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المؤلفون: Simo V. Zhang, Gabor Bartha, Rachel Marty Pyke, Richard Chen, Sean Michael Boyle, Jason Harris, John A. West, Michael Snyder, Sejal Desai, Rena McClory, Charles Abbott, Dattatreya Mellacheruvu, Nick A. Phillips, Steven Dea
المصدر: Mol Cell Proteomics
Molecular & Cellular Proteomics : MCPمصطلحات موضوعية: NMDP, National Marrow Donor Program, False discovery rate, Proteome, Computer science, Biochemistry, Immunoproteomics, Epitope, Analytical Chemistry, immunology, Major Histocompatibility Complex, SHERPA, Systematic HLA Epitope Ranking Pan Algorithm, Immune Epitope Database and Analysis Resource, GFP, green fluorescent protein, next generation sequencing, Antigen Presentation, 0303 health sciences, biology, Antigen processing, 030302 biochemistry & molecular biology, Technological Innovation and Resources, immunopeptidomics, G, gene propensity (model feature), ELISA, enzyme-linked immunosorbent assay, B, binding pocket (model feature), machine learning, P, peptide (model feature), H, hotspot score (model feature), F, flanking regions (model feature), cancer vaccines, Algorithms, L, peptide length (model feature), FDR, false discovery rate, T, protein abundance as measured by TPM (model feature), Decision tree, Computational biology, Human leukocyte antigen, Major histocompatibility complex, Cell Line, 03 medical and health sciences, TPM, transcripts per million, Special Issue: Immunopeptidomics, Antigens, Neoplasm, cancer, MHC, major histocompatibility complex, Humans, Gene, Molecular Biology, 030304 developmental biology, ATCC, American Type Culture Collection, IEDB, Immune Epitope Database and Analysis Resource, pMHC, major histocompatibility complex-peptide, HLA, human leukocyte antigen, Research, Models, Theoretical, neoantigen prediction, IMGT, International ImMunoGeneTics Information System, LOO, leave one out model, biology.protein, Gradient boosting, MHC, LC-MS/MS, liquid chromatography with tandem mass spectrometry, Peptides, Transcriptome, P-models, primary models, neoantigens
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d51c6de9d4672b239c32b76dd7d0721
https://doi.org/10.1016/j.mcpro.2023.100506 -
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المؤلفون: Gang Chen, Jin-Liang Kong, Hua-Fu Zhou, Yu Zhang, Li Gao, Juan He, Jian-Di Li, Guo-Sheng Li
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6229-6239 (2021)مصطلحات موضوعية: LUAD, TF, transcription factor, Coronavirus disease 2019 (COVID-19), Microarray, Biophysics, FPKM, fragments per kilobase per million, PPI, protein-to-protein interaction, Computational biology, GTEx, Genotype-tissue Expression, Biology, HPA, human protein atlas, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Biochemistry, Interactome, Article, Structural Biology, DEG, differentially expressed genes, WGCNA, weighted gene co-expression network analysis, Genetics, medicine, DEG, Clinical significance, Gene, ComputingMethodologies_COMPUTERGRAPHICS, COVID-19, coronavirus disease 2019, Lung, WGCNA, COVID-19, FC, fold change, LUAD, lung adenocarcinoma, medicine.disease, SROC, summarized receiver’s operating characteristics, TPM, transcripts per million reads, Computer Science Applications, Immune infiltration, CI, confidence interval, medicine.anatomical_structure, Susceptibility, SMD, standard mean difference, RNA splicing, Adenocarcinoma, TP248.13-248.65, IHC, immunohistochemistry, Biotechnology
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المؤلفون: Mete Civelek, Judith Knehr, Samuel W. French, Brie K. Fuqua, Simon T. Hui, Chinweike Ukomadu, Calvin Pan, Kevin Wroblewski, Margarete Mehrabian, Rita M. Cantor, Ashot Asaryan, Joseph Loureiro, Sara G. Haroutunian, Jason Borawski, Brian W. Parks, Aldons J. Lusis, Walter Carbone, Clara E. Magyar, Nicole A. Renaud, Simon W. Beaven, Kara Clerkin, Iina Tuominen, Guglielmo Roma
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 199-220 (2021)
