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1دورية أكاديمية
المؤلفون: Alan C. Cheng, Elizabeth M. Doherty, Sheree Johnstone, Erin F. DiMauro, Jennifer Dao, Abhinav Luthra, Jay Ye, Jie Tang, Thomas Nixey, Xiaoshan Min, Philip Tagari, Les P. Miranda, Zhulun Wang
المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
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المؤلفون: Brad Herberich, Thomas Nixey, Lin Yin, Tayo Ikotun, Kelvin K. C. Sham, Jason Long, Hongyan Li, Charles Glaus, Xuhai Be, Les P. Miranda, Yuan Cheng, Marcus Soto, James R. Falsey, Bryan D. Moyer, Robert S. Foti, Christopher M. Tegley, Chawita Netirojjanakul, Linh Tran, Kip P. Conner, Jennifer Aral, Liyue Huang, Kaustav Biswas, Justin K. Murray, Bin Wu, Loren Berry, Dean Hickman, Dan A. Rock
المصدر: Drug Metabolism and Disposition. 47:1111-1121
مصطلحات موضوعية: Male, Immunoconjugates, Metabolic Clearance Rate, In silico, Drug Evaluation, Preclinical, Pharmaceutical Science, Peptide, Receptors, Fc, Mice, Neonatal Fc receptor, In vivo, medicine, Animals, Tissue Distribution, Receptor, Cryopreservation, Mice, Knockout, Voltage-Gated Sodium Channel Blockers, Pharmacology, chemistry.chemical_classification, Drug discovery, Histocompatibility Antigens Class I, NAV1.7 Voltage-Gated Sodium Channel, Antibodies, Monoclonal, In vitro, Macaca fascicularis, medicine.anatomical_structure, Biochemistry, chemistry, Hepatocyte, Hepatocytes, Administration, Intravenous, Chronic Pain, Peptides
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aafa704103c2cd45fe6f198cffc5d5f
https://doi.org/10.1124/dmd.119.087742 -
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المؤلفون: Bryan D. Moyer, Brad Herberich, Kaustav Biswas, Kenneth W. Walker, Beth D. Youngblood, Jennifer Aral, Tayo Ikotun, Min-Hwa Jasmine Lin, Linh Tran, Thomas Kornecook, Hongyan Li, Thomas Nixey, Joseph Ligutti, Shanti Amagasu, Li Yin, Xuhai Be, Kristin L. Andrews, Christopher M. Tegley, Charles Glaus, Marcus Soto, Les P. Miranda, James R. Falsey, Jason Long, Yuan Cheng, Robert S. Foti, Hossein Salimi-Moosavi, Kelvin Sham, Christopher P Ilch, Bin Wu, Justin K. Murray, Margaret Karow, Chawita Netirojjanakul, Liz Doherty
المصدر: ACS Chemical Biology. 14:806-818
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, 010405 organic chemistry, Drug discovery, Peptide, General Medicine, Pharmacology, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, chemistry, In vivo, Molecular Medicine, Potency, IC50, Linker, Conjugate
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المؤلفون: Kristin L. Andrews, J. Russell Lipford, Christine Sastri, Victor J. Cee, Jeff Winston, Andrew Tasker, Liping H. Pettus, Ryan Wurz, Christopher Mohr, Matthew R. Lee, Brian A. Lanman, Bin Wu, Nadia Guerrero, Thomas Nixey, Anthony B. Reed, Hui-Ling Wang
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:775-780
مصطلحات موضوعية: Models, Molecular, Gene isoform, Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, Biochemistry, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, hemic and lymphatic diseases, Drug Discovery, medicine, Humans, Potency, Structure–activity relationship, Amines, Protein Kinase Inhibitors, Molecular Biology, Drug discovery, Chemistry, Kinase, Organic Chemistry, Pim kinases, Molecular Medicine, Carcinogenesis, Carbolines
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المؤلفون: Jennifer Dao, Erin F. DiMauro, Elizabeth M. Doherty, Jie Tang, Philip Tagari, Alan C. Cheng, Jing Ye, Les P. Miranda, Xiaoshan Min, Thomas Nixey, Zhulun Wang, Abhinav Luthra, Sheree Johnstone
المصدر: Acta Crystallographica Section A Foundations and Advances. 75:a220-a220
مصطلحات موضوعية: Inorganic Chemistry, Structural Biology, Proof of concept, Chemistry, General Materials Science, Computational biology, Physical and Theoretical Chemistry, Condensed Matter Physics, Surface protein, Biochemistry, Small molecule, Dual (category theory)
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المؤلفون: Qingyian Liu, Kaustav Biswas, Frank Koegler, Tiffany L. Correll, Toni Williamson, Jodi Bradley, Jennifer R. Allen, Leeanne Zalameda, Darren L. Reid, Michael D. Bartberger, Joe Zhu, Stephen J. Wood, Randy Hungate, Yichin Liu, Frank Chavez, Robert M. Rzasa, Jianhua Zhang, John D. McCarter, Thomas Nixey, Paul H. Wen, Li Zhu, Shannon Rumfelt, Yi Luo, Safura Babu-Khan, Stephen Hitchcock, Ning Chen, Mqhele Ncube, Wenyuan Qian, Frenel Fils Demorin, Dean Hickman, Christopher M. Tegley, Jian J. Chen, Albert Amegadzie, Charles W. Dean, Chester Chenguang Yuan
