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1
المؤلفون: Todd Appleby, Martijn Fenaux, Thomas Butler, Mark Charles Whitcomb, Gregory Chin, Rick Lee, Gabriel Birkus, Aesop Cho, Michael O'neil Hanrahan Clarke, Thorsten A. Kirschberg, Darius Babusis, Vangelis Aktoudianakis, Lijun Zhang, Thomas E. Edwards, Eisuke Murakami, Jie Xu, Choung U. Kim, Daniel Byun, Neil H. Squires, Edward Doerffler, Willard Lew, Adrian S. Ray, Joy Y. Feng, Ona Barauskas, Sammy Metobo, Ting Wang, Huiling Yang, Yeojin Park, Mish Michael R, Neeraj Tirunagari, Hong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1840-1847
مصطلحات موضوعية: 0301 basic medicine, Halogenation, 030106 microbiology, Clinical Biochemistry, Mutant, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Methylation, Biochemistry, Cell Line, 03 medical and health sciences, Cricetinae, Drug Resistance, Viral, Drug Discovery, medicine, Animals, Humans, Point Mutation, Phosphoric Acids, Prodrugs, Nucleotide, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, Nucleosides, Phosphoramidate, Prodrug, Amides, Hepatitis C, Adenosine, Molecular Docking Simulation, Molecular Medicine, Caco-2 Cells, Nucleoside, Isopropyl, medicine.drug
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2
المؤلفون: Christopher T. Jones, Yujin Wang, Kevin Klucher, Martijn Fenaux, Thorsten A. Kirschberg, Randall L. Halcomb, Xu Yingzi
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127465
مصطلحات موضوعية: Male, Nonalcoholic steatohepatitis, medicine.medical_specialty, Isostere, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Liver steatosis, Fibrosis, Internal medicine, Drug Discovery, medicine, Animals, Molecular Biology, Oxadiazoles, Triiodothyronine, Thyroid hormone receptor, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Target engagement, Thyroid Hormone Receptors beta, medicine.disease, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Endocrinology, Molecular Medicine
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3
المؤلفون: Stacey Eng, Thorsten A. Kirschberg, Darius Babusis, Christian Voitenleitner, Gabriel Birkus, Ting Wang, Yili Xu, Neeraj Tirunagari, Huiling Yang, Martijn Fenaux, Joy Y. Feng, Yeojin Park, Aesop Cho, Adrian S. Ray
المصدر: Antimicrobial Agents and Chemotherapy
مصطلحات موضوعية: 0301 basic medicine, nucleotide prodrug, Male, cathepsin A, Adenosine, 030106 microbiology, Administration, Oral, Hepacivirus, Pharmacology, Virus Replication, Antiviral Agents, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Oral administration, Animals, Humans, Pharmacology (medical), Nucleotide, Prodrugs, carboxyl esterase 1, Cells, Cultured, chemistry.chemical_classification, Alanine, Chemistry, Nucleotides, Triazines, Phosphoramidate, Prodrug, antiviral, Hepatitis C, Amino acid, Rats, 030104 developmental biology, Infectious Diseases, GS-6620, HCV, Nucleoside triphosphate, GS2, Efflux, Caco-2 Cells, Nucleoside, carboxyl esterase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf5d38328457e1cf32d7eb42e7cfc64
http://europepmc.org/articles/PMC6105845 -
4
المؤلفون: Choung U. Kim, Lijun Zhang, Ke-Yu Wang, Adrian S. Ray, Mish Michael R, Aesop Cho, Martijn Fenaux, Yeojin Park, Darius Babusis, Joy Y. Feng, Thorsten A. Kirschberg, Neil H. Squires
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:1040-1043
مصطلحات موضوعية: Halogenation, Pyrimidine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Antiviral Agents, Methylation, Biochemistry, Cell Line, chemistry.chemical_compound, Pyrimidine analogue, Drug Discovery, Humans, Phosphoric Acids, Prodrugs, Replicon, Molecular Biology, Polymerase, biology, Organic Chemistry, Cytidine, Phosphoramidate, Prodrug, Pyrimidine Nucleosides, RNA-Dependent RNA Polymerase, Amides, Hepatitis C, chemistry, biology.protein, Molecular Medicine, Derivative (chemistry)
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5
المؤلفون: Aesop Cho, Adrian S. Ray, Yeojin Park, Joy Y. Feng, Martijn Fenaux, Mish Michael R, Darius Babusis, Jie Xu, C. Sebastian Zonte, Choung U. Kim, Thorsten A. Kirschberg
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:3092-3095
مصطلحات موضوعية: Pyrimidine, Hepacivirus, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, RNA-dependent RNA polymerase, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, Ns5b polymerase, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Structure–activity relationship, heterocyclic compounds, Nucleotide, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, biology, organic chemicals, Organic Chemistry, Nucleosides, Phosphoramidate, Prodrug, Pyrimidine Nucleosides, RNA-Dependent RNA Polymerase, biology.organism_classification, chemistry, Molecular Medicine
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6
