المؤلفون: Shukkwan K. Chen, Zachary C.E. Hawley, Maria I. Zavodszky, Sam Hana, Daniel Ferretti, Branka Grubor, Michael Hawes, Shanqin Xu, Stefan Hamann, Galina Marsh, Patrick Cullen, Ravi Challa, Thomas M. Carlile, Hang Zhang, Wan-Hung Lee, Andrea Peralta, Pete Clarner, Cong Wei, Kathryn Koszka, Feng Gao, Shih-Ching Lo

المصدر: Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102057- (2023)

مصطلحات موضوعية: MT: oligonucleotides: therapies, adeno-associated virus, ALS, SOD1, gene therapy, primary miRNA scaffold, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253123002755; https://doaj.org/toc/2162-2531

URL الوصول: https://doaj.org/article/5ec0da9397c241b68917b1eaa7b24e0e

المؤلفون: Alex R. D. Delbridge, Dann Huh, Margot Brickelmaier, Jeremy C. Burns, Chris Roberts, Ravi Challa, Naideline Raymond, Patrick Cullen, Thomas M. Carlile, Katelin A. Ennis, Mei Liu, Chao Sun, Normand E. Allaire, Marianna Foos, Hui-Hsin Tsai, Nathalie Franchimont, Richard M. Ransohoff, Cherie Butts, Michael Mingueneau

المصدر: Frontiers in Cellular Neuroscience, Vol 14 (2020)

مصطلحات موضوعية: microglia, neuroinflammation, brain slice culture, LPS, TNF, GM-CSF, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2020.592005/full; https://doaj.org/toc/1662-5102

URL الوصول: https://doaj.org/article/366580e0c4aa470182ab0d8f5cdc3740

المؤلفون: Thomas M. Carlile, Wendy V. Gilbert, Tristan A Bell, Nicole M. Martinez, Boris Zinshteyn, Amanda Su, Cassandra Schaening

المصدر: Nature chemical biology

مصطلحات موضوعية: Saccharomyces cerevisiae, medicine.disease_cause, Article, Gene Expression Regulation, Enzymologic, Pseudouridine, 03 medical and health sciences, chemistry.chemical_compound, Gene Expression Regulation, Fungal, Gene expression, medicine, Humans, RNA, Messenger, Nucleic acid structure, Structural motif, Molecular Biology, Hydro-Lyases, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Messenger RNA, Mutation, Chemistry, 030302 biochemistry & molecular biology, RNA, Cell Biology, Cell biology, Nucleic Acid Conformation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee8f0e4787396a87d5d568889d0b676
https://doi.org/10.1038/s41589-019-0353-z

المؤلفون: Christina S. Alves, Chongfeng Xu, Yizhou Zhou, Baohong Zhang, Justin Crisafulli, Eric Marshall, Patrick Cullen, Fergal Casey, Thomas M. Carlile, Chao Sun, Dongdong Lin, Joost Groot

المصدر: Biotechnology journalREFERENCES. 16(8)

مصطلحات موضوعية: Transgene, Clone (cell biology), Robustness (evolution), High-Throughput Nucleotide Sequencing, General Medicine, Computational biology, Biology, Amplicon, Applied Microbiology and Biotechnology, DNA sequencing, Cell Line, Benchmarking, Cell culture, Mutation, False positive paradox, Molecular Medicine, Humans, Transgenes, Throughput (business)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7ec4f571cfa5cc295a3e29b246dc19
https://pubmed.ncbi.nlm.nih.gov/34018310

المؤلفون: Melissa Bennion, Justin W. Nicholatos, Andreas Weihofen, Joost Groot, Thomas M. Carlile, Isin Dalkilic-Liddle, Lori Hrdlicka, David T. Tran, Shekhar Dhokai, Warren D. Hirst

المصدر: eNeuro

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Parkinson's disease, cell-based assays, Cell, lipids, Neuroblastoma, synuclein, hemic and lymphatic diseases, neurotoxicity, medicine, Animals, Humans, Neurons, Gene knockdown, business.industry, General Neuroscience, Neurodegeneration, Neurotoxicity, Parkinson Disease, General Medicine, medicine.disease, Rats, SCD, medicine.anatomical_structure, Toxicity, Cancer research, Synuclein, alpha-Synuclein, Parkinson’s disease, Disorders of the Nervous System, Neuron, business, Stearoyl-CoA Desaturase, Research Article: New Research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113ae30442d1325f7906cb63d467e0e5
https://pubmed.ncbi.nlm.nih.gov/34301719

