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المؤلفون: R. James White, Carlos Jerjes-Sanchez, Gisela Martina Bohns Meyer, Tomas Pulido, Pablo Sepulveda, Kuo Yang Wang, Ekkehard Grünig, Shirish Hiremath, Zaixin Yu, Zhang Gangcheng, Wei Luen James Yip, Shuyang Zhang, Akram Khan, C. Q. Deng, Rob Grover, Victor F. Tapson, Graciela Noemi Svetliza, Adrian Jose Lescano, Guillermo Roberto Bortman, Fabian Antonio Diez, Christian Edgardo Botta, John Fitzgerald, Eelke Feenstra, Fiona Dawn Kermeen, Anne Margaret Keogh, Trevor John Williams, Peter Paul Yousseff, Benjamin Joh-Han Ng, David McNaughton Smallwood, Nathan Brent Dwyer, Martin Russell Brown, Irene M Lang, Regina Steringer-Mascherbauer, Jaquelina Sonoe Ota Arakaki, Frederico Thadeu Assis Figueiredo Campos, Ricardo de Amorim Correa, Rogerio de Souza, Gisela M. Bohns Meyer, Maria Auxiliadora Carmo Moreira, Hugo Hyung Bok Yoo, Monica Silveira Lapa, John Swiston, Naushad Hirani, Sanjay Mehta, Evangelos Michelakis, Pablo Andres Sepulveda, Monica Maria Zagolin Blancaire, Jimming Liu, Zhang Shuyang, Lei Pan, Bao Chunde, Yi Qun, Cheng Xiaoshu, Yu Zaixin, Xinli Li, Yao Hua, Xianyang Zhu, Yundai Chen, Cheng Zhaozhong, Yuanhua Yang, Zhou Daxin, Shen Jieyan, Jens Erik Nielsen-Kudsk, Jorn Carlsen, Arnaud Bourdin, Eric Hachulla, Claire Dromer, Ari Chaouat, Martine Reynaud-Gauber, Marie-France Seronde, Hans Klose, Michael Halank, Gert Hoffken, Ralf Ewert, Stephan Rosenkranz, Ekkehard Grunig, Ulrich Kruger, Juliane Kronsbein, Barbara Monika Hauptmeier, Andrea Koch, Matthias Held, Tobias Johannes Lange, Claus Neurohr, Heinrike Wilkens, Hubert Rolf Wilhelm Wirtz, Stavros Konstantinides, Paraskevi Argyropoulou-Pataka, Stylianos Orfanos, Prafulla Gopinath Kerkar, Pujar Venkateshacharya Suresh, Hemang Ashwinkumar Baxi, Abraham Oomman, Rajpal Kanaklal Abhaichand, Padma Kumar Edla Arjun, Vijay Chopra, Rahul Mehrotra, Rajeev Kumar Rajput, Jitendra Pal Singh Sawhney, Subir Bimalendu, Kamal Harishchandra Sharma, Bhagavathula Kutumba Srinivasa Sastry, Mordechai Reuben Kramer, Michael Jonathan Segel, Issahar Ben-Dov, Neville Berkman, Mordechai Yigla, Yochai Adir, Michael D’Alto, Carmine Dario Vizza, Laura Scelsi, Patrizio Vitulo, Tomas Rene Pulido, Anko Boonstra, Madelon Clementina Vonk, Bozena Sobkowicz, Tatiana Mularek-Kubzdela, Adam Torbicki, Piotr Podolec, Lim Soo Teik, Hyuk-Jae Chang, Hyung-Kwan Kim, Jun-Bean Park, Sung-A Chang, Duk-Kyung Kim, Wook-Jin Chung, Jong-Min Song, Magnus Nissell, Clara Hjalmarsson, Bengt Rundqvist, Wei-Chun Huang, Chin-Chang Cheng, Chih-Hsin Hsu, Hsao-Hsun Hsu, Kuo-Yang Wang, John Gerard Coghlan, David Gerard Kiely, Joanna Wanda Pepke-Zaba, James Lawrence Lordan, Paul Anthony Corris, Linda Cadaret, Sif Hansdottir, Ronald Jack Oudiz, David B. Badesch, Michael Mathier, Robert Schilz, Nicholas Hill, Aaron Waxman, Catherine J. Markin, Diane Lynn Zwicke, Micah Fisher, Veronica Franco, Namita Sood, Myung H. Park, Roblee Allen, Jeremy P. Feldman, Vijay Balasubramanian, Vandana Kavita Seeram, Abubakr Bajwa, Austin B. Thompson, Christina Migliore, Jean Elwing, John W. McConnell, Jinesh P. Mehta, Franck Farzad Rahaghi, J. Eduardo Rame, Bela Patel, Ron M. Oren, James R. Klinger, Hassan Alnuaimat, Samuel Allen, William Harvey, Michael S. Eggert, Antoine Hage, Chad E. Miller, Rana Lee Adawi Awdish, Hector Cajigas, Daniel Grinnan, Benjamin Howard Trichon, Clark McDonough, Franz Rischard
