المؤلفون: Talwelkar SS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; Institute of Biomedicine and MediCity Research Laboratories, University of Turku, Finland., Mäyränpää MI; Department of Pathology, Helsinki University Hospital and University of Helsinki, Finland., Schüler J; Charles River Research Services, Germany GmbH, Freiburg im Breisgau, Germany., Linnavirta N; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland., Hemmes A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland., Adinolfi S; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Kankainen M; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland., Sommergruber W; Cancer Cell Signalling, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.; Department of Biotechnology, University of Applied Sciences, Vienna, Austria., Levonen AL; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Räsänen J; Department of Thoracic Surgery, Heart and Lung Center, Helsinki University Hospital, Finland., Knuuttila A; Department of Pulmonary Medicine, Heart and Lung Center and Cancer Center, Helsinki University Hospital, Finland., Verschuren EW; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, Finland.; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Finland., Wennerberg K; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland.; Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Denmark.

المصدر: Molecular oncology [Mol Oncol] 2023 May; Vol. 17 (5), pp. 747-764. Date of Electronic Publication: 2023 Jan 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/pathology, Humans ; Phosphatidylinositol 3-Kinases ; Receptor Protein-Tyrosine Kinases/metabolism ; Anaplastic Lymphoma Kinase/genetics ; Protein Kinase Inhibitors/adverse effects ; ErbB Receptors/genetics

المؤلفون: Talwelkar SS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland; Institute of Biomedicine and MediCity Research Laboratories, University of Turku, Turku 20520, Finland., Lähdeniemi IAK; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland., Mäyränpää MI; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Hemmes A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland., Linnavirta N; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland., Räsänen J; Department of Thoracic Surgery, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland., Knuuttila A; Department of Pulmonary Medicine, Heart and Lung Center and Cancer Center, Helsinki University Hospital, Helsinki, Finland., Wennerberg K; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland; BRIC - Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: krister.wennerberg@bric.ku.dk., Verschuren EW; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland. Electronic address: emmy.verschuren@helsinki.fi.

المصدر: STAR protocols [STAR Protoc] 2022 Dec 16; Vol. 3 (4), pp. 101720. Date of Electronic Publication: 2022 Sep 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms*, Humans ; Epithelial Cells

المؤلفون: Lähdeniemi IAK; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Devlin JR; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Nagaraj AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Talwelkar SS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Bao J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Linnavirta N; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Şeref Vujaklija C; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Kiss EA; University of Helsinki and Wihuri Research Institute, Helsinki, Finland., Hemmes A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Verschuren EW; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

المصدر: Biology open [Biol Open] 2022 Dec 15; Vol. 11 (12). Date of Electronic Publication: 2022 Dec 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101578018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-6390 (Electronic) Linking ISSN: 20466390 NLM ISO Abbreviation: Biol Open Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Adenosquamous*/genetics , Lung Neoplasms*/genetics , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Squamous Cell*/genetics , Carcinoma, Squamous Cell*/pathology , Adenocarcinoma*/pathology, Humans ; ErbB Receptors/genetics ; Tumor Microenvironment

المؤلفون: Gao Y; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY., Päivinen P; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Tripathi S; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Domènech-Moreno E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Wong IPL; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Vaahtomeri K; Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki and Wihuri Research Institute, Helsinki, Finland., Nagaraj AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Talwelkar SS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Foretz M; Université de Paris, Institut Cochin, CNRS, INSERM, Paris, France., Verschuren EW; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Viollet B; Université de Paris, Institut Cochin, CNRS, INSERM, Paris, France., Yan Y; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland. yany@mskcc.org.; HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Mäkelä TP; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.; HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Jan 01; Vol. 28 (1), pp. 227-237. Date of Electronic Publication: 2021 Oct 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma of Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/genetics , Lung Neoplasms*/pathology, AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Animals ; Antigen Presentation ; Humans ; Immune Evasion ; Mice ; Tumor Microenvironment

المؤلفون: Talwelkar SS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland., Mäyränpää MI; HUSLAB, Division of Pathology, Helsinki University Hospital and University of Helsinki, Helsinki 00029, Finland.; Department of Pathology, University of Helsinki, Helsinki 00014, Finland., Søraas L; Pontoppidans Gate 9B, 0462 Oslo, Norway., Potdar S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland., Bao J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland., Hemmes A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland., Linnavirta N; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland., Lømo J; Department of Pathology, Oslo University Hospital, Oslo, Norway., Räsänen J; Department of Thoracic Surgery, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland., Knuuttila A; Department of Pulmonary Medicine, Heart and Lung Center, and Cancer Center, Helsinki University Hospital, Helsinki, Finland., Wennerberg K; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.; BRIC-Biotech Research & Innovation Centre and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, 2200 Copenhagen, Denmark., Verschuren EW; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki 00014, Finland.

