المؤلفون: Teo AE, Ng AC, Venkataraman K, Tai ES, Lee YS, Khoo EY, Khoo CM, Sadananthan SA, Velan SS, Zagorodnov V, Chong YS, Gluckman P, Leow MK

المصدر: BMC Proceedings, Vol 6, Iss Suppl 4, p P43 (2012)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1753-6561

URL الوصول: https://doaj.org/article/a3adcf27c0bf4d25b95021268f661b1d

المؤلفون: Lim SG; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, National University Health System, Singapore. Electronic address: mdclimsg@nus.edu.sg., Teo AE; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chan ES; Singapore Clinical Research Institute, Consortium for Clinical Research and Innovation Singapore, Singapore; Cochrane Singapore, Singapore; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore., Phyo WW; Division of Gastroenterology and Hepatology, National University Health System, Singapore., Chen DHY; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Hargreaves CA; Data Analytics Consulting Centre, Faculty of Science, National University of Singapore, Singapore.

المصدر: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2024 Jun 12. Date of Electronic Publication: 2024 Jun 12.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE

المؤلفون: Tng EL; Department of Medicine, Ng Teng Fong General Hospital, 1 Jurong East Street 21, Tower A Level 8, Singapore, 609606, Singapore. tngengloon@gmail.com., Teo AE; Department of Medicine, Division of Endocrinology, National University Health System, 1E Kent Ridge Road, NUHS Tower Block Level 10, Singapore, 119228, Singapore., Aung AT; Ministry of Health Holdings, 1 Maritime Square, #11-25 HarbourFront Centre, Singapore, 099253, Singapore.

المصدر: Journal of medical case reports [J Med Case Rep] 2023 Mar 17; Vol. 17 (1), pp. 96. Date of Electronic Publication: 2023 Mar 17.

نوع المنشور: Review; Case Reports; Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101293382 Publication Model: Electronic Cited Medium: Internet ISSN: 1752-1947 (Electronic) Linking ISSN: 17521947 NLM ISO Abbreviation: J Med Case Rep Subsets: MEDLINE

مواضيع طبية MeSH: Prolactinoma* , Pituitary Neoplasms*/pathology, Male ; Humans ; Middle Aged ; Dopamine Agonists/therapeutic use ; Cabergoline/therapeutic use ; Ergolines/therapeutic use ; Prolactin

المؤلفون: Puar TH; Department of Endocrinology, Changi General Hospital (CGH).; Duke-NUS Medical School., Khoo CM; Division of Endocrinology, National University Health System (NUHS).; Yong Loo Lin School of Medicine, National University of Singapore (NUS)., Tan CJ; Department of Radiology, ParkwayHealth Radiology., Tong AKT; Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital (SGH)., Tan MCS; Department of Laboratory Medicine, CGH., Teo AE; Division of Internal Medicine, NUHS., Ng KS; Department of Radiology, CGH.; Department of Diagnostic Radiology, Mount Alvernia Hospital., Wong KM; Department of Radiology, CGH., Reilhac A; Clinical Imaging Research Centre (CIRC), NUS, Singapore., O'Doherty J; Clinical Imaging Research Centre (CIRC), NUS, Singapore., Gomez-Sanchez CE; Division of Endocrinology, Medical Service, G.V. (Sonny) Montgomery VA Medical Center and Department of Pharmacology and Medicine, University of Mississippi Medical Centre, Mississippi, USA., Kek PC; Department of Endocrinology, SGH., Yee S; Division of Endocrinology, Ng Teng Fong General Hospital., Tan AWK; Department of Endocrinology, Tan Tock Seng Hospital., Chuah MB; Department of Endocrinology, Sengkang General Hospital., Lee DHM; Department of General Medicine, Khoo Teck Puat Hospital., Wang KW; Wang Kuo Weng Diabetes and Endocrine Practice, Gleneagles Medical Center., Zheng CQ; Duke-NUS Medical School.; Department of Epidemiology, Singapore Clinical Research Institute., Shi L; Duke-NUS Medical School.; Department of Epidemiology, Singapore Clinical Research Institute., Robins EG; Clinical Imaging Research Centre (CIRC), NUS, Singapore.; Department of Radiochemistry, Singapore Bioimaging Consortium., Foo RSY; Yong Loo Lin School of Medicine, National University of Singapore (NUS).; Cardiovascular Research Institute, NUHS.; Genome Institute of Singapore.