المساهمون: ACS - Pulmonary hypertension & thrombosis, Pulmonary medicine, University of Rochester Medical Center (URMC), Unidad de Investigación Clínica En Medicina, Complexo Hospitalar da Santa Casa de Misericórdia de Porto Alegre, Instituto Nacional de Cardiologia Ignacio Chavez, Pontificia Universidad Católica de Chile (UC), Taichung Veterans General Hospital, Heidelberg University Hospital [Heidelberg], Ruby Hall Clinic, The Second Xiangya Hospital of Central South University [Hunan, China], Wuhan Asia Heart Hospital, National Heart Centre Singapore & Duke-National University of Singapore, Peking Union Medical College Hospital [Beijing] (PUMCH), Oregon Health and Science University [Portland] (OHSU), United Therapeutics Corporation, Cedars-Sinai Medical Center
المصدر: White, R J, Jerjes-Sanchez, C, Bohns Meyer, G M, Pulido, T, Sepulveda, P, Wang, K Y, Grünig, E, Hiremath, S, Yu, Z, Gangcheng, Z, Yip, W L J, Zhang, S, Khan, A, Deng, C Q, Grover, R, Tapson, V F & FREEDOM-EV 2020, ' Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension : A Double-Blind Placebo-controlled Clinical Trial ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 6, pp. 707-717 . https://doi.org/10.1164/rccm.201908-1640OC
American Journal of Respiratory and Critical Care Medicine, 201(6), 707-717. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine
White, R J, Jerjes-Sanchez, C, Meyer, G M B, Pulido, T, Sepulveda, P, Wang, K Y, Grünig, E, Hiremath, S, Yu, Z, Zhang, G, Yip, W L J, Zhang, S, Khan, A, Deng, C Q, Grover, R, Tapson, V F, Svetliza, G N, Lescano, A J, Bortman, G R, Diez, F A, Botta, C E, Fitzgerald, J, Feenstra, E, Kermeen, F D, Keogh, A M, Williams, T J, Yousseff, P P, Ng, B J H, Smallwood, D M N, Dwyer, N B, Brown, M R, Lang, I M, Steringer-Mascherbauer, R, Arakaki, J O, Campos, F, De Amorim Correa, R, De Souza, R, Meyer, G M B, Moreira, M C, Yoo, H, Lapa, M S, Swiston, J, Hirani, N, Mehta, S, Michelakis, E, Sepulveda, P, Zagolin, M, Liu, J, Zhang, S, Pan, L, Chunde, B, Qun, Y, Cheng, X, Yu, Z, Li, X, Hua, Y, Zhang, G, Zhu, X, Chen, Y, Cheng, Z, Yang, Y, Zhou, D, Shen, J, Nielsen-Kudsk, J E, Carlsen, J, Bourdin, A, Hachulla, E, Dromer, C, Chaouat, A, Reynaud-Gauber, M, Seronde, M F, Klose, H, Halank, M, Hoffken, G, Ewert, R, Rosenkranz, S, Grunig, E, Kruger, U, Kronsbein, J, Hauptmeier, B M, Koch, A, Held, M, Lange, T J, Neurohr, C, Wilkens, H, Wirtz, H, Konstantinides, S, Argyropoulou-Pataka, P, Orfanos, S, Hiremath, S, Kerkar, P G, Suresh, P V, Baxi, H A, Oomman, A, Abhaichand, R K, Edla Kumar, P K, Chopra, V, Mehrotra, R, Rajput, R K, Sawhney, J S, Bimalendu, S, Sharma, K H, Srinivasa Sastry, B K, Kramer, M R, Segel, M J, Ben-Dov, I, Berkman, N, Yigla, M, Adir, Y, D'Alto, M, Vizza, C D, Scelsi, L, Vitulo, P, Pulido, T R, Jerjes-Sanchez, C, Boonstra, A, Vonk, M C, Sobkowicz, B, Mularek-Kubzdela, T, Torbicki, A, Podolec, P, Teik, L S, Yip, W L J, Chang, H J, Kim, H K, Park, J B, Chang, S A, Kim, D K, Chung, W J, Song, J M, Nissell, M, Hjalmarsson, C, Rundqvist, B, Huang, W C, Cheng, C