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المؤلفون: Rupesh Kumar, Shazia Haider
المصدر: IBRO Neuroscience Reports, Vol 12, Iss, Pp 25-44 (2022)
IBRO Neuroscience Reportsمصطلحات موضوعية: Neurosciences. Biological psychiatry. Neuropsychiatry, BC, Betweenness centrality, MND, Motor neuron disease, ALS, Amyotrophic Lateral Sclerosis, SOD1, Superoxide dismutase, CDC5L, Cell division cycle5-likeprotein, SMN, Survival of motor neuron, TP53, FUS, Fused in sarcoma, SMA, Spinal muscular atrophy, Bn-H, Bottleneck-hub, SNW1, SNW domain-containing protein 1, ALS-PPIN, Amyotrophic Lateral Sclerosis Protein-Protein Interaction Network, General Neuroscience, SNW1, ALS-PPIN, SOD1, CDC5L, ALSoD, Amyotrophic Lateral Sclerosis online database, TP53, Tumor protein p53, VCP, Valosin containing protein, MCODE, Molecular Complex Detection, Bottleneck-hubs, ALS, VCP, Research Paper, RC321-571
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23dbfa5e2c81d371bd122e6d9e27c4d
https://doi.org/10.1016/j.ibneur.2021.12.002 -
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المؤلفون: Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)مصطلحات موضوعية: Genome instability, PD-L1, programmed death ligand 1, BRCA, breast cancer susceptibility gene, ICI, immune checkpoint inhibitor, medicine.medical_treatment, MUTYH, MutY homolog, cGAS, cyclic GMP–AMP synthase, Review, DNA damage response, Malignant transformation, ORR, objective response rate, PCR, polymerase chain reaction, 0302 clinical medicine, SCNAs, somatic copy number alterations, FDA, United State Food and Drug Administration, Cancer immunotherapy, MGMT, O6-methylguanine methyltransferase, PD-1, RB1, retinoblastoma 1, General Pharmacology, Toxicology and Pharmaceutics, BER, base excision repair, RAD51C, RAD51 homolog C, 0303 health sciences, TME, tumor microenvironment, TP53, tumor protein P53, cGAS–STING, MSI, microsatellite instability, TRIF, Toll-interleukin 1 receptor domain-containing adaptor inducing INF-β, PFS, progression-free survival, STAT, signal transducer and activator of transcription, NEK1, NIMA-related kinase 1, Tumor microenvironment, PALB2, partner and localizer of BRCA2, RSR, replication stress response, 030220 oncology & carcinogenesis, Immunotherapy, PARP, poly-ADP ribose polymerase, JAK, Janus kinase, IHC, immunohistochemistry, Genomic instability, PD-L1, DSBs, double-strand breaks, DNA repair, DNA damage, CHK1, checkpoint kinase 1, IRF1, interferon regulatory factor 1, MLH1, MutL homolog 1, RM1-950, MMR, mismatch repair, STING, stimulator of interferon genes, Biology, MNT, MAX network transcriptional repressor, DDR, DNA damage response, MSH2/6, MutS protein homologue-2/6, OS, overall survival, RPA, replication protein A, 03 medical and health sciences, GSK3β, glycogen synthase kinase 3β, NER, nucleotide excision repair, NSCLC, non-small cell lung cancer, MyD88, myeloid differentiation factor 88, ssDNA, single-stranded DNA, medicine, DAMP, damage-associated molecular patterns, DR, direct repair, 030304 developmental biology, BAP1, BRCA1-associated protein 1, BRAF, v-RAF murine sarcoma viral oncogene homologue B, TLR4, Toll-like receptor 4, Cancer, NGS, next generation sequencing, ATM, ataxia-telangiectasia mutated, NIMA, never-in-mitosis A, medicine.disease, CHEK, cell-cycle checkpoint kinase, PD-1, programmed death 1, MAD1, mitotic arrest deficient-like 1, body regions, IFNγ, interferon gamma, TILs, tumor-infiltrating lymphocytes, TBK1, TANK-binding kinase 1, ATR, ataxia telangiectasia and Rad3 related, Cancer research, NHEJ, nonhomologous end-joining, Therapeutics. Pharmacology, HMGB1, high mobility group box-1, HRR, homologous recombination repair, XRCC4, X-ray repair cross complementing protein 4, TMB, tumor mutational burden