Cellular and molecular gastroenterology and hepatology, vol 11, iss 1
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: bp, base pair, HMDP, Hybrid Mouse Diversity Panel, 0301 basic medicine, Liver Cirrhosis, Male, CCl4, Candidate gene, Genome-wide association study, eQTL, expression quantitative trait locus, Oral and gastrointestinal, Mice, 0302 clinical medicine, Fibrosis, CCl4, carbon tetrachloride, CCl(4), 2.1 Biological and endogenous factors, Gene Regulatory Networks, MUP, mouse urinary protein, Carbon Tetrachloride, Original Research, Genetics, education.field_of_study, WGCNA, weighted gene coexpression network analysis, Systems Genetics, Liver Disease, Gastroenterology, SNP, single nucleotide polymorphism, HSC, hepatic stellate cell, ECM, extracellular matrix, Liver, HCV, hepatitis C virus, 030211 gastroenterology & hepatology, NASH, nonalcoholic steatohepatitis, Injections, Intraperitoneal, Biotechnology, Population, Quantitative Trait Loci, Chronic Liver Disease and Cirrhosis, Biology, Injections, 03 medical and health sciences, TPM, transcripts per million, medicine, Animals, Humans, Genetic Predisposition to Disease, Intraperitoneal, lcsh:RC799-869, GWAS, genome-wide association study, education, Genetic association, Hepatology, Animal, Human Genome, medicine.disease, Genetic architecture, Disease Models, Animal, 030104 developmental biology, Expression quantitative trait loci, Disease Models, CPA%, collagen proportionate area, Hepatic stellate cell, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, SD, standard deviation, Digestive Diseases, Liver Toxicity and Injury, Genome-Wide Association Study
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536618b237e4093c54e4e8a03f67626f
http://www.sciencedirect.com/science/article/pii/S2352345X2030134X -
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المؤلفون: Guang-Bo Ge, Saisai Tian, Yili Yang, Ting Shi, Hua-Wu Zeng, Feng Zhang, Jing Zhao, Jian Yang, Shiyi Zhao, Weidong Zhang, Xin Xu, Dong-Zhu Tu, Dong Lu, Yuejuan Zheng
المصدر: Phytomedicine
مصطلحات موضوعية: Male, PRR, pattern recognition receptor, Anti-Inflammatory Agents, Drug target, AKT1, PTGS1, Pharmaceutical Science, ETCM, the Encyclopedia of Traditional Chinese medicine, STITCH, Search Tool for Interactions of Chemicals, Mice, 0302 clinical medicine, Drug Discovery, Medicine, Chinese Traditional, 0303 health sciences, COVID-19, Coronavirus disease 2019, Pattern recognition receptor, PPP, platelet poor plasma, Molecular Docking Simulation, Interleukin 10, GTEx, Genotype-Tissue Expression Portal, 030220 oncology & carcinogenesis, Molecular Medicine, LPS, lipopolysaccharide, Quercetin, Rabbits, NEN, N-ethyl-1,8-naphthalimide, TCM, traditional Chinese medicine, Signal Transduction, Systems pharmacology, SymMap, Symptom Mapping, Computational biology, Biology, Antiviral Agents, Article, 03 medical and health sciences, PGE2, prostaglanding E2, Text mining, Traditional Chinese medicine, TPM, transcripts per million, ACE2, Angiotensin-converting enzyme 2, HLMs, human liver microsomes, ELISA, enzyme linked immunosorbent assay, Animals, Humans, PRP, rich platelet plasma, Mode of action, STRING, the Search Tool for the Retrieval of Interacting Genes, 030304 developmental biology, Flavonoids, Pharmacology, Cell growth, business.industry, SARS-CoV-2, Hesperidin, Computational Biology, COVID-19, Glycyrrhizic Acid, COVID-19 Drug Treatment, RAW 264.7 Cells, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2, Complementary and alternative medicine, AP-MS, affinity purification mass spectrometry, business, Drugs, Chinese Herbal, Network pharmacology, Pathway, QFPDD, Qing-Fei-Pai-Du decoction
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المؤلفون: Nancy Antoine, Lucie Ruiz, Holger Klein, Patrick Gilon, Anne Wojtusciszyn, Fiona M. Gribble, Frank Reimann, Robert Augustin, Bao-Khanh Lai, Bilal Singh, Michael P. Pieper, Eva Gatineau, Nano Rita, Mohammed Bensellam, Pedro Luis Herrera, Birgit Stierstorfer, Firas Khattab, Heeyoung Chae, Lorenzo Piemonti, Davide Brusa, Michael Mark, Eric Mayoux, Christophe Broca
