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1دورية أكاديمية
المؤلفون: Thomas Löhr, Pietro Sormanni, Michele Vendruscolo
المصدر: Biomolecules, Vol 12, Iss 5, p 718 (2022)
مصطلحات موضوعية: antibody design, antibody engineering, protein design, metadynamics, molecular dynamics, Microbiology, QR1-502
وصف الملف: electronic resource
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المؤلفون: Z. Faidon Brotzakis, Thomas Löhr, Steven Truong, Samuel E. Hoff, Massimiliano Bonomi, Michele Vendruscolo
المساهمون: University of Cambridge [UK] (CAM), Département de Biologie structurale et Chimie - Department of Structural Biology and Chemistry, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Centre National de la Recherche Scientifique (CNRS), Z.F.B. would like to acknowledge the Federation of European Biochemical Societies (FEBS) for financial support (LTF). M.B. and S.E.H. acknowledge the support of the French Agence Nationale de la Recherche (ANR), under grant ANR-20-CE45-0002 (project EMMI)., ANR-20-CE45-0002,EMMI,Modélisation intégrative de la structure et de la dynamique des protéines avec la cryo-EM(2020)
مصطلحات موضوعية: MEMMI, Structural Biology, IAPP, [SDV]Life Sciences [q-bio], macromolecular substances, Molecular Dynamics, Cryo-EM
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0351634e64f93aec5281c7cd2a1353a5
https://hal.science/hal-03834207/file/2022.05.29.493873v1.full.pdf -
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المصدر: ACS chemical neuroscience. 13(12)
مصطلحات موضوعية: Intrinsically Disordered Proteins, Amyloid beta-Peptides, Physiology, Alzheimer Disease, Cognitive Neuroscience, Entropy, Humans, Cell Biology, General Medicine, Biochemistry, Peptide Fragments
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المؤلفون: Michele Vendruscolo, Pietro Sormanni, Thomas Löhr
المساهمون: Lohr, Thomas [0000-0003-2969-810X], Sormanni, Pietro [0000-0002-6228-2221], Vendruscolo, Michele [0000-0002-3616-1610], Apollo - University of Cambridge Repository, Löhr, Thomas [0000-0003-2969-810X]
المصدر: Biomolecules; Volume 12; Issue 5; Pages: 718
مصطلحات موضوعية: conformational entropy, antibody engineering, complementarity determining region, Entropy, Molecular Conformation, antibody design, Single-Domain Antibodies, Biochemistry, protein design, metadynamics, molecular dynamics, Complementarity Determining Regions, Antibodies, nanobody, antibody, Molecular Biology
وصف الملف: application/zip; text/xml; application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66437ec6813a51e5cf6210c9e8579ef6
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المؤلفون: Didier Portran, Eva Nogales, Thomas Löhr, Michele Vendruscolo, Rui Zhang, Lisa Eshun-Wilson, Maxence V. Nachury, Daniel B. Toso, James S. Fraser, Massimiliano Bonomi
المساهمون: University of California [Berkeley], University of California, Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Department of Biochemistry [Cambridge], University of Cambridge [UK] (CAM)
المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 21
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (21), pp.10366-10371. ⟨10.1073/pnas.1900441116⟩مصطلحات موضوعية: Swine, Cryo-electron microscopy, 1.1 Normal biological development and functioning, macromolecular substances, α tubulin, Microtubules, Microtubule stabilization, 03 medical and health sciences, Molecular dynamics, 0302 clinical medicine, tubulin modifications, Underpinning research, Tubulin, Microtubule, 2.1 Biological and endogenous factors, Animals, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Aetiology, Conformational sampling, Conformational ensembles, ComputingMilieux_MISCELLANEOUS, Protein Processing, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Chemistry, MD, Cryoelectron Microscopy, Post-Translational, Acetylation, Biological Sciences, Biophysics and Computational Biology, Biophysics, cryo-EM, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Function (biology), Alpha-tubulin acetylation, microtubule
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b2d799528e00039db6eb53ecd85561
https://doi.org/10.1073/pnas.1900441116 -
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المؤلفون: Michele Vendruscolo, Thomas Löhr, Z. Faidon Brotzakis
المساهمون: Vendruscolo, Michele [0000-0002-3616-1610], Apollo - University of Cambridge Repository
المصدر: Chemical Science
مصطلحات موضوعية: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Cryo-electron microscopy, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Spike, FOS: Health sciences, Molecular Dynamics, Therapeutic targeting, Vaccine Related, 03 medical and health sciences, 0302 clinical medicine, Biodefense, Transmembrane glycoprotein, Binding site, Lung, 030304 developmental biology, 0303 health sciences, 34 Chemical Sciences, Chemistry, Prevention, COVID-19, 3 Good Health and Well Being, Pneumonia, General Chemistry, Cell biology, Infectious Diseases, Emerging Infectious Diseases, Pneumonia & Influenza, Spike (software development), CryoEM, 030217 neurology & neurosurgery
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae61c19c5bd6ce4cf5f718c8290ddbb2
https://doi.org/10.26434/chemrxiv.13222073.v1 -
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المؤلفون: Eric Wang, Zev A Ripstein, John L. Rubinstein, Alexander E. Conicella, Ai Nguyen, Lewis E. Kay, Peter Schuck, Rui Huang, Thomas Löhr, Michele Vendruscolo
المصدر: Proc Natl Acad Sci U S A
