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المؤلفون: Christopher Negron, Wenting Ma, Alexey Teplyakov, Winnie Chan, Sandeep Somani, Thomas J. Malia, Lauren E. Boucher, Gary L. Gilliland, Jinquan Luo, Galina Obmolova, Steven Jacobs
المصدر: Proteins: Structure, Function, and Bioinformatics. 90:270-281
مصطلحات موضوعية: Hot Temperature, Protein Stability, Chemistry, Fibronectin Type III Domain, Protein domain, Beta sheet, Thermoanaerobacter, Cooperativity, Calorimetry, Molecular Dynamics Simulation, Sodium Chloride, Biochemistry, Free energy perturbation, Crystallography, Molecular dynamics, Differential scanning calorimetry, Bacterial Proteins, Protein Domains, Structural Biology, Salt bridge, Molecular Biology
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المؤلفون: Thomas J. Malia, Marc Vandermeeren, Hong Sun, Kristof Van Kolen, Marc Mercken, Rupesh Nanjunda, Gallen Triana-Baltzer, M. Borgers, Astrid Bottelbergs, Eilyn R. Lacy, Alexey Teplyakov, Tom Van De Casteele, John Q. Trojanowski, Clara Theunis, Hervé Maurin, Peter Larsen, Robin Ernst, Sheng-Jiun Wu, Cindy Wintmolders, Roland Willems, Randy Slemmon, Wendy Galpern, Jinquan Luo
المصدر: Journal of Alzheimer's Disease. 77:1397-1416
مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, medicine.medical_treatment, Tau protein, tau Proteins, Antibodies, Monoclonal, Humanized, Monoclonal antibody, Neutralization, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Animals, Humans, Phosphorylation, Mice, Knockout, Mice, Inbred BALB C, biology, Chemistry, General Neuroscience, Antibodies, Monoclonal, General Medicine, Immunotherapy, In vitro, Protein Structure, Tertiary, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Cancer research, biology.protein, Immunohistochemistry, Geriatrics and Gerontology, Antibody, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6c6c8a8bbb34392a44d1677aa443be
https://doi.org/10.3233/jad-200544 -
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المؤلفون: Yonghong Zhao, Alexey Teplyakov, Gary L. Gilliland, G. Mark Anderson, Thomas J. Malia, Susann Taudte, Bingyuan Wu, Galina Obmolova
المصدر: Cellular Signalling. 36:139-144
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell signaling, medicine.drug_class, Angiogenesis, Integrin, 030204 cardiovascular system & hematology, Crystallography, X-Ray, Monoclonal antibody, Protein Structure, Secondary, Epitope, Thromboplastin, Epitopes, Immunoglobulin Fab Fragments, Mice, 03 medical and health sciences, Tissue factor, 0302 clinical medicine, medicine, Animals, Humans, Binding site, biology, Chemistry, Antibodies, Monoclonal, Cell Biology, Molecular biology, 030104 developmental biology, biology.protein, Signal transduction, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69200b40effe4dcd6b3bc11f2afb5a27
https://doi.org/10.1016/j .cellsig.2017.05.004 -
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المؤلفون: Gary L. Gilliland, Galina Obmolova, Thomas J. Malia, Alexey Teplyakov
المصدر: Acta Crystallographica. Section F, Structural Biology Communications
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Amino Acid Motifs, Gene Expression, Antigen-Antibody Complex, Crystallography, X-Ray, Ligands, Biochemistry, Epitope, Research Communications, Mice, Structural Biology, Sf9 Cells, antibodies, Cloning, Molecular, Receptor, Antibodies, Monoclonal, Condensed Matter Physics, Ligand (biochemistry), medicine.symptom, Baculoviridae, Protein Binding, Agonist, crystal structure, medicine.drug_class, tumor necrosis factor, Recombinant Fusion Proteins, Genetic Vectors, Biophysics, Biology, Spodoptera, Monoclonal antibody, 03 medical and health sciences, Immunoglobulin Fab Fragments, cysteine-rich domain, Genetics, medicine, Animals, Humans, Protein Interaction Domains and Motifs, Binding site, Mode of action, CD27, Binding Sites, epitopes, Molecular biology, Antibodies, Neutralizing, Tumor Necrosis Factor Receptor Superfamily, Member 7, 030104 developmental biology, HEK293 Cells, Mechanism of action, Protein Conformation, beta-Strand, Sequence Alignment, CD27 Ligand
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المؤلفون: Gary L. Gilliland, Karyn O'neil, Thomas J. Malia, Galina Obmolova, Steven Jacobs, Alexey Teplyakov
المصدر: Protein Engineering, Design and Selection. 30:31-37
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Bioengineering, Crystallography, X-Ray, Protein Engineering, Biochemistry, DNA-binding protein, Antibodies, Protein Structure, Secondary, Epitope, 03 medical and health sciences, Molecular dynamics, 0302 clinical medicine, Animals, Humans, Amino Acid Sequence, Binding site, Receptor, Molecular Biology, Interleukin-13, Chemistry, Ankyrin Repeat, Macaca fascicularis, 030104 developmental biology, DARPin, Biophysics, Ankyrin repeat, Signal transduction, 030217 neurology & neurosurgery, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec330b538b74d176d7726eb54bf68870
https://doi.org/10.1093/protein/gzw059 -
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المؤلفون: Jinquan Luo, Juan Carlos Almagro, Galina Obmolova, Alexey Teplyakov, Thomas J. Malia, Salman Muzammil, Raymond Sweet, Gary L. Gilliland
