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1
المؤلفون: Michael A. Poss, Ming Chang, Dora M. Schnur, Timothy F. Herpin, Ruth R. Wexler, Jacques Y. Roberge, Maredith Arcuri, Robert P. Rehfuss, Deborah Celani, Yalei Liu, Huji Turdi, Angela Cacace, Christine Huang, William A. Schumacher, Martin L. Ogletree, Hannguang Chao, Qimin Wu, Anne B. Stewart, Ji Hua, R. Michael Lawrence, Jeffrey S. Bostwick, Thomas E. Steinbacher, Laura Price, Lynn M. Abell
المصدر: Journal of Medicinal Chemistry. 56:1704-1714
مصطلحات موضوعية: Male, Bleeding Time, Platelet Aggregation, Pyridines, Arterial Occlusive Diseases, Pharmacology, Structure-Activity Relationship, P2Y12, Fibrinolytic Agents, Bleeding time, Drug Discovery, Antithrombotic, medicine, Animals, Humans, Urea, Platelet activation, Thrombus, medicine.diagnostic_test, Chemistry, Phenylurea Compounds, Purinergic receptor, Antagonist, Thrombosis, medicine.disease, Rats, Blockade, HEK293 Cells, Purinergic P2Y Receptor Antagonists, Molecular Medicine
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2
المؤلفون: Zheming Ruan, S. M. Seiler, Herbert E. Klei, Jing Zhang, Jeffrey A. Robl, Stephen P. O'connor, Mengxiao Shi, Liang Schweizer, John E. Macor, R. Michael Lawrence, Karnail S. Atwal, William A. Schumacher, Eddie C.-K. Liu, Sharon N. Bisaha, Doree F. Sitkoff, Ying Wang, Chi Li, Thomas E. Steinbacher, Yan Shi, Philip D. Stein, Kevin Kish
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7516-7521
مصطلحات موضوعية: Serine Proteinase Inhibitors, Lactams, medicine.drug_mechanism_of_action, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Enzyme activator, Drug Discovery, medicine, Humans, Structure–activity relationship, Binding site, Molecular Biology, Piperidones, Binding Sites, Aryl, Organic Chemistry, Anticoagulants, Combinatorial chemistry, Protein Structure, Tertiary, Enzyme Activation, chemistry, Factor Xa, Molecular Medicine, Bioisostere, Pharmacophore, Factor Xa Inhibitors
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3
المؤلفون: Joseph Yanchunas, Eddie C.-K. Liu, Christine Huang, S. M. Seiler, Yan Shi, Ying Wang, Karnail S. Atwal, Thomas E. Steinbacher, Doree F. Sitkoff, Andrew T. Pudzianowski, William A. Schumacher, Karen S. Hartl, Sharon N. Bisaha, Chi Li, Stephen P. O'connor, Kevin Kish, Mengxiao Shi, Philip D. Stein, Herbert E. Klei, Jing Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6882-6889
مصطلحات موضوعية: Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Factor Xa Inhibitor, Pharmaceutical Science, Carboxamide, Guanidines, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Cytochrome P-450 CYP3A, Humans, Structure–activity relationship, Guanidine, Molecular Biology, Cytochrome P-450 CYP3A Inhibitors, biology, Chemistry, Organic Chemistry, Anticoagulants, Enzyme inhibitor, biology.protein, Lactam, Molecular Medicine, Factor Xa Inhibitors
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4
المؤلفون: Eddie C.-K. Liu, Martin L. Ogletree, William A. Schumacher, Steven E. Seiler, Anne B. Stewart, Jeffrey S. Bostwick, Karen S. Hartl, Thomas E. Steinbacher
المصدر: European Journal of Pharmacology. 570:167-174
مصطلحات موضوعية: Male, Pharmacology, Factor XIa, Hemostatics, Piperazines, Rats, Sprague-Dawley, Fibrinolytic Agents, Bleeding time, Animals, Humans, Medicine, Thromboplastin, Carotid Artery Thrombosis, Thrombus, Venous Thrombosis, Prothrombin time, medicine.diagnostic_test, business.industry, medicine.disease, Rats, Venous thrombosis, Hemostasis, Anesthesia, Prothrombin Time, Azetidines, Partial Thromboplastin Time, Tryptases, business, Ex vivo, Partial thromboplastin time
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5
المؤلفون: Jergen Baumann, William A. Schumacher, Thomas E. Steinbacher, Jean H.M. Feyen, Joseph Tamasi, Yizhi Liu, Eileen Bird, James K. Tamura, Anne B. Stewart, Jeffrey S. Bostwick
المصدر: Thrombosis Research. 120:549-558
مصطلحات موضوعية: Male, Carboxypeptidase B2, medicine.medical_specialty, Drug Evaluation, Preclinical, Hemorrhage, Tissue plasminogen activator, Rats, Sprague-Dawley, Fibrinolytic Agents, Bleeding time, Internal medicine, medicine, Animals, Drug Interactions, Protease Inhibitors, Thrombus, Plant Proteins, Dose-Response Relationship, Drug, integumentary system, medicine.diagnostic_test, business.industry, T-plasminogen activator, Thrombosis, Hematology, medicine.disease, Potato carboxypeptidase inhibitor, Rats, Disease Models, Animal, Venous thrombosis, Endocrinology, Tissue Plasminogen Activator, Conventional PCI, business, medicine.drug
