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1دورية أكاديمية
المؤلفون: Banerjee SK; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15219, USA., Thurlow LR; Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7450, USA., Kannan K; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15219, USA., Richardson AR; Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15219, USA. Electronic address: anthony.richardson@pitt.edu.
المصدر: Cell reports [Cell Rep] 2024 Jul 23; Vol. 43 (7), pp. 114486. Date of Electronic Publication: 2024 Jul 10.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
مواضيع طبية MeSH: Methicillin-Resistant Staphylococcus aureus* , Glucose Transporter Type 1*/metabolism , Glucose Transporter Type 1*/genetics , Soft Tissue Infections*/microbiology , Soft Tissue Infections*/metabolism , Soft Tissue Infections*/pathology, Animals ; Mice ; PPAR gamma/metabolism ; Staphylococcal Skin Infections/microbiology ; Staphylococcal Skin Infections/metabolism ; Staphylococcal Skin Infections/pathology ; Staphylococcal Skin Infections/drug therapy ; Mice, Inbred C57BL ; Macrophages/metabolism ; Macrophages/microbiology ; Staphylococcal Infections/metabolism ; Staphylococcal Infections/microbiology
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2دورية أكاديمية
المؤلفون: Genito CJ; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Darwitz BP; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Reber CP; Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA., Moorman NJ; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Graves CL; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Monteith AJ; Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA., Thurlow LR; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
المصدر: MBio [mBio] 2024 Jun 12; Vol. 15 (6), pp. e0086224. Date of Electronic Publication: 2024 May 20.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
مواضيع طبية MeSH: Staphylococcus aureus*/immunology , TOR Serine-Threonine Kinases*/metabolism , TOR Serine-Threonine Kinases*/genetics , Staphylococcal Infections*/immunology , Staphylococcal Infections*/microbiology , Signal Transduction* , Phagocytes*/immunology , Phagocytes*/metabolism , Phagocytes*/microbiology , Glucose Transporter Type 1*/metabolism , Glucose Transporter Type 1*/genetics, Humans ; Animals ; Free Radicals/metabolism ; Mice ; Mice, Inbred C57BL
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3دورية أكاديمية
المؤلفون: Darwitz BP; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Genito CJ; Division of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill Adams School of Dentistry, Chapel Hill, North Carolina, USA., Thurlow LR; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.; Division of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill Adams School of Dentistry, Chapel Hill, North Carolina, USA.
المصدر: Infection and immunity [Infect Immun] 2024 Mar 25, pp. e0050923. Date of Electronic Publication: 2024 Mar 25.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE
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4دورية أكاديمية
المؤلفون: Zhang Y; Department of Bioengineering, University of California, Los Angeles, CA 90095.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 9009.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.; Biomedical Engineering, School of Engineering, Westlake University, Hangzhou, Zhejiang 310012, China., Bharathi V; University of North Carolina Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Dokoshi T; Department of Dermatology, University of California San Diego, La Jolla, CA 92093., de Anda J; Department of Bioengineering, University of California, Los Angeles, CA 90095.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 9009.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095., Ursery LT; University of North Carolina Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Kulkarni NN; Department of Dermatology, University of California San Diego, La Jolla, CA 92093., Nakamura Y; Department of Dermatology, University of California San Diego, La Jolla, CA 92093., Chen J; Department of Bioengineering, University of California, Los Angeles, CA 90095.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 9009.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095., Luo EWC; Department of Bioengineering, University of California, Los Angeles, CA 90095.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 9009.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095., Wang L; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215., Xu H; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215., Coady A; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093., Zurich R; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093., Lee MW; Department of Bioengineering, University of California, Los Angeles, CA 90095.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 9009.