-
1
المؤلفون: Corey Strickland, Bridget Carragher, Winifred W. Prosise, Theresa M. Kelly, Clinton S. Potter, Alan Hruza, Venkata P. Dandey, Todd Mayhood, Zhening Zhang, Giovanna Scapin
المصدر: Nature
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, medicine.medical_treatment, Crystallography, X-Ray, Article, 03 medical and health sciences, medicine, Humans, Insulin, Glucose homeostasis, Binding site, Multidisciplinary, biology, Chemistry, Cryoelectron Microscopy, Receptor, Insulin, Single Molecule Imaging, Cell biology, Insulin receptor, Transmembrane domain, 030104 developmental biology, Ectodomain, biology.protein, Protein Multimerization, Signal transduction, Apoproteins, Tyrosine kinase, Signal Transduction
-
2
المؤلفون: Theresa M. Kelly, John W. Clader, Dmitri A. Pissarnitski, Johannes H. Voigt, Duane A. Burnett, David Cole, Giovanna Scapin, Wen-Lian Wu, Zuliang Yao, Aileen Soriano, Zhiqiang Zhao, Martin S. Domalski, Mary Ann Powles
المصدر: Bioorganic & Medicinal Chemistry. 24:5534-5545
مصطلحات موضوعية: Blood Glucose, Male, Models, Molecular, 0301 basic medicine, Guanine, Molecular model, Stereochemistry, Dipeptidyl Peptidase 4, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Scaffold hopping, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Molecular Biology, Dipeptidyl peptidase-4, chemistry.chemical_classification, Dipeptidyl-Peptidase IV Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Drug discovery, Chemistry, Organic Chemistry, Glucose Tolerance Test, Xanthine, 0104 chemical sciences, Mice, Inbred C57BL, 030104 developmental biology, Xanthines, Molecular Medicine, Tricyclic
-
3
المؤلفون: Pei Huo, Yan Cui, Paul A. Fischer, Ravi P. Nargund, Mark D. Erion, Songnian Lin, Qing Dallas-Yang, David E. Kelley, James Mu, Danqing Dennis Feng, Ruojing Yang, Ying Qian, Theresa M. Kelly, Lin Yan, Xinghai Li, Xiaolan Shen, Ge Dai, Margaret Wu
المصدر: JCI Insight. 3
مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Receptors, Cell Surface, 030209 endocrinology & metabolism, Endogeny, Carbohydrate metabolism, Hypoglycemia, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Antigens, CD, Diabetes mellitus, Internal medicine, medicine, Animals, Hypoglycemic Agents, Insulin, Lectins, C-Type, biology, Chemistry, Macrophages, General Medicine, Metabolism, medicine.disease, Receptor, Insulin, Rats, Mice, Inbred C57BL, Disease Models, Animal, Insulin receptor, Glucose, Mannose-Binding Lectins, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Liver, biology.protein, Mannose Receptor, Mannose receptor, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044e98e20b8fad0b0bd3b422242afafd
https://doi.org/10.1172/jci.insight.97476 -
4
المؤلفون: Theresa M. Kelly, Franklin Liu, Ravi P. Nargund, Margaret van Heek, Pei Huo, Shuai Shi, Yan Cui, Joseph L. Duffy, Mark D. Erion, Sandra C. Souza, Aimie Ogawa, Ester Carballo-Jane, Vijay Bhasker G. Reddy, Songnian Lin, Valentyn Antochshuk, Yonghua Zhu, James Mu, Ge Dai, David E. Kelley, Lin Yan, Niels C. Kaarsholm, Margaret Wu, Peter Zafian, Wolfgang Seghezzi
المصدر: Diabetes
مصطلحات موضوعية: 0301 basic medicine, Male, Swine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Drug Evaluation, Preclinical, Ligands, 0302 clinical medicine, Insulin, Regular, Human, Receptor, biology, Recombinant Proteins, Swine, Miniature, Erratum, Mannose Receptor, Animals, Inbred Strains, Half-Life, medicine.medical_specialty, Metabolic Clearance Rate, 030209 endocrinology & metabolism, Receptors, Cell Surface, CHO Cells, Hypoglycemia, Binding, Competitive, 03 medical and health sciences, Therapeutic index, Cricetulus, Dogs, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Animals, Humans, Hypoglycemic Agents, Lectins, C-Type, Glycemic, Dose-Response Relationship, Drug, business.industry, Insulin, medicine.disease, Receptor, Insulin, Insulin receptor, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 1, Mannose-Binding Lectins, Drug Design, Hyperglycemia, Regular insulin, biology.protein, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ffb20c894b16f7e60595e946fe4c91
https://pubmed.ncbi.nlm.nih.gov/29487114 -
5
