المؤلفون: Narendar K; Centre for Natural Products & Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Rao BS; Centre for Natural Products & Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Tirunavalli S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India., Jadav SS; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India., Andugulapati SB; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India., Ramalingam V; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Babu KS; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.

المصدر: Natural product research [Nat Prod Res] 2024 Jul; Vol. 38 (13), pp. 2207-2214. Date of Electronic Publication: 2023 Jan 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

مواضيع طبية MeSH: Pentacyclic Triterpenes*/pharmacology , Pentacyclic Triterpenes*/chemistry , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/chemical synthesis , Thiazoles*/pharmacology , Thiazoles*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Apoptosis*/drug effects, Mice ; Animals ; Humans ; RAW 264.7 Cells ; Cell Line, Tumor ; Interleukin-6/metabolism ; Molecular Structure ; Lupanes

المؤلفون: Shah P; Department of Pharmaceutics, Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi, 394350, Surat, Gujarat, India. pranav.shah@utu.ac.in., Patel M; Department of Pharmaceutics, Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi, 394350, Surat, Gujarat, India., Kansara Y; Department of Pharmaceutics, Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi, 394350, Surat, Gujarat, India., Vyas B; Department of Pharmacology, Maliba Pharmacy College, Uka Tarsadia University, Surat, Gujarat, India., Prajapati P; Department Pharmaceutical Analysis & Quality Assurance, Maliba Pharmacy College, Uka Tarsadia University, Surat, Gujarat, India., Pradhan M; Department of Pharmaceutics, Gracious College of Pharmacy, Abhanpur, Chhattisgarh, India., Jain S; Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar (Mohali), Punjab, India.

المصدر: AAPS PharmSciTech [AAPS PharmSciTech] 2024 Sep 25; Vol. 25 (7), pp. 222. Date of Electronic Publication: 2024 Sep 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE

مواضيع طبية MeSH: Thiazoles*/pharmacokinetics , Thiazoles*/chemistry , Thiazoles*/administration & dosage , Drug Carriers*/chemistry , Acetanilides*/pharmacokinetics , Acetanilides*/administration & dosage , Acetanilides*/chemistry , Nanostructures*/chemistry , Drug Liberation* , Biological Availability* , Lipids*/chemistry , Particle Size*, Animals ; Rats ; Administration, Oral ; Chemistry, Pharmaceutical/methods ; Molecular Docking Simulation/methods ; Male ; Rats, Wistar ; Urinary Bladder, Overactive/drug therapy

المؤلفون: Ivanova Y; KU Leuven, Department of Chemistry, Sustainable Chemistry for Metals and Molecules, Celestijnenlaan 200F, B-3001 Leuven, Belgium., Spittaels S; KU Leuven, Department of Chemistry, Sustainable Chemistry for Metals and Molecules, Celestijnenlaan 200F, B-3001 Leuven, Belgium., Gao LJ; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Herestraat 49, box 1030, 3000 Leuven, Belgium., Schols D; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, box 1043, 3000 Leuven, Belgium. steven.dejonghe@kuleuven.be., Van Meervelt L; KU Leuven, Department of Chemistry, Biomolecular Architecture, Celestijnenlaan 200F, B-3001 Leuven, Belgium., Froeyen M; KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, Herestraat 49, box 1030, 3000 Leuven, Belgium., Dehaen W; KU Leuven, Department of Chemistry, Sustainable Chemistry for Metals and Molecules, Celestijnenlaan 200F, B-3001 Leuven, Belgium., De Jonghe S; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, box 1043, 3000 Leuven, Belgium. steven.dejonghe@kuleuven.be.

المصدر: Organic & biomolecular chemistry [Org Biomol Chem] 2024 Sep 18; Vol. 22 (36), pp. 7373-7389. Date of Electronic Publication: 2024 Sep 18.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry , Pyridines*/chemistry , Pyridines*/pharmacology , Pyridines*/chemical synthesis , Thiazoles*/chemistry , Thiazoles*/pharmacology , Thiazoles*/chemical synthesis, Humans ; Structure-Activity Relationship ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Models, Molecular ; Molecular Structure ; Intracellular Signaling Peptides and Proteins

المؤلفون: Zou P; Daiichi Sankyo Inc., Basking Ridge, New Jersey, USA., Zahir H; Biogen Inc., Cambridge, Massachusetts, USA., Duggal A; Daiichi Sankyo Inc., Basking Ridge, New Jersey, USA., Pandya G; Daiichi Sankyo Inc., Basking Ridge, New Jersey, USA., Jin J; Daiichi Sankyo Inc., Basking Ridge, New Jersey, USA., Leil TA; Daiichi Sankyo Inc., Basking Ridge, New Jersey, USA.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Sep; Vol. 116 (3), pp. 736-746. Date of Electronic Publication: 2024 Feb 18.

