المؤلفون: Staupe RP; Infectious Diseases and Vaccines, MRL, Merck & Co., Inc, West Point, PA, USA., Lodge KE; LAR, Integrative Vet Medicine, MRL, Merck & Co., Inc., West Point, PA, USA., Thambi N; Infectious Diseases and Vaccines, MRL, Merck & Co., Inc, West Point, PA, USA., Toole D; Atlas Data Systems, Berkeley Heights, NJ, USA.; Large Data Delivery Services, MRL, Merck & Co., Inc, West Point, PA, USA., Tamburino AM; Genome & Biomarker Sciences, MRL, Merck & Co., Inc, West Point, PA, USA., Chang D; Genome & Biomarker Sciences, MRL, Merck & Co., Inc, Cambridge, MA, USA.; AbbVie Inc, Cambridge, MA, USA., Howell BJ; Infectious Diseases and Vaccines, MRL, Merck & Co., Inc, West Point, PA, USA.; Quantitative Biosciences, MRL, Merck & Co., Inc., West Point, PA, USA., Hazuda DJ; Infectious Diseases and Vaccines, MRL, Merck & Co., Inc, West Point, PA, USA.; Vaccine & Medical Affairs, Merck & Co., Inc., West Point, PA, USA., Vora KA; Infectious Diseases and Vaccines, MRL, Merck & Co., Inc, West Point, PA, USA., Sullivan NL; Infectious Diseases and Vaccines, MRL, Merck & Co., Inc, West Point, PA, USA. nicole.sullivan@merck.com.

المصدر: Communications biology [Commun Biol] 2022 Dec 21; Vol. 5 (1), pp. 1399. Date of Electronic Publication: 2022 Dec 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

مواضيع طبية MeSH: Plasma Cells* , Multiomics*, Mice ; Animals ; Antibody Formation ; Antibodies ; Primates ; Biomarkers

المؤلفون: Monroe JJ; Safety Assessment & Laboratory Animal Resources., Tanis KQ; Human Genetics & Pharmacogenomics., Podtelezhnikov AA; Human Genetics & Pharmacogenomics., Nguyen T; Safety Assessment & Laboratory Animal Resources., Machotka SV; Safety Assessment & Laboratory Animal Resources., Lynch D; Safety Assessment & Laboratory Animal Resources., Evers R; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Palamanda J; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Miller RR; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Pippert T; Safety Assessment & Laboratory Animal Resources., Cabalu TD; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Johnson TE; Safety Assessment & Laboratory Animal Resources., Aslamkhan AG; Safety Assessment & Laboratory Animal Resources., Kang W; Safety Assessment & Laboratory Animal Resources., Tamburino AM; Human Genetics & Pharmacogenomics., Mitra K; Safety Assessment & Laboratory Animal Resources.; Janssen Research & Development, LLC, Spring House, PA 19486., Agrawal NGB; Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc, West Point, Pennsylvania 19486., Sistare FD; Safety Assessment & Laboratory Animal Resources.

المصدر: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2020 Sep 01; Vol. 177 (1), pp. 281-299.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Chemical and Drug Induced Liver Injury* , Pharmaceutical Preparations*, Animals ; Drug Development ; Kelch-Like ECH-Associated Protein 1 ; Male ; NF-E2-Related Factor 2/metabolism ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar

المؤلفون: Podtelezhnikov AA; Human Genetics and Pharmacogenomics., Monroe JJ; Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, Pennsylvania 19486-0004., Aslamkhan AG; Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, Pennsylvania 19486-0004., Pearson K; Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, Pennsylvania 19486-0004., Qin C; Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, Pennsylvania 19486-0004., Tamburino AM; Human Genetics and Pharmacogenomics., Loboda AP; Human Genetics and Pharmacogenomics., Glaab WE; Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, Pennsylvania 19486-0004., Sistare FD; Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, Pennsylvania 19486-0004., Tanis KQ; Human Genetics and Pharmacogenomics.

المصدر: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2020 May 01; Vol. 175 (1), pp. 98-112.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Drug Development* , Transcriptome*, Chemical and Drug Induced Liver Injury/*etiology , Liver/*drug effects , Receptors, Cytoplasmic and Nuclear/*agonists , Transcription Factors/*agonists , Xenobiotics/*toxicity, Animals ; Chemical and Drug Induced Liver Injury/genetics ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Gene Expression Profiling ; Gene Regulatory Networks ; Liver/metabolism ; Liver/pathology ; Male ; Rats, Sprague-Dawley ; Rats, Wistar ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism ; Risk Assessment ; Signal Transduction ; Toxicity Tests ; Toxicogenetics ; Transcription Factors/genetics ; Transcription Factors/metabolism

