المؤلفون: Kenna, JG, Taskar, KS, Battista, C, Bourdet, DL, Brouwer, KLR, Brouwer, KR, Dai, D, Funk, C, Hafey, MJ, Lai, YR, Maher, J, Pak, YA, Pedersen, JM, Polli, JW, Rodrigues, AD, Watkins, PB, Yang, K, Yucha, RW

المصدر: Clinical pharmacology and therapeutics. 104(5):916-932

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:139556110

المؤلفون: Salem F; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK., Nguyen D; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA., Bush M; Clinical Pharmacology, ViiV Research & Development, Triangle Park, North Carolina, USA., Moore KP; Clinical Pharmacology Modeling and Simulation, Allucent, Cary, North Carolina, USA., Mudunuru J; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK., Stamatopoulos K; Biopharmaceutics, GlaxoSmithKline, R&D, Stevenage, UK., Thakkar N; Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA., Taskar KS; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 May 01. Date of Electronic Publication: 2024 May 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

المؤلفون: Lewis GJ; Drug Metabolism and Pharmacokinetics, In Vitro In Vivo Translation, Research, GlaxoSmithKline, Stevenage, UK., Ahire D; Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA., Taskar KS; Drug Metabolism and Pharmacokinetics, In Vitro In Vivo Translation, Research, GlaxoSmithKline, Stevenage, UK.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Apr; Vol. 13 (4), pp. 563-575. Date of Electronic Publication: 2024 Jan 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Progestins* , Cytochrome P-450 CYP3A*, Humans ; Female ; Contraceptives, Oral ; Drug Interactions ; Ethinyl Estradiol ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Models, Biological

المؤلفون: Salem F; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK., Nimavardi A; Simcyp Division, Certara UK Ltd., Sheffield, UK., Mudunuru J; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Collegeville, PA, USA., Tompson D; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK., Bloomer J; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK., Turner DB; Simcyp Division, Certara UK Ltd., Sheffield, UK., Taskar KS; Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, UK.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Jun; Vol. 12 (6), pp. 808-820. Date of Electronic Publication: 2023 Apr 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Felodipine*/pharmacokinetics , Celiac Disease*, Humans ; Cytochrome P-450 CYP3A/metabolism ; Drug Interactions ; Cytochrome P-450 CYP3A Inhibitors ; Models, Biological

المؤلفون: Taskar KS; Drug Metabolism and Pharmacokinetics, IVIVT, GlaxoSmithKline, Stevenage, UK., Yang X; Office of Clinical Pharmacology, Center of Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Neuhoff S; Certara UK Ltd., Simcyp Division, Sheffield, UK., Patel M; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA., Yoshida K; Clinical Pharmacology, Genentech Early Research and Development, South San Francisco, California, USA., Paine MF; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA., Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Chu X; Department of ADME and Discovery Toxicology, Merck & Co., Inc., Kenilworth, New Jersey, USA., Sugiyama Y; Laboratory of Quantitative System PK/Pharmacodynamics, School of Pharmacy, Josai International University, Tokyo, Japan., Cook J; Clinical Pharmacology, Global Product Development, Pfizer Inc., Groton, Connecticut, USA., Polli JW; Global Medical Sciences, ViiV Healthcare, Research Triangle Park, North Carolina, USA., Hanna I; Pharmacokinetic Sciences-Oncology, Novartis Institute for Biomedical Research, East Hanover, New Jersey, USA., Lai Y; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA., Zamek-Gliszczynski M; Drug Metabolism and Pharmacokinetics, IVIVT, GlaxoSmithKline, Upper Providence, Pennsylvania, USA.

مؤلفون مشاركون: ITC

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Sep; Vol. 112 (3), pp. 573-592. Date of Electronic Publication: 2022 Jun 22.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Membrane Transport Proteins*/metabolism , Neoplasm Proteins*/metabolism, ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Humans ; Liver/metabolism

المؤلفون: Asaumi R; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki, Japan., Nunoya KI; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki, Japan., Yamaura Y; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki, Japan., Taskar KS; Drug Metabolism and Pharmacokinetics, In Vitro In Vivo Translation, GlaxoSmithKline R&D, Stevenage, UK., Sugiyama Y; Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, School of Pharmacy, Josai International University, Tokyo, Japan.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2022 Jul; Vol. 11 (7), pp. 919-933. Date of Electronic Publication: 2022 Jun 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: ATP Binding Cassette Transporter, Subfamily B, Member 1* , Rifampin*/pharmacokinetics, ATP Binding Cassette Transporter, Subfamily B ; Cytochrome P-450 CYP3A/metabolism ; Digoxin/pharmacology ; Drug Interactions ; Humans ; Intestines ; Kidney/metabolism ; Liver/metabolism ; Membrane Transport Proteins ; Models, Biological ; Quinidine/pharmacology

