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1
المؤلفون: Dong-Ming Shen, Michael Wolff, Shirly Pinto, Deodial Guiadeen, Bindhu V. Karanam, James M. Balkovec, Arto D. Krikorian, Shuwen He, Maria Madeira, Donald M. Sperbeck, Andreas Verras, Judyann Wiltsie, Jian Liu, Jackie Shang, Tim Cernak, Beth Ann Murphy, Qingmei Hong, Christine C. Chung, Ravi P. Nargund, Kevin D. Dykstra, Judith N. Gorski, Robert J. DeVita, Sharon Tong, Tianying Jian, Lisa M. Sonatore, Jeffrey T. Kuethe, Jianying Xiao, Jinqi Liu, Zhong Lai, Zhicai Wu, Mikhail Reibarkh, Ginger X. Yang, Yang Yu
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1182-1186
مصطلحات موضوعية: Benzimidazole, Cyclohexane, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, 01 natural sciences, Biochemistry, Mass Spectrometry, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Isomerism, In vivo, Drug Discovery, Animals, Humans, Moiety, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Molecular Biology, Chromatography, High Pressure Liquid, Active metabolite, chemistry.chemical_classification, Cyclohexanones, 010405 organic chemistry, Chemistry, Organic Chemistry, In vitro, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Hepatocytes, Molecular Medicine, Benzimidazoles, Isomerization
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2
المؤلفون: Robert J. De Vita, Zhi-Cai Shi, Bindhu V. Karanam, Beth Ann Murphy, Shuwen He, Tianying Jian, Christine C. Chung, Maria Madeira, Qingmei Hong, Tim Cernak, Ravi P. Nargund, James M. Balkovec, Donald M. Sperbeck, Min Liu, Andreas Verras, Judyann Wiltsie, Jian Liu, Lisa M. Sonatore, Sharon Tong, Shirly Pinto, Deodial Guiadeen, Michael Wolff, Zhicai Wu, Dong-Ming Shen, Arto D. Krikorian, Yang Yu, Judith N. Gorski, Petr Vachal, Jianying Xiao, Jinqi Liu, Zhong Lai
المصدر: Bioorganicmedicinal chemistry letters. 29(11)
مصطلحات موضوعية: Library design, Benzimidazole, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Chemistry, Pharmaceutical, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Molecular Medicine, Humans, Benzimidazoles, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Molecular Biology, Diacylglycerol kinase
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3
المؤلفون: Harold B. Wood, Kunal Desai, Daming Feng, Jamie McCabe-Dunn, Yi-Heng Chen, Edward C. Sherer, Jane Y. Wu, Marc Poirier, Hong Li, Dongfang Meng, Ting Zhang, Kenneth P. Ellsworth, Liangqin Guo, Teruyuki Nishimura, Jiayi Xu, Tomokazu Hirabayashi, Sunita V. Dewnani, Patrick Andre, Louis-Charles Campeau, Richard Tschirret-Guth, Isao Sakurada, Paul Reichert, Cameron J. Smith, Robert K. Orr, Lisa M. Sonatore, Wayne M. Geissler, Thomas Bateman, Kazuto Araki, Joe Metzger, Alan Hruza, Richard A. Berger, Dann L. Parker, Tianying Jian
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:5437-5443
مصطلحات موضوعية: Drug, media_common.quotation_subject, Clinical Biochemistry, High selectivity, Administration, Oral, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Thrombin generation, Factor IXa, Pharmacokinetics, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, media_common, chemistry.chemical_classification, Molecular Structure, Chemistry, Organic Chemistry, Rats, Enzyme Activation, Human plasma, Drug Design, Pharmacodynamics, Molecular Medicine, Coagulation factor IXa, Heterocyclic Compounds, 3-Ring, Tricyclic
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4
المؤلفون: Shirly Pinto, Deodial Guiadeen, David X. Yang, Tianying Jian, Ravi P. Nargund, Donald M. Sperbeck, Tim Cernak, Qingmei Hong, James M. Balkovec, Christine C. Chung, Dong-Ming Shen, Jeffrey T. Kuethe, Sharon Tong, Pauline C. Ting, Judyann Wiltsie, Jack Gibson, Lisa M. Sonatore, Zhicai Wu, Ginger X. Yang, Michael Wolff, Judith N. Gorski, Robert J. DeVita, Yang Yu, Jian Liu, JeanMarie Lisnock, Zhong Lai, Shuwen He, Jianying Xiao, Jinqi Liu, Bindhu V. Karanam, Arto D. Krikorian, Kevin D. Dykstra, Maria Madeira
المصدر: ACS Medicinal Chemistry Letters. 5:1082-1087
مصطلحات موضوعية: Benzimidazole, Stereochemistry, Metabolite, Organic Chemistry, Pharmacology, Cyclohexanecarboxylic acid, Biology, Biochemistry, Ames test, chemistry.chemical_compound, chemistry, Free fraction, Drug Discovery, Moiety, Epimer, Selectivity
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5
