المؤلفون: Lin Lin, Fei Hua, Cristian Salinas, Carissa Young, Thierry Bussiere, Joshua F. Apgar, John M. Burke, Kumar Kandadi Muralidharan, Rajasimhan Rajagovindan, Ivan Nestorov

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 362-372 (2022)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/7f7bb9c94560451a90a1143017ac5a1c

المؤلفون: Catherine K. Xu, Sean R. A. Devenish, Fang Qian, Samuel I. A. Cohen, Oskar Hansson, Thierry Bussiere, Georg Meisl, Sara Linse, Tiernan T. O'Malley, Katja Bernfur, Tuomas P. J. Knowles, Michele Vendruscolo, Eimantas Sileikis, Paul H. Weinreb, Tom Scheidt, Christopher M. Dobson, Martin Lundqvist

المصدر: Nature Structural & Molecular Biology. 27:1125-1133

مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, biology, Chemistry, Peptide, 03 medical and health sciences, 0302 clinical medicine, Mechanism of action, Structural Biology, biology.protein, medicine, Biophysics, Structure–activity relationship, Bapineuzumab, Solanezumab, Aducanumab, Antibody, medicine.symptom, Gantenerumab, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::509d989428265cfa7f1a5b5d14c0adf4
https://doi.org/10.1038/s41594-020-0505-6

المؤلفون: Edward D. Plowey, Thierry Bussiere, Raj Rajagovindan, Jennifer Sebalusky, Stefan Hamann, Christian von Hehn, Carmen Castrillo-Viguera, Alfred Sandrock, Samantha Budd Haeberlein, Christopher H. van Dyck, Anita Huttner

المصدر: Acta neuropathologica. 144(1)

مصطلحات موضوعية: Aged, 80 and over, Amyloid, Amyloid beta-Peptides, Clinical Trials, Phase I as Topic, Neurofibrillary Tangles, Plaque, Amyloid, Antibodies, Monoclonal, Humanized, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Alzheimer Disease, Positron-Emission Tomography, Humans, Female, Neurology (clinical), Randomized Controlled Trials as Topic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1b5f2313ceec8788b74f6643c2ba7d
https://pubmed.ncbi.nlm.nih.gov/35581440

المؤلفون: Lin Lin, Fei Hua, Cristian Salinas, Carissa Young, Thierry Bussiere, Joshua F. Apgar, John M. Burke, Kumar Kandadi Muralidharan, Rajasimhan Rajagovindan, Ivan Nestorov

المصدر: CPT: pharmacometricssystems pharmacology. 11(3)

مصطلحات موضوعية: Amyloid beta-Peptides, Alzheimer Disease, Modeling and Simulation, Brain, Humans, Pharmacology (medical), Plaque, Amyloid, Network Pharmacology, Antibodies, Monoclonal, Humanized

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e22d53d7ce50029f5e08a50c56cd13
https://pubmed.ncbi.nlm.nih.gov/35029320

المؤلفون: Sara, Linse, Tom, Scheidt, Katja, Bernfur, Michele, Vendruscolo, Christopher M, Dobson, Samuel I A, Cohen, Eimantas, Sileikis, Martin, Lundqvist, Fang, Qian, Tiernan, O'Malley, Thierry, Bussiere, Paul H, Weinreb, Catherine K, Xu, Georg, Meisl, Sean R A, Devenish, Tuomas P J, Knowles, Oskar, Hansson

المصدر: Nature structuralmolecular biology. 27(12)

مصطلحات موضوعية: Models, Molecular, Kinetics, Protein Aggregates, Structure-Activity Relationship, Amyloid beta-Peptides, Neuroprotective Agents, Alzheimer Disease, Protein Conformation, Humans, Antibodies, Monoclonal, Humanized, Models, Biological, Peptide Mapping, Peptide Fragments

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f4b1809dfd1c1a20dcda6b246af44348
https://pubmed.ncbi.nlm.nih.gov/32989305

المؤلفون: Paul H. Weinreb, Lary C. Walker, Matthias Staufenbiel, Ruth E. Uhlmann, Rawaa Al-Shaana, Emily M. Ullrich Gavilanes, Søren Christensen, Frank Baumann, Ulrike Obermüller, Stephan A. Kaeser, Fredrik Kartberg, Mathias Jucker, Angelos Skodras, Jay Rasmussen, Holger Cynis, Lan Ye, Anika Buehler, Fang Qian, Carina Bergmann, Juliane Schelle, Sarah K. Fritschi, Thierry Bussiere, Jens-Ulrich Rahfeld, Christine Rother, Natalie Beschorner, Jeffrey B. Stavenhagen

المساهمون: Publica

المصدر: Nat Neurosci
Nature neuroscience 23(12), 1580-1588 (2020). doi:10.1038/s41593-020-00737-w

