المؤلفون: Henning Fenselau, Peter Kloppenburg, Tim Klöckener, Isabella Gaziano, Michael Sué, Frank Thomas Wunderlich, Amin Abbasloo, Jonas Schumacher, Jens C. Brüning, Stefan Vollmar, Fiona M. Gribble, Claudia M. Wunderlich, Frank Reimann, Paul Klemm, Weiyi Chen, Lars Paeger, Tamara Sotelo-Hitschfeld, Nasim Biglari, Jan Radermacher, Svenja Corneliussen, Frank Edenhofer

المصدر: Nature Neuroscience

مصطلحات موضوعية: 0301 basic medicine, Pro-Opiomelanocortin, Transgene, Hypothalamus, Mice, Transgenic, Biology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Arcuate nucleus, medicine, Animals, Homeostasis, Receptor, Neurons, Leptin receptor, General Neuroscience, Feeding Behavior, Glucagon-like peptide-1, Electrophysiology, 030104 developmental biology, medicine.anatomical_structure, nervous system, Feeding behaviour, Neuron, Energy Metabolism, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30ba8ecc46d457e3ce6960d9b200cfa
http://europepmc.org/articles/PMC8249241

المؤلفون: Corinne Rocher, Aimo Kannt, Andreas Nygaard Madsen, Torsten Haack, Ralf Elvert, Tim Klöckener, Andreas Evers, Wolfgang Hennerici, Zsolt Bocskei, Bart Staels, Jean-Claude Guillemot, Katrin Lorenz, Michael Wagner, Vincent Mikol, Martin Bossart, François Pattou, Claire Kammermeier

مصطلحات موضوعية: medicine.medical_specialty, Combination therapy, business.industry, Internal medicine, medicine, Incretin, Non alcoholic, Steatohepatitis, business, medicine.disease, Gastroenterology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2ec5853457dab57752d19eead36f87dd
https://doi.org/10.1111/dom.14035/v2/response1

المؤلفون: Zsolt Bocskei, Corinne Rocher, Andreas Evers, Ralf Elvert, Tim Klöckener, Martin Bossart, Claire Kammermeier, Michael Wagner, Katrin Lorenz, Aimo Kannt, Bart Staels, Vincent Mikol, Jean-Claude Guillemot, Wolfgang Hennerici, Andreas Nygaard Madsen, Torsten Haack, François Pattou

المساهمون: SANOFI (Research and Development), Research and Development, Experimental Pharmacology (Medical Faculty Mannheim), Gubra, SANOFI Recherche, Recherche translationnelle sur le diabète - U 1190 (RTD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-16-RHUS-0006,PreciNASH,PreciNASH(2016), Publica, Derudas, Marie-Hélène, PreciNASH - - PreciNASH2016 - ANR-16-RHUS-0006 - RHUS - VALID

المصدر: Diabetes, Obesity and Metabolism
Diabetes, Obesity and Metabolism, Wiley, 2020, Online ahead of print. ⟨10.1111/dom.14035⟩
Diabetes, Obesity and Metabolism, 2020, Online ahead of print. ⟨10.1111/dom.14035⟩

مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Incretin, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Pharmacology, Glucagon, Incretins, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Mice, 0302 clinical medicine, Endocrinology, Weight loss, Fibrosis, Non-alcoholic Fatty Liver Disease, Internal Medicine, medicine, Receptors, Glucagon, Animals, Receptor, experimental pharmacology, GIP, business.industry, Liraglutide, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, glucagon, fatty liver disease, incretin therapy, medicine.symptom, Steatohepatitis, business, GLP-1, Glucagon receptor, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d52297c98710de472b2dd6203ac7d2f
https://pubmed.ncbi.nlm.nih.gov/32196896

المؤلفون: Jürgen Staszewski, Stefan Zittrich, Kathrin Weckmüller, Mechthild M. Schroeter, Gabriele Pfitzer, Sandra Pütz, Hristo Gagov, Dilyana Filipova, Tim Klöckener, Johannes Welter, Lubomir T. Lubomirov, Harald Metzner, Symeon Papadopoulos, Mostafa A. Ardestani, Doris Metzler

المصدر: Journal of Cerebral Blood Flow & Metabolism. 37:1014-1029

مصطلحات موضوعية: Aging, medicine.medical_specialty, Nitric Oxide Synthase Type III, Nitric Oxide Synthase Type I, 030204 cardiovascular system & hematology, Biology, Muscle, Smooth, Vascular, Mice, Myosin-Light-Chain Phosphatase, 03 medical and health sciences, Basal (phylogenetics), chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Enos, Internal medicine, medicine.artery, medicine, Basilar artery, Animals, Enzyme Inhibitors, Phosphorylation, Acetophenones, Original Articles, biology.organism_classification, Protein Subunits, Endocrinology, Neurology, chemistry, Vasoconstriction, Basilar Artery, Apocynin, Neurology (clinical), Myosin-light-chain phosphatase, medicine.symptom, Cardiology and Cardiovascular Medicine, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b2456adf3abcf6163e6a5f4569622c
https://doi.org/10.1177/0271678x16649402

