المؤلفون: Menghao Huang, Kushan Chowdhury, Zhigang Fang, X. Charlie Dong, Ming O. Li, Suthat Liangpunsakul, Hyeong-Geug Kim

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 921-942 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Sestrins, MPO, myeloperoxidase, Mitogen-Activated Protein Kinase Kinase 7, RC799-869, DMSO, dimethyl sulfoxide, FoxO, forkhead box O, Sesn1/2/3, sestrin1/2/3, medicine.disease_cause, TKO, triple knockout, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, GSH, glutathione, Phosphorylation, NF-κB, nuclear factor kappa B, Original Research, Cat, catalase, Mice, Knockout, Sestrin, Gpx3, glutathione peroxidase 3, Il6, interleukin 6, WD, Western diet, biology, Chemistry, Kinase, Fatty liver, Tgfbr1, transforming growth factor beta receptor 1, Gastroenterology, Col1a1, collagen type 1 alpha 1, Nox1, NADPH oxidase 1, Diseases of the digestive system. Gastroenterology, Dgat2, diacylglycerol O-acyltransferase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, C-Jun N-Terminal Kinase, Liver, Lipotoxicity, c-Jun N-terminal kinases, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, Disease Susceptibility, Signal transduction, NASH, nonalcoholic steatohepatitis, Gss, glutathione synthetase, Pdgfrb, platelet-derived growth factor receptor beta, Timp1, tissue inhibitor of metalloproteinase 1, Fasn, fatty acid synthase, Fatty Liver Disease, Sod, superoxide dismutase, Acta2, smooth muscle actin alpha 2, ER, endoplasmic reticulum, PA, palmitic acid, 03 medical and health sciences, 4-HNE, 4-hydroxynonenal, MKK, mitogen-activated protein kinase kinase, medicine, Animals, Humans, Srebp, sterol regulatory element-binding protein, Protein kinase A, KD, knockdown, MDA, malondialdehyde, Inflammation, KO, knockout, Hepatology, NRF2, nuclear factor erythroid 2-related like 2, JNK Mitogen-Activated Protein Kinases, Lipid Metabolism, medicine.disease, Tgfb1, transforming growth factor beta 1, WT, wild-type, mTORC, mechanistic target of rapamycin complex, Fatty Liver, AMPK, AMP-activated protein kinase, Disease Models, Animal, Oxidative Stress, Scd1, stearoyl-CoA desaturase 1, 030104 developmental biology, Gene Expression Regulation, Cytoprotection, Hepatocytes, biology.protein, BSA, bovine serum albumin, SD, standard deviation, DHE, dihydroethidium, PERK, protein kinase R-like endoplasmic reticulum kinase, Tnf, tumor necrosis factor, Biomarkers, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574bc0f082fa7f7fd23bf88f6f9c6fc
http://www.sciencedirect.com/science/article/pii/S2352345X21000862

المؤلفون: Kelly, Carolyn M., Zeiger, Peter J., Narayanan, Vinodh, Ramsey, Keri, Sondermann, Holger

المصدر: The Journal of Biological Chemistry
The journal of biological chemistry 298(1), 101438 (2022). doi:10.1016/j.jbc.2021.101438

مصطلحات موضوعية: Protein Conformation, membrane tethering, MLV, multilamellar vesicle, DRP, dynamin-related protein, FRET, Förster resonance energy transfer, HSN, hereditary sensory neuropathy, EEG, electroencephalogram, GTP Phosphohydrolases, ER, endoplasmic reticulum, GTP-Binding Proteins, Humans, ddc:610, CP, cerebral palsy, GED, GTPase effector domain, GTPase, HSP, hereditary spastic paraplegia, Spastic Paraplegia, Hereditary, BSE, bundle signaling element, Membrane Proteins, ATL1, atlastin-1, WT, wild-type, Mutagenesis, Insertional, TKO, triple-knockout, Mutation, ACTH, adrenocorticotropic hormone, neuropathy, MRI, magnetic resonance imaging, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ae4587531d6d7ae408deb09c6a347e
http://europepmc.org/articles/PMC8688574

المؤلفون: Helmut Grasberger, Fong-Fong Chu, James H. Doroshow, Qiang Gao, Thomas L. Leto, Ágnes Donkó, R. Steven Esworthy, Binghui Shen

المصدر: Redox Biology
Redox Biology, Vol 11, Iss, Pp 144-156 (2017)