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المصدر: Advanced Drug Delivery Reviews
مصطلحات موضوعية: ICAM1, Intercellular adhesion molecule–1, PLA, Poly(lactide), GEMM, Genetically modified mouse model, RAG, Rag-deficient, 02 engineering and technology, Metastasis, CCPM, Core-crosslinked block copolymer micelle, TME, Tumor microenvironment, TAM, Tumor-associated macrophages, Breast cancer, NIR, Near-infrared, Th2, Type 2 T helper, NK, Natural killer, AGM, Aminoglutethimide, Medicine, NF1, Neurofibromin 1, BRCA1, Breast cancer type 1 susceptibility protein, SPIO, Superparamagnetic iron oxide nanoparticle, 0303 health sciences, education.field_of_study, ERS1, Estrogen receptor gene, BRCA2, Breast cancer type 2 susceptibility protein, Organoids, CHEK2, Checkpoint kinase 2, Patient-derived xenografts, Nanomedicine, PTBPC, Poly(2‐((tert‐butoxycarbonyl)amino)‐3‐propyl carbonate, DOX, Doxorubicin, 0210 nano-technology, PDOX, Patient-derived organoid-derived xenograft, TNBC, Triple negative breast cancer, NOG, NOD/Shi-scid/γc−/− null, FITC, Fluorescein isothiocyanate, Antineoplastic Agents, 2D, Two-dimensional, MMDOX, Doxorubicin-loaded mixed micelles, Article, NOD-SCID, non-obese diabetic-severe combined immunodeficient, WHO, World Health Organization, FA, Folic acid, PyMT, Polyoma middle tumor-antigen, 03 medical and health sciences, HPMA, Hydroxypropyl methacrylamide, Drug Development, NMU, N-methyl-n-nitrosourea, Humans, SCID, Severe combined immunodeficient, education, WAP, Whey acidic protein, Immune status, MDR1, Multidrug resistance protein 1, PTEN, Phosphatase and tensin homolog, pDNA, Plasmid desoxyribonucleic acid, AuNR, Gold nanorod, medicine.disease, NP, Nanoparticle, VIP, Vasoactive intestinal peptide, Clinical trial, PLGA, poly(lactide-co-glycolide), Nanoparticles, HER2, Epidermal growth factor receptor 2, MMP, Metallopeptidases, Th1, Type 1 T helper, PGA, Poly-L-glutamic acid, Biomarkers, ROS, Reactive oxygen species, IHC, Immunohistochemistry, MMTV, Mouse mammary tumor virus, IO, Iron oxide, IONP, Iron oxide nanoparticle, Pharmaceutical Science, TP53, tumor protein p53, Bioinformatics, ATM, Ataxia-telangiectasia mutated, PALB2, Partner and localizer of BRCA2, Drug Delivery Systems, NSG, NOD scid gamma, uPAR, Urokinase plasminogen activator receptor, PDNA, Plasmid DNA, GSH, Glutathione, LTR, Long terminal repeat, Drug Carriers, EPR, Enhanced permeability and retention, PPTT, Plasmonic photothermal therapy, TPGS, D-α-tocopheryl polyethylene glycol 1000 succinate, DC, Dendritic cells, HIF1α, Hypoxia-inducible factor 1 alpha, MEF, Mouse embryonic fibroblasts, CAF, Cancer-associated fibroblasts, PR, Progesterone receptor, 021001 nanoscience & nanotechnology, Nanomedicines, Animal models, ER, Estrogen receptor, Nude, Athymic nude, DMBA, 7,12-dimethylbenzantracene, PEG, Polyethylene glycol, Female, MUC1, Mucin 1, QbD, Quality by design, 3D, Three-dimensional, PDX, Patient-derived xenograft, Population, Breast Neoplasms, Enhanced