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1دورية أكاديمية
المؤلفون: Samantha K. Sarkar, Angela Matyas, Ikhuosho Asikhia, Zhenkun Hu, Mia Golder, Kaitlyn Beehler, Tanja Kosenko, Thomas A. Lagace
المصدر: Frontiers in Physiology, Vol 13 (2022)
مصطلحات موضوعية: LDLR, low density lipoprotein receptor, LDL-C, LDL-cholesterol, PCSK9, proprotein convertase subtilisin/kexin type 9, FH, familial hypercholesterolemia, GOF, gain-of-function, Physiology, QP1-981
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: My-Anh Nguyen, Tanja Kosenko, Thomas A. Lagace
المصدر: Journal of Lipid Research, Vol 55, Iss 2, Pp 266-275 (2014)
مصطلحات موضوعية: endosome, degradation, ligand dissociation, Biochemistry, QD415-436
وصف الملف: electronic resource
Relation: http://www.sciencedirect.com/science/article/pii/S0022227520350343; https://doaj.org/toc/0022-2275
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3دورية أكاديمية
المؤلفون: Aldo Grefhorst, Markey C. McNutt, Thomas A. Lagace, Jay D. Horton
المصدر: Journal of Lipid Research, Vol 49, Iss 6, Pp 1303-1311 (2008)
مصطلحات موضوعية: proprotein convertase subtilisin/kexin type 9, LDL-cholesterol, sterol-regulatory element binding protein, Biochemistry, QD415-436
وصف الملف: electronic resource
Relation: http://www.sciencedirect.com/science/article/pii/S0022227520423740; https://doaj.org/toc/0022-2275
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4دورية أكاديمية
المؤلفون: Thomas A. Lagace, David M. Byers, Harold W. Cook, Neale D. Ridgway
المصدر: Journal of Lipid Research, Vol 40, Iss 1, Pp 109-116 (1999)
مصطلحات موضوعية: sphingomyelin, 25-hydroxycholesterol, oxysterol binding protein, ceramide, Biochemistry, QD415-436
وصف الملف: electronic resource
Relation: http://www.sciencedirect.com/science/article/pii/S0022227520333459; https://doaj.org/toc/0022-2275
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المؤلفون: Sébastien Soubeyrand, Thomas A. Lagace, Paulina Lau, Kaitlyn Beehler, Majid Nikpay, Ruth McPherson, AnhThu Dang
المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 41:2252-2262
مصطلحات موضوعية: 0301 basic medicine, Messenger RNA, Chemistry, Transfection, Molecular biology, Bone morphogenetic protein 1, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, LDL receptor, Allele, Signal transduction, Cardiology and Cardiovascular Medicine, Receptor, Lipoprotein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e0880e08a6b6c9734c049781723537de
https://doi.org/10.1161/atvbaha.121.316473 -
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المصدر: Atherosclerosis. 304:39-43
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Untranslated region, DNA Copy Number Variations, Hypercholesterolemia, USF1, 030204 cardiovascular system & hematology, 03 medical and health sciences, PCSK9 Gene, 0302 clinical medicine, Enhancer binding, Gene duplication, Humans, Coding region, Copy-number variation, Genetics, biology, 3. Good health, 030104 developmental biology, Hepatocyte Nuclear Factor 4, Chromosomal region, biology.protein, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Proprotein Convertase 9, Cardiology and Cardiovascular Medicine
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المؤلفون: Alexander C.Y. Foo, Ikhuosho Asikhia, Ariela Vergara-Jaque, Samantha K. Sarkar, Angela Matyas, Tanja Kosenko, Thomas A. Lagace, Natalie K. Goto
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Proline, Endosome, Allosteric regulation, Familial hypercholesterolemia, Biochemistry, Protein Structure, Secondary, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, conformational change, Protein Domains, lipid metabolism, medicine, Humans, low-density lipoprotein (LDL), Molecular Biology, computer modeling, lipoprotein metabolism, allostery, familial hypercholesterolemia, 030102 biochemistry & molecular biology, PCSK9, Hep G2 Cells, Cell Biology, intrinsically disordered protein, Proprotein convertase, medicine.disease, Lipids, allosteric regulation, Lipoproteins, LDL, HEK293 Cells, 030104 developmental biology, Amino Acid Substitution, Receptors, LDL, chemistry, Low-density lipoprotein, Mutation, LDL receptor, Biophysics, Tyrosine, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, cholesterol regulation, Peptides, Hydrophobic and Hydrophilic Interactions, Protein Binding, proprotein convertase subtilisin/kexin type 9 (PCSK9)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481f4569db516fc372524c2a466537e1
https://doi.org/10.1074/jbc.ra119.010221 -
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المؤلفون: Kaitlyn, Beehler, Majid, Nikpay, Paulina, Lau, Anh-Thu, Dang, Thomas A, Lagace, Sébastien, Soubeyrand, Ruth, McPherson
المصدر: Arteriosclerosis, thrombosis, and vascular biology. 41(8)
مصطلحات موضوعية: Fatty Acid Desaturases, Polymorphism, Genetic, Protein Stability, RNA Stability, Cholesterol, LDL, Bone Morphogenetic Protein 1, Cell Line, Transforming Growth Factor beta1, MicroRNAs, Delta-5 Fatty Acid Desaturase, Gene Expression Regulation, Receptors, LDL, Proteolysis, Hepatocytes, Humans, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::aac4b4600d3e6984e1ce13274b7a5497
https://pubmed.ncbi.nlm.nih.gov/34134519 -
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المؤلفون: Mary Lynn Cottee, Taylor Dennison, Richard G. Lee, Thomas A. Lagace, Antonietta Pietrangelo, Hailey Wyatt, Sabrina Robichaud, My-Anh Nguyen, Adil Rasheed, Michele Geoffrion, Mireille Ouimet, Katey J. Rayner
المصدر: Arteriosclerosis, thrombosis, and vascular biology. 40(5)
مصطلحات موضوعية: 0301 basic medicine, Male, Necrotic core, Mice, Knockout, ApoE, Necroptosis, Cell, Aortic Diseases, Endosomes, 030204 cardiovascular system & hematology, Mixed Lineage Kinase, 03 medical and health sciences, chemistry.chemical_compound, Necrosis, 0302 clinical medicine, medicine, Macrophage, Animals, Cholesterol, Oligonucleotides, Antisense, Atherosclerosis, Plaque, Atherosclerotic, Cell biology, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, chemistry, Apoptosis, Receptor-Interacting Protein Serine-Threonine Kinases, Domain (ring theory), Macrophages, Peritoneal, Female, Cardiology and Cardiovascular Medicine, Protein Kinases, Foam Cells, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d627bed782f685c0880fe4887d0d1980
https://pubmed.ncbi.nlm.nih.gov/32212851 -
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المؤلفون: Samantha K. Sarkar, Angela Matyas, Thomas A. Lagace, Alexander C.Y. Foo, Natalie K. Goto, Ariela Vergara-Jaque, Tanja Kosenko
مصطلحات موضوعية: 0303 health sciences, Endosome, PCSK9, Allosteric regulation, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Proprotein convertase, medicine.disease, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Low-density lipoprotein, LDL receptor, medicine, Biophysics, Kexin, lipids (amino acids, peptides, and proteins), 030304 developmental biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9111aa7a9eb011601eeca9a40d21fa53