المصدر: mAbs
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Stereochemistry, Immunology, phage library, CDR canonical structure, Complementarity determining region, Biology, Protein Engineering, Immunoglobulin light chain, VH:VL packing, 03 medical and health sciences, Protein structure, Report, Humans, Immunology and Allergy, Antibody structure, Peptide sequence, Antibody Diversity, Protein engineering, Single-Domain Antibodies, Complementarity Determining Regions, HEK293 Cells, 030104 developmental biology, CDR H3, biology.protein, Immunoglobulin heavy chain, Immunoglobulin Light Chains, Antibody, Immunoglobulin Heavy Chains, Synchrotrons
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المؤلفون: Xuesong Liu, Marc Vandermeeren, Raymond Sweet, Robin Ernst, Jinquan Luo, Thomas J. Malia, Marc Mercken, Alexey Teplyakov, Eilyn R. Lacy, Gary L. Gilliland, Sheng-Jiun Wu
المصدر: Proteins
مصطلحات موضوعية: Models, Molecular, Phosphopeptides, Threonine, 0301 basic medicine, Protein Folding, Gene Expression, Peptide, Peptide binding, X‐ray crystallography, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Epitope, Epitopes, 0302 clinical medicine, Structural Biology, antibody, Serine, tau, Phosphorylation, Research Articles, chemistry.chemical_classification, biology, Phosphopeptide, Chemistry, Antibodies, Monoclonal, Alzheimer's disease, Recombinant Proteins, Receptor–ligand kinetics, Research Article, Protein Binding, crystal structure, Tau protein, tau Proteins, Immunoglobulin Fab Fragments, 03 medical and health sciences, mental disorders, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Molecular Biology, Combinatorial chemistry, Phosphorylated Peptide, HEK293 Cells, 030104 developmental biology, Epitope mapping, biology.protein, Binding Sites, Antibody, Epitope Mapping, 030217 neurology & neurosurgery
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المؤلفون: Rupesh Nanjunda, Andre Marreiro, Astrid Bottelbergs, Tom Van De Casteele, Luc Ver Donck, Roland Willems, Marc Vandermeeren, John A. Kemp, Cindy Wintmolders, Kristof Van Kolen, Peter Paul De Deyn, Thomas J. Malia, Lore Delbroek, Cristiano Sousa, Debby Van Dam, Clara Theunis, Guy Daneels, Bruno Vasconcelos, Koen Dockx, M. Borgers, Marc Mercken, Eilyn R. Lacy
المساهمون: Molecular Neuroscience and Ageing Research (MOLAR)
المصدر: Journal of alzheimers disease, 65(1), 265-281. IOS Press
Journal of Alzheimer's diseaseمصطلحات موضوعية: Male, 0301 basic medicine, HUMAN P301S TAU, PROPAGATION, Epitope, Mice, 0302 clinical medicine, TAUOPATHIES, Mice, Knockout, TRANSGENIC MICE, biology, Chemistry, PAIRED HELICAL FILAMENTS, General Neuroscience, Antibodies, Monoclonal, Brain, General Medicine, Cell biology, ALZHEIMERS-DISEASE, Psychiatry and Mental health, Clinical Psychology, in vivo seeding, Immunohistochemistry, Female, immunotherapy, Antibody, medicine.drug_class, PROTEINS, Tau protein, Epitope mapping, tau Proteins, Monoclonal antibody, 03 medical and health sciences, Alzheimer Disease, In vivo, tau antibodies, mental disorders, medicine, Animals, Humans, IDENTIFICATION, Immunization, Passive, Surface Plasmon Resonance, AGGREGATION, In vitro, PATHOLOGY, HEK293 Cells, 030104 developmental biology, Mutation, biology.protein, Human medicine, Geriatrics and Gerontology, 030217 neurology & neurosurgery
وصف الملف: pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1317f66f775c6f76fa8530c7ca6d40b
https://research.rug.nl/en/publications/8e06689d-d8de-4ef6-a82c-eabafd8b0c89 -
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المؤلفون: Gallen Triana-Baltzer, Wendy Galpern, Maarten Timmers, Hong Sun, Hartmuth C. Kolb, Kristof Van Kolen, Partha Nandy, Luc Van Nueten, Tom Jacobs, Marc Mercken, Thomas J. Malia, Katrin Haeverans, Luc Janssens
المصدر: Alzheimer's & Dementia. 15:P252-P253
مصطلحات موضوعية: biology, Epidemiology, business.industry, Health Policy, Healthy subjects, Safety tolerability, Pharmacology, Phospho tau, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Pharmacokinetics, biology.protein, Medicine, Neurology (clinical), Geriatrics and Gerontology, Antibody, business
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المؤلفون: Judith Ann Connor, Christian Martinez, Gopalan Raghunathan, Hong Zhou, Gary L. Gilliland, Wilson Edwards, Alexey Teplyakov, Galina Obmolova, Ellen Chi, Thomas J. Malia, Heena Beck, Matthew Husovsky, Johan E. S. Fransson, Sandra Fenton, Juan Carlos Almagro
المصدر: mAbs
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, crystal structure, Phage display, humanization, Immunology, Vernier zone, Antibody Affinity, Immunogenetics, Biology, Antibodies, Monoclonal, Humanized, Protein Engineering, germline, Germline, Thromboplastin, Affinity maturation, 03 medical and health sciences, Tissue factor, Mice, Antigen, Report, antibody, Immunology and Allergy, Animals, Humans, Framework region, affinity maturation, tissue factor, Complementarity Determining Regions, Cell biology, 030104 developmental biology, biology.protein, Antibody, induced fit