permeability and retention effect, Pre-clinical models, CSC, Cancer stem cells, ALOX5, Arachidonate 5-lipoxygenase, iPSC, induced pluripotent stem cells, ECM, Extracellular matrix, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, PI3KCA, Phosphatidylinositol 3-kinase, business.industry, SSMM, Sterically-stabilized mixed phospholipid nanomicelle, Cancer, FDA, Food and Drug Administration, PIMs, Porcine pulmonary intravascular macrophages, EGFR, Epithelial growth factor receptor, CDX, Cell-derived xenograft, STK11, Serine/Threonine Kinase 11, business
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المؤلفون: Liang Ouyang, Yao Liu, Jie Liu, Lu Feng, Guan Wang, Yi Chen, Meng Wang, Tingting Jiang
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NTRK, neurotrophic receptor tyrosine kinase, FISH, fluorescence in situ hybridization, Review, Tropomyosin receptor kinase B, HNSCC, head and neck squamous cell carcinoma, Tropomyosin receptor kinase A, HTS, high-throughput screening, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, Tropomyosin receptor kinase C, LMNA, lamin A/C, Receptor tyrosine kinase, TPM3, tropomyosin 3, 0302 clinical medicine, MASC, mammary analogue secretory carcinoma, PROTAC proteolysis targeting chimera, QKI, SQSTM1, sequestosome 1, TPR, translocated promoter region, General Pharmacology, Toxicology and Pharmaceutics, RABGTPase activating protein 1-like, RFWD2, AML, acute myeloid leukemia, 0303 health sciences, ICC, intrahepatic cholangiocarcinoma, TRK, tropomyosin receptor kinase, Neurotrophic receptor tyrosine kinase fusions, PPL, periplakin, TP53, tumor protein P53, SBC, secretory breast carcinoma, OAK, osteoarthritis of the knee, TFG, TRK-fused gene, ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2, NT3, neurotrophin-3, quaking I protein, RABGAP1L, ETV6, ETS translocation variant 6, 030220 oncology & carcinogenesis, CR, complete response, CRC, colorectal cancer, BCAN, brevican, BDNF, brain-derived neurotrophic factor, BTBD1, BTB (POZ) domain containing 1, RTK, receptor tyrosine kinase, DOR, durable objective responses, CDK-2, cyclin-dependent kinase 2, Tyrosine kinase, EWG, electron-withdrawing group, ORR, overall response rate, Neurotrophin, NCCN, National Comprehensive Cancer Network, VCL, vinculin, NGF, nerve growth factor, MPRIP, myosin phosphatase Rho interacting protein, Biology, PAN3, poly(A) nuclease 3, TRIM24, tripartite motif containing 24, Small-molecule inhibitor, NTRK fusion cancer, SCYL3, SCY1 like pseudokinase 3, 03 medical and health sciences, NACC2, NACC family member 2, NSCLC, non-small cell lung cancer, SAR, structure–activity relationship, Protein kinase B, VEGFR2, vascular endothelial growth factor receptor 2, 030304 developmental biology, DFG, Asp-Phe-Gly, CTCs, sequencing of circulating tumor cells, lcsh:RM1-950, GBM, glioblastoma multiforme, NFASC, neurofascin, NGS, next-generation sequencing of tumor tissue, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, nervous system, Trk receptor, IG-C2, Ig-like C2 type I, Cancer research, biology.protein, Tropomyosin receptor kinase, AFAP1, actin filament-associated protein 1
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المؤلفون: Yulong He, Jianbo Xu, Peng Shi, Xinde Ou, Wen Zhou, Shirong Cai, Jin Li, Yujie Yuan, Jianjun Peng, Taiqiang Su, Liangliang Lin, Qinbo Cai