المساهمون: Université Catholique de Louvain = Catholic University of Louvain (UCL), Boehringer Ingelheim Pharma GmbH & Co. KG, University of Geneva [Switzerland], Addenbrooke's Hospital, Cambridge University NHS Trust, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Lausanne University Hospital, IRCCS Ospedale San Raffaele [Milan, Italy], Chae, Heeyoung, Augustin, Robert, Gatineau, Eva, Mayoux, Eric, Bensellam, Mohammed, Antoine, Nancy, Khattab, Fira, Lai, Bao-Khanh, Brusa, Davide, Stierstorfer, Birgit, Klein, Holger, Singh, Bilal, Ruiz, Lucie, Pieper, Michael, Mark, Michael, Herrera, Pedro L, Gribble, Fiona M, Reimann, Frank, Wojtusciszyn, Anne, Broca, Christophe, Rita, Nano, Piemonti, Lorenzo, Gilon, Patrick, Gribble, Fiona [0000-0002-4232-2898], Reimann, Frank [0000-0001-9399-6377], Apollo - University of Cambridge Repository
المصدر: Molecular Metabolism
Molecular metabolism, vol. 42, pp. 101071
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 42, pp.101071. ⟨10.1016/j.molmet.2020.101071⟩
Molecular Metabolism (2020) P. 101071
Molecular Metabolism, Vol 42, Iss, Pp 101071-(2020)مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, medicine.medical_treatment, IC50, half maximal inhibitory concentration, SGLT2i, sodium-glucose cotransporter 2 inhibitors, MESH: Insulin Secretion, MESH: Glucosides, MESH: Insulin-Secreting Cells, chemistry.chemical_compound, Mice, αMG, α-methyl-D-glucopyranoside, EGP, endogenous glucose production, 0302 clinical medicine, Glucosides, Glucagon-Like Peptide 1, Insulin-Secreting Cells, FACS, fluorescence-activated cell sorting, Insulin Secretion, Insulin, ddc:576.5, MESH: Animals, Dapagliflozin, geography.geographical_feature_category, Chemistry, MESH: Glucagon, BW, body weight, Diabetes, SGLT2 inhibitor, MESH: Pancreas, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Islet, 3. Good health, SGLT, sodium-glucose cotransporter, MESH: Glucose, MESH: Sodium-Glucose Transporter 2, No direct effect of SGLT2i on α- and β-cells, MESH: Sodium-Glucose Transporter 2 Inhibitors, Ketone bodies, Original Article, medicine.medical_specialty, lcsh:Internal medicine, endocrine system, MESH: Rats, 030209 endocrinology & metabolism, MESH: Insulin, Glucagon, 03 medical and health sciences, Islets of Langerhans, Gliflozins, TPM, transcripts per million, Sodium-Glucose Transporter 2, G, glucose, In vivo, Internal medicine, Empagliflozin, medicine, MESH: Benzhydryl Compounds, Animals, Humans, Benzhydryl Compounds, lcsh:RC31-1245, Molecular Biology, MESH: Mice, Pancreas, Sodium-Glucose Transporter 2 Inhibitors, geography, MESH: Humans, MESH: Islets of Langerhans, Glucose transporter, MESH: Glucagon-Like Peptide 1, Cell Biology, Rats, 030104 developmental biology, Endocrinology, Glucose, Glucagon-Secreting Cells, MESH: Blood Glucose, MESH: Glucagon-Secreting Cells, Cmax, maximum serum concentration, diabetes, glucagon, insulin
وصف الملف: application/pdf
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المؤلفون: Qin Li, Hena Zhang, Hongyan Lai, Yuchen Li, Yan Li, Zhixiang Hu, Shenglin Huang, Xigan He
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2851-2859 (2020)مصطلحات موضوعية: Cell type, exLR-seq, extracellular vesicles long RNA sequencing, lcsh:Biotechnology, Cell, Biophysics, Biology, Matrix (biology), exLRs, extracellular vesicles long RNAs, Biochemistry, CSF, cerebrospinal fluid, Extracellular vesicles long RNA sequencing, GEP, gene expression profile, 03 medical and health sciences, 0302 clinical medicine, TPM, transcripts per million, Structural Biology, lcsh:TP248.13-248.65, Gene expression, Genetics, medicine, Liquid biopsy, 030304 developmental biology, ComputingMethodologies_COMPUTERGRAPHICS, Body fluid, 0303 health sciences, RNA, EVs, extracellular vesicles, Tissue-cellular origin, Tissue-specific genes, Circulating EVs, Computer Science Applications, Cell biology, Haematopoiesis, medicine.anatomical_structure, TSS, tissue-specific score, TSGs, tissue-specific genes, 030220 oncology & carcinogenesis, Biotechnology, Research Article
