يعرض 1 - 10 نتائج من 41 نتيجة بحث عن '"Terrence Peter Kenakin"', وقت الاستعلام: 0.87s تنقيح النتائج
  1. 1
    Diarylureas Containing 5-Membered Heterocycles as CB1 Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation

    المؤلفون: Thuy Nguyen, Jenny L. Wiley, Yanan Zhang, Tiffany L. Langston, Ann M. Decker, Terrence Peter Kenakin, Charlotte E. Farquhar, Brian F. Thomas, Thomas F. Gamage, Nadezhda German

    المصدر: ACS Chemical Neuroscience. 10:518-527

    مصطلحات موضوعية: Agonist, 0303 health sciences, Allosteric modulator, Physiology, medicine.drug_class, Stereochemistry, Chemistry, Cognitive Neuroscience, Ligand binding assay, Allosteric regulation, Cooperative binding, Cooperativity, Cell Biology, General Medicine, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, medicine, Structure–activity relationship, Receptor, 030217 neurology & neurosurgery, 030304 developmental biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eaf5a42846e6c8ead52eea9d09ca4bd6
    https://doi.org/10.1021/acschemneuro.8b00396

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  2. 2
    Neutrophil priming that turns natural FFA2R agonists into potent activators of the superoxide generating NADPH-oxidase

    المؤلفون: Jonas Mårtensson, Lena Björkman, Huamei Forsman, Martina Sundqvist, Michael Gabl, Terrence Peter Kenakin, André Holdfeldt, Claes Dahlgren

    المصدر: Journal of Leukocyte Biology. 104:1117-1132

    مصطلحات موضوعية: Cyclopropanes, 0301 basic medicine, Agonist, Neutrophils, medicine.drug_class, Immunology, Allosteric regulation, Receptors, Cell Surface, Acetates, Peptides, Cyclic, Receptors, G-Protein-Coupled, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Superoxides, Free fatty acid receptor 2, medicine, Humans, Immunology and Allergy, Calcium Signaling, Receptor, Cells, Cultured, G protein-coupled receptor, chemistry.chemical_classification, Reactive oxygen species, CD11b Antigen, NADPH oxidase, biology, Tumor Necrosis Factor-alpha, Superoxide, NADPH Oxidases, Cell Biology, Cell biology, Enzyme Activation, Thiazoles, 030104 developmental biology, Pertussis Toxin, chemistry, biology.protein, GTP-Binding Protein alpha Subunits, Gq-G11, Acetanilides, Oligopeptides

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc0ee3106f161b169dd0eead2cc5f6e
    https://doi.org/10.1002/jlb.2a0318-130rr

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  3. 3
    PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?

    المؤلفون: Ryan T. Strachan, Terrence Peter Kenakin

    المصدر: Trends in Pharmacological Sciences. 39:748-765

    مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Allosteric regulation, Ligands, Toxicology, Receptors, G-Protein-Coupled, Structure-Activity Relationship, 03 medical and health sciences, Allosteric Regulation, In vivo, medicine, Animals, Humans, Receptor, Pharmacology, Chemistry, Drug discovery, Kinetics, 030104 developmental biology, Endothelin receptor, Receptor theory, Neuroscience, Allosteric Site, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6ea92f3afe597f7d5403542d8ec598
    https://doi.org/10.1016/j.tips.2018.05.001

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  4. 4
    Characterization of the various functional pathways elicited by synthetic agonists or antagonists at the melatonin MT1 and MT2 receptors

    المؤلفون: Preety Shabajee, Olivier Nosjean, Clémence Dupré, Céline Legros, Adeline Giganti, Chantal Brasseur, Olivier Bruno, Jean A. Boutin, Anne Bonnaud, Terrence Peter Kenakin, Damien Valour

    المصدر: Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)

    مصطلحات موضوعية: biased ligands, media_common.quotation_subject, melatonin, RM1-950, Cell morphology, 030226 pharmacology & pharmacy, Chemical library, Melatonin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, melatonin receptors, General Pharmacology, Toxicology and Pharmaceutics, Binding site, Receptor, Internalization, media_common, Chemistry, HEK 293 cells, signaling pathways, Cell biology, Neurology, 030220 oncology & carcinogenesis, Therapeutics. Pharmacology, Signal transduction, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7a9151eda474215bfd95f132e4a5c0
    https://doaj.org/article/08643ceb060e4077bb6c6bb5129fe136

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  5. 5
    Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity

    المؤلفون: Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton

    المصدر: Journal of Medicinal Chemistry. 60:6649-6663

    مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e16d6e6b4f8608876f69c7501545a8c8
    https://doi.org/10.1021/acs.jmedchem.7b00597

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  6. 6
    Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor

    المؤلفون: Terrence Peter Kenakin, Melanie E. M. Kelly, Lesley A. Stevenson, Ganesh A. Thakur, David R. Janero, Maria Grazia Cascio, Pushkar M. Kulkarni, Eileen M. Denovan-Wright, Roger G. Pertwee, Jeffrey R. Deschamps, Robert B. Laprairie

