المؤلفون: Vlachodimou A; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands., Bouma J; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands., De Cleyn M; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium., Berthelot D; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium., Pype S; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium., Bosmans JP; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium., van Vlijmen H; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium., Wroblowski B; Janssen Research and Development, Antwerpseweg 30, 2340, Beerse, Belgium., Heitman LH; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands., IJzerman AP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands. ijzerman@lacdr.leidenuniv.nl.

المصدر: Purinergic signalling [Purinergic Signal] 2024 Apr; Vol. 20 (2), pp. 193-205. Date of Electronic Publication: 2023 Jul 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 101250499 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-9546 (Electronic) Linking ISSN: 15739538 NLM ISO Abbreviation: Purinergic Signal Subsets: MEDLINE

مواضيع طبية MeSH: Thioinosine*/metabolism , Thioinosine*/pharmacology , Equilibrative Nucleoside Transporter 1*/chemistry , Equilibrative Nucleoside Transporter 1*/metabolism, Humans ; Biological Transport

المؤلفون: Ghigo G; Department of Applied Science and Technology, Politecnico di Torino, 10129, Turin, Italy. gianluca.ghigo@polito.it.; Istituto Nazionale di Fisica Nucleare, Sezione di Torino, 10125, Turin, Italy. gianluca.ghigo@polito.it., Torsello D; Department of Applied Science and Technology, Politecnico di Torino, 10129, Turin, Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Torino, 10125, Turin, Italy., Gozzelino L; Department of Applied Science and Technology, Politecnico di Torino, 10129, Turin, Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Torino, 10125, Turin, Italy., Fracasso M; Department of Applied Science and Technology, Politecnico di Torino, 10129, Turin, Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Torino, 10125, Turin, Italy., Bartoli M; Center for Sustainable Future Technologies, Italian Institute of Technology, 10144, Turin, Italy.; Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), 50121, Florence, Italy., Pira C; Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, 35020, Legnaro, Italy., Ford D; Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, 35020, Legnaro, Italy., Marconato G; Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, 35020, Legnaro, Italy., Fretto M; Istituto Nazionale di Ricerca Metrologica, 10135, Turin, Italy., De Carlo I; Istituto Nazionale di Ricerca Metrologica, 10135, Turin, Italy.; Department of Electronics and Telecommunications, Politecnico di Torino, 10129, Turin, Italy., Pompeo N; Department of Industrial, Electronic and Mechanical Engineering, Università Roma Tre, 00146, Rome, Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, 00146, Rome, Italy., Silva E; Department of Industrial, Electronic and Mechanical Engineering, Università Roma Tre, 00146, Rome, Italy.; Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, 00146, Rome, Italy.

المصدر: Scientific reports [Sci Rep] 2023 Jun 08; Vol. 13 (1), pp. 9315. Date of Electronic Publication: 2023 Jun 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: PubMed not MEDLINE; MEDLINE

مواضيع طبية MeSH: Motion Pictures* , Thioinosine*, Electric Impedance ; Magnetic Fields

المؤلفون: Chen X; Department of Neurosurgery, the First People's Hospital of Jingmen City, Hubei, China., Luo X, Hu H, Xu Q

المصدر: Neuroreport [Neuroreport] 2021 Dec 08; Vol. 32 (17), pp. 1341-1348.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100935 Publication Model: Print Cited Medium: Internet ISSN: 1473-558X (Electronic) Linking ISSN: 09594965 NLM ISO Abbreviation: Neuroreport Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Equilibrative Nucleoside Transporter 1/*antagonists & inhibitors , NLR Family, Pyrin Domain-Containing 3 Protein/*drug effects , Neuroinflammatory Diseases/*metabolism , Proto-Oncogene Proteins c-bcl-2/*drug effects , Subarachnoid Hemorrhage/*metabolism , Thioinosine/*analogs & derivatives, Animals ; Disease Models, Animal ; Equilibrative Nucleoside Transporter 1/drug effects ; Equilibrative Nucleoside Transporter 1/metabolism ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Thioinosine/pharmacology

المؤلفون: Wright NJ; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA., Lee SY; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA. seok-yong.lee@duke.edu.