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095., Matsui T; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025., Lee H; Division of Molecular Medicine, Harbor-University of California Los Angeles Medical Center, Los Angeles County, Torrance, CA 90502., Chan LC; Division of Molecular Medicine, Harbor-University of California Los Angeles Medical Center, Los Angeles County, Torrance, CA 90502.; Division of Infectious Diseases, Harbor-University of California Los Angeles Medical Center, Los Angeles County, Torrance, CA 90502.; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Institute for Infection & Immunity, Lundquist Institute for Biomedical Innovation, Harbor-University of California Los Angeles Medical Center, Torrance, CA 90502., Schepmoes AA; Environmental Molecular Science Division, Pacific Northwest National Laboratory, Richland, WA 99354., Lipton MS; Environmental Molecular Science Division, Pacific Northwest National Laboratory, Richland, WA 99354., Zhao R; Environmental Molecular Science Division, Pacific Northwest National Laboratory, Richland, WA 99354., Adkins JN; Biological Science Division, Pacific Northwest National Laboratory, Richland, WA 99354., Clair GC; Biological Science Division, Pacific Northwest National Laboratory, Richland, WA 99354., Thurlow LR; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Schisler JC; McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Wolfgang MC; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Hagan RS; Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Yeaman MR; Division of Molecular Medicine, Harbor-University of California Los Angeles Medical Center, Los Angeles County, Torrance, CA 90502.; Division of Infectious Diseases, Harbor-University of California Los Angeles Medical Center, Los Angeles County, Torrance, CA 90502.; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Institute for Infection & Immunity, Lundquist Institute for Biomedical Innovation, Harbor-University of California Los Angeles Medical Center, Torrance, CA 90502., Weiss TM; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025., Chen X; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215., Li MMH; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095., Nizet V; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093., Antoniak S; Department of Pathology and Laboratory Medicine, University of North Carolina Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Mackman N; University of North Carolina Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Gallo RL; Department of Dermatology, University of California San Diego, La Jolla, CA 92093., Wong GCL; Department of Bioengineering, University of California, Los Angeles, CA 90095.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 9009.; California NanoSystems Institute, University of California, Los Angeles, CA 90095.; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Feb 06; Vol. 121 (6), pp. e2300644120. Date of Electronic Publication: 2024 Feb 02.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
مواضيع طبية MeSH: SARS-CoV-2* , COVID-19*, Humans ; Animals ; Mice ; Endothelial Cells ; Proteome ; Peptides
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5دورية أكاديمية
المؤلفون: Genito CJ; Division of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill Adams School of Dentistry , Chapel Hill, North Carolina, USA., Darwitz BP; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina, USA., Greenwald MA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina, USA.; Marsico Lung Institute, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina, USA., Wolfgang MC; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina, USA.; Marsico Lung Institute, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina, USA., Thurlow LR; Division of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill Adams School of Dentistry , Chapel Hill, North Carolina, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine , Chapel Hill, North Carolina, USA.
المصدر: Microbiology spectrum [Microbiol Spectr] 2023 Dec 12; Vol. 11 (6), pp. e0229923. Date of Electronic Publication: 2023 Nov 07.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
مواضيع طبية MeSH: Staphylococcal Infections*/microbiology , Hyperglycemia* , Diabetes Mellitus* , Pseudomonas Infections*/microbiology, Humans ; Animals ; Mice ; Staphylococcus aureus ; Pseudomonas aeruginosa ; Virulence ; Biofilms
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6دورية أكاديمية
المؤلفون: Stephens AC; Department of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA., Thurlow LR; Department of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA., Richardson AR; Department of Microbiology and Molecular Genetics, University of Pittsburghgrid.21925.3d, Pittsburgh, Pennsylvania, USA.
المصدر: Microbiology spectrum [Microbiol Spectr] 2022 Aug 31; Vol. 10 (4), pp. e0206322. Date of Electronic Publication: 2022 Jul 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
مواضيع طبية MeSH: Staphylococcal Infections* , Staphylococcus aureus*/metabolism, Adenosine Triphosphate/metabolism ; Amino Acids/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Humans ; Quorum Sensing ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Virulence Factors/genetics ; Virulence Factors/metabolism
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7دورية أكاديمية
المؤلفون: Thurlow LR; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA., Stephens AC; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA., Hurley KE; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA., Richardson AR; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. anthony.richardson@pitt.edu.