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:6447-6454
مصطلحات موضوعية: Enzyme complex, Clinical Biochemistry, Cell, Pharmaceutical Science, Pharmacology, Cleavage (embryo), Biochemistry, Rats, Sprague-Dawley, Cerebrospinal fluid, Alzheimer Disease, Oral administration, Drug Discovery, medicine, Animals, Humans, Potency, Molecular Biology, Cell potency, chemistry.chemical_classification, Organic Chemistry, Amides, Rats, HEK293 Cells, Enzyme, medicine.anatomical_structure, chemistry, Picolines, Molecular Medicine, Amyloid Precursor Protein Secretases
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المؤلفون: Dah-Ren Hwang, Geraldine Hill Della Puppa, Jamie Wong, Essa Hu, Thomas Nixey, Silke Miller, Hang Chen, Jessica Able, Dianna Lester-Zeiner, James J. S. Treanor, Robert Cho, Santosh Talreja, Roxanne Kunz, Jianxia Shi, Ji Ma, David C. Immke, Jennifer R. Allen, Christopher Biorn, Amy Porter, Klaus Michelsen, Shannon Rumfelt, Stephen Hitchcock
المصدر: Journal of Medicinal Chemistry. 55:4776-4787
مصطلحات موضوعية: Male, Phosphodiesterase Inhibitors, Aminopyridines, Striatum, In Vitro Techniques, Tritium, Permeability, Cell Line, Rats, Sprague-Dawley, Dogs, Tandem Mass Spectrometry, In vivo, TRACER, Drug Discovery, Animals, Humans, Tissue Distribution, ATP Binding Cassette Transporter, Subfamily B, Member 1, Radionuclide Imaging, Phosphoric Diester Hydrolases, Drug discovery, Chemistry, Brain, Phosphodiesterase, Stereoisomerism, Surface Plasmon Resonance, Molecular biology, Small molecule, Rats, Pyridazines, Rapid identification, Quinolines, Pyrazoles, Molecular Medicine, PDE10A, Radiopharmaceuticals, Chromatography, Liquid, Protein Binding
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المؤلفون: John B. Jordan, Leszek Poppe, Wenge Zhong, Paul D. Schnier, Yax Sun, Thomas Nixey, Xiaoyang Xia, Alan C. Cheng, Klaus Michelsen, Heather Eastwood
المصدر: Journal of Medicinal Chemistry. 55:678-687
مصطلحات موضوعية: Quantitative structure–activity relationship, 19f nmr spectroscopy, Fragment (logic), Chemistry, Drug Discovery, Fragment-based lead discovery, Molecular Medicine, Nuclear magnetic resonance spectroscopy, Fluorine-19 NMR, Combinatorial chemistry, Heteronuclear single quantum coherence spectroscopy
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المؤلفون: Timothy Powers, Stephen J. Wood, Ted Judd, Vivian S. W. Li, James Brown, E. Allen Sickmier, Klaus Michelsen, David J. St. Jean, Yi Luo, Dean Hickman, Yuan Cheng, Kui Chen, Stephen Hitchcock, Steven W. Louie, Patricia Lopez, Brad Jordan, Thomas Nixey, Robert T. Fremeau, Michael D. Bartberger, Paul H. Wen, Robert C. Wahl, Claire Rattan
المصدر: Journal of Medicinal Chemistry. 54:5836-5857
مصطلحات موضوعية: Male, Models, Molecular, Molecular model, Drug Evaluation, Preclinical, Crystallography, X-Ray, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, In vivo, Catalytic Domain, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Potency, Enzyme Inhibitors, Aminoquinolines, IC50, chemistry.chemical_classification, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Molecular Structure, biology, Ligand, Brain, Combinatorial chemistry, Protein Structure, Tertiary, Rats, HEK293 Cells, Enzyme, Models, Chemical, Biochemistry, chemistry, Biocatalysis, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases
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المؤلفون: Linda F. Epstein, Josette Carnahan, Manory Fernando, Douglas A. Whittington, Jeffrey Petkus, Joseph L. Kim, Matthew R. Lee, Adrian L. Smith, Nick A. Paras, Qi Huang, Pedro J. Beltran, Elizabeth M. Doherty, Thomas Nixey, Quynh Le, Mark J. Rose, Frenel Fils Demorin, Kristen Hess, Carol Babij
المصدر: Journal of Medicinal Chemistry. 52:6189-6192
مصطلحات موضوعية: Male, Models, Molecular, Proto-Oncogene Proteins B-raf, MAP Kinase Signaling System, Mutant, Molecular Conformation, Administration, Oral, Biological Availability, Substrate Specificity, Mice, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Transferase, Benzamide, Protein Kinase Inhibitors, chemistry.chemical_classification, Chemistry, Kinase, Isoquinolines, In vitro, Rats, Enzyme, Biochemistry, Mutation, Molecular Medicine, Mutant Proteins, Signal transduction