المؤلفون: Carocci A; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', via Orabona 4, 70126 Bari, Italy., Corbo F; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', via Orabona 4, 70126 Bari, Italy., Lentini G; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', via Orabona 4, 70126 Bari, Italy., Cavalluzzi MM; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', via Orabona 4, 70126 Bari, Italy., Franchini C; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', via Orabona 4, 70126 Bari, Italy., Catalano A; Department of Pharmacy-Drug Sciences, University of Bari 'Aldo Moro', via Orabona 4, 70126 Bari, Italy.

المصدر: Current medicinal chemistry [Curr Med Chem] 2018; Vol. 25 (42), pp. 5822-5834.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Arrhythmia Agents/*chemical synthesis , Tocainide/*analogs & derivatives, Anti-Arrhythmia Agents/pharmacokinetics ; Anti-Arrhythmia Agents/therapeutic use ; Arrhythmias, Cardiac/drug therapy ; Half-Life ; Humans ; NAV1.4 Voltage-Gated Sodium Channel/chemistry ; NAV1.4 Voltage-Gated Sodium Channel/metabolism ; Quantitative Structure-Activity Relationship ; Tocainide/pharmacokinetics ; Tocainide/therapeutic use ; Voltage-Gated Sodium Channel Blockers/chemical synthesis ; Voltage-Gated Sodium Channel Blockers/pharmacokinetics ; Voltage-Gated Sodium Channel Blockers/therapeutic use

المؤلفون: De Bellis M; Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Carbonara R; Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Roussel J; Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Farinato A; Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Massari A; Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Pierno S; Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Muraglia M; Section of Medicinal Chemistry, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Corbo F; Section of Medicinal Chemistry, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Franchini C; Section of Medicinal Chemistry, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Carratù MR; Section of Pharmacology, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70126 Bari, Italy., De Luca A; Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Conte Camerino D; Section of Pharmacology, Department of Pharmacy and Drug Sciences, University of Bari Aldo Moro, 70125, Bari, Italy., Desaphy JF; Section of Pharmacology, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70126 Bari, Italy. Electronic address: jeanfrancois.desaphy@uniba.it.

المصدر: Neuropharmacology [Neuropharmacology] 2017 Feb; Vol. 113 (Pt A), pp. 206-216. Date of Electronic Publication: 2016 Oct 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Myotonia/*prevention & control , NAV1.4 Voltage-Gated Sodium Channel/*physiology , Tocainide/*pharmacology , Voltage-Gated Sodium Channel Blockers/*pharmacology, Animals ; Dose-Response Relationship, Drug ; Ether-A-Go-Go Potassium Channels/physiology ; Humans ; Male ; Mexiletine/pharmacology ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiology ; Myotonia/physiopathology ; Rats ; Rats, Wistar ; Reflex, Righting/drug effects ; Rotarod Performance Test ; Tocainide/adverse effects ; Tocainide/analogs & derivatives ; Tocainide/therapeutic use ; Voltage-Gated Sodium Channel Blockers/adverse effects ; Voltage-Gated Sodium Channel Blockers/therapeutic use

المؤلفون: Muraglia M; Dipartimento di Farmacia-Scienze del Farmaco, ‡Sezione di Farmacologia, Università degli Studi di Bari 'Aldo Moro' , via E. Orabona n. 4, 70126 Bari, Italy., De Bellis M, Catalano A, Carocci A, Franchini C, Carrieri A, Fortugno C, Bertucci C, Desaphy JF, De Luca A, Conte Camerino D, Corbo F

