sciences, business, 010606 plant biology & botany, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb11e7f0cebf1afc920e71bba3d8a03f
http://www.sciencedirect.com/science/article/pii/S1319562X19301214

المؤلفون: Natalia Ninkina, Owen M. Peters, Natalie Connor-Robson, Kirill D. Chaprov, Holger B. Kramer, Dominic J. Withers, Arthur T. Kopylov, Vladimir L. Buchman, Steven Millership, Alex Montoya

المساهمون: Wellcome Trust ISSF Funding, Medical Research Council

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: MPTP toxicity, MPP+, 1-methyl-4-phenylpyridinium, animal diseases, Parkinson's disease, Dopamine, Vesicular monoamine transporter 2, Biochemistry, chemistry.chemical_compound, Mice, neurodegenerative disease, synapse, DAT, dopamine transporter, Synuclein Family, 11 Medical and Health Sciences, Mice, Knockout, vesicles, biology, Cell Death, MPTP, CLIP, crosslink immunoprecipitation, Dopaminergic, LFQ, label-free quantitation, PSM, peptide-spectrum match, Cell biology, SNpc, substantia nigra pars compacta, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, iBAQ, intensity-based absolute quantification, Synaptic Vesicles, 03 Chemical Sciences, TKO, triple α/β/γ-synuclein null mutant mice, Research Article, Biochemistry & Molecular Biology, FDR, false discovery rate, TH, tyrosine hydroxylase, MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Substantia nigra, transgenic mice, Synaptic vesicle, synuclein, beta-Synuclein, mental disorders, GO, Gene Ontology, Animals, Molecular Biology, AADC, aromatic l-amino acid decarboxylase, neurotransmitter vesicular uptake, dopaminergic neurons, Pars compacta, Cell Biology, 06 Biological Sciences, nervous system diseases, Vesicular monoamine transporter, chemistry, nervous system, VMAT-2, vesicular monoamine transporter 2, biology.protein, Parkinson’s disease, DTSSP, 3,3′-dithiobis(sulfosuccinimidylpropionate)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c25bdcdb04d42ed3e6e25fe31cef99
http://europepmc.org/articles/PMC8633583

المؤلفون: David Olivares, Xudong Huang, Lars Branden, Nigel H. Greig, Jack T. Rogers

المصدر: International Journal of Molecular Sciences, Vol 10, Iss 3, Pp 1226-1260 (2009)

مصطلحات موضوعية: PD: Parkinson's disease, AD: Alzheimer's disease, α-syn: alpha-synuclein, PLD2: phospholipase D2, CNS: central nervous system, ER: endoplasmatic reticulum, PM: plasmatic membrane, LBs: Lewy bodies, LNs: Lewy neurites, GCIs: glial cytoplasmic inclusions, DLB: dementia with Lewy Bodies, DA: dopamine, DAT: dopamine transporter, NAC: non-amyloidogenic component, 5-UTR: 5'-untranslated region, IRE: iron responsive element, IRPs: interacting binding proteins, wt: wild-type, ROS: reactive oxygen species, GSH: reduced gluthatione, 6-OHDA: 6-hydroxydopamine, MPTP: 1-methyl 4-phenyl 1, 6 tetrapyridine, TfR: transferrin receptor, TH: tyrosine hydroxylase, nt: nucleotide(s), aa: amino acid(s), Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1422-0067/10/3/1226/; https://doaj.org/toc/1422-0067

URL الوصول: https://doaj.org/article/822a5085d4da46cd845096a9d48b92bf