المؤلفون: Jeffrey M. Zigman, Tim Klöckener, Andreas Husch, Bradford B. Lowell, Jens C. Brüning, Linda A W Verhagen, Bengt F. Belgardt, Kevin W. Williams, Lars Paeger, Joel K. Elmquist, Tamas L. Horvath, Peter Kloppenburg, Jong Woo Sohn, Simon Hess, Harveen Dhillon, Brigitte Hampel

المصدر: Nature Neuroscience; Vol 14
Nature neuroscience
Nature Neuroscience

مصطلحات موضوعية: Blood Glucose, Leptin, Male, Steroidogenic factor 1, Patch-Clamp Techniques, Time Factors, medicine.medical_treatment, Action Potentials, Steroidogenic Factor 1, Energy homeostasis, Impaired glucose tolerance, Eating, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Insulin, Glucose homeostasis, Enzyme Inhibitors, Neurons, 2. Zero hunger, 0303 health sciences, General Neuroscience, Age Factors, Hypothalamus, Female, Signal Transduction, medicine.medical_specialty, Tolbutamide, Green Fluorescent Proteins, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Calorimetry, In Vitro Techniques, Biology, Article, 03 medical and health sciences, Internal medicine, medicine, Animals, Hypoglycemic Agents, Obesity, RNA, Messenger, PI3K/AKT/mTOR pathway, Injections, Intraventricular, 030304 developmental biology, Dose-Response Relationship, Drug, Body Weight, Glucose Tolerance Test, medicine.disease, Dietary Fats, Receptor, Insulin, Mice, Inbred C57BL, Insulin receptor, Endocrinology, Animals, Newborn, Gene Expression Regulation, Ventromedial Hypothalamic Nucleus, biology.protein, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f92ad996139439228bbe1c160ccb87d
https://doi.org/10.1038/nn.2847

المؤلفون: A. Christine Könner, Tim Klöckener, Jens C. Brüning

المصدر: Physiology & Behavior. 97:632-638

مصطلحات موضوعية: Leptin, Lateral hypothalamus, media_common.quotation_subject, medicine.medical_treatment, Experimental and Cognitive Psychology, Biology, Energy homeostasis, Behavioral Neuroscience, Arcuate nucleus, medicine, Animals, Homeostasis, Humans, Insulin, media_common, digestive, oral, and skin physiology, Arcuate Nucleus of Hypothalamus, Appetite, medicine.disease, Obesity, Ventral tegmental area, medicine.anatomical_structure, Energy Metabolism, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c14ec78669a5ec02bbc057d509d97ce
https://doi.org/10.1016/j.physbeh.2009.03.027

المؤلفون: Eva Rother, Peter Kloppenburg, Marianne B. Ernst, F. Thomas Wunderlich, Bengt F. Belgardt, Andreas Husch, Brigitte Hampel, Jens C. Brüning, Dario R. Alessi, Tim Klöckener

المصدر: Cell Metabolism. 7:291-301

مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, Pro-Opiomelanocortin, animal structures, Physiology, Transgene, HUMDISEASE, Hypothalamus, Mice, Transgenic, FOXO1, Hyperphagia, Protein Serine-Threonine Kinases, Biology, MOLNEURO, Energy homeostasis, 3-Phosphoinositide-Dependent Protein Kinases, Mice, Stress, Physiological, Internal medicine, medicine, Animals, Insulin, Protein kinase A, Molecular Biology, PI3K/AKT/mTOR pathway, Regulation of gene expression, Forkhead Box Protein O1, Body Weight, digestive, oral, and skin physiology, Forkhead Transcription Factors, Cell Biology, Mice, Inbred C57BL, Pro-Opiomelanocortin Deficiency, Endocrinology, Gene Expression Regulation, nervous system, SIGNALING, Pituitary Gland, Female, Corticotropic cell, Corticosterone, Energy Metabolism, Gene Deletion, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d843896130f3fecdf489c1af8cbb243
https://doi.org/10.1016/j.cmet.2008.01.006

المؤلفون: Tim, Klöckener

مصطلحات موضوعية: ddc:570

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______199::8a42a8aa659104df1863cb6bbffe5dc6
https://kups.ub.uni-koeln.de/5071/