مصطلحات موضوعية: 0301 basic medicine, DKO, double knockout of GPx1 and GPx2 genes, GPX1, Pathology, Very-early-onset inflammatory-bowel-disease, NOX2, gp91phox, aka Cybb or cytochrom b-245 beta polypeptide, Clinical Biochemistry, MPO, myeloperoxidase, Apoptosis, Nox1-TKO, triple-knockout mice with disrupted Nox1, GPx1 and GPx2 genes, Biochemistry, TKO, triple knockout, Mice, Onium Compounds, Glutathione Peroxidase GPX1, DTI, di-2-thienyliodonium, GPx1/2, glutathione peroxidase-1 and -2, Ileitis, DSS, dextran sodium sulfate, lcsh:QH301-705.5, DUOX 2, dual oxidase-2, GFP, green fluorescent protein, Mice, Knockout, lcsh:R5-920, Mmp, metalloproteinase, IBD, inflammatory bowel disease, 129, 129S1/SvimJ, Double-knockout mouse, GI, gastrointestinal, Intestinal epithelium, NOX, NADPH oxidase, Dual Oxidases, 3. Good health, Knockout mouse, Dual oxidase-2, cardiovascular system, NADPH Oxidase 1, NCF1, neutrophil cytosolic factor 1, aka p47phox, TUNEL, terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling, lcsh:Medicine (General), Oxidation-Reduction, IHC, immunohistochemistry, Research Paper, medicine.medical_specialty, T4, L-thyroxine, Colon, Crypt, nsSNP, non-synonymous single-nucleotide polymorphism, Thiophenes, Biology, Duoxa-TKO, triple-knockout mice with disrupted Duoxa, GPx1 and GPx2 genes, digestive system, B6, C57BL6/J, 03 medical and health sciences, ROS, reactive oxygen species, THZ, thioridazine, medicine, VEO, very-early-onset, Animals, Humans, TNFR1, tumor-necrosis-factor receptor 1, Duoxa, Duox activator, IQR, interquartile range, Inflammation, Glutathione Peroxidase, NADPH oxidase, Crypt Epithelium, Organic Chemistry, Dual oxidase 2, Lyz1, lysozyme 1, medicine.disease, Inflammatory Bowel Diseases, Molecular biology, WT, wild-type, Hmox1, heme oxygenase-1, MitoQ, mitoquinone, 030104 developmental biology, lcsh:Biology (General), H&E, hematoxylin and eosin, Non-DKO, mice having a wild-type allele of GPx1 or GPx2, Crypt Abscess, SD, standard deviation, Reactive Oxygen Species

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a54b22e5cada3cf80abe9a6fdd933d
http://europepmc.org/articles/PMC5148781

المؤلفون: Marissa Ashton, Martin Weber, Mark P. Jedrychowski, Thimo Kurz, Daniel Finley, Hai Ngu, Eric J. Brown, Alexandra M. Whiteley, Stefanie A. H. de Poot, Mervyn J. Monteiro, Amy Easton, John Szpyt, Sara L. Dominguez, Steven P. Gygi, Joao A. Paulo, Miguel A. Prado

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, Proteomics, 0301 basic medicine, KI, knock-in, Mutant, Autophagy-Related Proteins, Biochemistry, TKO, triple knockout, UBQLN2, Mice, 0302 clinical medicine, AA, active avoidance, Ubiquitin, UBQLN, ubiquilin proteins, ITI, intertrial interval, BCA, bicinchoninic acid assay, Cycloheximide, Mice, Knockout, Neurons, fALS, familial genetic variants of ALS, 0303 health sciences, biology, Protein Stability, Neurodegeneration, neurodegeneration, RNA-Binding Proteins, ALS, amyotrophic lateral sclerosis, Cell biology, Ubiquitin ligase, FC, fear conditioning, DNA-Binding Proteins, UBL, ubiquitin-like, Frontotemporal Dementia, Proteome, UBA, ubiquitin-binding domain, Research Article, Signal Transduction, Proteasome Endopeptidase Complex, Serotonin, Ubiquitin-Protein Ligases, UCS, unconditioned stimuli, Protein degradation, ubiquitin ligase, Cell Line, 03 medical and health sciences, CFP, cyan fluorescent protein, Gene knockin, ubiquitin, medicine, RFP+, red fluorescent protein positive, Animals, Humans, Molecular Biology, Gene, GO, gene ontology, Adaptor Proteins, Signal Transducing, 030304 developmental biology, 030102 biochemistry & molecular biology, Amyotrophic Lateral Sclerosis, TMT, tandem mass tag, Cell Biology, ACN, acetonitrile, AHA, azido-homo-alanine, medicine.disease, Disease Models, Animal, proteasome, HEK293 Cells, 030104 developmental biology, Gene Expression Regulation, Proteasome, Proteolysis, Trans-Activators, biology.protein, iNeuron, induced neuron, ALS, qPCR, quantitative PCR, Apoptosis Regulatory Proteins, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4817136e59d4fb8136c5a4764e71e673
https://doi.org/10.1101/2020.02.22.956524

المؤلفون: Hidetaka Hara, David K. C. Cooper

المصدر: EBioMedicine
EBioMedicine, Vol 71, Iss, Pp 103562-(2021)

مصطلحات موضوعية: Clinical team, Medicine (General), medicine.medical_specialty, Swine, Xenotransplantation, medicine.medical_treatment, Transplantation, Heterologous, Review, Kidney, General Biochemistry, Genetics and Molecular Biology, Translational Research, Biomedical, TKO, Triple-knockout (i.e., in a pig in which the three known carbohydrate xenoantigens have been deleted), Clinical, NHP, Nonhuman primate, R5-920, Patient selection, Nonhuman primate, medicine, Animals, Humans, Pig, genetically-engineered, CMV, Cytomegalovirus, Intensive care medicine, Kidney transplantation, Clinical Trials as Topic, Therapeutic regimen, Graft rejection, business.industry, Pig kidney, General Medicine, medicine.disease, Kidney Transplantation, Preclinical, Clinical trial, Public Opinion, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b06df7bc5b8799824998d99e5e42c4f
https://doi.org/10.1016/j.ebiom.2021.103562