المؤلفون: Linda Chang, Yanqing Kan, Alison M. Strack, Yan Guo, Judith N. Gorski, Linus S. Lin, Maria Madeira, Oksana C. Palyha, Thomas J. Lanza, Randy R. Miller, Jasminka Dragovic, Theresa M. Kelly, Ping Liu, Marc L. Reitman, Ravi P. Nargund, Joseph M. Metzger, Harry R. Chobanian, Donald J. Marsh, Kathy Lyons, Jianmei Pang, Kate A. Raustad, Marc D. Chioda, Xiao-Ming Guan, Sheng-Ping Wang
المصدر: ACS Medicinal Chemistry Letters. 3:252-256
مصطلحات موضوعية: Agonist, Benzodiazepine, Atropisomer, medicine.drug_class, business.industry, Organic Chemistry, Pharmacology, Biochemistry, chemistry.chemical_compound, chemistry, Pharmacokinetics, Pharmacodynamics, Drug Discovery, medicine, Bombesin Receptor Subtype-3, Penetrant (biochemical), business
-
6
المؤلفون: Oksana C. Palyha, Terry D. Faidley, Joseph M. Metzger, Xiao-Ming Guan, Sheng-Ping Wang, Jennifer A. Kosinski, Ravi P. Nargund, Stephanie K. Spann, Marc L. Reitman, Liming Yang, Linus S. Lin, Lauren P. Shearman, Kate A. Raustad, Donald J. Marsh, Kathy Lyons, Theresa M. Kelly, Stephanie Craw, Alison M. Strack, Yanqing Kan, Hong Yu, Jasminka Dragovic, Iyassu K. Sebhat
المصدر: Journal of Pharmacology and Experimental Therapeutics. 336:356-364
مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, medicine.drug_class, Blood Pressure, Pharmacology, Energy homeostasis, Rats, Sprague-Dawley, Eating, Mice, Dogs, Heart Rate, Weight loss, Internal medicine, medicine, Animals, Receptor, Dose-Response Relationship, Drug, Chemistry, Body Weight, Imidazoles, Rats, Bombesin receptor, Mice, Inbred C57BL, Receptors, Bombesin, Dose–response relationship, Blood pressure, Endocrinology, Pyrazoles, Molecular Medicine, Bombesin Receptor Subtype-3, Anti-Obesity Agents, medicine.symptom, Energy Metabolism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f83aba6c5ca83619726b27f1351081f
https://doi.org/10.1124/jpet.110.174763 -
7
المؤلفون: Corey Strickland, Theresa M. Kelly, Venkata P. Dandey, Zhening Zhang, Bridget Carragher, Alan Hruza, Winifred W. Prosise, Clinton S. Potter, Todd Mayhood, Giovanna Scapin
المصدر: Acta Crystallographica Section A Foundations and Advances. 74:a100-a100
مصطلحات موضوعية: biology, Cryo-electron microscopy, Chemistry, Insulin, medicine.medical_treatment, Condensed Matter Physics, Biochemistry, Inorganic Chemistry, Insulin receptor, Structural Biology, biology.protein, Biophysics, medicine, Particle, General Materials Science, Physical and Theoretical Chemistry
-
8
المؤلفون: Franklin Liu, Joseph L. Duffy, Niels C. Kaarsholm, Ge Dai, Margaret Wu, Peter Zafian, Ravi P. Nargund, Valentyn Antochshuk, Theresa M. Kelly, Vijay Bhasker G. Reddy, Margaret van Heek, Shuai Shi, Mark D. Erion, Sandra C. Souza, Lin Yan, Yan Cui, Wolfgang Seghezzi, Aimie Ogawa, James Mu, Ester Carballo-Jane, Pei Huo, David E. Kelley, Songnian Lin, Yonghua Zhu
المصدر: Diabetes. 67:1030-1030
مصطلحات موضوعية: Gerontology, business.industry, Endocrinology, Diabetes and Metabolism, Published Erratum, Glucose responsiveness, Insulin, medicine.medical_treatment, Section (typography), MEDLINE, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal Medicine, medicine, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83e035c6cf3db4d9d2dd2b640da29f0
https://doi.org/10.2337/db18-er05a -
9
المؤلفون: Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1913-1917
مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Molecular Biology, Biphenyl, Chemistry, Drug discovery, fungi, Organic Chemistry, Imidazoles, Rats, Bombesin receptor, Bioavailability, Receptors, Bombesin, Molecular Medicine, Bombesin Receptor Subtype-3
-
10
المؤلفون: Dana E. Vanderwall, Anthony M. Paiva, Joanne M. Williamson, Theresa M. Kelly, John W. Kozarich, John S. Blanchard
المصدر: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1545:67-77
مصطلحات موضوعية: Models, Molecular, Oxidoreductases Acting on CH-CH Group Donors, Dihydrodipicolinate Reductase, Protein Conformation, Antitubercular Agents, Biophysics, Diaminopimelic Acid, Biochemistry, Mycobacterium tuberculosis, Bacterial Proteins, Structural Biology, Enzyme Inhibitors, Structural motif, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Binding Sites, Molecular Structure, biology, Active site, Hydrogen Bonding, biology.organism_classification, Kinetics, Enzyme, Drug development, chemistry, Enzyme inhibitor, Essential gene, Drug Design, biology.protein, Oxidoreductases