المؤلفون: Tchasovnikarova, IA, Timms, RT, Douse, CH, Roberts, RC, Dougan, G, Kingston, RE, Modis, Y, Lehner, PJ

المساهمون: Tchasovnikarova, Iva [0000-0002-0477-0956], Timms, Richard [0000-0001-7275-597X], Douse, Christopher [0000-0002-1604-8944], Dougan, Gordon [0000-0003-0022-965X], Modis, Yorgo [0000-0002-6084-0429], Lehner, Paul [0000-0001-9383-1054], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Adenosine Triphosphatases, Neurons, Lysine, Mutation, Missense, Histone-Lysine N-Methyltransferase, Epigenetic Repression, Chromatin Assembly and Disassembly, Methylation, Histone Code, Histones, Protein Domains, Charcot-Marie-Tooth Disease, Heterochromatin, Multiprotein Complexes, Protein Interaction Mapping, Humans, Gene Silencing, Protein Methyltransferases, Transgenes, CRISPR-Cas Systems, Protein Processing, Post-Translational, HeLa Cells, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad26ec477e0185d9f39a294b97b753ba
https://www.repository.cam.ac.uk/handle/1810/265278

المؤلفون: Danac JMC; The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK., Matthews RE; The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK., Gungi A; The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK., Qin C; The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK., Parsons H; Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK., Antrobus R; Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK., Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK., Tchasovnikarova IA; The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. Electronic address: it257@cam.ac.uk.

المصدر: Molecular cell [Mol Cell] 2024 Aug 08; Vol. 84 (15), pp. 2870-2881.e5. Date of Electronic Publication: 2024 Jul 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Gene Silencing*, Humans ; HEK293 Cells ; Histones/metabolism ; Histones/genetics ; Retroelements/genetics ; Epigenesis, Genetic ; Long Interspersed Nucleotide Elements/genetics ; Signal Transduction ; Interferons/metabolism ; Interferons/immunology ; Interferons/genetics ; HeLa Cells

المؤلفون: Shimshon A; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Dahan K; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Israel-Gueta M; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Olmayev-Yaakobov D; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre , Cambridge, UK., Bekturova A; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Makaros Y; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Elledge SJ; Department of Genetics, Harvard Medical School, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA., Koren I; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.

المصدر: The Journal of cell biology [J Cell Biol] 2024 Aug 05; Vol. 223 (8). Date of Electronic Publication: 2024 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Dipeptidyl-Peptidases and Tripeptidyl-Peptidases*/metabolism , Dipeptidyl-Peptidases and Tripeptidyl-Peptidases*/genetics , Protein Stability* , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics, Humans ; Degrons ; Dipeptidases/metabolism ; Dipeptidases/genetics ; HEK293 Cells ; Protein Sorting Signals ; Proteolysis

المؤلفون: Chen X; MOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China.; Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China., Raiff A; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 5290002, Israel., Li S; MOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China., Guo Q; MOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China., Zhang J; MOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China., Zhou H; MOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China., Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK., Yao X; MOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China., Elledge SJ; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Koren I; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 5290002, Israel. itay.koren@biu.ac.il., Zhang K; MOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China. kmzhang@ustc.edu.cn., Xu C; MOE Key Laboratory for Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China. xuchaor@ustc.edu.cn.; Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, PR China. xuchaor@ustc.edu.cn.

المصدر: Nature communications [Nat Commun] 2024 Apr 26; Vol. 15 (1), pp. 3558. Date of Electronic Publication: 2024 Apr 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ubiquitination* , Cryoelectron Microscopy* , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Ubiquitin-Protein Ligases*/chemistry , NEDD8 Protein*/metabolism , NEDD8 Protein*/genetics , Receptors, Interleukin-17*, Humans ; Proline/metabolism ; Protein Multimerization ; HEK293 Cells ; Protein Binding ; Substrate Specificity ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/chemistry ; Models, Molecular ; Cullin Proteins/metabolism ; Cullin Proteins/chemistry ; Cullin Proteins/genetics ; Degrons

المؤلفون: Timms RT; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK., Mena EL; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA., Leng Y; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA., Li MZ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA., Tchasovnikarova IA; Wellcome/CRUK Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge, UK., Koren I; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Elledge SJ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA. selledge@genetics.med.harvard.edu.