المصدر: Science advances [Sci Adv] 2020 Nov 13; Vol. 6 (46). Date of Electronic Publication: 2020 Nov 13 (Print Publication: 2020).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
مواضيع طبية MeSH: Diabetes Mellitus* , Hyperglycemia* , Staphylococcal Infections*/microbiology, Glucose ; Humans ; Staphylococcus aureus ; Virulence
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8دورية أكاديمية
المؤلفون: Thurlow LR; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA., Joshi GS; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA., Richardson AR; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: anthony.richardson@pitt.edu.
المصدر: Cell host & microbe [Cell Host Microbe] 2018 Aug 08; Vol. 24 (2), pp. 261-270.e4. Date of Electronic Publication: 2018 Jul 26.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
مواضيع طبية MeSH: Host-Pathogen Interactions/*physiology , PPAR gamma/*immunology , Staphylococcal Skin Infections/*etiology, Abscess/drug therapy ; Abscess/etiology ; Animals ; Female ; Glucose/metabolism ; Male ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Methicillin-Resistant Staphylococcus aureus/physiology ; Mice, Inbred C57BL ; Mice, Transgenic ; PPAR gamma/agonists ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Rosiglitazone/pharmacology ; Staphylococcal Skin Infections/drug therapy
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9دورية أكاديمية
المؤلفون: Grosser MR; Department of Microbiology and Immunology University of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States of America., Paluscio E; Department of Microbiology and Molecular Genetics University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Thurlow LR; Department of Microbiology and Molecular Genetics University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Dillon MM; Department of Microbiology and Molecular Genetics University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Cooper VS; Department of Microbiology and Molecular Genetics University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America., Kawula TH; Paul G. Allen School for Global Animal Health Washington State University, Pullman, Washington, United States of America., Richardson AR; Department of Microbiology and Molecular Genetics University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
المصدر: PLoS pathogens [PLoS Pathog] 2018 Mar 19; Vol. 14 (3), pp. e1006907. Date of Electronic Publication: 2018 Mar 19 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
مواضيع طبية MeSH: Bacterial Proteins/*genetics , Immunity, Innate/*immunology , Nitric Oxide/*pharmacology , Staphylococcal Skin Infections/*immunology , Staphylococcus aureus/*drug effects , Virulence/*immunology, Animals ; Gene Expression Regulation, Bacterial ; Gene Library ; Immunity, Innate/drug effects ; Immunity, Innate/genetics ; Mice ; Mice, Inbred C57BL ; Staphylococcal Skin Infections/genetics ; Staphylococcal Skin Infections/microbiology ; Staphylococcus aureus/immunology ; Virulence/drug effects ; Virulence/genetics
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10دورية أكاديمية
المؤلفون: Hagar JA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Edin ML; Division of Intramural Research, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709., Lih FB; Division of Intramural Research, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709., Thurlow LR; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219., Koller BH; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Cairns BA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; and.; North Carolina Jaycee Burn Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Zeldin DC; Division of Intramural Research, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709., Miao EA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; emiao@med.unc.edu.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2017 Nov 15; Vol. 199 (10), pp. 3634-3643. Date of Electronic Publication: 2017 Oct 16.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE
مواضيع طبية MeSH: Congenital Hyperinsulinism/*drug therapy , Insulin/*therapeutic use , Salmonella Infections/*drug therapy , Salmonella typhimurium/*immunology , Sepsis/*drug therapy, Animals ; Caspases/genetics ; Caspases/metabolism ; Caspases, Initiator ; Cells, Cultured ; Complement System Proteins/metabolism ; Congenital Hyperinsulinism/immunology ; Female ; Humans ; Lipopolysaccharides/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Salmonella Infections/immunology ; Sepsis/immunology ; Signal Transduction ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism