يعرض 1 - 3 نتائج من 3 نتيجة بحث عن '"Tadano Lohr M"', وقت الاستعلام: 0.85s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Metabolic activation of mefenamic acid leading to mefenamyl-S-acyl-glutathione adduct formation in vitro and in vivo in rat.

    المؤلفون: Grillo MP; Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA. grillo@amgen.com, Tadano Lohr M, Wait JC

    المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2012 Aug; Vol. 40 (8), pp. 1515-26. Date of Electronic Publication: 2012 May 10.

    نوع المنشور: Journal Article

    بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

    مواضيع طبية MeSH: Biotransformation*, Glutathione/*pharmacokinetics , Mefenamic Acid/*pharmacokinetics, Animals ; Chromatography, Liquid ; Hepatocytes/metabolism ; Humans ; In Vitro Techniques ; Rats ; Tandem Mass Spectrometry

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  2. 2
    دورية أكاديمية
    Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interaction.

    المؤلفون: Wong SG; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, USA. simon.wong@amgen.com, Fan PW, Subramanian R, Tonn GR, Henne KR, Johnson MG, Tadano Lohr M, Wong BK

    المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2010 May; Vol. 38 (5), pp. 841-50. Date of Electronic Publication: 2010 Jan 25.

    نوع المنشور: Journal Article

    بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

    مواضيع طبية MeSH: Cytochrome P-450 CYP3A/*drug effects , Cytochrome P-450 CYP3A/*metabolism , Glutathione/*metabolism , Indoles/*metabolism , Receptors, Immunologic/*antagonists & inhibitors , Receptors, Prostaglandin/*antagonists & inhibitors, Animals ; Area Under Curve ; Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors ; Aryl Hydrocarbon Hydroxylases/drug effects ; Aryl Hydrocarbon Hydroxylases/metabolism ; Biocatalysis/drug effects ; Cytochrome P-450 CYP3A Inhibitors ; Cytochrome P-450 Enzyme Inhibitors ; Cytochrome P-450 Enzyme System/drug effects ; Cytochrome P-450 Enzyme System/metabolism ; Drug Interactions ; Horseradish Peroxidase/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Indinavir/metabolism ; Indinavir/pharmacokinetics ; Indoles/pharmacology ; Kinetics ; Magnetic Resonance Spectroscopy ; Male ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/drug effects ; Membrane Proteins/metabolism ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Midazolam/metabolism ; Midazolam/pharmacokinetics ; Models, Biological ; Molecular Structure ; NADP/metabolism ; Pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry

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  3. 3
    دورية أكاديمية
    Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes.

    المؤلفون: Grillo MP; Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, CA 94080, USA. grillo@amgen.com, Wait JC, Tadano Lohr M, Khera S, Benet LZ

    المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2010 Jan; Vol. 38 (1), pp. 133-42.

    نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

    بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

    مواضيع طبية MeSH: Acyl Coenzyme A/*biosynthesis , Benzoxazoles/*chemistry , Benzoxazoles/*metabolism , Esters/*metabolism , Glutathione/*metabolism , Hepatocytes/*metabolism , Sulfhydryl Compounds/*metabolism, Acyl Coenzyme A/metabolism ; Acylation ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/metabolism ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Benzoxazoles/pharmacokinetics ; Biocatalysis ; Biotransformation ; Camphanes/pharmacology ; Chromatography, High Pressure Liquid ; Enzyme Inhibitors/pharmacology ; Glucuronic Acid/metabolism ; Glutathione/chemistry ; Hepatocytes/drug effects ; Hepatocytes/enzymology ; Ibuprofen/metabolism ; Kinetics ; Lauric Acids/pharmacology ; Male ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism ; Tandem Mass Spectrometry

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