المؤلفون: Jing Zhu, Xiaomei Peng, Alex Pellerin, Brian T. Hopkins, Dipen Sangurdekar, Michael Mingueneau, Urjana Poreci, Eris Bame, Joseph C Santoro, Prince Robin, Katherine Riester, Mike Palte, Allie M Roach, Klaus Michelsen, Bin Ma, Hao Tang, Million Arefayene, Stephen J Rubino, Devangi Mehta, Fergal Casey, Patrick Cullen, Patrick Trapa, Bekim Bajrami, Thomas M. Carlile, Davide Gianni, Marx Isaac, Douglas Donaldson, Baohong Zhang, Jeremy C. Burns, Param Muragan, Alex Coppell, Shibeshih Belachew, Nathalie Franchimont, Matthew Scaramozza

المصدر: Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)

مصطلحات موضوعية: 0301 basic medicine, Myeloid, Immunology, Antigen presentation, B-cell receptor, Fc receptor, multiple sclerosis, 03 medical and health sciences, 0302 clinical medicine, medicine, Immunology and Allergy, Bruton's tyrosine kinase, General Nursing, B cell, B cells, biology, B‐cell receptor, Chemistry, BTK inhibitor, Germinal center, Original Articles, RC581-607, 030104 developmental biology, medicine.anatomical_structure, myeloid cells, biology.protein, Cancer research, Original Article, Immunologic diseases. Allergy, Tyrosine kinase, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188cf6754afaaa237193991f00885497
https://doi.org/10.1002/cti2.1295

المؤلفون: Patrick Cullen, Chelsea Parker Harp, Jorge Vera Rebollar, Taylor L. Reynolds, Rebecca Basile, Christie-Ann McCarl, Benjamin A. Smith, Angela Li, Jeremy C. Burns, John Silbereis, Jing Zhu, Ellen Cahir-McFarland, Alex Pellerin, Michael Mingueneau, Stephen J Rubino, Hao Tang, Nathalie Franchimont, Thomas M. Carlile, Baohong Zhang, Jennifer Sybulski, Thomas O. Cameron, Kathryn Pellerin, Richard M. Ransohoff, Luke Jandreski

المصدر: Brain : a journal of neurology. 144(8)

مصطلحات موضوعية: Microglia, biology, medicine.drug_class, Fc receptor, Brain, Receptors, Fc, Monoclonal antibody, Oligodendrocyte, Cell biology, Mice, medicine.anatomical_structure, Downregulation and upregulation, Spinal Cord, medicine, biology.protein, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Myelin-Oligodendrocyte Glycoprotein, Neurology (clinical), Signal transduction, Receptor, Autoantibodies, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4631f0f58502257fef331949582c1a
https://pubmed.ncbi.nlm.nih.gov/34382068

المؤلفون: Chao Sun, Justin Crisafulli, Dongdong Lin, Baohong Zhang, Yizhou Zhou, Patrick Cullen, Eric Marshall, Joost Groot, Thomas M. Carlile, Christina S. Alves, Fergal Casey, Chongfeng Xu

مصطلحات موضوعية: Cell culture, Transgene, False positive paradox, Robustness (evolution), Benchmarking, Computational biology, Manufacturing cell, Biology, Amplicon, DNA sequencing

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::673eb23f17e8240401d01b49c93bb93b
https://doi.org/10.22541/au.160397369.95796795/v1

المؤلفون: Zobaida Alsum, Soraya Boucherit, Lluis Quintana-Murci, Peng Zhang, Luigi D. Notarangelo, Joseph A. Church, Daxing Gao, Rabih Halwani, Lazaro Lorenzo, Thomas M. Carlile, Maria F. Rojas-Duran, Ahmed Aziz Bousfiha, Yuval Itan, Laurent Abel, Flore Rozenberg, Fabien G. Lafaille, Wendy V. Gilbert, Jean-Laurent Casanova, Vimel Rattina, Marc Tessier-Lavigne, Lorenz Studer, Trine H. Mogensen, Bastian Zimmer, Benoit Henry, Søren R. Paludan, Shen-Ying Zhang, Franck Rapaport, Gregory A. Smith, Saleh Al-Muhsen, Michael J. Ciancanelli, Gaspard Kerner, Jessica L. McAlpine, Kerry Dobbs, Madalina E. Carter-Timofte, Laura Marques, Oliver Harschnitz, Osefame Ewaleifoh, Mary Hasek, Dominik Paquet, Marc Tardieu, Naima Amenzoui, Yoon Seung Lee, Dylan Kwart

