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المؤلفون: Sharat Singh, Tamara J. van Steeg, Geert R. D'Haens, J.F. Brandse, Sophie E. Berends, Ron A. A. Mathôt, Maurice J. Ahsman
المساهمون: Graduate School, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AII - Infectious diseases, Gastroenterology and Hepatology, Pharmacy, ACS - Pulmonary hypertension & thrombosis, Gastroenterology and hepatology
المصدر: Journal of pharmacokinetics and pharmacodynamics, 46(6). Springer New York
Berends, S E, van Steeg, T J, Ahsman, M J, Singh, S, Brandse, J F, D’Haens, G R A M & Mathôt, R A A 2019, ' Tumor necrosis factor-mediated disposition of infliximab in ulcerative colitis patients ', Journal of Pharmacokinetics and Pharmacodynamics, vol. 46, no. 6, pp. 543-551 . https://doi.org/10.1007/s10928-019-09652-5
Journal of Pharmacokinetics and Pharmacodynamics, 46(6), 543-551. Springer New York
Journal of Pharmacokinetics and Pharmacodynamicsمصطلحات موضوعية: Adult, Male, Monoclonal antibody, medicine.medical_specialty, medicine.drug_class, 030226 pharmacology & pharmacy, Inflammatory bowel disease, Gastroenterology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Humans, Aged, Pharmacology, Original Paper, Target-mediated drug disposition, Tumor Necrosis Factor-alpha, business.industry, Antibodies, Monoclonal, Middle Aged, medicine.disease, Ulcerative colitis, Infliximab, NONMEM, Nonlinear Dynamics, 030220 oncology & carcinogenesis, Pharmacodynamics, Colitis, Ulcerative, Female, Tumor necrosis factor alpha, business, medicine.drug
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المؤلفون: Julie A. Stone, Huub Jan Kleijn, Eline M. T. van Maanen, Mary J. Savage, Maria S. Michener, Matthew E. Kennedy, Tamara J. van Steeg, Maurice J. Ahsman, Meindert Danhof
المصدر: Journal of Pharmacology and Experimental Therapeutics. 365:507-518
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Model refinement, biology, Metabolite, Cleavage (embryo), Oligomer, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, mental disorders, Amyloid precursor protein, biology.protein, Molecular Medicine, γ secretase, Formation rate, 030217 neurology & neurosurgery, Systems pharmacology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::73ed61ef3a7f9abe38bdca2d3a0add1f
https://doi.org/10.1124/jpet.117.244699 -
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المؤلفون: Emir Mesic, Piet H. van der Graaf, James R. Gosset, Sonia Roberts, Diana Hijdra, Jolie Harris, Kevin Beaumont, Tamara J. van Steeg, Kristina Ulrich, Wendy J. Winchester, Ian Lightbown, Sophie Glatt, Tomomi Matsuura, Neil Attkins
المصدر: European Journal of Pharmaceutical Sciences. 109:S161-S167
مصطلحات موضوعية: Pain, TRPM Cation Channels, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, Body Temperature, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Sensation, TRPM8, Animals, Humans, Pharmacokinetics, Core (anatomy), Trpm8 channel, Chemistry, Pharmacokinetic pharmacodynamic, Safety pharmacology, Body Weight, Cold pressor test, Rats, Blockade, Cold Temperature, Pharmaceutical Preparations, 030217 neurology & neurosurgery
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المؤلفون: Tamara J. van Steeg, Akihiko Goto, Takeshi Wakabayashi, Toshiya Moriwaki, Yoshihiko Tagawa, Joost DeJongh, Yoshiyuki Furukawa, Sho Sato, Tetsuya Tsukamoto, Yuu Moriya, Satoru Asahi
المصدر: Biopharmaceutics & Drug Disposition. 38:373-380
مصطلحات موضوعية: Male, 0301 basic medicine, Physiologically based pharmacokinetic modelling, Repeated dosing, Pharmaceutical Science, Adipose tissue, Pharmacology, Body weight, Models, Biological, 030226 pharmacology & pharmacy, Rats, Sprague-Dawley, 03 medical and health sciences, Dogs, 0302 clinical medicine, Pharmacokinetics, Animals, Toxicokinetics, Computer Simulation, Pharmacology (medical), Chemistry, General Medicine, 030104 developmental biology, Adipose Tissue, Indenes, Biochemistry, Plasma concentration