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 857-880 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Chemokine, Atrophic gastritis, RELA, RELA proto-oncogene, nuclear factor-κB subunit, TP53, tumor protein p53, BrdU, bromodeoxyuridine, Chemokine receptor, 0302 clinical medicine, CG, chronic gastritis, GSEA, gene set enrichment analysis, CXCL, C-X-C motif chemokine ligand, GEO, Gene Expression Omnibus, CXC chemokine receptors, Helicobacter, MOI, multiplicity of infection, Original Research, biology, H pylori, Gastroenterology, IM, intestinal metaplasia, MNU, N-methyl-N-nitrosourea, mRNA, messenger RNA, PMSS1, pre-mouse Sydney strain 1, ChIP, chromatin immunoprecipitation, medicine.anatomical_structure, CXCR2, C-X-C motif chemokine receptor 2, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, CagA, cytotoxin-associated gene A, CDKN, cyclin-dependent kinase inhibitor, Gastritis, Atrophic, Senescence, PBS, phosphate-buffered saline, IHC, immunohistochemical, NF-κB, nuclear factor-κB, SASP, senescence-associated secretory phenotype, C-X-C Motif Chemokine Receptor 2, NFKB1, nuclear factor-κB subunit 1, Helicobacter Infections, Senescent Cell, 03 medical and health sciences, Gastric mucosa, medicine, Humans, lcsh:RC799-869, Helicobacter pylori, Hepatology, Mucosa Atrophy, AG, atrophic gastritis, biology.organism_classification, medicine.disease, IL, interleukin, 030104 developmental biology, biology.protein, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, DP, dysplasia, Atrophy
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51feee4d86b3f3b985a29b089d53c44
http://www.sciencedirect.com/science/article/pii/S2352345X2030179X -
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المؤلفون: Wolfgang Walther, Annika Wulf-Goldenberg, Ulrike Stein, Johannes Merk, Iduna Fichtner, Keziban M. Alp, Giannino Patone, Tamara Kanashova, Christine Sers, Philipp Mertins, Maria Rivera, Jens Hoffmann
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)مصطلحات موضوعية: Proteomics, 0301 basic medicine, Cancer Research, Proteome, Colorectal cancer, Fluorescent Antibody Technique, TP53, tumor protein p53, Proto-Oncogene Mas, EREG, epiregulin, Metastasis, Mice, 0302 clinical medicine, BTC, betacellulin, Molecular Targeted Therapy, Epidermal growth factor receptor, Precision Medicine, biology, Cetuximab, GCN, gene copy number, TDT, tumor doubling time, APC, adenomatous polyposis coli, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Primary tumor, Colorectal carcinoma, EpCAM, epithelial cell adhesion molecule, 030220 oncology & carcinogenesis, CRC, colorectal cancer, BRAF, proto-oncogene B-RAF, Heterografts, AKT, Serine threonine protein kinase AKT, Erlotinib, AREG, Amphiregulin, Technology Platforms, Colorectal Neoplasms, TNM, tumor nodule metastasis classification, medicine.drug, Original article, endocrine system, DNA Copy Number Variations, TGFα, transforming growth factor alfa, In vivo drug testing, Antineoplastic Agents, KRAS, Kirsten rat sarcoma virus oncogene homolog, mTOR, mammalian target of rapamycin, PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinaseM catalytic subunit alfa, lcsh:RC254-282, Genomic Instability, NSG mice, NOD scid gamma mice, 03 medical and health sciences, PDX, patient derived xenograft, Biomarkers, Tumor, medicine, Animals, Humans, IHC, imunno histochemistry, neoplasms, FFPE, formalin fixed paraffin