المصدر: Journal of medicinal chemistry [J Med Chem] 2014 Mar 27; Vol. 57 (6), pp. 2589-600. Date of Electronic Publication: 2014 Mar 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Arrhythmia Agents/*pharmacology , Muscle, Skeletal/*drug effects , Tocainide/*analogs & derivatives , Tocainide/*pharmacology , Voltage-Gated Sodium Channel Blockers/*chemical synthesis , Voltage-Gated Sodium Channel Blockers/*pharmacology, Animals ; Anti-Arrhythmia Agents/chemical synthesis ; Chromatography, Affinity ; Chromatography, High Pressure Liquid ; Humans ; Models, Molecular ; Patch-Clamp Techniques ; Protein Binding ; Quantitative Structure-Activity Relationship ; Rats ; Serum Albumin/metabolism ; Sodium Channels/drug effects ; Structure-Activity Relationship ; Tocainide/chemical synthesis

المؤلفون: Catalano A; Department of Medicinal Chemistry, University of Bari, via E. Orabona n. 4, 70125 Bari, Italy., Carocci A, Corbo F, Franchini C, Muraglia M, Scilimati A, De Bellis M, De Luca A, Camerino DC, Sinicropi MS, Tortorella V

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2008 Nov; Vol. 43 (11), pp. 2535-40. Date of Electronic Publication: 2008 Jan 31.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0223-5234 (Print) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Myotonia*, Muscle, Skeletal/*drug effects , Sodium Channel Blockers/*chemical synthesis , Sodium Channel Blockers/*pharmacology , Tocainide/*chemical synthesis , Tocainide/*pharmacology, Molecular Structure ; Muscle, Skeletal/metabolism ; Sodium Channel Blockers/chemistry ; Structure-Activity Relationship ; Tocainide/analogs & derivatives ; Tocainide/chemistry

المؤلفون: De Luca A; Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari Aldo Moro, Italy., De Bellis M, Corbo F, Franchini C, Muraglia M, Catalano A, Carocci A, Camerino DC

المصدر: Neuromuscular disorders : NMD [Neuromuscul Disord] 2012 Jan; Vol. 22 (1), pp. 56-65. Date of Electronic Publication: 2011 Jul 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 9111470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2364 (Electronic) Linking ISSN: 09608966 NLM ISO Abbreviation: Neuromuscul Disord Subsets: MEDLINE

مواضيع طبية MeSH: Muscle, Skeletal/*drug effects , Sodium Channel Blockers/*pharmacology , Tocainide/*analogs & derivatives, Animals ; Muscle, Skeletal/metabolism ; Patch-Clamp Techniques ; Proline/chemistry ; Rana esculenta ; Sodium Channel Blockers/chemistry ; Sodium Channels/metabolism ; Sodium Channels/physiology ; Structure-Activity Relationship ; Tocainide/chemistry ; Tocainide/pharmacology

المؤلفون: Ghelardini C; Department of Preclinical and Clinical Pharmacology, Faculty of Pharmacy, University of Florence, Florence, Italy., Desaphy JF, Muraglia M, Corbo F, Matucci R, Dipalma A, Bertucci C, Pistolozzi M, Nesi M, Norcini M, Franchini C, Camerino DC

المصدر: Neuroscience [Neuroscience] 2010 Aug 25; Vol. 169 (2), pp. 863-73. Date of Electronic Publication: 2010 May 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

مواضيع طبية MeSH: Analgesics/*pharmacology , Pain/*drug therapy , Peripheral Nervous System Diseases/*drug therapy , Sodium Channel Blockers/*pharmacology , Sodium Channels/*physiology , Tocainide/*analogs & derivatives , Tocainide/*pharmacology, Analgesics/therapeutic use ; Animals ; Cell Line ; Cell Survival/drug effects ; Humans ; Hyperalgesia/drug therapy ; Male ; Muscle Proteins/antagonists & inhibitors ; NAV1.4 Voltage-Gated Sodium Channel ; NAV1.7 Voltage-Gated Sodium Channel ; Patch-Clamp Techniques ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; Serum Albumin/metabolism ; Sodium Channel Blockers/therapeutic use ; Tocainide/therapeutic use

المؤلفون: Carrieri A; Dipartimento Farmaco-Chimico, Università degli Studi di Bari, via Orabona 4, 70125 Bari, Italy. carrieri@farmchim.uniba.it, Muraglia M, Corbo F, Pacifico C

