المؤلفون: Tan SPF; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester M13 9PL, U.K., Tillmann A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester M13 9PL, U.K., Murby SJ; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester M13 9PL, U.K., Rostami-Hodjegan A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester M13 9PL, U.K.; Certara Predictive Technologies (CPT), Certara Inc., 1 Concourse Way, Sheffield S1 2BJ, U.K., Scotcher D; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester M13 9PL, U.K., Galetin A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester M13 9PL, U.K.

المصدر: Molecular pharmaceutics [Mol Pharm] 2024 Sep 02; Vol. 21 (9), pp. 4603-4617. Date of Electronic Publication: 2024 Aug 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Organic Anion Transport Protein 1*/metabolism , Organic Anion Transporters, Sodium-Independent*/metabolism, Humans ; Biological Transport/physiology ; Kidney/metabolism ; Animals ; Kidney Tubules, Proximal/metabolism ; Serum Albumin/metabolism ; Serum Albumin, Human/metabolism ; Cell Line

المؤلفون: Al-Qassabi J; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK; University of Technology and Applied Sciences, Oman., Tan SPF; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK., Phonboon P; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK., Galetin A; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK., Rostami-Hodjegan A; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK; Simcyp Division, Certara UK Limited, Sheffield, UK., Scotcher D; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK. Electronic address: daniel.scotcher@manchester.ac.uk.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Jun; Vol. 113 (6), pp. 1664-1673. Date of Electronic Publication: 2024 Feb 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Protein Binding* , Blood Proteins*/metabolism , Models, Biological*, Humans ; Pharmaceutical Preparations/metabolism ; Pharmaceutical Preparations/blood ; Orosomucoid/metabolism ; Aged ; Child ; Pharmacokinetics

المؤلفون: Tan SPF; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK., Willemin ME; Janssen Pharmaceutical Companies of Johnson & Johnson, Janssen Research & Development, Beerse, Belgium., Snoeys J; Janssen Pharmaceutical Companies of Johnson & Johnson, Janssen Research & Development, Beerse, Belgium., Shen H; Bristol Myers Squibb, Princeton, New Jersey, USA., Rostami-Hodjegan A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK.; Certara UK Limited (Simcyp Division), Sheffield, UK., Scotcher D; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK., Galetin A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 Dec; Vol. 114 (6), pp. 1243-1253. Date of Electronic Publication: 2023 Sep 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Pyridoxic Acid* , Renal Insufficiency, Chronic*/drug therapy, Humans ; Probenecid/pharmacology ; Kidney ; Drug Interactions ; Biomarkers ; Models, Biological

المؤلفون: Lin J; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.; A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore 138648 , Republic of Singapore., Chin SY; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #01-02, Singapore 138669, Republic of Singapore., Tan SPF; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.; A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore 138648 , Republic of Singapore., Koh HC; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.; A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore 138648 , Republic of Singapore.; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Republic of Singapore., Cheong EJY; A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore 138648 , Republic of Singapore.; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #01-02, Singapore 138669, Republic of Singapore., Chan ECY; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543, Republic of Singapore., Chan JCY; Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Republic of Singapore.; A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #06-06, Singapore 138648 , Republic of Singapore.; Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #01-02, Singapore 138669, Republic of Singapore.

المصدر: Environmental science & technology [Environ Sci Technol] 2023 May 02; Vol. 57 (17), pp. 6825-6834. Date of Electronic Publication: 2023 Apr 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0213155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5851 (Electronic) Linking ISSN: 0013936X NLM ISO Abbreviation: Environ Sci Technol Subsets: MEDLINE

مواضيع طبية MeSH: Caprylates* , Fluorocarbons*/pharmacokinetics, Humans ; Toxicokinetics ; Risk Assessment ; Membrane Transport Proteins ; Models, Biological

المؤلفون: Tan SPF; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK., Scotcher D; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK., Rostami-Hodjegan A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK.; Certara UK (Simcyp Division), Sheffield, UK., Galetin A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Sep; Vol. 112 (3), pp. 643-652. Date of Electronic Publication: 2022 Jun 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Organic Anion Transporters*/metabolism , Renal Insufficiency, Chronic*/metabolism, Glomerular Filtration Rate ; Humans ; Kidney/metabolism ; Renal Elimination

المؤلفون: Tan SPF; Skin Research Institute of Singapore, Agency for Science Technology and Research, Singapore.; Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore., Chan ECY; Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore.; Department of Pharmacy, National University of Singapore, Singapore., Chan JCY; Skin Research Institute of Singapore, Agency for Science Technology and Research, Singapore.; Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore.; Singapore Institute of Food and Biotechnology Innovation, Agency for Science, Technology and Research, Singapore.

المصدر: ALTEX [ALTEX] 2021; Vol. 38 (2), pp. 253-268. Date of Electronic Publication: 2020 Nov 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological* , Xenobiotics*, Animals ; Drug Interactions ; Humans ; Liver ; Rosuvastatin Calcium

المؤلفون: Thakur A; Innovations in Food and Chemical Safety, Agency for Science, Technology, and Research, Singapore City, Singapore.; Skin Research Institute of Singapore, Agency for Science, Technology, and Research, Singapore City, Singapore., Tan SPF; Innovations in Food and Chemical Safety, Agency for Science, Technology, and Research, Singapore City, Singapore.; Skin Research Institute of Singapore, Agency for Science, Technology, and Research, Singapore City, Singapore., Chan JCY; Innovations in Food and Chemical Safety, Agency for Science, Technology, and Research, Singapore City, Singapore.; Skin Research Institute of Singapore, Agency for Science, Technology, and Research, Singapore City, Singapore.; Singapore Institute of Food and Biotechnology Innovation, Agency for Science, Technology, and Research, Singapore City, Singapore.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2020 Dec; Vol. 108 (6), pp. 1176-1184. Date of Electronic Publication: 2020 Oct 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19 Drug Treatment*, Antiviral Agents/*pharmacokinetics , Lopinavir/*pharmacokinetics , Ritonavir/*pharmacokinetics, Area Under Curve ; Asian People ; Dose-Response Relationship, Drug ; HIV Infections/drug therapy ; Half-Life ; Humans ; Lopinavir/pharmacology ; Lung/metabolism ; Metabolic Clearance Rate ; Models, Biological ; Ritonavir/pharmacology ; SARS-CoV-2 ; White People

المؤلفون: Chan JCY; Skin Research Institute of Singapore, Agency for Science Technology and Research, Singapore.; Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore., Tan SPF; Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore.; Department of Pharmacy, National University of Singapore, Singapore., Upton Z; Skin Research Institute of Singapore, Agency for Science Technology and Research, Singapore.; Institute of Medical Biology, Agency for Science Technology and Research, Singapore., Chan ECY; Innovations in Food and Chemical Safety, Agency for Science Technology and Research, Singapore.; Department of Pharmacy, National University of Singapore, Singapore.

المصدر: ALTEX [ALTEX] 2019; Vol. 36 (4), pp. 597-612. Date of Electronic Publication: 2019 May 10.

نوع المنشور: Journal Article; Validation Study

بيانات الدورية: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX

مواضيع طبية MeSH: Animal Testing Alternatives/*methods , Fluvastatin/*toxicity , Hydroxymethylglutaryl-CoA Reductase Inhibitors/*toxicity , Quinolines/*toxicity , Rosuvastatin Calcium/*toxicity, Animal Testing Alternatives/standards ; Caco-2 Cells ; HEK293 Cells ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; In Vitro Techniques ; Intestinal Mucosa/metabolism ; Kinetics ; Models, Biological