مؤلفون مشاركون: for the PA CURE investigators

المصدر: Journal of hypertension [J Hypertens] 2022 Jun 01; Vol. 40 (6), pp. 1179-1188.

نوع المنشور: Clinical Trial; Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: Netherlands NLM ID: 8306882 Publication Model: Print Cited Medium: Internet ISSN: 1473-5598 (Electronic) Linking ISSN: 02636352 NLM ISO Abbreviation: J Hypertens Subsets: MEDLINE

مواضيع طبية MeSH: Hyperaldosteronism*/diagnostic imaging , Hyperaldosteronism*/surgery, Adrenal Glands/blood supply ; Aldosterone ; Carbon Radioisotopes ; Etomidate/analogs & derivatives ; Humans ; Pilot Projects ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Retrospective Studies

المؤلفون: Wan JC; School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Teo AE; School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., McMurran CE; School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Rawji V; Sobell Department of Motor Neuroscience and Movement Disorders, University College London, UK.

المصدر: The clinical teacher [Clin Teach] 2018 Aug; Vol. 15 (4), pp. 346-347. Date of Electronic Publication: 2017 Oct 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Pub Country of Publication: England NLM ID: 101227511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-498X (Electronic) Linking ISSN: 17434971 NLM ISO Abbreviation: Clin Teach Subsets: MEDLINE

مواضيع طبية MeSH: Career Choice*, Biomedical Research/*education , Education, Medical/*organization & administration, Education, Medical, Graduate/organization & administration ; Humans ; Time Factors ; United Kingdom

المؤلفون: Teo AE; From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke's Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke's Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.); and Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)., Garg S; From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke's Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke's Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.); and Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)., Johnson TI; From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke's Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke's Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.); and Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)., Zhao W; From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke's Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke's Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.); and Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)., Zhou J; From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke's Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke's Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.); and Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)., Gomez-Sanchez CE; From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke's Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke's Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.); and Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)., Gurnell M; From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke's Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke's Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.); and Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.)., Brown MJ; From the Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrooke's Hospital (A.E.D.T., S.G., J.Z., M.J.B.), Tissue Bank, Department of Histopathology, Addenbrooke's Hospital (W.Z.), NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital (M.G.), MRC Cancer Unit, Hutchison/MRC Research Centre (T.I.J.), and Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science (M.G.), University of Cambridge, United Kingdom; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, United Kingdom (J.Z., M.J.B.); Division of Endocrinology, Department of Medicine, The University of Mississippi Medical Centre, Jackson (C.E.G.-S.); and Research and Medicine Services, G.V. (Sonny) Montgomery VA Medical Centre, Jackson, MS (C.E.G.-S.). morris.brown@qmul.ac.uk.

المصدر: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2017 Jun; Vol. 69 (6), pp. 1207-1216. Date of Electronic Publication: 2017 Apr 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation*, Adrenal Cortex Neoplasms/*genetics , Extracellular Matrix Proteins/*genetics , Hyperaldosteronism/*genetics , Kidney Glomerulus/*metabolism, Adrenal Cortex/metabolism ; Adrenal Cortex Neoplasms/pathology ; Adrenal Cortex Neoplasms/surgery ; Aldosterone/blood ; Cytochrome P-450 CYP11B2/metabolism ; Humans ; Hyperaldosteronism/pathology ; Hyperaldosteronism/surgery ; Hypertension/genetics ; Hypertension/physiopathology ; Immunohistochemistry ; Microarray Analysis ; Real-Time Polymerase Chain Reaction/methods ; Role ; Tumor Cells, Cultured ; Up-Regulation ; Wnt Signaling Pathway/genetics ; Zona Glomerulosa/metabolism

المؤلفون: Wan JC; a School of Clinical Medicine, University of Cambridge , Cambridge , UK., McMurran CE; a School of Clinical Medicine, University of Cambridge , Cambridge , UK., Teo AE; a School of Clinical Medicine, University of Cambridge , Cambridge , UK.