embedded, EGF, epidermal growth factor, Betacellulin, Oncogene, business.industry, Gene Expression Profiling, medicine.disease, Xenograft Model Antitumor Assays, Personalized medicine, c-MET, tyrosine protein kinase MET, digestive system diseases, EGFR, epidermal growth factor receptor, 030104 developmental biology, Drug Resistance, Neoplasm, Patient-derived xenograft models, T/C, treated to control value, Mutation, Cancer research, biology.protein, 5-FU, 5-fluorouracil, HER2,3,4, human epidermal growth factor receptor 2,3,4, business, MAPK, mitogen activated protein kinase
وصف الملف: application/pdf; application/msword
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المؤلفون: Sabine Matou-Nasri, Hala Alajmi, Safia A. Messaoudi, Anuradha Venktraman, Zeyad Alehaideb, Mohammed Syed Ali, Saranya Rameshbabu, Hamad Al-Eidi
المصدر: Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 28, Iss 8, Pp 985-993 (2020)مصطلحات موضوعية: BC, breast cancer, Pharmaceutical Science, Apoptosis, AL, aqueous extract of A. hierochuntica’s leaf, Cell cycle, NP40, Nonidet P-40, TP53, tumor protein p53, Pharmacology, AST, aqueous extract of A. hierochuntica’s stem, Article, Flow cytometry, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, Western blot, medicine, STS, Staurosporine, Viability assay, MSD, methanolic extract of A. hierochuntica’s seed, MCF-7, Michigan Cancer Foundation-7, CDK, cyclin-dependent kinase, 030304 developmental biology, chemistry.chemical_classification, P53, Natural products, ASD, aqueous extract of A. hierochuntica’s seed, 0303 health sciences, medicine.diagnostic_test, MST, methanolic extract of A. hierochuntica’s stem, Chemistry, lcsh:RM1-950, lcsh:Therapeutics. Pharmacology, Enzyme, MCF-7, 030220 oncology & carcinogenesis, DNA fragmentation, ML, methanolic extract of A. hierochuntica’s leaf, Anastatica hierochuntica
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المؤلفون: Yeon Sook Kim, Seongjin Choi, Ho-Young Lee, Shinhye Cheon, Hye Won Jeong, Su-Hyung Park, Hyeongseok Jeong, Seongju Jeong, Eui-Soon Kim, Eui-Cheol Shin, Galam Leem
المصدر: The Journal of Allergy and Clinical Immunology
مصطلحات موضوعية: Male, IL-1, interleukin-1, STAT3, signal transducer and activator of transcription 3, PID, pathway interaction database, cCD56dim, conventional CD56dimCD16pos, Cell, NK cells, Lymphocyte Activation, GSVA, gene set variation analysis, GSEA, gene set enrichment analysis, Immunology and Allergy, Longitudinal Studies, Prospective Studies, RNA-Seq, Cytotoxicity, innate immunity, COVID-19, coronavirus disease 2019, education.field_of_study, EBV, Epstein-Barr virus, tp53, tumor protein p53, TCPTP, T-cell protein tyrosine phosphatase, Middle Aged, Killer Cells, Natural, medicine.anatomical_structure, TNFA, tumor necrosis factor alpha, CRP, C-reactive protein, cytotoxicity, KIRs, inhibitory killer-cell immunoglobulin-like receptors, NK, natural killer, WBC, white blood cell, Adult, PBMC, peripheral blood mononuclear cell, TIGIT, T cell immunoglobulin and ITIM domain, uCD56dim, unconventional CD56dimCD16neg, Immunology, Population, HLH, hemophagocytic lymphohistiocytosis, Peripheral blood mononuclear cell, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, KEGG, Kyoto Encyclopedia of Genes and Genomes, Article, Proinflammatory cytokine, PPI, protein-protein interaction, Immune system, medicine, Humans, IFN, interferon, cCD56bright, conventional CD56brightCD16neg, education, ARDS, acute respiratory distress syndrome, GO, gene ontology, Hemophagocytic lymphohistiocytosis, Innate immune system, business.industry, SARS-CoV-2, ILC, innate lymphoid cells, RNA-seq, RNA sequencing, COVID-19, medicine.disease, unconventional CD56dimCD16neg NK cells, business, NFKB1, nuclear factor kappa B subunit 1
