المؤلفون: Tavares AMV; Programa de Pós-Graduação em Ciências Biológicas: Fisiologia - UFRGS, Rua Ramiro Barcelos, 2600, Porto Alegre, CEP: 90035-003, RS, Brazil., Gonzalez EA; Centro de Pesquisa Experimental- Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, CEP 90035-903, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular - UFRGS Av. Bento Gonçalves, 9500, Porto Alegre, CEP 91501970, RS, Brazil., Viana IS; Centro de Pesquisa Experimental- Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, CEP 90035-903, RS, Brazil., Visioli F; Centro de Pesquisa Experimental- Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, CEP 90035-903, RS, Brazil., Vera LNP; Centro de Pesquisa Experimental- Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, CEP 90035-903, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular - UFRGS Av. Bento Gonçalves, 9500, Porto Alegre, CEP 91501970, RS, Brazil., Baldo G; Programa de Pós-Graduação em Ciências Biológicas: Fisiologia - UFRGS, Rua Ramiro Barcelos, 2600, Porto Alegre, CEP: 90035-003, RS, Brazil; Centro de Pesquisa Experimental- Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, Porto Alegre, CEP 90035-903, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular - UFRGS Av. Bento Gonçalves, 9500, Porto Alegre, CEP 91501970, RS, Brazil. Electronic address: gbaldo@hcpa.edu.br.

المصدر: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology [Cardiovasc Pathol] 2023 Nov-Dec; Vol. 67, pp. 107575. Date of Electronic Publication: 2023 Sep 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9212060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1336 (Electronic) Linking ISSN: 10548807 NLM ISO Abbreviation: Cardiovasc Pathol Subsets: MEDLINE

عنوان ترانسليتريتد: Efeitos do Óleo de Copaíba em Marcadores Periféricos de Estresse Oxidativo em um Modelo de Cor Pulmonale em Ratos.

المؤلفون: Campos C; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Turck P; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Tavares AMV; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Corssac G; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Lacerda D; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Araujo A; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil., Llesuy S; Hospital Italiano de Buenos Aires, Buenos Aires - Argentina., Klein AB; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS - Brasil.

المصدر: Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2021 Dec; Vol. 117 (6), pp. 1106-1112.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sociedad Brasileira De Cardiologia Country of Publication: Brazil NLM ID: 0421031 Publication Model: Print Cited Medium: Internet ISSN: 1678-4170 (Electronic) Linking ISSN: 0066782X NLM ISO Abbreviation: Arq Bras Cardiol Subsets: MEDLINE

مواضيع طبية MeSH: Hypertension, Pulmonary* , Pulmonary Heart Disease*/drug therapy, Animals ; Male ; Monocrotaline ; Oxidative Stress ; Rats ; Rats, Wistar

المؤلفون: Gonzalez EA; Postgraduate Program in Genetic and Molecular Biology, UFRGS, Porto Alegre, Brazil.; Cells, Tissues, and Genes Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Tobar Leitão SA; Cardiovascular Research Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Postgraduate Program in Health Science: Cardiology and Cardiovascular Science, UFRGS, Porto Alegre, Brazil., Soares DDS; Cardiovascular Research Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Postgraduate Program in Health Science: Cardiology and Cardiovascular Science, UFRGS, Porto Alegre, Brazil., Tavares AMV; Cells, Tissues, and Genes Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Giugliani R; Postgraduate Program in Genetic and Molecular Biology, UFRGS, Porto Alegre, Brazil.; Cells, Tissues, and Genes Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Department of Genetics, UFRGS, Porto Alegre, Brazil., Baldo G; Postgraduate Program in Genetic and Molecular Biology, UFRGS, Porto Alegre, Brazil.; Cells, Tissues, and Genes Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Department of Genetics, UFRGS, Porto Alegre, Brazil., Matte U; Postgraduate Program in Genetic and Molecular Biology, UFRGS, Porto Alegre, Brazil.; Cells, Tissues, and Genes Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Department of Genetics, UFRGS, Porto Alegre, Brazil.

المصدر: Journal of inherited metabolic disease [J Inherit Metab Dis] 2021 May; Vol. 44 (3), pp. 740-750. Date of Electronic Publication: 2020 Nov 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 7910918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2665 (Electronic) Linking ISSN: 01418955 NLM ISO Abbreviation: J Inherit Metab Dis Subsets: MEDLINE

مواضيع طبية MeSH: Heart Diseases/*pathology , Losartan/*pharmacology , MAP Kinase Signaling System/*drug effects , Mucopolysaccharidosis I/*drug therapy , Ventricular Remodeling/*drug effects, Animals ; Disease Models, Animal ; Echocardiography ; Female ; Heart Diseases/drug therapy ; Heart Diseases/genetics ; Iduronidase/genetics ; MAP Kinase Signaling System/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mucopolysaccharidosis I/genetics ; Mucopolysaccharidosis I/pathology ; Mutation

