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المؤلفون: Teresa Aja, Giovanni Roxas, Nancy Tryder, Carlos F. Barbas, Curt Bradshaw, Mysore P. Ramprasad, Francesca Fang Liao, Lingna Li, David A. Griffith, Venkata Doppalapudi
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:501-506
مصطلحات موضوعية: Endothelin A Receptor Antagonists, medicine.drug_class, Clinical Biochemistry, Lysine, Molecular Conformation, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, CHO Cells, Monoclonal antibody, Biochemistry, Antibodies, Mice, Structure-Activity Relationship, Cricetulus, In vivo, Cricetinae, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Receptors, Endothelin, Chemistry, Organic Chemistry, Biological activity, Small molecule, In vitro, Endothelin B Receptor Antagonists, Cell culture, Molecular Medicine, Indicators and Reagents, Endothelin receptor, Neoplasm Transplantation
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2
المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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المؤلفون: Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
مصطلحات موضوعية: Peptidomimetic, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Oxamyl, Apoptosis, Peptide, Biochemistry, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Caspase, chemistry.chemical_classification, Dipeptide, biology, Organic Chemistry, Neurodegenerative Diseases, Dipeptides, Caspase Inhibitors, In vitro, Stroke, Kinetics, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Carbamates
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المؤلفون: Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
مصطلحات موضوعية: chemistry.chemical_classification, Programmed cell death, biology, Chemistry, Organic Chemistry, Clinical Biochemistry, Leaving group, Pharmaceutical Science, Inflammation, Cysteine Proteinase Inhibitors, Caspase Inhibitors, Biochemistry, In vitro, Structure-Activity Relationship, Enzyme, Enzyme inhibitor, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, medicine.symptom, Molecular Biology, Caspase
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المؤلفون: Teresa Aja, André Sauter, Donald S. Karanewsky, Markus Rudin, Rachel May, Peter R. Allegrini, Bastian Hengerer, Robert O. Sayers, Christoph Wiessner, Steve Linton, Albert Schmitz, Giorgio Rovelli, Kevin J. Tomaselli, Patricia C. Contreras, Joe C. Wu, Silvio Roggo, Kip Nalley, Lisa M. Adams, Thomas L. Deckwerth
المصدر: Drug Development Research. 52:579-586
مصطلحات موضوعية: biology, business.industry, Central nervous system, Ischemia, Caspase 3, Pharmacology, medicine.disease, Neuroprotection, medicine.anatomical_structure, Apoptosis, Anesthesia, medicine.artery, Drug Discovery, Middle cerebral artery, medicine, biology.protein, Artery occlusion, business, Caspase
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المؤلفون: Christian Leist, Kim Hoang, Anu Srinivasan, Donald S. Karanewsky, Tam Vu, Lawrence C. Fritz, Robert C. Armstrong, Joe C. Wu, Bryan Pham, Teresa Aja, Rob Sayers, Albert Schmitz, Angela M. Wong, Joseph F. Krebs, Aileen Aboy, Kevin J. Tomaselli
المصدر: The Journal of Cell Biology
مصطلحات موضوعية: caspase, Cytochrome c Group, Caspase 3, Cell Line, Coumarins, Zymogen, Humans, Bcl-2, programmed cell death, Caspase, Enzyme Precursors, biology, Hydrolysis, Cytochrome c, apoptosis, Membrane Proteins, Cell Biology, Caspase Inhibitors, Cell biology, Enzyme Activation, Cytosol, cytochrome c, Membrane, Proto-Oncogene Proteins c-bcl-2, Cytoplasm, Caspases, biology.protein, Oligopeptides, Intracellular, Subcellular Fractions, Regular Articles
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789f6e636e676d741d6d8f50362f45a9
https://doi.org/10.1083/jcb.144.5.915 -
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المؤلفون: Kevin J. Tomaselli, Smita Gaur, Emad S. Alnemri, Teresa Aja, Donald S. Karanewsky, Xu Bai, Kim Hoang, Robert C. Armstrong, Gerald Litwack, Lawrence C. Fritz
المصدر: The Journal of Neuroscience. 17:553-562
مصطلحات موضوعية: Proteases, Programmed cell death, medicine.medical_treatment, Protein subunit, Glutamic Acid, Apoptosis, Cysteine Proteinase Inhibitors, Biology, Culture Media, Serum-Free, Amino Acid Chloromethyl Ketones, Cerebellar Cortex, Mice, Necrosis, Coumarins, medicine, Animals, Cycloheximide, Cells, Cultured, Nucleic Acid Synthesis Inhibitors, Protein Synthesis Inhibitors, Enzyme Precursors, Protease, Affinity labeling, Caspase 3, General Neuroscience, Granule (cell biology), Articles, Dipeptides, Ketones, Molecular biology, Cell biology, Enzyme Activation, Mice, Inbred C57BL, Blot, Cysteine Endopeptidases, Caspases, Potassium, Oligopeptides
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1bee7fc57d62d2812e35934ac24105
https://doi.org/10.1523/jneurosci.17-02-00553.1997 -
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المؤلفون: Joseph F. Krebs, Jialing Xiang, Smita Gaur, Lawrence C. Fritz, Xu Bai, Kevin J. Tomaselli, Stanley J. Korsmeyer, Teresa Aja, Donald S. Karanewsky, Robert C. Armstrong, Kim Hoang
المصدر: Journal of Biological Chemistry. 271:16850-16855
مصطلحات موضوعية: Proteases, Programmed cell death, medicine.medical_treatment, Molecular Sequence Data, Caspase 1, Apoptosis, Cysteine Proteinase Inhibitors, Proto-Oncogene Mas, Biochemistry, Jurkat cells, Cell Line, Enzyme activator, Proto-Oncogene Proteins, medicine, Humans, Amino Acid Sequence, fas Receptor, Molecular Biology, Caspase, Protease, biology, Caspase 3, Hydrolysis, fungi, Cell Biology, Molecular biology, Cell biology, Enzyme Activation, Cysteine Endopeptidases, Proto-Oncogene Proteins c-bcl-2, Caspases, biology.protein, Protein Processing, Post-Translational
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc541b7846591585e609d45b148ec91
https://doi.org/10.1074/jbc.271.28.16850 -
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المؤلفون: Teresa Aja, Kevin J. Tomaselli, Edward D. Robinson, Joe C. Wu, Steven D. Linton, Xin Gu, Robert O. Sayers, Steven P. Meduna, Kip Nalley, Lalitha Kodandapani, Silvio Roggo, Vincent J. Kalish, Jose-Luis Diaz, Donald S. Karanewsky, Ning Chen, Albert Schmitz, Julia Herrmann, Brett R. Ullman, Joseph J. Krebs, Robert J. Ternansky
المصدر: Bioorganicmedicinal chemistry letters. 15(15)
مصطلحات موضوعية: Programmed cell death, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Naphthols, Cysteine Proteinase Inhibitors, Biochemistry, Chemical synthesis, Models, Biological, Mice, Structure-Activity Relationship, Heterocyclic Compounds, Drug Discovery, Animals, Molecular Biology, Caspase, Cells, Cultured, chemistry.chemical_classification, Aspartic Acid, biology, Bicyclic molecule, Cell Death, Organic Chemistry, Valine, Ketones, Caspase Inhibitors, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Cellular model