المؤلفون: Donald Nelson, Gary G. Chicchi, James Dellureficio, Ravi P. Nargund, Peter H. Dobbelaar, Liangqin Guo, Kwei-Lan Tsao, Janet S. Kerr, Bei Zhang, Zhong Lai, Patricia R. Bunting, Shrenik K. Shah, Raman K. Bakshi, Qingmei Hong, Hongbo Qi, Guillermo Fernandez, Mikhail Reibarkh, Qing Shao, Quang Truong, Koppara Samuel, Jian Liu, Sylvia Volksdorf, Zhixiong Ye, Yun-Ping Zhou, Margaret Wu, Cai Li, Stan Mitelman, Andrew D. Howard, Wu Du, Maria E. Trujillo, George J. Eiermann, Shuwen He, Vijay Bhasker G. Reddy, Tianying Jian, Pierre Morissette, Patrick Fitzgerald, Dorina Trusca, Sharon Tong, William K. Hagmann
المصدر: ACS Medicinal Chemistry Letters. 5:748-753
مصطلحات موضوعية: biology, business.industry, Organic Chemistry, hERG, Antagonist, In vitro toxicology, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, QT interval, Somatostatin, Drug Discovery, biology.protein, Medicine, cardiovascular diseases, Receptor, business, Antagonism
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6
المؤلفون: David Won-Shik Kim, Ravi P. Nargund, Zhicai Wu, Maria Madeira, Jian Liu, JeanMarie Lisnock, Tianying Jian, Jeffrey T. Kuethe, Bindhu V. Karanam, Qingmei Hong, Dong-Ming Shen, Michael Wolff, Sharon Tong, Jack Gibson, Zhong Lai, Shirly Pinto, Deodial Guiadeen, Yang Yu, Donald M. Sperbeck, Beth Ann Murphy, James M. Balkovec, Christine C. Chung, Dunlu Chen, Judyann Wiltsie, Jinqi Liu, Xiaoli Chen, Shuwen He, Arto D. Krikorian, Lisa M. Sonatore, Pauline C. Ting, Judith N. Gorski, Robert J. DeVita, Ginger X. Yang
المصدر: ACS Medicinal Chemistry Letters. 4:773-778
مصطلحات موضوعية: Benzimidazole, Stereochemistry, Metabolite, Organic Chemistry, Cyclohexanecarboxylic acid, Biology, Biochemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Moiety, Epimer, Selectivity, Active metabolite
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7
المؤلفون: Janet Kerr, Gary G. Chicchi, Margaret Wu, Cai Li, Shuwen He, Vijay Bhasker G. Reddy, Sharon Tong, William K. Hagmann, Patrick Fitzgerald, Guillermo Fernandez, Andrew D. Howard, Tianying Jian, Zhe Feng, Raman K. Bakshi, Dorina Trusca, Peter H. Dobbelaar, Donald Nelson, Mikhail Reibarkh, Qing Shao, Liangqin Guo, Yun-Ping Zhou, Ravi P. Nargund, Kwei-Lan Tsao, Edward C. Sherer, Stan Mitelman, Pierre Morissette, Maria E. Trujillo, Quang Truong, Zhixiong Ye, James D. Dellureficio, Hongbo Qi, Melissa Lin, Shrenik K. Shah, Sylvia Volksdorf, Jian Liu, Qingmei Hong, Koppara Samuel, Alexander Pasternak, George J. Eiermann, Patricia B. Bunting, Wu Du, Bei B. Zhang
المصدر: Bioorganicmedicinal chemistry letters. 26(6)
مصطلحات موضوعية: QTC PROLONGATION, congenital, hereditary, and neonatal diseases and abnormalities, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, 010402 general chemistry, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, cardiovascular diseases, Receptors, Somatostatin, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, 0104 chemical sciences, Rats, biology.protein, Molecular Medicine, Antagonism, Carbolines
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8
المؤلفون: Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
مصطلحات موضوعية: Agonist, medicine.medical_specialty, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Spiro Compounds, Obesity, Molecular Biology, Mice, Knockout, Chemistry, Body Weight, Organic Chemistry, Amides, Rats, Endocrinology, Drug development, Anorectic, Receptor, Melanocortin, Type 4, Molecular Medicine
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9
المؤلفون: Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2106-2110
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Cricetulus, Dogs, Erectile Dysfunction, Cricetinae, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Receptor, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Haplorhini, Rats, Bioavailability, Indans, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
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10
المؤلفون: Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1913-1917
مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Molecular Biology, Biphenyl, Chemistry, Drug discovery, fungi, Organic Chemistry, Imidazoles, Rats, Bombesin receptor, Bioavailability, Receptors, Bombesin, Molecular Medicine, Bombesin Receptor Subtype-3