المؤلفون: Huiling Yang, X. Christopher Sheng, Neeraj Tirunagari, Choung U. Kim, Thorsten A. Kirschberg, Amoreena C. Corsa, Neil H. Squires, Yang Tian
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:969-972
مصطلحات موضوعية: medicine.medical_treatment, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, Context (language use), Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Peptide bond, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, NS3, Protease, Molecular Structure, Chemistry, Organic Chemistry, virus diseases, Sulfonamide, Enzyme Activation, Inhibitory potency, Hcv ns3 protease, Molecular Medicine
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7
المؤلفون: Roman Sakowicz, Thorsten A. Kirschberg, Gabriel Birkus, Anita Niedziela-Majka, Hyock Joo Kwon, Ona Barauskas, Xiaohong Liu, Joy Y. Feng, Brian E. Schultz, Mike Clarke, Weimei Xing, Perry Weissburg
المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0181969 (2017)مصطلحات موضوعية: RNA viruses, 0301 basic medicine, Viral Diseases, viruses, lcsh:Medicine, medicine.disease_cause, Biochemistry, Polymerases, law.invention, Endonuclease, Transcription (biology), law, Influenza A virus, Enzyme Inhibitors, lcsh:Science, Pathology and laboratory medicine, Polymerase, Multidisciplinary, biology, Physics, virus diseases, Medical microbiology, Recombinant Proteins, Enzymes, Physical sciences, Nucleic acids, Chemistry, Infectious Diseases, Ribonucleoproteins, Viruses, Recombinant DNA, Pathogens, Research Article, Chemical physics, Nucleic acid synthesis, Protein subunit, 030106 microbiology, RNA-dependent RNA polymerase, Microbiology, Inhibitory Concentration 50, Viral Proteins, 03 medical and health sciences, DNA-binding proteins, medicine, Influenza viruses, Chemical synthesis, RNA, Messenger, RNA synthesis, Medicine and health sciences, Messenger RNA, Biology and life sciences, lcsh:R, Organisms, Viral pathogens, Proteins, Dimers (Chemical physics), biochemical phenomena, metabolism, and nutrition, Endonucleases, RNA-Dependent RNA Polymerase, Molecular biology, Influenza, Microbial pathogens, Research and analysis methods, Enzyme Activation, Biosynthetic techniques, 030104 developmental biology, Enzymology, biology.protein, RNA, lcsh:Q, Orthomyxoviruses
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8
المؤلفون: Rebecca Hluhanich, Eric B. Lansdon, Neil H. Squires, Mini Balakrishnan, Thorsten A. Kirschberg, Wei Huang, Nilima Kutty, Albert Liclican, Damian J. McColl
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1131-1134
مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Transferase, Binding site, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Reverse-transcriptase inhibitor, Chemistry, Organic Chemistry, Triazoles, Nucleotidyltransferase, HIV Reverse Transcriptase, Reverse transcriptase, Enzyme, Enzyme inhibitor, HIV-1, biology.protein, Reverse Transcriptase Inhibitors, Molecular Medicine, Nucleoside, medicine.drug
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9
المؤلفون: Thorsten A. Kirschberg, William C. Thomas, Maria Fardis, Jie Xu, Zhang Jennifer R, Lee Chong, Xiaohong Liu, Ameneh Zeynalzadegan, William A. Lee, Magdeleine Hung, Aesop Cho, Wei Huang, James M. Chen, Nicole Collins, William J. Watkins
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3479-3483
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Organophosphonates, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mycophenolic acid, Structure-Activity Relationship, IMP Dehydrogenase, IMP dehydrogenase, Drug Discovery, medicine, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Organic Chemistry, Stereoisomerism, Biological activity, Mycophenolic Acid, Acido micofenolico, Enzyme Activation, Transplantation, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, medicine.drug
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المؤلفون: Anita Niedziela-Majka, Kato Darryl, Guofeng Cheng, Weimei Xing, Hyock Joo Kwon, Xiaohong Liu, John O. Link, Katie Chan, Katherine M. Brendza, Roman Sakowicz, Thorsten A. Kirschberg
المصدر: PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0122844 (2015)مصطلحات موضوعية: Ledipasvir, viruses, Molecular Sequence Data, lcsh:Medicine, Plasma protein binding, Hepacivirus, Biology, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, law.invention, chemistry.chemical_compound, law, Cell Line, Tumor, Drug Resistance, Viral, medicine, Humans, Replicon, Amino Acid Sequence, NS5A, lcsh:Science, Fluorenes, Multidisciplinary, lcsh:R, virus diseases, Transfection, biochemical phenomena, metabolism, and nutrition, Virology, Molecular biology, digestive system diseases, Recombinant Proteins, Kinetics, Mechanism of action, chemistry, Viral replication, Mutation, Recombinant DNA, Hepatocytes, lcsh:Q, Benzimidazoles, medicine.symptom, Protein Binding, Research Article