مصطلحات موضوعية: 0301 basic medicine, Male, pharmacology [Tissue Extracts], pharmacokinetics [Antibodies, Monoclonal, Humanized], Plaque, Amyloid, Protein aggregation, pharmacology [Antibodies, Monoclonal, Humanized], neuroscience, pathology [Alzheimer Disease], Amyloid beta-Protein Precursor, Mice, 0302 clinical medicine, Neurofilament Proteins, antagonists & inhibitors [Amyloid beta-Protein Precursor], Aged, 80 and over, biology, Chemistry, General Neuroscience, aducanumab, Middle Aged, Alzheimer's disease, Cell biology, Aducanumab, Antibody, pharmacology [Antibodies, Blocking], metabolism [Alzheimer Disease], Genetically modified mouse, Amyloid, Immunoprecipitation, Transgene, metabolism [Amyloid beta-Peptides], Mice, Transgenic, Antibodies, Monoclonal, Humanized, Article, 03 medical and health sciences, In vivo, Alzheimer Disease, Animals, Humans, ddc:610, pathology [Plaque, Amyloid], Antibodies, Blocking, Aged, Brain Chemistry, Amyloid beta-Peptides, Tissue Extracts, cerebrospinal fluid [Neurofilament Proteins], Mice, Inbred C57BL, 030104 developmental biology, biology.protein, diseases of the nervous system, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304ff0cfb27901cbd3f5fac431ae6943
https://publica.fraunhofer.de/handle/publica/269747

المؤلفون: Sara Linse, Christopher M. Dobson, Tiernan T. O'Malley, Eimantas Sileikis, Paul H. Weinreb, Tom Scheidt, Katja Bernfur, Michele Vendruscolo, Sean R. A. Devenish, Tuomas P. J. Knowles, Catherine K. Xu, Georg Meisl, Thierry Bussiere, Oskar Hansson, Samuel Cohen, Martin Lundquist, Fang Qian

مصطلحات موضوعية: chemistry.chemical_classification, biology, Chemistry, Aggregation kinetics, Peptide, Computational biology, medicine, biology.protein, Bapineuzumab, Solanezumab, Aducanumab, Amyloid cascade, Antibody, Gantenerumab, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5c7e7c45196a97662812ce573a11e7

المؤلفون: Anthone W. Dunah, Thierry Bussiere, Kenneth J. Rhodes, Hairuo Peng, Lin Xu, Mahin Arastu, Gnanasambandam Kumaravel, Joy Wang, Melanie S. Brennan, Pamela A. Snodgrass-Belt, Arthur G. Taveras, Mi-young Jung, Tina Talreja, Sowmya Chollate, Zhili Xin, Diana Fahrer, Robert Dunstan, Robert H. Scannevin, Ellen Rohde, H. Moore Arnold

المصدر: Neuropharmacology. 103:57-68

مصطلحات موضوعية: Male, 0301 basic medicine, Gene isoform, Pathology, medicine.medical_specialty, Central nervous system, BACE1-AS, Plaque, Amyloid, Cleavage (embryo), Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Alzheimer Disease, Amyloid precursor protein, medicine, Animals, Protein Isoforms, Pharmacology, Aldehydes, Amyloid beta-Peptides, Dose-Response Relationship, Drug, biology, P3 peptide, Brain, medicine.disease, Rats, Inbred F344, Rats, Disease Models, Animal, Macaca fascicularis, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Amyloid Precursor Protein Secretases, Alzheimer's disease, Amyloid precursor protein secretase, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c58874b2fa09f0f97a25626acfb40
https://doi.org/10.1016/j.neuropharm.2015.12.006

المؤلفون: Sowmya Chollate, Paul H. Weinreb, Fang Qian, Alfred Sandrock, Omar Quintero-Monzon, Thierry Bussiere, Mahin Arastu, Melanie S. Brennan, Mingwei Li, Jan Grimm, Yaming Hang, James Ferrero, Tianle Chen, John O'Gorman, Robert Dunstan, Thomas Engber, Roger M. Nitsch, Marcel Maier, Jeff Sevigny, Ping Chiao, Kenneth J. Rhodes, Alvydas Mikulskis, Yan Ling, Robert H. Scannevin, H. Moore Arnold, Leslie Williams, Christoph Hock, Stephen Salloway

المصدر: Nature

مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, business.industry, Neurotoxicity, medicine.disease, Biochemistry of Alzheimer's disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Crenezumab, Immunology, medicine, Verubecestat, Dementia, Solanezumab, Aducanumab, Gantenerumab, business, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6af16349ff35f219bea2af5a81efc0

المؤلفون: Thierry Bussiere, Krishna Praneeth Kilambi, Joseph Arndt, Paul H. Weinreb, Fang Qian, Thomas Cameron, Chao Quan, Benjamin A. Smith, R. B. Pepinsky, Martin Bush, Thomas Walz, S. Hamann

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, lcsh:Medicine, Enzyme-Linked Immunosorbent Assay, Peptide, Antibodies, Monoclonal, Humanized, Article, Epitope, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Alzheimer Disease, Humans, Avidity, Binding site, lcsh:Science, chemistry.chemical_classification, Amyloid beta-Peptides, Multidisciplinary, Linear epitope, lcsh:R, Surface Plasmon Resonance, Receptor–ligand kinetics, Molecular Docking Simulation, Kinetics, 030104 developmental biology, chemistry, Biophysics, lcsh:Q, Binding Sites, Antibody, Immunotherapy, Aducanumab, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7501c2c151ae49170e6dc941654cef8a
https://doi.org/10.1038/s41598-018-24501-0