المصدر: Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Jul; Vol. 26 (7), pp. 599-606. Date of Electronic Publication: 2019 Jun 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Adenosine/*metabolism , Dilazep/*pharmacology , Equilibrative Nucleoside Transporter 1/*antagonists & inhibitors , Equilibrative Nucleoside Transporter 1/*chemistry , Thioinosine/*analogs & derivatives, Crystallography, X-Ray ; Dilazep/chemistry ; Equilibrative Nucleoside Transporter 1/metabolism ; Humans ; Models, Molecular ; Protein Conformation/drug effects ; Thioinosine/chemistry ; Thioinosine/pharmacology

المؤلفون: Karbanova S; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Sorf A; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Jiraskova L; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Lalinska A; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Ptackova Z; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Staud F; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Cerveny L; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic. cervenyl@faf.cuni.cz.

المصدر: Pharmaceutical research [Pharm Res] 2020 Feb 21; Vol. 37 (3), pp. 58. Date of Electronic Publication: 2020 Feb 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

مواضيع طبية MeSH: ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors , Biological Transport/*drug effects , Neoplasm Proteins/*antagonists & inhibitors , Thioinosine/*analogs & derivatives, ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacokinetics ; Cell Line ; Dogs ; Female ; Humans ; Madin Darby Canine Kidney Cells ; Neoplasm Proteins/metabolism ; Placenta/drug effects ; Placenta/metabolism ; Pregnancy ; Rats ; Rats, Wistar ; Thioinosine/pharmacology

المؤلفون: Chambers ED; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, RI, USA., White A; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, RI, USA., Vang A; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, RI, USA., Wang Z; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, RI, USA., Ayala A; Division of Surgical Research, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA., Weng T; Departments of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, Houston, TX, USA., Blackburn M; Departments of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, Houston, TX, USA., Choudhary G; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, RI, USA., Rounds S; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, RI, USA., Lu Q; Vascular Research Laboratory, Providence Veterans Affairs Medical Center, Alpert Medical School of Brown University, Providence, RI, USA.

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Jan; Vol. 34 (1), pp. 1516-1531. Date of Electronic Publication: 2019 Dec 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: Acute Lung Injury/*drug therapy , Equilibrative Nucleoside Transporter 1/*antagonists & inhibitors , Equilibrative-Nucleoside Transporter 2/*antagonists & inhibitors , Inflammasomes/*metabolism , NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism , Pseudomonas Infections/*drug therapy , Pseudomonas aeruginosa/*metabolism , Thioinosine/*analogs & derivatives, Acute Lung Injury/metabolism ; Acute Lung Injury/microbiology ; Acute Lung Injury/pathology ; Animals ; Equilibrative Nucleoside Transporter 1/metabolism ; Equilibrative-Nucleoside Transporter 2/metabolism ; Male ; Mice ; Pseudomonas Infections/metabolism ; Pseudomonas Infections/pathology ; Thioinosine/pharmacology

المؤلفون: Singh SB; Merck & Co., Inc., Kenilworth, NJ 07033, USA. Electronic address: sbsingh101@gmail.com., Tan CM; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Kaelin D; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Meinke PT; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Miesel L; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Olsen DB; Merck & Co., Inc., West Point, PA 19486, USA., Fukuda H; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Kishii R; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Takei M; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Ohata K; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Takeuchi T; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Shibue T; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Takano H; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Nishimura A; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Fukuda Y; Kyorin Pharmaceutical Co., Ltd., 1848 Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Electronic address: yasumichi.fukuda@gmail.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Nov 01; Vol. 75, pp. 128808. Date of Electronic Publication: 2022 May 21.

نوع المنشور: Clinical Trial, Phase III; Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Topoisomerase Inhibitors*/chemistry , Topoisomerase Inhibitors*/pharmacology, DNA Gyrase/metabolism ; DNA Topoisomerase IV ; Microbial Sensitivity Tests ; Staphylococcus aureus/metabolism ; Structure-Activity Relationship ; Thioinosine/analogs & derivatives ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology

المؤلفون: Kokot M; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia; The Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Weiss M; The Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Zdovc I; Institute of Microbiology and Parasitology, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia., Anderluh M; The Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Hrast M; The Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. Electronic address: martina.hrast@ffa.uni-lj.si., Minovski N; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia. Electronic address: nikola.minovski@ki.si.