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2009 Apr; Vol. 44 (4), pp. 1477-85. Date of Electronic Publication: 2008 Oct 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Quantitative Structure-Activity Relationship*, Mexiletine/*chemistry , Mexiletine/*pharmacology , Sodium Channel Blockers/*chemistry , Sodium Channel Blockers/*pharmacology , Tocainide/*chemistry , Tocainide/*pharmacology, Crystallography, X-Ray ; Mexiletine/analogs & derivatives ; Protein Isoforms/antagonists & inhibitors ; Sodium Channels/metabolism ; Substrate Specificity ; Tocainide/analogs & derivatives

المؤلفون: De Luca A; Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Via Orabona 4, Campus, 70125 Bari, Italy., Pierno S, Liantonio A, Desaphy JF, Natuzzi F, Didonna MP, Ferrannini E, Jockusch H, Franchini C, Lentini G, Corbo F, Tortorella V, Camerino DC

المصدر: Neuromuscular disorders : NMD [Neuromuscul Disord] 2004 Jul; Vol. 14 (7), pp. 405-16.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 9111470 Publication Model: Print Cited Medium: Print ISSN: 0960-8966 (Print) Linking ISSN: 09608966 NLM ISO Abbreviation: Neuromuscul Disord Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Arrhythmia Agents/*therapeutic use , Mexiletine/*therapeutic use , Myotonic Disorders/*drug therapy , Tocainide/*therapeutic use, Action Potentials/drug effects ; Analysis of Variance ; Animals ; Anti-Arrhythmia Agents/blood ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Electric Conductivity ; Electromyography/methods ; Female ; In Vitro Techniques ; Inhibitory Concentration 50 ; Male ; Mexiletine/blood ; Mice ; Mice, Mutant Strains ; Muscle Contraction/drug effects ; Myotonic Disorders/blood ; Patch-Clamp Techniques/methods ; Sodium Channels/drug effects ; Sodium Channels/physiology ; Structure-Activity Relationship ; Time Factors ; Tocainide/analogs & derivatives ; Tocainide/blood

المؤلفون: Białasiewicz W; Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, Poland., Kwapiszewski W, Zurek E, Olczak A, Główka M, Polakowski R

المصدر: Acta poloniae pharmaceutica [Acta Pol Pharm] 2004 May-Jun; Vol. 61 (3), pp. 215-21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Polski Towarzystwo Farmaceutyczne Country of Publication: Poland NLM ID: 2985167R Publication Model: Print Cited Medium: Print ISSN: 0001-6837 (Print) Linking ISSN: 00016837 NLM ISO Abbreviation: Acta Pol Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Aniline Compounds/*chemistry , Anti-Arrhythmia Agents/*chemistry , Lidocaine/*chemistry , Tocainide/*analogs & derivatives, Aniline Compounds/chemical synthesis ; Aniline Compounds/toxicity ; Animals ; Anti-Arrhythmia Agents/chemical synthesis ; Anti-Arrhythmia Agents/toxicity ; Crystallography, X-Ray ; Female ; Lidocaine/chemical synthesis ; Lidocaine/toxicity ; Male ; Mice ; Rabbits ; Structure-Activity Relationship ; Tocainide/chemistry ; Tocainide/toxicity

المؤلفون: Hyun MH; Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Pusan 609-735, South Korea. mhhyun@pusan.ac.kr, Min HJ, Cho YJ

المصدر: Journal of chromatography. A [J Chromatogr A] 2003 May 09; Vol. 996 (1-2), pp. 233-7.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print Cited Medium: Print ISSN: 0021-9673 (Print) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE

مواضيع طبية MeSH: Crown Ethers*, Chromatography, High Pressure Liquid/*methods , Tocainide/*chemistry , Tocainide/*isolation & purification, Acetates ; Silica Gel ; Silicon Dioxide ; Stereoisomerism ; Tocainide/analogs & derivatives