نوع المنشور: Journal Article; Clinical Trial, Phase I

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Pyridines*/pharmacokinetics , Pyridines*/adverse effects , Pyridines*/administration & dosage , Pyridines*/blood , Thiazoles*/pharmacokinetics , Thiazoles*/adverse effects , Thiazoles*/administration & dosage , Thiazoles*/blood , Venous Thromboembolism*/drug therapy , Factor Xa Inhibitors*/pharmacokinetics , Factor Xa Inhibitors*/adverse effects , Factor Xa Inhibitors*/administration & dosage, Humans ; Child ; Child, Preschool ; Adolescent ; Infant ; Male ; Female ; Infant, Newborn ; Dose-Response Relationship, Drug ; Age Factors ; Administration, Oral ; Area Under Curve

المؤلفون: Hu Y; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China., Zhang Y; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China., Guo J; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Chen S; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Jin J; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Li P; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Pan Y; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Lei S; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China., Li J; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Wu S; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Bu B; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China., Fu L; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, China. Electronic address: lei.fu@xjtlu.edu.cn.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107588. Date of Electronic Publication: 2024 Jun 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Cell Proliferation*/drug effects , Mitochondria*/drug effects , Mitochondria*/metabolism , Drug Screening Assays, Antitumor* , Thiazoles*/pharmacology , Thiazoles*/chemistry , Thiazoles*/chemical synthesis , Membrane Potential, Mitochondrial*/drug effects , Apoptosis*/drug effects , Dose-Response Relationship, Drug* , Reactive Oxygen Species*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Structure ; Cell Line, Tumor ; Organophosphorus Compounds/pharmacology ; Organophosphorus Compounds/chemistry ; Organophosphorus Compounds/chemical synthesis

المؤلفون: Nasr EE; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Tawfik SS; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Massoud MAM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Mostafa AS; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.; Pharmacy Center of Scientific Excellence, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Sep; Vol. 357 (9), pp. e2400044. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/drug therapy , Drug Design* , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/chemical synthesis , Cholinesterase Inhibitors*/chemistry , Molecular Docking Simulation* , Thiazoles*/pharmacology , Thiazoles*/chemical synthesis , Thiazoles*/chemistry , Piperazines*/pharmacology , Piperazines*/chemical synthesis , Piperazines*/chemistry , Amyloid beta-Peptides*/antagonists & inhibitors , Amyloid beta-Peptides*/metabolism , Acetylcholinesterase*/metabolism, Humans ; Structure-Activity Relationship ; Rats ; Molecular Structure ; Animals ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; PC12 Cells ; Butyrylcholinesterase/metabolism ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/pharmacology ; Computer Simulation

المؤلفون: Moharram EA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt., El-Sayed SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt; Pharmacy Center of Scientific Excellence, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: salwanmahmoud@mans.edu.eg., Ghabbour HA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt., El-Subbagh HI; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt; Pharmacy Center of Scientific Excellence, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: subbagh@mans.edu.eg.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107538. Date of Electronic Publication: 2024 Jun 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Thiazoles*/chemistry , Thiazoles*/pharmacology , Thiazoles*/chemical synthesis , Receptor, ErbB-2*/antagonists & inhibitors , Receptor, ErbB-2*/metabolism , Drug Screening Assays, Antitumor* , ErbB Receptors*/antagonists & inhibitors , ErbB Receptors*/metabolism , Cell Proliferation*/drug effects , Tetrahydrofolate Dehydrogenase*/metabolism , Folic Acid Antagonists*/pharmacology , Folic Acid Antagonists*/chemical synthesis , Folic Acid Antagonists*/chemistry, Humans ; Structure-Activity Relationship ; Animals ; Molecular Structure ; Dose-Response Relationship, Drug ; Mice ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Imidazoles/chemical synthesis ; Models, Molecular ; Cell Line, Tumor