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المؤلفون: Tamara J. van Steeg, Nazzareno Dimasi, Kris Sachsenmeier, Balaji Agoram, Kirsten Riber Bergmann
المصدر: mAbs
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Bispecific antibody, binding, medicine.drug_class, Immunology, Computational biology, bispecific, Monoclonal antibody, Monovalent, 03 medical and health sciences, 0302 clinical medicine, avidity, Antibodies, Bispecific, medicine, mathematical, Immunology and Allergy, Computer Simulation, Avidity, Single agent, model, Chemistry, Models, Immunological, Molecular biology, In vitro binding, spatial, 030104 developmental biology, Affinity, limitation, 030220 oncology & carcinogenesis, Reports
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المؤلفون: Piet H. van der Graaf, Anne Keunecke, Jan Berkhout, Lindsay B. Avery, Tamara J. van Steeg, Hannah M. Jones, Alison Betts
المصدر: mAbs. 10(5)
مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, medicine.drug_class, Metabolic Clearance Rate, Immunology, Population, Endogeny, Mice, Transgenic, Population pharmacokinetics, Receptors, Fc, Biology, Pharmacology, Monoclonal antibody, 030226 pharmacology & pharmacy, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Species Specificity, medicine, Immunology and Allergy, Animals, Humans, Tissue Distribution, education, education.field_of_study, fungi, Histocompatibility Antigens Class I, food and beverages, Antibodies, Monoclonal, Macaca fascicularis, 030104 developmental biology, Immunoglobulin G, Algorithms
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المؤلفون: Eline M T, van Maanen, Tamara J, van Steeg, Maurice J, Ahsman, Maria S, Michener, Mary J, Savage, Matthew E, Kennedy, Huub Jan, Kleijn, Julie, Stone, Meindert, Danhof
المصدر: The Journal of pharmacology and experimental therapeutics. 365(3)
مصطلحات موضوعية: Amyloid beta-Protein Precursor, Proteolysis, Animals, Amyloid Precursor Protein Secretases, Enzyme Inhibitors, Macaca mulatta, Models, Biological
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3c799fcd8eb9bbb3ec7549d934ae22ac
https://pubmed.ncbi.nlm.nih.gov/29563326 -
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المؤلفون: Maria S. Michener, Tamara J. van Steeg, Julie A. Stone, Matthew E. Kennedy, Juliya Kalinina, Mary J. Savage, Eline M.T. van Maanen, Meindert Danhof, Eric M. Parker
المصدر: Alzheimer's & Dementia. 13
مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, chemistry, Epidemiology, Order (business), Health Policy, Biophysics, Neurology (clinical), Geriatrics and Gerontology, Oligomer, Systems pharmacology
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المؤلفون: Meindert Danhof, Juliya Kalinina, Mary J. Savage, Matthew E. Kennedy, Julie A. Stone, Tamara J. van Steeg, Eline M. T. van Maanen, Maria S. Michener
المصدر: Alzheimer's & Dementia. 13
مصطلحات موضوعية: biology, Epidemiology, Mechanism (biology), Chemistry, Health Policy, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Amyloid precursor protein, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Resilience (network), Neuroscience, Gamma secretase, Systems pharmacology
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المؤلفون: Ankur Karmokar, Jacquelline H. Fok, Anna Staniszewska, Michael Davies, Tamara J. van Steeg, Andy Sykes, Antonio Ramos-Montoya, Neil H. James, Emma Dean, Elaine Cadogan, Frederick W. Goldberg, Joost de Jongh
المصدر: Cancer Research. 79:3511-3511
مصطلحات موضوعية: Protein kinase complex, Cancer Research, education.field_of_study, Population, Cancer, Pharmacology, medicine.disease, Olaparib, chemistry.chemical_compound, Oncology, chemistry, Pharmacokinetics, Pharmacodynamics, medicine, education, Protein kinase A, DNA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2cffbbefec9a10fab92c4634af30f239
https://doi.org/10.1158/1538-7445.am2019-3511