المؤلفون: Schuh RS; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil., Gonzalez EA; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Campus do Vale, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, RS, Brazil., Tavares AMV; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Fisiologia da Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saúde, R. Sarmento Leite 500, 90035-190, Porto Alegre, RS, Brazil., Seolin BG; Programa de Pós-Graduação em Fisiologia da Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saúde, R. Sarmento Leite 500, 90035-190, Porto Alegre, RS, Brazil., Elias LS; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil., Vera LNP; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Campus do Vale, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, RS, Brazil., Kubaski F; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Campus do Vale, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, RS, Brazil., Poletto E; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Campus do Vale, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, RS, Brazil., Giugliani R; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Campus do Vale, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, RS, Brazil., Teixeira HF; Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil., Matte U; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil. umatte@hcpa.edu.br.; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Campus do Vale, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, RS, Brazil. umatte@hcpa.edu.br., Baldo G; Centro de Terapia Gênica, Serviço de Pesquisa Experimental - Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Campus do Vale, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Fisiologia da Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saúde, R. Sarmento Leite 500, 90035-190, Porto Alegre, RS, Brazil.

المصدر: Gene therapy [Gene Ther] 2020 Feb; Vol. 27 (1-2), pp. 74-84. Date of Electronic Publication: 2019 Dec 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE

مواضيع طبية MeSH: Iduronidase/*genetics , Mucopolysaccharidosis I/*therapy , RNA, Untranslated/*genetics, Animals ; Animals, Newborn ; Bone Diseases/genetics ; CRISPR-Cas Systems/genetics ; Cardiovascular System/metabolism ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Disease Models, Animal ; Female ; Gene Editing/methods ; Genetic Therapy/methods ; Glycosaminoglycans/metabolism ; Iduronidase/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mucopolysaccharidosis I/genetics ; Mucopolysaccharidosis I/physiopathology ; Phenotype ; RNA, Untranslated/metabolism

المؤلفون: Bruxel MA; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Tavares AMV; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Zavarize Neto LD; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., de Souza Borges V; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Schroeder HT; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Bock PM; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Rodrigues MIL; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Belló-Klein A; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Homem de Bittencourt PI Jr; Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: pauloivo@ufrgs.br.

المصدر: Biochimie [Biochimie] 2019 Jan; Vol. 156, pp. 33-46. Date of Electronic Publication: 2018 Sep 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE

مواضيع طبية MeSH: Heat-Shock Response* , Hyperthermia, Induced*, Aorta/*metabolism , Atherosclerosis/*therapy, Animals ; Atherosclerosis/chemically induced ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cholesterol/adverse effects ; Cholesterol/pharmacology ; Dietary Fats/adverse effects ; Dietary Fats/pharmacology ; Gene Expression Regulation ; Heat-Shock Proteins/biosynthesis ; Hot Temperature ; Male ; Mice ; Mice, Knockout ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Sirtuin 1/biosynthesis

المؤلفون: Campos-Carraro C; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Turck P; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., de Lima-Seolin BG; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Tavares AMV; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Dos Santos Lacerda D; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Corssac GB; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Teixeira RB; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Hickmann A; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Llesuy S; Faculty of Pharmacy and Biochemistry, Universidad de Buenos Aires, Buenos Aires, Argentina., da Rosa Araujo AS; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Belló-Klein A; Department of Physiology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

المصدر: Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2018 Nov; Vol. 72 (5), pp. 214-221.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Print Cited Medium: Internet ISSN: 1533-4023 (Electronic) Linking ISSN: 01602446 NLM ISO Abbreviation: J Cardiovasc Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Fabaceae*/chemistry , Monocrotaline* , Myocardium*/metabolism , Myocardium*/pathology, Apoptosis/*drug effects , Cardiovascular Agents/*pharmacology , Hypertension, Pulmonary/*drug therapy , Hypertrophy, Right Ventricular/*prevention & control , Plant Oils/*pharmacology , Ventricular Dysfunction, Right/*prevention & control , Ventricular Function, Right/*drug effects , Ventricular Remodeling/*drug effects, Animals ; Cardiovascular Agents/isolation & purification ; Disease Models, Animal ; Hypertension, Pulmonary/chemically induced ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/pathology ; Hypertrophy, Right Ventricular/chemically induced ; Hypertrophy, Right Ventricular/metabolism ; Hypertrophy, Right Ventricular/pathology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Plant Oils/isolation & purification ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats, Wistar ; Signal Transduction/drug effects ; Ventricular Dysfunction, Right/chemically induced ; Ventricular Dysfunction, Right/metabolism ; Ventricular Dysfunction, Right/pathology ; bcl-2-Associated X Protein/metabolism