المصدر: Nature cell biology [Nat Cell Biol] 2024 Feb; Vol. 26 (2), pp. 305.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Zhang Z, Sie B, Chang A, Leng Y, Nardone C, Timms RT, Elledge SJ

المصدر: Molecular cell [Mol Cell] 2023 Nov 16; Vol. 83 (22), pp. 4191-4192. Date of Electronic Publication: 2023 Nov 16.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Timms RT; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, UK., Mena EL; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA., Leng Y; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA., Li MZ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA., Tchasovnikarova IA; Wellcome/CRUK Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge, UK., Koren I; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Elledge SJ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham asnd Women's Hospital, Howard Hughes Medical Institute, Boston, MA, USA. selledge@genetics.med.harvard.edu.

المصدر: Nature cell biology [Nat Cell Biol] 2023 Oct; Vol. 25 (10), pp. 1535-1545. Date of Electronic Publication: 2023 Sep 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Ubiquitin-Protein Ligases*/metabolism , Proteasome Endopeptidase Complex*/metabolism, Clustered Regularly Interspaced Short Palindromic Repeats ; Ubiquitin/genetics ; Ubiquitin/metabolism

المؤلفون: Bruno PM; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Timms RT; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Abdelfattah NS; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Leng Y; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Lelis FJN; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wesemann DR; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA., Elledge SJ; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA. selledge@genetics.med.harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. selledge@genetics.med.harvard.edu.

المصدر: Nature biotechnology [Nat Biotechnol] 2023 Jul; Vol. 41 (7), pp. 980-992. Date of Electronic Publication: 2023 Jan 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine* , Histocompatibility Antigens Class I*/genetics , Histocompatibility Antigens Class I*/metabolism, Ligands ; Peptides/metabolism ; Epitopes, T-Lymphocyte/genetics ; Protein Binding

المؤلفون: Makaros Y; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel., Raiff A; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel., Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, Cambridgeshire CB2 0AW, UK., Wagh AR; Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3525433, Israel., Gueta MI; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel., Bekturova A; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel., Guez-Haddad J; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel., Brodsky S; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel., Opatowsky Y; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel., Glickman MH; Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3525433, Israel., Elledge SJ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA., Koren I; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel. Electronic address: itay.koren@biu.ac.il.

المصدر: Molecular cell [Mol Cell] 2023 Jun 01; Vol. 83 (11), pp. 1921-1935.e7. Date of Electronic Publication: 2023 May 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Ubiquitin*/genetics , Ubiquitin*/metabolism , Proteasome Endopeptidase Complex*/metabolism, Humans ; Proteolysis ; Proteins/metabolism ; Ubiquitination ; Cell Cycle Proteins/metabolism

المؤلفون: Shrock EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA., Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Kula T; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA., Mena EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Guo R; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Lee IH; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., McKay LGA; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA., Bi C; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Leng Y; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA., Fujimura E; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA., Horns F; Department of Bioengineering, Department of Applied Physics, Chan Zuckerberg Biohub and Stanford University, Stanford, CA 94305, USA., Li M; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA., Wesemann DR; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139 USA., Griffiths A; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA., Gewurz BE; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Graduate Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Elledge SJ; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.

المصدر: Science (New York, N.Y.) [Science] 2023 Apr 07; Vol. 380 (6640), pp. eadc9498. Date of Electronic Publication: 2023 Apr 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Antibody Formation* , Immunodominant Epitopes*/chemistry , Immunodominant Epitopes*/genetics , Immunoglobulin Heavy Chains*/genetics , Immunoglobulin Heavy Chains*/immunology , Amino Acid Motifs* , Immunoglobulin Light Chains*/genetics , Immunoglobulin Light Chains*/immunology , Host-Pathogen Interactions*/genetics , Host-Pathogen Interactions*/immunology, Animals ; Humans ; Mice ; Germ Cells ; Epitope Mapping