المصدر: Medical teacher [Med Teach] 2016 Oct; Vol. 38 (10), pp. 1072. Date of Electronic Publication: 2016 Aug 30.

نوع المنشور: Letter

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 7909593 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1466-187X (Electronic) Linking ISSN: 0142159X NLM ISO Abbreviation: Med Teach Subsets: MEDLINE

مواضيع طبية MeSH: Journalism* , Students, Medical*, Education, Medical, Undergraduate ; Humans ; Medicine ; Serial Publications ; United Kingdom

المؤلفون: Xie CB; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK., Shaikh LH; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK., Garg S; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK., Tanriver G; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK., Teo AE; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK., Zhou J; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK., Maniero C; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK., Zhao W; Human Research Tissue Bank, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK., Kang S; Department of Chemistry, Chemistry of Life Processes Institute, and Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, USA., Silverman RB; Department of Chemistry, Chemistry of Life Processes Institute, and Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208-3113, USA., Azizan EA; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK.; Department of Medicine, Faculty of Medicine, The National University of Malaysia (UKM) Medical Centre, Kuala Lumpur 56000, Malaysia., Brown MJ; Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK.; Barts Heart Centre, William Harvey Research Institute, Queen Mary University London, London EC1M 6BQ, UK.

المصدر: Scientific reports [Sci Rep] 2016 Apr 21; Vol. 6, pp. 24697. Date of Electronic Publication: 2016 Apr 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Aldosterone/*metabolism , Calcium Channels, L-Type/*metabolism, Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/genetics ; Cell Line ; Cells, Cultured ; Genotype ; Humans ; Mutation ; Nifedipine/pharmacology ; Protein Transport

المؤلفون: Teo AE, Brown MJ

المصدر: The New England journal of medicine [N Engl J Med] 2016 Apr 14; Vol. 374 (15), pp. 1494.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE

مواضيع طبية MeSH: Adenoma/*genetics , Adrenal Gland Neoplasms/*genetics , Hyperaldosteronism/*etiology , Pregnancy Complications, Neoplastic/*genetics , beta Catenin/*genetics, Female ; Humans ; Pregnancy

المؤلفون: Teo AE; Center for Stem Cell and Regenerative Medicine, Brown Foundation, Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), University of Texas-Health Science Center at Houston, Houston, TX, USA., Chen Z; Center for Stem Cell and Regenerative Medicine, Brown Foundation, Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), University of Texas-Health Science Center at Houston, Houston, TX, USA., Miranda RN; Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., McDonnell T; Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Medeiros LJ; Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., McCarty N; Center for Stem Cell and Regenerative Medicine, Brown Foundation, Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), University of Texas-Health Science Center at Houston, Houston, TX, USA.

المصدر: Leukemia [Leukemia] 2016 Mar; Vol. 30 (3), pp. 580-93. Date of Electronic Publication: 2015 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, B-Lymphocytes/*metabolism , Drug Resistance, Neoplasm/*genetics , Lymphoma, Mantle-Cell/*genetics , PAX5 Transcription Factor/*genetics, Animals ; Antineoplastic Agents/pharmacology ; B-Lymphocytes/pathology ; Cell Adhesion ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cyclin D1/genetics ; Cyclin D1/metabolism ; High-Throughput Screening Assays ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lymphoma, Mantle-Cell/diagnosis ; Lymphoma, Mantle-Cell/drug therapy ; Lymphoma, Mantle-Cell/mortality ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/pathology ; Mice ; PAX5 Transcription Factor/antagonists & inhibitors ; PAX5 Transcription Factor/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Prognosis ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Xenograft Model Antitumor Assays