C, Hsu, C H, Hsu, H H, Wang, K Y, Coghlan, J G, Kiely, D G, Pepke-Zaba, J W, Lordan, J L, Corris, P A, Cadaret, L, Hansdottir, S, Oudiz, R J, Badesch, D B, Mathier, M, Schilz, R, Hill, N, Waxman, A, Markin, C J, Zwicke, D L, Fisher, M, Franco, V, Sood, N, Park, M H, Allen, R, Feldman, J P, Balasubramanian, V, Seeram, V K, Bajwa, A, Thompson, A B, Migliore, C, Elwing, J, McConnell, J W, Mehta, J P, Rahaghi, F F, Rame, J E, Khan, A, Patel, B, Oren, R M, Klinger, J R, Alnuaimat, H, Allen, S, Harvey, W, Eggert, M S, Hage, A, Miller, C E, Awdish, R, Cajigas, H, Grinnan, D, Trichon, B H, McDonough, C, White, R J & Rischard, F 2020, ' Combination therapy with oral treprostinil for pulmonary arterial hypertension : A double-blind placebo-controlled clinical trial ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 6, pp. 707-717 . https://doi.org/10.1164/rccm.201908-1640OC
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2020, 201 (6), pp.707-717. ⟨10.1164/rccm.201908-1640OC⟩
White, R J, Jerjes-Sanchez, C, Bohns Meyer, G M, Pulido, T, Sepulveda, P, Wang, K Y, Grünig, E, Hiremath, S, Yu, Z, Gangcheng, Z, Yip, W L J, Zhang, S, Khan, A, Deng, C Q, Grover, R, Tapson, V F, FREEDOM-EV Investigators, Svetliza, G N, Lescano, A J, Bortman, G R, Carlsen, J, McDonough, C, White, J R & Rischard, F 2020, ' Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension : A Double-Blind Placebo-controlled Clinical Trial ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 6, pp. 707-717 . https://doi.org/10.1164/rccm.201908-1640OCمصطلحات موضوعية: Male, Administration, Oral, Oral treprostinil, Critical Care and Intensive Care Medicine, Pulmonary arterial hypertension, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, combination therapy, oral, epoprostenol, 0302 clinical medicine, pulmonary arterial hypertension, middle aged, Clinical endpoint, double-blind method, MESH: Double-Blind Method, Familial Primary Pulmonary Hypertension, 030212 general & internal medicine, humans, MESH: Aged, MESH: Middle Aged, Epoprostenol/analogs & derivatives, adult, Hazard ratio, Middle Aged, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, antihypertensive agents, 3. Good health, aged, female, MESH: Young Adult, oral treprostinil, MESH: Administration, Oral, young adult, Female, Pulmonary Arterial Hypertension/drug therapy, medicine.drug, Adult, Pulmonary and Respiratory Medicine, MESH: Pulmonary Arterial Hypertension, medicine.medical_specialty, Randomization, Adolescent, clinical study, sequential therapy, administration, oral, adolescent, male, placebos, Sequential therapy, MESH: Placebos, MESH: Epoprostenol, Lower risk, Placebo, administration, Clinical study, Young Adult, 03 medical and health sciences, Double-Blind Method, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, Combination therapy, Adverse effect, Placebos/therapeutic use, Aged, MESH: Adolescent, Pulmonary Vascular Disease, MESH: Antihypertensive Agents, MESH: Humans, business.industry, MESH: Adult, Original Articles, MESH: Male, Clinical trial, 030228 respiratory system, Antihypertensive Agents/administration & dosage, business, MESH: Female, Treprostinil
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