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المؤلفون: Huang, Kai, Zhang, Pan, Zhang, Zhenghao, Youn, Ji Youn, Zhang, Hongchun, Cai, Hua Linda
المصدر: Pharmacology & Therapeutics
مصطلحات موضوعية: PTGS2, Prostaglandin-endoperoxide synthase 2, TFs, transcription factors, CT, computerized tomography, DAVID, Database for Annotation, Visualization, and Integrated Discovery, MAPK, Mitogen-activated protein kinase, CVA, cough variant asthma, SIRS, systematic inflammatory response syndrome, Nrf2, nuclear factor erythroid 2-related factor 2, SOCS1, suppressor of cytokine signaling 1, Akt, Protein kinase B, 3CLpro, Coronavirus 3-chymotrypsin-like protease, TNF-α, Tumor Necrosis Factor Alpha, HIF-1, Hypoxia-Inducible Factor-1, PI3K, Phosphoinositide 3-kinase, UPLC-DAD-QTOF-MS, Ultra performance liquid chromatography coupled with diode-array detector and quadrupole time-of-flight mass spectrometry, Medicine, Chinese Traditional, RCT, randomized controlled trial, COVID-19, Coronavirus disease 2019, S protein, SARS-CoV-2 spike (S) glycoprotein, TCM, Traditional Chinese Medicine, ACE2, angiotensin converting enzyme 2, Traditional Chinese Medicine (TCM), HSP90AB1, Heat shock protein HSP 90-beta, ICU, intensive care unit, PCT, procalcitonin, PPARG, peroxisome proliferator-activated receptor gamma, Virus Diseases, CRP, C-reactive protein, XBJ, Xuebijing, Lung Cleansing and Detoxifying Decoction (LCDD), IC50, 50% inhibitory concentration, WBC, white blood cell, Xuebijing (XBJ), NCOA2, Nuclear receptor coactivator 2, NFkB, Nuclear factor kappa B, PTGS1, Prostaglandin-endoperoxide synthase 1, JHQG, Jinhua Qinggan granules, KEGG, Kyoto Encyclopedia of Genes and Genomes, Article, WHO, World Health Organization, CASP3, Caspase 3, PPI, protein-protein interaction, TCMID, Traditional Chinese Medicine Integrated Database, COX-2, Cyclooxygenase-2, ROS, reactive oxygen species, ARDS, Acute respiratory distress syndrome, HSBD, Huashibaidu granules, Humans, CCL2, C-C Motif Chemokine Ligand 2, Huashibaidu granules (HSBD), Coronavirus 3-chymotrypsin-like protease (3CLpro), IL-6, Interleukin-6, HNF4A, hepatocyte nuclear factor 4 alpha, GO, gene ontology, HXZQ, Huoxiang Zhengqi dropping pills, ESR, erythrocyte sedimentation rate, Viral infections, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, XFBD, Xuanfeibaidu granules, SARS-CoV-2, IP-10, Interferon gamma-induced protein 10, LCDD, Lung Cleansing and Detoxifying Decoction, COVID-19, BCL2, B-cell lymphoma 2, EGFR, epidermal growth factor receptor, HSP90AA1, Heat shock protein HSP 90-alpha, TP53, Tumor protein p53, COVID-19 Drug Treatment, Lianhua Qingwen capsules (LHQW), COVID, Coronavirus disease, Angiotensin converting enzyme 2 (ACE2), Interleukin-6 (IL-6), miRNAs, micro RNAs, LHQW, Lianhua Qingwen capsules, NOS2, Nitric Oxide Synthase 2 (inducible Nitric Oxide Synthase/iNOS), MCP-1, Monocyte Chemoattractant Protein-1, AGE-RAGE, Advanced glycation end products-Receptor for AGE, Xuanfeibaidu granules (XFBD), IFN-γ, Interferon gamma, Jinhua Qinggan granules (JHQG)