المصدر: Cell reports. Medicine [Cell Rep Med] 2021 Aug 17; Vol. 2 (8), pp. 100373. Date of Electronic Publication: 2021 Aug 17 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med

مواضيع طبية MeSH: Precision Medicine*, Lung Neoplasms/*diagnosis , Lung Neoplasms/*pathology, Adenocarcinoma of Lung/diagnosis ; Adenocarcinoma of Lung/pathology ; Adult ; Aged ; Animals ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/pathology ; Cellular Reprogramming ; Epithelial Cells/pathology ; Female ; Humans ; Male ; Mice ; Middle Aged ; Molecular Targeted Therapy ; Proto-Oncogene Proteins p21(ras)/genetics ; Signal Transduction ; Tumor Cells, Cultured

المؤلفون: Talwelkar SS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Nagaraj AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Devlin JR; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Hemmes A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Potdar S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Kiss EA; University of Helsinki and Wihuri Research Institute, Helsinki, Finland., Saharinen P; University of Helsinki and Wihuri Research Institute, Helsinki, Finland., Salmenkivi K; HUSLAB, Division of Pathology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Mäyränpää MI; HUSLAB, Division of Pathology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Department of Pathology, University of Helsinki, Helsinki, Finland., Wennerberg K; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark., Verschuren EW; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. emmy.verschuren@helsinki.fi.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2019 Oct; Vol. 18 (10), pp. 1863-1874. Date of Electronic Publication: 2019 Jul 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction*, ErbB Receptors/*antagonists & inhibitors , Lung Neoplasms/*genetics , Mutation/*genetics , Proto-Oncogene Proteins p21(ras)/*genetics , Receptor Protein-Tyrosine Kinases/*metabolism, Animals ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Line, Tumor ; Cell Proliferation ; Enzyme Activation ; ErbB Receptors/metabolism ; Genotype ; Humans ; Lung Neoplasms/drug therapy ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism

المؤلفون: Srivastava RK; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, 35294-0019, USA., Kaylani SZ; Division of Hematology/Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35294-0019, USA., Edrees N; Division of Hematology/Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35294-0019, USA., Li C; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, 35294-0019, USA., Talwelkar SS; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, 35294-0019, USA., Xu J; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, 35294-0019, USA., Palle K; Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604., Pressey JG; Division of Hematology/Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, 35294-0019, USA., Athar M; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, 35294-0019, USA.

المصدر: Oncotarget [Oncotarget] 2014 Dec 15; Vol. 5 (23), pp. 12151-65.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Pyridines/*pharmacology , Pyrimidines/*pharmacology , Rhabdomyosarcoma, Alveolar/*pathology , Rhabdomyosarcoma, Embryonal/*pathology , Signal Transduction/*drug effects, Animals ; Blotting, Western ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Flow Cytometry ; Fluorescent Antibody Technique ; Hedgehog Proteins/metabolism ; Humans ; Immunohistochemistry ; Mice ; Mice, Nude ; Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Rhabdomyosarcoma, Alveolar/metabolism ; Rhabdomyosarcoma, Embryonal/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Trans-Activators/antagonists & inhibitors ; Xenograft Model Antitumor Assays ; Zinc Finger Protein GLI1

المؤلفون: Chaudhary SC; Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294-0019. mathar@uab.edu., Singh T, Talwelkar SS, Srivastava RK, Arumugam A, Weng Z, Elmets CA, Afaq F, Kopelovich L, Athar M

المصدر: Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2014 Feb; Vol. 7 (2), pp. 186-98. Date of Electronic Publication: 2013 Nov 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101479409 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-6215 (Electronic) Linking ISSN: 19406215 NLM ISO Abbreviation: Cancer Prev Res (Phila) Subsets: MEDLINE

مواضيع طبية MeSH: Carcinogenesis/*drug effects , Oxazoles/*pharmacology , Skin Neoplasms/*prevention & control , Wnt Signaling Pathway/*drug effects, Animals ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinogenesis/radiation effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Down-Regulation/drug effects ; Estrogen Receptor beta/agonists ; Female ; Humans ; Mice ; Mice, Hairless ; Skin Neoplasms/etiology ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Ultraviolet Rays/adverse effects ; Wnt Signaling Pathway/radiation effects

المؤلفون: Arumugam A; Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America., Weng Z, Talwelkar SS, Chaudhary SC, Kopelovich L, Elmets CA, Afaq F, Athar M

المصدر: PloS one [PLoS One] 2013 Nov 08; Vol. 8 (11), pp. e80076. Date of Electronic Publication: 2013 Nov 08 (Print Publication: 2013).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Ornithine Decarboxylase Inhibitors*, Carcinoma, Squamous Cell/*drug therapy , Cyclooxygenase 2/*metabolism , Diclofenac/*pharmacology , Eflornithine/*pharmacology , MAP Kinase Signaling System/*drug effects , Proto-Oncogene Proteins c-akt/*metabolism , Skin Neoplasms/*drug therapy, Animals ; Carcinoma, Squamous Cell/metabolism ; Carrier Proteins/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cyclooxygenase 2 Inhibitors/pharmacology ; Down-Regulation/drug effects ; Female ; Humans ; Mice ; Mice, Nude ; Ornithine Decarboxylase/metabolism ; Phosphorylation/drug effects ; Signal Transduction/drug effects ; Skin Neoplasms/metabolism

المؤلفون: Yadav S; Developmental Toxicology Division, Indian Institute of Toxicology Research (CSIR-IITR), MG Marg-80, Lucknow 226001, India. sanjay@iitr.res.in, Pandey A, Shukla A, Talwelkar SS, Kumar A, Pant AB, Parmar D

المصدر: The Journal of biological chemistry [J Biol Chem] 2011 Oct 28; Vol. 286 (43), pp. 37347-57. Date of Electronic Publication: 2011 Aug 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Central Nervous System Depressants/*pharmacology , Cyclin D2/*metabolism , Ethanol/*pharmacology , MicroRNAs/*metabolism , Neurons/*metabolism , Proto-Oncogene Proteins c-bcl-2/*metabolism, 3' Untranslated Regions/genetics ; Apoptosis/genetics ; Cell Line, Tumor ; Cyclin D2/genetics ; Cytochromes c/genetics ; Cytochromes c/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Membrane Potential, Mitochondrial/genetics ; MicroRNAs/genetics ; Neurons/cytology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Reactive Oxygen Species/metabolism ; Time Factors