المؤلفون: Flavahan WA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Drier Y; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. yotam.drier@mail.huji.ac.il.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. yotam.drier@mail.huji.ac.il.; The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, The Hebrew University, Jerusalem, Israel. yotam.drier@mail.huji.ac.il., Johnstone SE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hemming ML; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, Boston, MA, USA., Tarjan DR; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hegazi E; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shareef SJ; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Javed NM; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Raut CP; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Eschle BK; Experimental Therapeutics Core, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Gokhale PC; Experimental Therapeutics Core, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA., Hornick JL; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Sicinska ET; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Demetri GD; Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. George_Demetri@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, Boston, MA, USA. George_Demetri@dfci.harvard.edu.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. George_Demetri@dfci.harvard.edu., Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Bernstein.Bradley@mgh.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Bernstein.Bradley@mgh.harvard.edu.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. Bernstein.Bradley@mgh.harvard.edu.

المصدر: Nature [Nature] 2019 Nov; Vol. 575 (7781), pp. 229-233. Date of Electronic Publication: 2019 Oct 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Chromosome Aberrations*, Carcinogenesis/*genetics , Gastrointestinal Stromal Tumors/*genetics , Gastrointestinal Stromal Tumors/*pathology , Oncogenes/*genetics , Succinate Dehydrogenase/*deficiency, Animals ; CRISPR-Cas Systems/genetics ; DNA Methylation ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic ; Fibroblast Growth Factor 4/genetics ; Gastrointestinal Stromal Tumors/enzymology ; Humans ; Mice ; Mutation ; Proto-Oncogene Proteins c-kit/antagonists & inhibitors ; Receptors, Fibroblast Growth Factor/antagonists & inhibitors ; Succinate Dehydrogenase/genetics

المؤلفون: Tarjan DR; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Flavahan WA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA. bernstein.bradley@mgh.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. bernstein.bradley@mgh.harvard.edu.

المصدر: Nature communications [Nat Commun] 2019 Sep 18; Vol. 10 (1), pp. 4258. Date of Electronic Publication: 2019 Sep 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: CCCTC-Binding Factor/*genetics , CRISPR-Associated Protein 9/*genetics , Carcinogenesis/*genetics , DNA (Cytosine-5-)-Methyltransferases/*genetics , Gene Editing/*methods , Recombinant Fusion Proteins/*genetics, Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; CRISPR-Cas Systems/genetics ; Carcinogenesis/pathology ; Cell Line ; DNA Methylation ; DNA Methyltransferase 3A ; Epigenesis, Genetic/genetics ; Genome, Human/genetics ; HEK293 Cells ; Humans ; Promoter Regions, Genetic/genetics ; Repressor Proteins/metabolism

المؤلفون: Ryan RJH; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Petrovic J; Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Rausch DM; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Zhou Y; Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Lareau CA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Kluk MJ; Department of Pathology, Weill Cornell School of Medicine, New York, NY 10065, USA., Christie AL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Lee WY; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA., Tarjan DR; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Guo B; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Donohue LKH; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Gillespie SM; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA., Nardi V; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Hochberg EP; Department of Medicine, MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02140, USA., Blacklow SC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Faryabi RB; Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Bernstein BE; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA. Electronic address: bernstein.bradley@mgh.harvard.edu., Aster JC; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: jaster@rics.bwh.harvard.edu., Pear WS; Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: wpear@mail.med.upenn.edu.

المصدر: Cell reports [Cell Rep] 2017 Oct 17; Vol. 21 (3), pp. 784-797.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic* , Oncogenes* , Signal Transduction*, B-Lymphocytes/*metabolism , Lymphoma, B-Cell/*genetics , Lymphoma, B-Cell/*pathology , Receptors, Notch/*metabolism, Animals ; Biopsy ; Cell Differentiation/genetics ; Cell Line, Tumor ; Enhancer Elements, Genetic/genetics ; Gene Rearrangement ; Humans ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Mice ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Receptors, Notch/genetics ; Tumor Microenvironment ; Xenograft Model Antitumor Assays

