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1
المؤلفون: Tanya Michelle Jewell, Robert Steven Kania, Anand Sistla, Bennett Michael John, Michael R. Gehring, Evan Smith, Zehnder Luke Raymond, Shinji Yamazaki, Karen A. Maegley, Elena Z. Dovalsantos, Ben Burke, Fen Wang, Sacha Ninkovic, Jeff Wang, Joe Zhongxiang Zhou, Pei-Pei Kung, Min-Jean Yin, Michael J. Hickey, Martin James Wythes, Jerry Meng, Buwen Huang, Ping Kang, John F. Braganza, Ketan S. Gajiwala, Tatlock John H, Pramod P. Mehta
المصدر: Journal of Medicinal Chemistry. 54:3368-3385
مصطلحات موضوعية: Pyrimidine, biology, Chemistry, Stereochemistry, medicine.drug_class, Carboxamide, Metabolic stability, Combinatorial chemistry, Hsp90, Bioavailability, chemistry.chemical_compound, Heat shock protein, Drug Discovery, Alkoxy group, biology.protein, medicine, Molecular Medicine, Potency
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2
المؤلفون: Sarah Johnson, Maria Angelica Linton, Javier González, Julie Blazel, Matt Drowns, Tatlock John H, Hui Li, Tanya Michelle Jewell, Leena Patel, Martha A. Ornelas
المصدر: Synthesis. 2010:4015-4020
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Reducing agent, Yield (chemistry), Organic Chemistry, Condensation, Organic chemistry, Knoevenagel condensation, Methylene, Alkylation, Catalysis, Pyrone
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3e987a3048633b8d76f1faadb65a5c96
https://doi.org/10.1055/s-0030-1258276 -
3
المؤلفون: Julie Blazel, Robert Hoffman, Tatlock John H, Sarah Johnson, Tanya Michelle Jewell, Mingnam Tang, Leena Patel, Angelica Linton, Javier González, Matt Drowns, Hui Li
المصدر: Synlett. 2010:796-800
مصطلحات موضوعية: Pyridine synthesis, Chemistry, Stereochemistry, Heck reaction, Organic Chemistry, Polymerase inhibitor, Clinical evaluation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8e58f45585bc5da3e23ddb8f0a1c3bea
https://doi.org/10.1055/s-0029-1219352 -
4
المؤلفون: Javier Gonzalez, Jim Nonomiya, Angelica Linton, Leena Patel, Hui Li, Fannie Chau, Hans E. Parge, Sadayappan V. Rahavendran, Heather Skor, Michael J. Hickey, Tanya Michelle Jewell, Matthew Drowns, Stephanie T. Shi, Robert P. Hunter, Cristina Lewis, Sarah Ludlum, Tatlock John H, Koleen J. Herlihy, Xiu Yu
المصدر: Journal of Medicinal Chemistry. 52:1255-1258
مصطلحات موضوعية: Models, Molecular, Dihydropyran, Stereochemistry, Hepatitis C virus, Administration, Oral, Hepacivirus, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Cytochrome P-450 CYP2D6 Inhibitors, RNA polymerase, Drug Discovery, medicine, Animals, Transferase, chemistry.chemical_classification, Bicyclic molecule, biology, virus diseases, Stereoisomerism, Triazoles, RNA-Dependent RNA Polymerase, digestive system diseases, Rats, Macaca fascicularis, Enzyme, Solubility, chemistry, Pyrones, Enzyme inhibitor, Microsomes, Liver, biology.protein, Molecular Medicine, Lactone
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5
المؤلفون: Tatlock John H, Cristina Lewis, Mel Abreo, Stephanie T. Shi, Michele Yang, Shella A. Fuhrman, Heather Skor, Sarah Ludlum, Tanya Michelle Jewell, Mike Goble, Angelica Linton, Julie Blazel, Allen J. Borchardt, Ravi Rahavendran, Hui Li, Javier Gonzalez, Matthew Drowns, Leena Patel
المصدر: Journal of Medicinal Chemistry. 50:3969-3972
مصطلحات موضوعية: Stereochemistry, Allosteric regulation, Administration, Oral, Biological Availability, Stereoisomerism, Hepacivirus, Viral Nonstructural Proteins, Antiviral Agents, Permeability, Structure-Activity Relationship, Allosteric Regulation, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Replicon, Polymerase, chemistry.chemical_classification, biology, Chemistry, Rats, Enzyme, Biochemistry, Pyrones, Enzyme inhibitor, biology.protein, Molecular Medicine, Caco-2 Cells, Linker, Half-Life
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6
المؤلفون: Angelica Linton, Julie Blazel, Chau Doan, Robert A. Love, Javier Gonzalez, Allen J. Borchardt, Hans E. Parge, Tom Prins, Peter S. Dragovich, Stephanie T. Shi, Ru Zhou, Tatlock John H, Rohit Duggal, Shella A. Fuhrman, Cristina Lewis, Tanya Michelle Jewell, Hui Li, Michael J. Hickey
المصدر: Bioorganicmedicinal chemistry letters. 16(18)
مصطلحات موضوعية: Models, Molecular, Conformational change, Hepatitis C virus, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Transferase, Binding site, Molecular Biology, Polymerase, chemistry.chemical_classification, biology, Molecular Structure, Organic Chemistry, virus diseases, DNA-Directed RNA Polymerases, RNA-Dependent RNA Polymerase, digestive system diseases, Enzyme, chemistry, Enzyme inhibitor, Pyrones, biology.protein, Molecular Medicine, Hydrogen