المؤلفون: Li Y; Safety Assessment and Laboratory Animal Resources., Evers R; Pharmacokinetics, Pharmacodynamics and Drug Metabolism., Hafey MJ; Pharmacokinetics, Pharmacodynamics and Drug Metabolism., Cheon K; Biometrics Research., Duong H; Safety Assessment and Laboratory Animal Resources., Lynch D; Safety Assessment and Laboratory Animal Resources., LaFranco-Scheuch L; Safety Assessment and Laboratory Animal Resources., Pacchione S; Safety Assessment and Laboratory Animal Resources., Tamburino AM; Genetics and Pharmacogenomics, MRL, West Point, PA 19486., Tanis KQ; Genetics and Pharmacogenomics, MRL, West Point, PA 19486., Geddes K; Pharmacokinetics, Pharmacodynamics and Drug Metabolism., Holder D; Biometrics Research., Zhang NR; Pharmacokinetics, Pharmacodynamics and Drug Metabolism., Kang W; Safety Assessment and Laboratory Animal Resources., Gonzalez RJ; Safety Assessment and Laboratory Animal Resources., Galijatovic-Idrizbegovic A; Safety Assessment and Laboratory Animal Resources., Pearson KM; Safety Assessment and Laboratory Animal Resources., Lebron JA; Safety Assessment and Laboratory Animal Resources., Glaab WE; Safety Assessment and Laboratory Animal Resources., Sistare FD; Safety Assessment and Laboratory Animal Resources.

المصدر: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2019 Jul 01; Vol. 170 (1), pp. 180-198.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Disease Models, Animal*, ATP Binding Cassette Transporter, Subfamily B, Member 11/*antagonists & inhibitors , Chemical and Drug Induced Liver Injury/*etiology , Chemical and Drug Induced Liver Injury/*metabolism , Pharmaceutical Preparations/*administration & dosage, ATP Binding Cassette Transporter, Subfamily B, Member 11/genetics ; Animals ; Bilirubin/blood ; Gene Knockdown Techniques ; Male ; RNA, Small Interfering/genetics ; Rats ; Rats, Wistar ; Taurochenodeoxycholic Acid/blood ; Transaminases/blood

المؤلفون: Tamburino AM; Program in Systems Biology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Kaymak E; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA., Shrestha S; Program in Systems Biology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Holdorf AD; Program in Systems Biology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Ryder SP; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA., Walhout AJM; Program in Systems Biology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

المصدر: Translation (Austin, Tex.) [Translation (Austin)] 2017 Feb 28; Vol. 5 (1), pp. e1295130. Date of Electronic Publication: 2017 Feb 28 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101601190 Publication Model: eCollection Cited Medium: Print ISSN: 2169-074X (Print) Linking ISSN: 21690731 NLM ISO Abbreviation: Translation (Austin) Subsets: PubMed not MEDLINE

المؤلفون: Fuxman Bass JI; Program in Systems Biology, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA, Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA and Divisions of Rheumatology and Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Tamburino AM, Mori A, Beittel N, Weirauch MT, Reece-Hoyes JS, Walhout AJ

المصدر: Nucleic acids research [Nucleic Acids Res] 2014 Jan; Vol. 42 (1), pp. 153-62. Date of Electronic Publication: 2013 Sep 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation* , Introns* , Promoter Regions, Genetic*, Caenorhabditis elegans/*genetics , Transcription Factors/*metabolism, Animals ; Gene Regulatory Networks ; Multigene Family

المؤلفون: Tamburino AM; Program in Systems Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA., Ryder SP, Walhout AJ

المصدر: G3 (Bethesda, Md.) [G3 (Bethesda)] 2013 Feb; Vol. 3 (2), pp. 297-304. Date of Electronic Publication: 2013 Feb 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE

مواضيع طبية MeSH: Caenorhabditis elegans/*genetics , Caenorhabditis elegans Proteins/*metabolism , RNA-Binding Proteins/*metabolism, 3' Untranslated Regions ; Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Gene Expression Regulation ; Genome ; MicroRNAs/metabolism ; Phosphorylation ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; Software ; Transcription Factors/genetics ; Transcription Factors/metabolism

المؤلفون: Roberts AE; Harvard Partners Center for Genetics and Genomics and Harvard Medical School, Boston, Massachusetts 02115, USA., Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS

المصدر: Nature genetics [Nat Genet] 2007 Jan; Vol. 39 (1), pp. 70-4. Date of Electronic Publication: 2006 Dec 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1061-4036 (Print) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Germ-Line Mutation*, Noonan Syndrome/*genetics , SOS1 Protein/*genetics, Adolescent ; Adult ; Child ; Child, Preschool ; DNA Mutational Analysis ; Female ; Genetic Testing ; Humans ; Infant ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Models, Biological ; Models, Molecular ; Protein Tyrosine Phosphatase, Non-Receptor Type 11 ; Protein Tyrosine Phosphatases/genetics ; SOS1 Protein/chemistry