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6
المؤلفون: Jack Z. Gougoutas, Karen S. Hartl, R. Michael Lawrence, Doree F. Sitkoff, Gregory S. Bisacchi, Steven M. Seiler, Andrew T. Pudzianowski, William A. Schumacher, Philip D. Stein, Eddie C.-K. Liu, Thomas E. Steinbacher, Zhaoxiao Zhang, James C. Sutton
المصدر: Letters in Drug Design & Discovery. 2:625-630
مصطلحات موضوعية: Series (mathematics), medicine.drug_mechanism_of_action, Stereochemistry, Factor Xa Inhibitor, Caprolactam, Pharmaceutical Science, Combinatorial chemistry, chemistry.chemical_compound, Lead (geology), chemistry, Drug Discovery, medicine, Molecular Medicine, Identification (biology)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a7cee05c3fc0caebfd7b297901137ea0
https://doi.org/10.2174/157018005774717316 -
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المؤلفون: Carl Thibeault, Ruth R. Wexler, Dora M. Schnur, John Lloyd, Zulan Pi, Rejean Ruel, Patrick Y.S. Lam, William A. Schumacher, Ji Hua, Jennifer X. Qiao, Patricia A. McDonnell, Lynn M. Abell, Ming Chang, Christine Huang, Laura Price, Qi Gao, Robert P. Rehfuss, Baoqing Ma, Gilles Bouthillier, Eddie C.-K. Liu, Jeffrey S. Bostwick, Tammy C. Wang, Qimin Wu, Alexandre L'Heureux, Steven A. Spronk, Sheldon Hiebert, Joanna Zheng, Thomas E. Steinbacher
المصدر: Journal of medicinal chemistry. 56(22)
مصطلحات موضوعية: Models, Molecular, Indoles, Stereochemistry, Molecular Conformation, Biological Availability, Rats, Sprague-Dawley, chemistry.chemical_compound, Receptors, Purinergic P2Y1, Drug Discovery, Antithrombotic, Animals, Humans, Urea, Spiro Compounds, Sequence Homology, Amino Acid, Phenylurea Compounds, Antagonist, Bioavailability, Rats, chemistry, Drug Design, Indoline, Purinergic P2Y Receptor Antagonists, Molecular Medicine, Piperidine, Lead compound
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8
المصدر: Journal of Pharmacological and Toxicological Methods. 35:3-10
مصطلحات موضوعية: Blood Platelets, Male, Platelet Aggregation, Thromboxane, In Vitro Techniques, Pharmacology, Toxicology, Vascular occlusion, Fibrin, Rats, Sprague-Dawley, Thromboxane A2, Species Specificity, medicine, Animals, Humans, Vasoconstrictor Agents, Platelet, Thrombus, Oxazoles, Whole blood, Aspirin, biology, business.industry, Ferrets, Thrombosis, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Electric Stimulation, Prostaglandin Endoperoxides, Synthetic, Rats, Disease Models, Animal, Microscopy, Electron, Carotid Arteries, Regional Blood Flow, 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, Anesthesia, Microscopy, Electron, Scanning, Prothrombin Time, biology.protein, Collagen, medicine.symptom, Carotid Artery Injuries, business, Platelet Aggregation Inhibitors, medicine.drug
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9
المؤلفون: William A. Schumacher, Thomas E. Steinbacher, Sonia Youssef, Christopher L. Heran, Martin L. Ogletree
المصدر: Journal of Cardiovascular Pharmacology. 22:526-533
مصطلحات موضوعية: Male, Bleeding Time, Epinephrine, Receptors, Thromboxane, Rats, Sprague-Dawley, chemistry.chemical_compound, Thromboxane A2, Bleeding time, Animals, Medicine, Carotid Artery Thrombosis, cardiovascular diseases, Thrombus, Oxazoles, Pharmacology, Aspirin, medicine.diagnostic_test, business.industry, digestive, oral, and skin physiology, Thrombosis, Prostaglandin antagonist, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Mesenteric Arteries, Rats, Disease Models, Animal, stomatognathic diseases, Venous thrombosis, chemistry, Hemostasis, Anesthesia, cardiovascular system, Venae Cavae, Propionates, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e06c12640efa00adffda77fc21e2e5
https://doi.org/10.1097/00005344-199310000-00004 -
10
المؤلفون: Pancras C. Wong, Thomas E. Steinbacher, Anne B. Stewart, Jeffrey S. Bostwick, William A. Schumacher, Baomin Xin
المصدر: Journal of cardiovascular pharmacology. 55(6)
مصطلحات موضوعية: Male, Bleeding Time, medicine.drug_mechanism_of_action, medicine.drug_class, Pyridones, Factor Xa Inhibitor, Antithrombin III, Rats, Sprague-Dawley, Bleeding time, medicine, Animals, Thrombus, Blood Coagulation, Pharmacology, Hemostasis, medicine.diagnostic_test, business.industry, Heparin, Anticoagulant, Anticoagulants, Thrombosis, Blood Coagulation Disorders, medicine.disease, Rats, Anesthesia, Prothrombin Time, Pyrazoles, Apixaban, Cardiology and Cardiovascular Medicine, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc4f569eb5832ff81ac0f4ab256e65c
https://pubmed.ncbi.nlm.nih.gov/20224421