نتائج البحث - "Thilo Focken"

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دورية أكاديمية

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

المؤلفون: JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield

المصدر: eLife, Vol 11 (2022)

مصطلحات موضوعية: epilepsy, SCN8A, NBI-921352, anti-seizure medicine, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/72468; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/ff1c4ccf767e411f85c1b12a0db8fe55

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دورية أكاديمية

Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

المؤلفون: Thilo Focken, Stephen Hanessian

المصدر: Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1848-1877 (2014)

مصطلحات موضوعية: conjugate addition, cyclopropanation, olefination, organophosphorus, phosphonamide, total synthesis, Science, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1860-5397

URL الوصول: https://doaj.org/article/4a90e1b3a4444103b6c380b25feec321

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Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310

المؤلفون: Sultan Chowdhury, Christoph Martin Dehnhardt, Tao Sheng, Clint Young, Rainbow Kwan, Michael Scott Wilson, Jun Chen, Matthew Waldbrook, Dinah Misner, C. Lee Robinette, Rebecca M. Reese, Elaine Chang, Henry Verschoof, Tanja S. Zabka, Girish Bankar, Philippe Bergeron, Luis Sojo, Karen Nelkenbrecher, Daniel P. Sutherlin, Amy Kim, Ivan William Hemeon, Andrea Lindgren, Jae H. Chang, Alla Yurevna Zenova, Shaoyi Sun, Jonathan Maher, Shannon D. Shields, Jun Li, Daniel F. Ortwine, David H. Hackos, Zhiwei Xie, Thilo Focken, Charles J. Cohen, Richard T. Dean, Shannon Decker, Janette Mezeyova, Kuldip Khakh, Antonio G. DiPasquale, Chien-An Chen, Andrew D. White, Brian Safina, Jodie Pang, Qi Jia, Sophia Lin, Jean-Christophe Andrez, J. P. Johnson, Steven J. McKerrall

المصدر: Journal of Medicinal Chemistry. 64:2953-2966

مصطلحات موضوعية: 0303 health sciences, Chemistry, Sulfonamide (medicine), Phase 1 trials, Pharmacology, Metabolic stability, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, Drug Discovery, NAV1, medicine, Molecular Medicine, Dosing, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a9431d81bf8ca2eed0fbbfbb36905
https://doi.org/10.1021/acs.jmedchem.1c00049

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NBI-921352, a First-in-Class, NaV1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of-Function Mice, and Wild-Type Mice and Rats

المؤلفون: Sultan Chowdhury, David Bogucki, Rostam Namdari, Girish Bankar, Wei Zhang, James Roy Empfield, Matthew Waldbrook, Stephanie M Lee, Lofstrand Verner Alexander, Karen Nelkenbrecher, Samuel J. Goodchild, Rhena Yoo, Noah G. Shuart, Wesolowski Steven Sigmund, Elaine Chang, Mandy Feng, Clint Young, Christoph Martin Dehnhardt, Jenny Li, Zhiwei Xie, Michael Edward Grimwood, Abid Hasan, Sophia Lin, Kristen Burford, Raymond J. Winquist, Charles J. Cohen, Alla Yurevna Zenova, Simon N. Pimstone, Michael R. Wilson, Parisa Karimi Tari, Kuldip Khakh, Celine Dube, Aaron M. Williams, Robin Sherrington, Luis Sojo, Andrea Lindgren, J. P. Johnson, Thilo Focken, Qi Jia, Jean-Christophe Andrez, Shannon Decker, Matthew Taron, Diana Weeratunge, Richard T. Dean, Janette Mezeyova, Shaoyi Sun, Wei Gong, Angela Hussainkhel, Gina de Boer, Alison Jane Cutts

مصطلحات موضوعية: Phenytoin, Glutamatergic, Lacosamide, Chemistry, Sodium channel, Excitatory postsynaptic potential, medicine, Carbamazepine, Pharmacology, Inhibitory postsynaptic potential, IC50, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::32e2e6674136369f3abcd5070b52e762
https://doi.org/10.1101/2021.08.29.458125

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NBI-921352, a first-in-class, Na