المؤلفون: Kassem AF; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Sabt A; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Korycka-Machala M; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland., Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt., Kawka M; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland., Dziadek B; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland., Kuzioła M; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland; Bio-Med-Chem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Lodz, Poland., Dziadek J; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland. Electronic address: jdziadek@cbm.pan.pl., Batran RZ; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: rasha_batran@yahoo.com.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107511. Date of Electronic Publication: 2024 May 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Coumarins*/pharmacology , Coumarins*/chemistry , Coumarins*/chemical synthesis , Antitubercular Agents*/pharmacology , Antitubercular Agents*/chemical synthesis , Antitubercular Agents*/chemistry , Mycobacterium tuberculosis*/drug effects , Mycobacterium tuberculosis*/enzymology , Microbial Sensitivity Tests* , Drug Design* , Thiazoles*/pharmacology , Thiazoles*/chemistry , Thiazoles*/chemical synthesis , Oxidoreductases*/antagonists & inhibitors , Oxidoreductases*/metabolism , Bacterial Proteins*/antagonists & inhibitors , Bacterial Proteins*/metabolism, Structure-Activity Relationship ; Humans ; Molecular Structure ; Animals ; Mice ; Dose-Response Relationship, Drug ; Models, Molecular ; Molecular Docking Simulation ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry

المؤلفون: Moein A; Faculty of Pharmaceutical Sciences, The University of British Columbia, Office 5505, Pharmaceutical Sciences Building, Vancouver, BC, Canada.; Genentech, Inc., South San Francisco, CA, USA., Jin JY; Genentech, Inc., South San Francisco, CA, USA., Wright MR; Genentech, Inc., South San Francisco, CA, USA., Wong H; Faculty of Pharmaceutical Sciences, The University of British Columbia, Office 5505, Pharmaceutical Sciences Building, Vancouver, BC, Canada. harvey.wong@ubc.ca.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 Sep; Vol. 94 (3), pp. 421-436. Date of Electronic Publication: 2024 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Fulvestrant*/administration & dosage , Fulvestrant*/therapeutic use , Class I Phosphatidylinositol 3-Kinases*/genetics , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Receptors, Estrogen*/metabolism , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/pharmacology , Receptor, ErbB-2*/genetics , Thiazoles*/administration & dosage , Thiazoles*/therapeutic use , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/administration & dosage , Mutation*, Humans ; Female ; Imidazoles/administration & dosage ; Imidazoles/therapeutic use ; Oxazepines/administration & dosage ; Oxazepines/pharmacology ; Oxazepines/therapeutic use ; Neoplasm Metastasis ; Middle Aged ; Estradiol/analogs & derivatives ; Estradiol/administration & dosage ; Estradiol/pharmacology ; Aged ; Longitudinal Studies

المؤلفون: Yamashita T; Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan., Igawa Y; Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan., Fukuzawa M; Japan Business Unit, Primary Medical Science Department, Cardiovascular Group, Daiichi Sankyo Co., Ltd., Tokyo, Japan., Hayashi T; Data Analysis Group, Data Intelligence Department, Global DX, Daiichi Sankyo Co., Ltd., Tokyo, Japan., Hennig S; Certara, Inc., Princeton, New Jersey, United States., Okumura K; Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto, Japan.

المصدر: Thrombosis and haemostasis [Thromb Haemost] 2024 Sep; Vol. 124 (9), pp. 874-882. Date of Electronic Publication: 2024 Apr 19.

نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase III

بيانات الدورية: Publisher: Thieme Country of Publication: Germany NLM ID: 7608063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-689X (Electronic) Linking ISSN: 03406245 NLM ISO Abbreviation: Thromb Haemost Subsets: MEDLINE

مواضيع طبية MeSH: Thiazoles*/pharmacokinetics , Thiazoles*/administration & dosage , Thiazoles*/adverse effects , Thiazoles*/blood , Thiazoles*/therapeutic use , Atrial Fibrillation*/drug therapy , Atrial Fibrillation*/complications , Atrial Fibrillation*/blood , Pyridines*/pharmacokinetics , Pyridines*/administration & dosage , Pyridines*/adverse effects , Pyridines*/therapeutic use , Hemorrhage*/chemically induced , Factor Xa Inhibitors*/pharmacokinetics , Factor Xa Inhibitors*/administration & dosage , Factor Xa Inhibitors*/adverse effects , Factor Xa Inhibitors*/therapeutic use , Factor Xa Inhibitors*/blood, Humans ; Male ; Female ; Aged, 80 and over ; Double-Blind Method ; Japan ; Platelet Aggregation Inhibitors/pharmacokinetics ; Platelet Aggregation Inhibitors/administration & dosage ; Platelet Aggregation Inhibitors/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Age Factors ; Risk Factors ; Treatment Outcome