المؤلفون: Deutschbauer A; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Price MN; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Wetmore KM; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Tarjan DR; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA Energy Biosciences Institute, University of California, Berkeley, California, USA., Xu Z; Department of Bioengineering, University of California, Berkeley, California, USA., Shao W; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Leon D; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA Energy Biosciences Institute, University of California, Berkeley, California, USA., Arkin AP; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA Energy Biosciences Institute, University of California, Berkeley, California, USA Department of Bioengineering, University of California, Berkeley, California, USA APArkin@lbl.gov skerker@berkeley.edu., Skerker JM; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA Energy Biosciences Institute, University of California, Berkeley, California, USA Department of Bioengineering, University of California, Berkeley, California, USA APArkin@lbl.gov skerker@berkeley.edu.

المصدر: Journal of bacteriology [J Bacteriol] 2014 Oct; Vol. 196 (20), pp. 3643-55. Date of Electronic Publication: 2014 Aug 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 2985120R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5530 (Electronic) Linking ISSN: 00219193 NLM ISO Abbreviation: J Bacteriol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Fitness*, Bacterial Proteins/*metabolism , Gene Expression Regulation, Bacterial/*physiology , Shewanella/*metabolism , Zymomonas/*metabolism, Bacterial Proteins/genetics ; Mutation ; Shewanella/genetics ; Zymomonas/genetics

المؤلفون: Lee S; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Geller JT; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Torok T; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Wu CH; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Singer M; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Reid FC; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Tarjan DR; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Hazen TC; Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Arkin AP; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America., Hillson NJ; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.

المصدر: PloS one [PLoS One] 2014 Aug 22; Vol. 9 (8), pp. e105689. Date of Electronic Publication: 2014 Aug 22 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Bacteria*/genetics , Bacteria*/growth & development , Water Microbiology* , Water Purification*, Carbon/*metabolism , Plants/*microbiology , Wastewater/*microbiology, Microbial Consortia/genetics

المؤلفون: Skerker JM; Energy Biosciences Institute, University of California, Berkeley, CA, USA., Leon D, Price MN, Mar JS, Tarjan DR, Wetmore KM, Deutschbauer AM, Baumohl JK, Bauer S, Ibáñez AB, Mitchell VD, Wu CH, Hu P, Hazen T, Arkin AP

المصدر: Molecular systems biology [Mol Syst Biol] 2013 Jun 18; Vol. 9, pp. 674. Date of Electronic Publication: 2013 Jun 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: EMBO Press Country of Publication: England NLM ID: 101235389 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE

مواضيع طبية MeSH: Models, Chemical* , Models, Genetic*, Cellulose/*metabolism , Ethanol/*metabolism , Saccharomyces cerevisiae/*metabolism , Zymomonas/*metabolism, Biomass ; Cellulose/chemistry ; Enzyme Inhibitors/isolation & purification ; Enzyme Inhibitors/pharmacology ; Fermentation ; Gene Library ; Genes, Bacterial ; Genes, Fungal ; Hydrolysis ; Mutation ; Pyruvaldehyde/metabolism ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/genetics ; Stress, Physiological ; Zymomonas/drug effects ; Zymomonas/genetics

المؤلفون: Montague M; Department of Synthetic Biology, The J. Craig Venter Institute , Rockville, Maryland 20850, USA. mmontagu@jcvi.org, McArthur GH 4th, Cockell CS, Held J, Marshall W, Sherman LA, Wang N, Nicholson WL, Tarjan DR, Cumbers J

المصدر: Astrobiology [Astrobiology] 2012 Dec; Vol. 12 (12), pp. 1135-42. Date of Electronic Publication: 2012 Nov 09.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101088083 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8070 (Electronic) Linking ISSN: 15578070 NLM ISO Abbreviation: Astrobiology Subsets: MEDLINE

مواضيع طبية MeSH: Extraterrestrial Environment* , Food* , Life Support Systems* , Space Flight*, Bioreactors ; Feasibility Studies ; Humans ; Minor Planets ; Moon ; Refuse Disposal ; Spirulina/metabolism ; Synthetic Biology ; Waste Disposal, Fluid