المؤلفون: J P, Johnson, Thilo, Focken, Kuldip, Khakh, Parisa Karimi, Tari, Celine, Dube, Samuel J, Goodchild, Jean-Christophe, Andrez, Girish, Bankar, David, Bogucki, Kristen, Burford, Elaine, Chang, Sultan, Chowdhury, Richard, Dean, Gina, de Boer, Shannon, Decker, Christoph, Dehnhardt, Mandy, Feng, Wei, Gong, Michael, Grimwood, Abid, Hasan, Angela, Hussainkhel, Qi, Jia, Stephanie, Lee, Jenny, Li, Sophia, Lin, Andrea, Lindgren, Verner, Lofstrand, Janette, Mezeyova, Rostam, Namdari, Karen, Nelkenbrecher, Noah Gregory, Shuart, Luis, Sojo, Shaoyi, Sun, Matthew, Taron, Matthew, Waldbrook, Diana, Weeratunge, Steven, Wesolowski, Aaron, Williams, Michael, Wilson, Zhiwei, Xie, Rhena, Yoo, Clint, Young, Alla, Zenova, Wei, Zhang, Alison J, Cutts, Robin P, Sherrington, Simon N, Pimstone, Raymond, Winquist, Charles J, Cohen, James R, Empfield

المصدر: eLife. 11

مصطلحات موضوعية: Neurons, Mice, Epilepsy, NAV1.6 Voltage-Gated Sodium Channel, Gain of Function Mutation, Mutation, Sodium, Animals, Rats, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3cf389ce4c308fb570995099c2f50504
https://pubmed.ncbi.nlm.nih.gov/35234610

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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy

المصدر: Journal of Medicinal Chemistry. 62:9618-9641

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::25eea9fc94c4d0a50d32b1585395b3e1
https://doi.org/10.1021/acs.jmedchem.9b01032

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Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity

المصدر: Journal of Medicinal Chemistry. 62:908-927

مصطلحات موضوعية: 0303 health sciences, Chemistry, Sodium channel, Pharmacology, 01 natural sciences, Molecular Docking Simulation, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, In vivo, Docking (molecular), Drug Discovery, Microsome, Molecular Medicine, Structure–activity relationship, Potency, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f65c95248ff36af0807edf4a8f95cad
https://doi.org/10.1021/acs.jmedchem.8b01621

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8

Discovery of Acyl-sulfonamide Na

المؤلفون: Brian S, Safina, Steven J, McKerrall, Shaoyi, Sun, Chien-An, Chen, Sultan, Chowdhury, Qi, Jia, Jun, Li, Alla Y, Zenova, Jean-Christophe, Andrez, Girish, Bankar, Philippe, Bergeron, Jae H, Chang, Elaine, Chang, Jun, Chen, Richard, Dean, Shannon M, Decker, Antonio, DiPasquale, Thilo, Focken, Ivan, Hemeon, Kuldip, Khakh, Amy, Kim, Rainbow, Kwan, Andrea, Lindgren, Sophia, Lin, Jonathan, Maher, Janette, Mezeyova, Dinah, Misner, Karen, Nelkenbrecher, Jodie, Pang, Rebecca, Reese, Shannon D, Shields, Luis, Sojo, Tao, Sheng, Henry, Verschoof, Matthew, Waldbrook, Michael S, Wilson, Zhiwei, Xie, Clint, Young, Tanja S, Zabka, David H, Hackos, Daniel F, Ortwine, Andrew D, White, J P, Johnson, C Lee, Robinette, Christoph M, Dehnhardt, Charles J, Cohen, Daniel P, Sutherlin

المصدر: Journal of medicinal chemistry. 64(6)

مصطلحات موضوعية: Rats, Sprague-Dawley, Voltage-Gated Sodium Channel Blockers, Sulfonamides, HEK293 Cells, Piperidines, Benzamides, Drug Discovery, NAV1.7 Voltage-Gated Sodium Channel, Animals, Azetidines, Humans, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d744b2a5894fa87236be1caf92c75b8b
https://pubmed.ncbi.nlm.nih.gov/33682420

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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain

المصدر: Journal of Medicinal Chemistry. 61:4810-4831

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Genetically modified mouse, Stereochemistry, Aryl, Sodium channel, In vitro, Sulfonamide, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, Drug Discovery, Lipophilicity, Molecular Medicine, Potency, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::301a3d7aee1781be0e40a336f69ca411
https://doi.org/10.1021/acs.jmedchem.7b01826

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10

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na

المصدر: Journal of medicinal chemistry. 62(21)

مصطلحات موضوعية: Central Nervous System, Models, Molecular, Epilepsy, Hep G2 Cells, Amides, Madin Darby Canine Kidney Cells, Mice, Structure-Activity Relationship, Dogs, Protein Domains, NAV1.6 Voltage-Gated Sodium Channel, Animals, Humans, Protein Isoforms, Sodium Channel Blockers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::83cdc1c0cbb195dcbc6825acef82c33c
https://pubmed.ncbi.nlm.nih.gov/31525968

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