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المؤلفون: Jennifer Landsberg, Dennis Niebel, Emma Grace Bawden, Holger Fröhlich, Judith Sirokay, Glen Kristiansen, Friedrich Bootz, Anne Fröhlich, Sophia Loick, Gonzalo Saavedra, Simon Fietz, Romina Zarbl, Jörn Dietrich, Gerrit H. Gielen, Dimo Dietrich, Eric Diekmann
المساهمون: Publica
المصدر: EBioMedicine, Vol 52, Iss, Pp-(2020)
EBioMedicineمصطلحات موضوعية: 0301 basic medicine, Research paper, medicine.medical_treatment, MAPK, Mitogen-activated protein kinase, lcsh:Medicine, Epigenesis, Genetic, 4-1BB, 0302 clinical medicine, Gene expression, Leukocytes, Neoplasm Metastasis, Melanoma, FFPET, Formalin-fixed and paraffin-embedded tissue, lcsh:R5-920, DNA methylation, NAT, Normal adjacent tissue, MR, Mixed response, CD137, PBMCs, Peripheral blood mononucleated cells, PD-1, Programmed cell death 1, General Medicine, Methylation, Prognosis, TNFRSF9, CTLA4, Cytotoxic T-lymphocyte associated protein 4, NA, Not assessable, Gene Expression Regulation, Neoplastic, Predictive biomarker, CpG site, Immune cell infiltration, NF-kB, Nuclear factor 'kappa-light-chain-enhancer' of activated B-cells, 030220 oncology & carcinogenesis, Cytokines, IDH1, Isocitrate dehydrogenase 1, 95% CI, 95% confidence interval, Immune checkpoint, Immunotherapy, LAG3, lymphocyte activating 3, lcsh:Medicine (General), PD, Progressive disease, IRB, Institutional Review Board, MYC, MYC proto-oncogene, Prognostic biomarker, n.c., Normalized counts, Tregs, Regulatory T cells, General Biochemistry, Genetics and Molecular Biology, TILs, Tumor infiltrating lymphocytes, TPM, Transcripts per million, Interferon-gamma, Tumor Necrosis Factor Receptor Superfamily, Member 9, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, CR, Complete response, PFS, Progression-free survival, Response prediction, Biomarkers, Tumor, medicine, Humans, RNA, Messenger, PD-L1, Programmed cell death 1 ligand 1, Epigenetics, Neoplasm Staging, TNFRS9, Tumor necrosis factor receptor super family 9, business.industry, qMSP, quantitative methylation-specific PCR, lcsh:R, NK cells, Natural killer cells, PR, Partial response, HIF1-α, Hypoxia-inducible factor 1-alpha, 030104 developmental biology, Case-Control Studies, OS, Overall survival, BRAF, V-raf murine sarcoma viral oncogene homolog B1, Cancer research, TCGA, The Cancer Genome Atlas, IL-2, Interleukin 2, LHR, Likelihood Ratio, Neoplasm Grading, SKCM, Skin cutaneous melanoma, business, ARID2, AT-rich interactive domain-containing protein 2, IFN-γ, Interferon gamma, TALs, Tumor-associated lymphocytes
وصف الملف: application/pdf
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المؤلفون: R.E.B. Hanna, Kathryn M. Huson, Nicola A.M. Oliver, Philip Best, J.P. Barley, Sam Haldenby, Mark W. Robinson, Tom N. McNeilly, Steve Paterson, Erwan Atcheson, Yongxiang Fang
المصدر: Molecular & Cellular Proteomics : MCP
مصطلحات موضوعية: α-CdE/S, anti–C. daubneyi excretory/secretory protein antibody, rumen fluke, Rumen, Host–pathogen interaction, AbD, antibody diluent, TCA, tricarboxylic acid, diagnostic, Virulence, Trematode Infections, Biochemistry, DE, differential expression, E/S, excretory/secretory, Analytical Chemistry, Microbiology, Transcriptome, Feces, 03 medical and health sciences, TPM, transcripts per million, FaBP, fatty acid–binding protein, Cysteine Proteases, parasitic diseases, Animals, Helminths, Parasite hosting, HDM, helminth defense molecule, Paramphistomatidae, Molecular Biology, Pathogen, FA, formic acid, Secretome, 030304 developmental biology, Life Cycle Stages, 0303 health sciences, biology, Host (biology), Research, Calicophoron daubneyi, 030302 biochemistry & molecular biology, coproantigen, paramphistome, Helminth Proteins, biology.organism_classification, NEJ, newly excysted juvenile, Antigens, Helminth, emPAI, exponentially modified protein abundance index, ELISA, Cattle