المؤلفون: Galluppi GR; Sunovion Pharmaceuticals, Inc., Marlborough, Massachusetts, USA., Brar S; Clinical Pharmacology, Global Product Development, Pfizer Inc., Groton, Connecticut, USA., Caro L; Quantitative Pharmacology and Pharmacometrics, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey, USA., Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., a member of the Roche Group, South San Francisco, California, USA., Frey N; Roche Pharma Research and Exploratory Development, Pharmaceutical Science, Roche Innovation Center, Basel, Switzerland., Grimm HP; Roche Pharma Research and Exploratory Development, Pharmaceutical Science, Roche Innovation Center, Basel, Switzerland., Rudd DJ; Quantitative Pharmacology and Pharmacometrics, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey, USA., Li CC; Department of Clinical Pharmacology, Genentech, member of the Roche group, South San Francisco, California, USA., Magee M; GlaxoSmithKline, Philadelphia, Pennsylvania, USA., Mukherjee A; Clinical Pharmacology, Global Product Development, Pfizer Inc., Groton, Connecticut, USA., Nagao L; Faegre Drinker Biddle & Reath, LLP, Washington, DC, USA., Purohit VS; Clinical Pharmacology, Global Product Development, Pfizer Inc., Groton, Connecticut, USA., Roy A; Bristol Myers, Inc., Woodbury, Connecticut, USA., Salem AH; Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, Illinois, USA.; Ain Shams University, Cairo, Egypt., Sinha V; Quantitative Pharmacology and Pharmacometrics, Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc., Kenilworth, New Jersey, USA., Suleiman AA; Clinical Pharmacology and Pharmacometrics, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany., Taskar KS; DMPK, IVIVT, GlaxoSmithKline, Ware, UK., Upreti VV; Clinical Pharmacology Modeling and Simulation, Amgen Inc., South San Francisco, California, USA., Weber B; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA., Cook J; Clinical Pharmacology, Global Product Development, Pfizer Inc., Groton, Connecticut, USA.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Nov; Vol. 110 (5), pp. 1172-1175. Date of Electronic Publication: 2021 May 15.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , United States Food and Drug Administration*/legislation & jurisprudence, Drug Approval/*methods , Drug Industry/*methods, Drug Approval/legislation & jurisprudence ; Drug Development/legislation & jurisprudence ; Drug Development/methods ; Drug Industry/legislation & jurisprudence ; Humans ; Pilot Projects ; United States

المؤلفون: Sychterz C; Cellular Biomarkers, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Galetin A; Division of Pharmacy and Optometry, Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, UK., Taskar KS; DMPK Modelling, GlaxoSmithKline, Hertfordshire, UK.

المصدر: Biopharmaceutics & drug disposition [Biopharm Drug Dispos] 2021 Apr; Vol. 42 (4), pp. 160-177. Date of Electronic Publication: 2021 Apr 26.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7911226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-081X (Electronic) Linking ISSN: 01422782 NLM ISO Abbreviation: Biopharm Drug Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Computer Simulation* , Models, Biological*, Pregnancy/*metabolism, Cytochrome P-450 Enzyme System/metabolism ; Dose-Response Relationship, Drug ; Drug Development/methods ; Drug Interactions ; Female ; Genotype ; Glucuronosyltransferase/genetics ; Glucuronosyltransferase/metabolism ; Humans ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/metabolism ; Pregnancy Trimesters

المؤلفون: Zamek-Gliszczynski MJ; Drug Meabolism and Pharmacokinetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Patel M; Pharmacokinetics and Drug Metabolism, Amgen Research, Cambridge, Massachusetts, USA., Yang X; Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland, USA., Lutz JD; Department of Clinical Pharmacology, Gilead Sciences, Inc, Foster City, California, USA., Chu X; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & CO., Inc, Kenilworth, New Jersey, USA., Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Lai Y; Drug Metabolism, Gilead Sciences, Inc., Foster City, California, USA., Lee CA; Nonclinical Development and Clinical Pharmacology, Arena Pharmaceuticals, San Diego, California, USA., Neuhoff S; Simcyp Division, Certara UK Limited, Sheffield, UK., Paine MF; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA., Sugiyama Y; Sugiyama Laboratory, RIKEN Baton Zone, Program, RIKEN Cluster for Science, RIKEN, Yokohama, Kanagawa, Japan., Taskar KS; Drug Meabolism and Pharmacokinetics, GlaxoSmithKline, Ware, UK., Galetin A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Jan; Vol. 109 (1), pp. 55-64. Date of Electronic Publication: 2020 Jul 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism , Drug Development/*methods , Intestines/*physiology , Liver/*metabolism , Liver-Specific Organic Anion Transporter 1/*metabolism, Biological Transport/physiology ; Hepatocytes/metabolism ; Humans ; Membrane Transport Proteins/metabolism

المؤلفون: Taskar KS; DMPK, IVIVT, GlaxoSmithKline R&D, Stevenage, United Kingdom., Harada I; DMPK, IVIVT, GlaxoSmithKline R&D, Stevenage, United Kingdom., Alluri RV; Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.

المصدر: Current drug metabolism [Curr Drug Metab] 2021; Vol. 22 (7), pp. 523-531.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 100960533 Publication Model: Print Cited Medium: Internet ISSN: 1875-5453 (Electronic) Linking ISSN: 13892002 NLM ISO Abbreviation: Curr Drug Metab Subsets: MEDLINE

مواضيع طبية MeSH: Drug Elimination Routes* , Drug Interactions* , Intestinal Absorption* , Pharmacokinetics*, Membrane Transport Proteins/*metabolism, Animals ; Humans ; Membrane Transport Proteins/drug effects ; Models, Biological