مصطلحات موضوعية: inorganic chemicals, Models, Molecular, congenital, hereditary, and neonatal diseases and abnormalities, Cryo-electron microscopy, Protein Conformation, Amino Acid Motifs, 03 medical and health sciences, chemistry.chemical_compound, Adenosine Triphosphate, hemic and lymphatic diseases, Humans, Nucleotide, Short linear motif, Lipid bilayer, 030304 developmental biology, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, Adenosine Triphosphatases, 0303 health sciences, Multidisciplinary, Chemistry, 030302 biochemistry & molecular biology, Nuclear Proteins, hemic and immune systems, Biological Sciences, AAA proteins, Adenosine Diphosphate, Intrinsically Disordered Proteins, Adenosine diphosphate, Proteostasis, Biophysics, Adenosine triphosphate, circulatory and respiratory physiology, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2fd7b17e802dc585b5e3535d006476
https://europepmc.org/articles/PMC7585011/ -
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مصطلحات موضوعية: Physics, Quantitative Biology::Biomolecules, Markov chain, Artificial neural network, Computer Networks and Communications, Stochastic process, Aβ peptide, Probabilistic logic, Markov model, Kinetic energy, Computer Science Applications, Microsecond, Molecular dynamics, Computer Science (miscellaneous), Human proteome project, Statistical physics
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ff5f09a23d447bcc4a0dba778656a6
https://doi.org/10.1101/2020.05.07.082818 -
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المؤلفون: Benedetta Mannini, Roberta Pierattelli, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Thomas C. T. Michaels, Francesco Simone Ruggeri, Gabriella T. Heller, Alfonso De Simone, Michele Vendruscolo, Francesco A. Aprile, Christopher M. Dobson, Ryan Limbocker, Michele Perni, Isabella C. Felli, Tuomas P. J. Knowles
المساهمون: Heller, Gabriella T [0000-0002-5672-0467], Aprile, Francesco A [0000-0002-5040-4420], Perni, Michele [0000-0001-7593-8376], Ruggeri, Francesco Simone [0000-0002-1232-1907], Mannini, Benedetta [0000-0001-6812-7348], Löhr, Thomas [0000-0003-2969-810X], Bonomi, Massimiliano [0000-0002-7321-0004], Camilloni, Carlo [0000-0002-9923-8590], De Simone, Alfonso [0000-0001-8789-9546], Felli, Isabella C [0000-0002-6018-9090], Pierattelli, Roberta [0000-0001-7755-0885], Knowles, Tuomas PJ [0000-0002-7879-0140], Dobson, Christopher M [0000-0002-5445-680X], Vendruscolo, Michele [0000-0002-3616-1610], Apollo - University of Cambridge Repository, Heller, G. T., Aprile, F. A., Michaels, T. C. T., Limbocker, R., Perni, M., Ruggeri, F. S., Mannini, B., Lohr, T., Bonomi, M., Camilloni, C., de Simone, A., Felli, I. C., Pierattelli, R., Knowles, T. P. J., Dobson, C. M., Vendruscolo, M., University of Cambridge [UK] (CAM), Imperial College London, Harvard University, Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano = University of Milan (UNIMI), University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli Studi di Firenze = University of Florence (UniFI), Funding: G.T.H. is supported by the Gates Cambridge Trust and the Rosalind Franklin Research Fellowship at Newnham College, Cambridge, F.A.A. is supported by UK Research and Innovation (Future Leaders Fellowship MR/S033947/1) and the Alzheimer’s Society, UK (317, 511), R.L. is supported by the Gates Cambridge Trust, TCTM by Peterhouse, Cambridge and the Swiss National Science Foundation, and F.S.R. is supported by Darwin College and the Swiss National Foundation (grant numbers P300P2_171219 and P2ELP2_162116, respectively). We acknowledge ARCHER UK National Supercomputing Service under ARCHER Leadership project (grant number e510) and PRACE for awarding us access to MareNostrum at Barcelona Supercomputing Center (BSC), Spain for metadynamic metainference simulations. Parameterization of 10074-G5 was performed using resources provided by the Cambridge Service for Data Driven Discovery (CSD3) operated by the University of Cambridge Research Computing Service (www.csd3.cam.ac.uk), provided by Dell EMC and Intel using Tier-2 funding from the Engineering and Physical Sciences Research Council (capital grant EP/P020259/1), and DiRAC funding from the Science and Technology Facilities Council (www.dirac.ac.uk). MALDI mass spectrometry measurements were performed by L. Packman at the Protein and Nucleic Acid Chemistry Facility (PNAC) at the Department of Biochemistry, University of Cambridge. The NMR measurements were supported by the iNEXT H2020 Programme (EC contract no. 653706). OW450 C. elegans were donated by E. Nollen. BLI measurements were performed in the Biophysics facility at the Department of Biochemistry, University of Cambridge. The work was also supported by the Centre for Misfolding Diseases and the INCEPTION project ANR-16-CONV-0005., ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Harvard University [Cambridge], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano [Milano] (UNIMI), University of Naples Federico II, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI)
المصدر: Science Advances 6 (2020) 45
Science Advances
Science Advances, 2020, 6 (45), pp.eabb5924. ⟨10.1126/sciadv.abb5924⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (45), pp.eabb5924. ⟨10.1126/sciadv.abb5924⟩
Science Advances, 6(45)مصطلحات موضوعية: Amyloid beta, In silico, Biophysics, Intrinsically disordered proteins, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Drug Discovery, medicine, Humans, Life Science, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Molecular Biology, Research Articles, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Amyloid beta-Peptides, biology, Drug discovery, Chemistry, SciAdv r-articles, Conformational entropy, Small molecule, Peptide Fragments, 3. Good health, Mechanism of action, biology.protein, Small molecule binding, medicine.symptom, Hydrophobic and Hydrophilic Interactions, 030217 neurology & neurosurgery, Research Article
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