المؤلفون: Rehberg N; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany., Sommer GA; Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany., Drießen D; Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany., Kruppa M; Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany., Adeniyi ET; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany., Chen S; Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China., Wang L; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany., Wolf K; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany., Tasch BOA; Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany., Ioerger TR; Department of Computer Science, Texas A&M University, 710 Ross St., College Station, Texas 77843, United States., Zhu K; Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China., Müller TJJ; Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany., Kalscheuer R; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12623-12641. Date of Electronic Publication: 2020 Oct 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Alkaloids/*chemistry , Anti-Bacterial Agents/*pharmacology , Indoles/*chemistry , Methicillin-Resistant Staphylococcus aureus/*drug effects, Alkaloids/metabolism ; Alkaloids/pharmacology ; Alkaloids/therapeutic use ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/therapeutic use ; Cell Line ; Cell Survival/drug effects ; Female ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Humans ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; Peritonitis/drug therapy ; Peritonitis/pathology ; Pyruvate Kinase/antagonists & inhibitors ; Pyruvate Kinase/metabolism ; Rabbits