    المصدر: ACS Chemical Neuroscience. 8:1188-1203

    مصطلحات موضوعية: 0301 basic medicine, Agonist, Indoles, Physiology, medicine.drug_class, Cognitive Neuroscience, medicine.medical_treatment, Allosteric regulation, Pharmacology, Biology, Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Isomerism, Receptor, Cannabinoid, CB1, medicine, Animals, Humans, Inverse agonist, Receptor, G protein-coupled receptor, Cannabinoid Receptor Agonists, Cell Biology, General Medicine, Molecular Pharmacology, 3. Good health, HEK293 Cells, 030104 developmental biology, Metabotropic receptor, Cannabinoid, Allosteric Site, 030217 neurology & neurosurgery

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aada10742914a0aa66ab92cb56d5940
    https://doi.org/10.1021/acschemneuro.6b00310

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  7. 7
    Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design

    المؤلفون: Michael Schemann, Sébastien Granier, Gareth A. Hicks, Michael R. Barnes, Damien Maurel, Victor W S Kung, John Broad, Terrence Peter Kenakin, Gareth J. Sanger

    المساهمون: Barts & The London School of Medicine and Dentistry [London, UK] (Blizard Institute), Queen Mary University of London (QMUL), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Departement /u661 : Pharmacologie Moleculaire, Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Tioga Pharmaceuticals [San Diego, CA, USA], Human Biology [Freising-Weihenstephan, Germany], Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), The William Harvey Research Institute [London, UK] (NIHR Barts Biomedical Research Centre), Deparment of Pharmacology [Chapel Hill, NC, USA], University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC), roussel, pascale, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

    المصدر: Scientific Reports
    Scientific Reports, Nature Publishing Group, 2016, 6, pp.30797. ⟨10.1038/srep30797⟩
    Scientific Reports, 2016, 6, pp.30797. ⟨10.1038/srep30797⟩

    مصطلحات موضوعية: 0301 basic medicine, Cell signaling, Pyrrolidines, Intrinsic activity, Receptor expression, [SDV]Life Sciences [q-bio], Immune receptor, Biology, Pharmacology, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Species Specificity, Acetamides, Animals, Humans, Intestinal Mucosa, Receptor, ComputingMilieux_MISCELLANEOUS, Multidisciplinary, Receptors, Opioid, kappa, Recombinant Proteins, Cell biology, [SDV] Life Sciences [q-bio], HEK293 Cells, 030104 developmental biology, Drug Design, Asimadoline, 5-HT1 receptor, Signal transduction, 030217 neurology & neurosurgery, Signal Transduction

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2cd017d504f5cca4cf8e353d9a10bf
    https://hal.archives-ouvertes.fr/hal-01940963

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  8. 8
    Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

    المؤلفون: Deane M. Nason, Keith Dlugolenski, Chewah Lee, Betty Pettersen, Gregory W. Kauffman, Lei Zhang, Carrie Northcott, Stephen Jenkinson, Yuxia Mao, Jennifer E. Davoren, Susan M. Lotarski, Veronica Reinhart, Damien Webb, Michelle R. Garnsey, Sarah Grimwood, John T. Lazzaro, Michael Aaron Brodney, Jeremy R. Edgerton, Jason Cordes, Stefanus J. Steyn, Romelia Salomon-Ferrer, Steven Victor O'neil, Terrence Peter Kenakin, Lisa Nottebaum, Michael Popiolek, Christopher John Helal, Anthony R. Harris

    المصدر: Journal of medicinal chemistry. 59(13)

    مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Models, Molecular, Allosteric modulator, Stereochemistry, medicine.drug_class, Carboxamide, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Muscarinic acetylcholine receptor, Drug Discovery, medicine, Structure–activity relationship, Animals, Picolinic Acids, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Receptor, Muscarinic M1, Rats, Thiazoles, 030104 developmental biology, Pyran, Molecular Medicine, Cholinergic, Female, Pharmacophore, 030217 neurology & neurosurgery

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fc61159c2c41b46e640509efcd4086
    https://pubmed.ncbi.nlm.nih.gov/27275946

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  9. 9
    Theoretical Aspects of GPCR-Ligand Complex Pharmacology

    المؤلفون: Terrence Peter Kenakin

    المصدر: Chemical reviews. 117(1)

    مصطلحات موضوعية: 0301 basic medicine, Chemistry, Drug Agonism, Allosteric regulation, Membrane Proteins, General Chemistry, Pharmacology, Ligand (biochemistry), Ligands, Receptors, G-Protein-Coupled, 03 medical and health sciences, Molecular dynamics, 030104 developmental biology, Allosteric Regulation, Models, Chemical, Receptor, Ternary complex, Function (biology), G protein-coupled receptor

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d37289fd946d2c6eb8f6fd62e28a16
    https://pubmed.ncbi.nlm.nih.gov/26856272

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  10. 10
    Casting a Wider Net: Whole-Cell Assays to Capture Varied and Biased Signaling: Fig 1

    المؤلفون: Terrence Peter Kenakin

    المصدر: Molecular Pharmacology. 82:571-574

    مصطلحات موضوعية: Pharmacology, Cell signaling, medicine.diagnostic_test, media_common.quotation_subject, Context (language use), Biology, Bioinformatics, Receptor internalization, Cell biology, Flow cytometry, Cytosol, medicine, Molecular Medicine, Internalization, Whole cell, Receptor, media_common

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ff341aa01ec9a4d13a3e4d250cbce5c4
    https://doi.org/10.1124/mol.112.081117

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