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8017f50fbe709749b3c449a9da955a1d
https://doi.org/10.1074/mcp.ra120.002175 -
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المؤلفون: Marie J. Parsons, Simon Keely
المصدر: Cellular and Molecular Gastroenterology and Hepatology
مصطلحات موضوعية: Carcinogenesis, Bioinformatics, Phosphatidylinositol 3-Kinases, AOM, azoxymethane, GSEA, gene set enrichment analysis, Tumor Microenvironment, Original Research, FOXO3, forkhead box O3, Mice, Knockout, Colon Cancer, IBD, inflammatory bowel disease, Forkhead Box Protein O3, FOXO3, Gastroenterology, MSI, microsatellite instability, PRECOG, prediction of clinical outcomes from genomic profiles, SNP, single nucleotide polymorphism, RNAseq, DE, differentially expressed, ADAMTS12, ADAM metallopeptidase with thrombospondin type 1 motif 12, Tumor Burden, MMP, matrix metalloproteinase, Gene Expression Regulation, Neoplastic, Editorial, TIMER, Tumor Immune Estimation Resource, Colonic Neoplasms, shRNA, short hairpin RNA, Disease Progression, qPCR, quantitative polymerase chain reaction, medicine.symptom, NK, natural killer, TLR, Toll-like receptor, FDR, false discovery rate, Colon, MEDLINE, Inflammation, TPM, transcripts per million, Text mining, DSS, dextran sulfate sodium, medicine, Animals, Humans, RNA, Messenger, Cell Proliferation, KO, knockout, Hepatology, business.industry, Gene Expression Profiling, CIBERSORT, cell-type identification by estimating relative subsets of RNA transcripts, ITGA2, integrin subunit alpha 2, HCT116 Cells, Inflammatory Bowel Diseases, WT, wild-type, Survival Analysis, RNAseq, mRNA sequencing, Mice, Inbred C57BL, Gene expression profiling, ST8SIA5, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5, NFκB, nuclear factor kappa B, IPA, ingenuity pathways analysis, TCGA, The Cancer Genome Atlas, business
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المؤلفون: Kathryn F. Tonissen, Maneet Bhatia, Giovanna Di Trapani, Mallory M. King, Kelly L. McGrath, Fenil Shah, F.M. Clarke, Pornpimol Charoentong
المصدر: Redox Biology, Vol 8, Iss C, Pp 68-78 (2016)
Redox Biologyمصطلحات موضوعية: RFU, relative fluorescence units, 0301 basic medicine, Clinical Biochemistry, Gene Expression, TXNIP, thioredoxin interacting protein, Biochemistry, H2DCF-DA, 2′,7′-dichlorodihydrofluorescein diacetate, Metastasis, Thioredoxins, 0302 clinical medicine, Breast cancer, Cell Movement, Trx, thioredoxin, lcsh:QH301-705.5, GFP, green fluorescent protein, TCGA, the cancer genome atlas, lcsh:R5-920, MTT, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Cell migration, Prognosis, VEGF, vascular endothelial growth factor, Cell invasion, ATL, adult T-cell leukemia, MMP, matrix metalloproteinase, 030220 oncology & carcinogenesis, Female, TIMP, tissue inhibitor of metalloproteinase, Thioredoxin, lcsh:Medicine (General), Oxidation-Reduction, Research Paper, medicine.drug, Thioredoxin Reductase 1, TrxR, thioredoxin reductase, Auranofin, Cell Survival, TNB, 2-nitro-5-thiobenzoate anion, Breast Neoplasms, Biology, OS, overall survival, 03 medical and health sciences, ROS, reactive oxygen species, TPM, transcripts per million, FBS, fetal bovine serum, Cell Line, Tumor, HUVEC, human umbilical vein endothelial cells, medicine, Humans, Cell Proliferation, DTNB, 5,5′-Dithio-Bis (2-Nitrobenzoic Acid), Cell growth, Gene Expression Profiling, Organic Chemistry, Cancer, medicine.disease, HR, hazard ratio, CI, confidence interval, DFS, disease free survival, 030104 developmental biology, lcsh:Biology (General), DTT, dithiothreitol, Cancer cell, Immunology, Cancer research, Patient survival, DMFS, distant-metastasis free survival, Extracellular Space, Reactive Oxygen Species, Transcriptome
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1bbe4ecc6f7479b84181edf4ab715b
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