المساهمون: Rockefeller University [New York], Memorial Sloane Kettering Cancer Center [New York], Laboratory of Human Genetics of Infectious Diseases (Necker Branch - INSERM U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Northwestern University Feinberg School of Medicine, Aarhus University Hospital, National Institutes of Health [Bethesda] (NIH), Yale University [New Haven], Service de Virologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Sharjah, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Ibn Rochd University Hospital of Casablanca, University Hassan II of Casablanca, Morocco., King Saud University [Riyadh] (KSU), Centro Hospitalar do Porto, University of Southern California (USC), Service de neurologie pédiatrique et maladies métaboliques, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Stanford University, This work was funded in part by the National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Clinical and Translational Science Award program (grant nos. UL1TR000043 and UL1TR001866), NIH grants (nos. R01AI088364 to J.L.C. and S.Y.Z., R01NS072381 to J.-L.C. and S.-Y.Z. and R01GM101316 to W.G.), a grant from the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (no. ANR-10-LABX-62-IBEID to L.A.) and the French National Research Agency (ANR) under the ‘Investments for the future’ program (no. ANR-10-IAHU-01 to L.A.), the ANR grant IEIHSEER (no. ANR-14-CE14-0008-01 to S.-Y.Z.), the Lundbeck Foundation (grant no. R268-2016-3927 to S.R.P.), the Rockefeller University, INSERM, Paris Descartes University and the St Giles Foundation., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-14-CE14-0008,IEIHSEER,L'encéphalite Herpétique de l'enfant résulte de déficits héréditaires d'immunité contre l'HSV-1: une exception ou une règle?(2014), ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010), Hôpital Cochin [AP-HP], Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Southern California [Los Angeles, CA, USA], Université Paris Diderot - Paris 7 (UPD7)-Hôpital Robert Debré-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

المصدر: Lafaille, F G, Harschnitz, O, Lee, Y S, Zhang, P, Hasek, M L, Kerner, G, Itan, Y, Ewaleifoh, O, Rapaport, F, Carlile, T M, Carter-Timofte, M E, Paquet, D, Dobbs, K, Zimmer, B, Gao, D, Rojas-Duran, M F, Kwart, D, Rattina, V, Ciancanelli, M J, McAlpine, J L, Lorenzo, L, Boucherit, S, Rozenberg, F, Halwani, R, Henry, B, Amenzoui, N, Alsum, Z, Marques, L, Church, J A, Al-Muhsen, S, Tardieu, M, Bousfiha, A A, Paludan, S R, Mogensen, T H, Quintana-Murci, L, Tessier-Lavigne, M, Smith, G A, Notarangelo, L D, Studer, L, Gilbert, W, Abel, L, Casanova, J L & Zhang, S Y 2019, ' Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis ', Nature Medicine, vol. 25, no. 12, pp. 1873-1884 . https://doi.org/10.1038/s41591-019-0672-3
Nature Medicine
Nature Medicine, 2019, 25 (12), pp.1873-1884. ⟨10.1038/s41591-019-0672-3⟩
Nature Medicine, Nature Publishing Group, 2019, 25 (12), pp.1873-1884. ⟨10.1038/s41591-019-0672-3⟩
Nature medicine

مصطلحات موضوعية: Adult, Central Nervous System, Male, 0301 basic medicine, Intrinsic immunity, viruses, Central nervous system, Herpesvirus 1, Human, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Interferon, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine, Humans, RNA, Small Nucleolar, Genetic Predisposition to Disease, Small nucleolar RNA, Neurons, Immunity, Infant, RNA, General Medicine, Middle Aged, 3. Good health, Cell biology, 030104 developmental biology, medicine.anatomical_structure, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Child, Preschool, 030220 oncology & carcinogenesis, Forebrain, Metagenome, Female, Encephalitis, Herpes Simplex, Small nuclear RNA, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbe9bd2041435e0df6ada9573bd2856
https://pure.au.dk/portal/da/publications/human-snora31-variations-impair-cortical-neuronintrinsic-immunity-to-hsv1-and-underlie-herpes-simplex-encephalitis(81007800-1ad6-46e3-ab81-f589b19898cf).html

المؤلفون: Kristen M. Bartoli, Thomas M. Carlile, Cassandra Schaening, Wendy V. Gilbert

مصطلحات موضوعية: chemistry.chemical_compound, Messenger RNA, Methyltransferase, Biochemistry, Chemistry, Immunoprecipitation, MRNA modification, Ribose, Transfer RNA, RNA, Methylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb025ff0f78b18d29ac21763492bc34
https://doi.org/10.1101/271916