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المؤلفون: Jinquan Cai, Ruijia Wang, Lin Lin, Hengyuan Pang, Magafurov Dinislam, Ziwei Li, Shihong Zhao, Qun Chen, Chuanlu Jiang, Pengfei Wu, Caijun Zha, Chunbin Duan, Xiangqi Meng, Bo Han
المصدر: EBioMedicine
مصطلحات موضوعية: Research paper, DNA Repair, Cellular differentiation, medicine.medical_treatment, ATRX, alpha thalassemia/mental retardation syndrome X-linked, SAA1, serum amyloid A1, Transcriptome, Mice, 0302 clinical medicine, GSEA, gene set enrichment analysis, GME, glioma microenvironment, MEM, Minimum Essential Media, BER, base excision repair, Midkine, TNFSF4, TNF superfamily member 4, NADP, nicotinamide adenine dinucleotide phosphate, General Medicine, DSBR, DNA double-strand break repair, 030220 oncology & carcinogenesis, NHEJ, nonhomologous end joining, Microglia, IHC, immunohistochemistry, γH2AX, phosphorylated on serine 139 on H2A histone family member X, CNV, copy number variation, IL6, interleukin 6, ATM, ataxia telangiectasia-mutated gene, IGV, Integrative Genomics Viewer, MDK, midkine, KEGG, Kyoto Encyclopedia of Genes and Genomes, PI, protease inhibitor, DDR, DNA damage response, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mrc1, mannose receptor C-type 1, NER, nucleotide excision repair, Glioma, Humans, PTEN, IF, immunofluorescence, GCM, glioma-conditioned medium, IDH, isocitrate dehydrogenase (NADP(+)), Tumor microenvironment, SSBR, DNA single-strand break repair, TMZ, temozolomide, Macrophages, medicine.disease, Mice, Inbred C57BL, body regions, 030104 developmental biology, Pen/Strep, penicillin/streptomycin, HR, homologous recombination, DAPI, 4′,6-diamidino-2-phenylindole, p53, 0301 basic medicine, ATR, Ataxia Telangiectasia And Rad3-Related Protein, qRT-PCR, Quantitative real-time reverse transcription-polymerase chain reaction, DAB, Diaminobenzidine, ChIP, Chromatin immunoprecipitation, Tumor Microenvironment, DNA damage repair, FA, Fanconi anemia, MGMT, O6-methylguanine-DNA methyltransferase, biology, LGG, lower grade glioma, TLS, trans-lesion synthesis, TP53, tumor protein P53, HRP, horseradish peroxidase, Cell Differentiation, Fizz1, found in inflammatory zone 1, SNP, single nucleotide polymorphism, TCGA, The Cancer Genome Atlas dataset, Cytokine, TNFA, tumor necrosis factor alpha, Female, Arg1, arginase 1, DNA repair, SWI/SNF, SWItch/Sucrose Non-Fermentable, MMR, mismatch repair, DMEM, Dulbecco's Modified Eagle Medium, AKT, protein kinase B, CCL2, C-C motif chemokine ligand 2, CGGA, The Chinese Glioma Genome Atlas dataset, C5, Complement C5, Cell Line, Glioma microenvironment, VEGFA, vascular endothelial growth factor A, FBS, fetal bovine serum, PBS, phosphate buffered saline, Cell Line, Tumor, medicine, Animals, ELISA, Enzyme-Linked Immunosorbent Assay, DR, direct repair, GO, gene ontology, ssGSEA, single sample gene set enrichment analysis, FC, fold change, PTEN, phosphatase and tensin homolog, EGFR, epidermal growth factor receptor, TBST, Tris-buffered Saline with Tween 20, NFκB, nuclear factor kappa B, biology.protein, Cancer research, GBM, glioblastoma, EM/PM classification, EGFR module / PDGFRA (platelet derived growth factor receptor A) -based molecular classification, Tumor Suppressor Protein p53
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