المؤلفون: Schuh RS; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Av. Ipiranga 2752, 90610-000 Porto Alegre, RS, Brazil., Poletto É; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Campus do Vale, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre, RS, Brazil., Pasqualim G; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Campus do Vale, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre, RS, Brazil., Tavares AMV; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Fisiologia da Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saúde, R. Sarmento Leite, 500, 90035-190 Porto Alegre, RS, Brazil., Meyer FS; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil., Gonzalez EA; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Campus do Vale, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre, RS, Brazil., Giugliani R; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Campus do Vale, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre, RS, Brazil., Matte U; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Campus do Vale, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre, RS, Brazil., Teixeira HF; Programa de Pós-Graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Av. Ipiranga 2752, 90610-000 Porto Alegre, RS, Brazil., Baldo G; Centro de Terapia Gênica do Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos 2350, 90035-903 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Fisiologia da Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saúde, R. Sarmento Leite, 500, 90035-190 Porto Alegre, RS, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular da Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Genética, Campus do Vale, Av. Bento Gonçalves, 9500, 91501-970 Porto Alegre, RS, Brazil. Electronic address: gbaldo@hcpa.edu.br.

المصدر: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2018 Oct 28; Vol. 288, pp. 23-33. Date of Electronic Publication: 2018 Aug 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing* , Genetic Therapy*, Mucopolysaccharidosis I/*genetics , Mucopolysaccharidosis I/*therapy, Animals ; CRISPR-Cas Systems ; Cell Survival/drug effects ; Cells, Cultured ; Female ; Fibroblasts/drug effects ; Humans ; Iduronidase/metabolism ; Liposomes ; Male ; Mice, Inbred C57BL ; Mucopolysaccharidosis I/metabolism ; Tissue Distribution

المؤلفون: Siqueira R; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Colombo R; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Conzatti A; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., de Castro AL; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Carraro CC; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Tavares AMV; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Fernandes TRG; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Araujo ASDR; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Belló-Klein A; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

المصدر: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2018 Mar; Vol. 96 (3), pp. 295-303. Date of Electronic Publication: 2017 Aug 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1205-7541 (Electronic) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antioxidants/*metabolism , Heart Ventricles/*drug effects , Heart Ventricles/*metabolism , Hypertension, Pulmonary/*chemically induced , Hypertension, Pulmonary/*metabolism , Monocrotaline/*adverse effects , Ovariectomy/*adverse effects, Adaptation, Physiological/drug effects ; Animals ; Female ; Gene Expression Regulation/drug effects ; Heart Ventricles/physiopathology ; Hemodynamics/drug effects ; Hypertension, Pulmonary/physiopathology ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Ventricular Remodeling/drug effects

المؤلفون: Gonzalez EA; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Post-Graduation Program in Genetics and Molecular Biology, UFRGS, Porto Alegre, Brazil., Martins GR; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Tavares AMV; Post-Graduation Program in Physiology, UFRGS, Porto Alegre, Brazil; Ritter dos Reis University Center, UniRitter, Porto Alegre, Brazil., Viegas M; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Poletto E; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Post-Graduation Program in Genetics and Molecular Biology, UFRGS, Porto Alegre, Brazil., Giugliani R; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Post-Graduation Program in Genetics and Molecular Biology, UFRGS, Porto Alegre, Brazil; Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Matte U; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Post-Graduation Program in Genetics and Molecular Biology, UFRGS, Porto Alegre, Brazil., Baldo G; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Post-Graduation Program in Genetics and Molecular Biology, UFRGS, Porto Alegre, Brazil; Post-Graduation Program in Physiology, UFRGS, Porto Alegre, Brazil. Electronic address: gbaldo@hcpa.edu.br.

المصدر: Life sciences [Life Sci] 2018 Mar 01; Vol. 196, pp. 102-109. Date of Electronic Publication: 2018 Jan 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cardiovascular System/*pathology , Cathepsin B/*antagonists & inhibitors , Cysteine Proteinase Inhibitors/*therapeutic use , Dipeptides/*therapeutic use , Mucopolysaccharidosis I/*diagnostic imaging , Mucopolysaccharidosis I/*drug therapy, Animals ; Aorta/pathology ; Aorta/physiopathology ; Cardiovascular System/diagnostic imaging ; Cathepsin B/metabolism ; Collagenases/metabolism ; Female ; Fibroblasts/metabolism ; Heart Function Tests ; Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/drug therapy ; Heart Valve Diseases/pathology ; Humans ; Lysosomes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mucopolysaccharidosis I/pathology ; Pancreatic Elastase/metabolism