المصدر: Bioorganic chemistry [Bioorg Chem] 2022 Nov; Vol. 128, pp. 106087. Date of Electronic Publication: 2022 Aug 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , DNA Gyrase*/metabolism, DNA Topoisomerase IV ; Escherichia coli/metabolism ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Microbial Sensitivity Tests ; Naphthyridines/chemistry ; Structure-Activity Relationship ; Thioinosine/analogs & derivatives ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology

المؤلفون: Robijns K; Dutch Foundation for Quality Assessment in Medical Laboratories (SKML), Section Therapeutic Drug Monitoring and Clinical Toxicology (KKGT), PO Box 43100, NL 2504 AC, The Hague, The Netherlands.; Central Hospital Pharmacy, The Hague, The Netherlands.; Haga Teaching Hospital, The Hague, The Netherlands.; CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+, Maastricht, The Netherlands, Phone: +31-70-3217217, Fax: +31-70-3080140., van Luin M; Dutch Foundation for Quality Assessment in Medical Laboratories (SKML), Section Therapeutic Drug Monitoring and Clinical Toxicology (KKGT), The Hague, The Netherlands.; Department of Clinical Pharmacy, Rijnstate Hospital, Arnhem, The Netherlands., Jansen RTP; Dutch Foundation for Quality Assessment in Medical Laboratories (SKML), Nijmegen, The Netherlands., Neef C; CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.; Dutch Foundation for Quality Assessment in Medical Laboratories (SKML), Section Therapeutic Drug Monitoring and Clinical Toxicology (KKGT), The Hague, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+, Maastricht, The Netherlands., Touw DJ; Dutch Foundation for Quality Assessment in Medical Laboratories (SKML), Section Therapeutic Drug Monitoring and Clinical Toxicology (KKGT), The Hague, The Netherlands.; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands.; University of Groningen, Groningen Research Institute of Pharmacy, Department of Pharmacokinetics Toxicology and Targeting, Groningen, The Netherlands.

المصدر: Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2018 Sep 25; Vol. 56 (10), pp. 1715-1721.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Walter De Gruyter Country of Publication: Germany NLM ID: 9806306 Publication Model: Print Cited Medium: Internet ISSN: 1437-4331 (Electronic) Linking ISSN: 14346621 NLM ISO Abbreviation: Clin Chem Lab Med Subsets: MEDLINE

مواضيع طبية MeSH: Quality Control*, Guanine Nucleotides/*analysis , Thioinosine/*analogs & derivatives , Thionucleotides/*analysis, Chromatography, High Pressure Liquid/standards ; Guanine Nucleotides/standards ; Laboratories, Hospital ; Limit of Detection ; Reference Standards ; Thioinosine/analysis ; Thioinosine/metabolism ; Thioinosine/standards ; Thionucleotides/metabolism ; Thionucleotides/standards

المؤلفون: Nazir M; Department of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan., Tousif MI; Department of Chemistry, Division of Science and Technology, University of Education Lahore, Lahore, 32200, Pakistan., Khalid M; Department of Chemistry, Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan, 64200, Pakistan., Parveen S; Department of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan., Akhter N; Department of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan., Farooq N; Department of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan., Khan MU; Department of Chemistry, University of Okara, Okara, 56300, Pakistan., Mehmood RF; Department of Chemistry, Division of Science and Technology, University of Education Lahore, Lahore, 32200, Pakistan., Mahomoodally MF; Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, 230, Réduit, Mauritius., Muhammad S; Department of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia., Alarfaji SS; Department of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia.

المصدر: Chemistry & biodiversity [Chem Biodivers] 2022 Apr; Vol. 19 (4), pp. e202100843. Date of Electronic Publication: 2022 Mar 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

مواضيع طبية MeSH: SARS-CoV-2* , COVID-19 Drug Treatment*, Actinomyces ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pandemics ; Thioinosine