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المؤلفون: Mototsugu Ito, Tomasz Wojtkowski, Ronald A. Smulders, Akihiro Yamada, Ronald Goldwater, Akira Koibuchi, Tolga Uz, Sitra Tauscher-Wisniewski, Gerard J. Marek
المصدر: Muscle & Nerve. 65:110-120
مصطلحات موضوعية: Physiology, business.industry, Pharmacology, Placebo, Bioavailability, Cellular and Molecular Neuroscience, Pharmacokinetics, Tolerability, Physiology (medical), Pharmacodynamics, Medicine, Peroxisome proliferator-activated receptor delta, Neurology (clinical), Adverse effect, business, Receptor
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المؤلفون: Eugenii A. Rabiner, Ayla Mansur, Wei Yin, Terry Brown, Graham E. Searle, Tolga Uz, Joy Atienza, Johannes Tauscher, Jeremy M. T. J. Dennison, Jan Passchier, Jingtao Wu, Roger N. Gunn, Grace Chen, Adam J. Schwarz, Yvonne Lewis
المصدر: Neuropsychopharmacology. 47:1405-1412
مصطلحات موضوعية: Pharmacology, Agonist, medicine.drug_class, business.industry, Putamen, Central nervous system, Ventral striatum, Dopaminergic, Binding potential, Human brain, Psychiatry and Mental health, medicine.anatomical_structure, Dopamine, medicine, business, medicine.drug
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المؤلفون: Amit Desai, Gregory A. Light, Lev Gertsik, Tong Zhu, Paul Maruff, Tolga Uz, Lauren Benner, Ruishan Wu, Gerard J. Marek
المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 46, iss 6
مصطلحات موضوعية: Psychiatry, Pharmacology, Oncology, Psychomotor function, medicine.medical_specialty, business.industry, Psychology and Cognitive Sciences, Mismatch negativity, Schizoaffective disorder, Placebo, medicine.disease, Medical and Health Sciences, law.invention, Psychiatry and Mental health, Mood, Randomized controlled trial, Tolerability, law, Schizophrenia, Internal medicine, medicine, business
وصف الملف: application/pdf
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المصدر: Psychopharmacology
مصطلحات موضوعية: Adult, Male, Adolescent, Phosphodiesterase Inhibitors, medicine.medical_treatment, TAK-063, Placebo, Young Adult, Double-Blind Method, medicine, Clinical endpoint, Humans, Drug Interactions, Ketamine, Antipsychotic, Original Investigation, Pharmacology, Cross-Over Studies, Risperidone, Resting state fMRI, medicine.diagnostic_test, Phosphoric Diester Hydrolases, business.industry, fMRI, Brain, Electroencephalography, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Healthy Volunteers, Pyridazines, Schizophrenia, Anesthesia, Pyrazoles, business, Excitatory Amino Acid Antagonists, BOLD, PDE-10 inhibitor, medicine.drug
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المؤلفون: Mototsugu, Ito, Sitra, Tauscher-Wisniewski, Ronald A, Smulders, Tomasz, Wojtkowski, Akihiro, Yamada, Akira, Koibuchi, Tolga, Uz, Gerard J, Marek, Ronald D, Goldwater
المصدر: Musclenerve. 65(1)
مصطلحات موضوعية: Adult, Dose-Response Relationship, Drug, Double-Blind Method, Sulfates, Area Under Curve, Imidazoles, Administration, Oral, Humans, PPAR delta, Caproates, Healthy Volunteers
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المؤلفون: Arjan Blokland, Marlies van Duinen, Anke Sambeth, Gezim Lahu, Pim R. A. Heckman, Max Tsai, Jos Prickaerts, Tolga Uz
المساهمون: Section Psychopharmacology, RS: FPN NPPP II, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, Promovendi MHN
المصدر: Neurobiology of Aging, 77, 37-43. Elsevier Science
مصطلحات موضوعية: 0301 basic medicine, Cyclopropanes, Aging, Placebo-controlled study, Aminopyridines, Verbal memory, DISEASE, Healthy Aging, 0302 clinical medicine, Cyclic AMP, Aged, 80 and over, Cross-Over Studies, Long-term memory, General Neuroscience, Cognition, EDUCATION, Middle Aged, Stimulation, Chemical, PHOSPHODIESTERASE-4 INHIBITOR, LONG-TERM-MEMORY, Benzamides, Animal studies, medicine.drug, medicine.medical_specialty, NORMATIVE DATA, ROLIPRAM, 03 medical and health sciences, AGE, ENHANCEMENT, Double-Blind Method, Memory, Internal medicine, medicine, Humans, Adverse effect, N-OXIDE, Roflumilast, Aged, Cognition enhancement, Dose-Response Relationship, Drug, business.industry, Verbal Behavior, Crossover study, 030104 developmental biology, Mental Recall, COGNITION, Neurology (clinical), Phosphodiesterase 4 Inhibitors, Geriatrics and Gerontology, CAMP, business, 030217 neurology & neurosurgery, Developmental Biology
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المؤلفون: Tolga Uz, Mitul A. Mehta, Sukhi Shergill, Frank Ogrinc, Lorena Valdearenas, James Gilleen, Max Tsai, Steve C.R. Williams, Yakub Farah, Gez Lahu, Sarah Kerins, Avi Reichenberg, Cate Davison
المصدر: Psychopharmacology
Gilleen, J, Farah, Y, Davison, C, Kerins, S, Valdearenas, L, Uz, T, Lahu, G, Tsai, M, Ogrinc, F, Reichenberg, A, Williams, S C, Mehta, M A & Shergill, S S 2018, ' An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients ', Psychopharmacology, vol. 0, no. 0, pp. 1-11 . https://doi.org/10.1007/s00213-018-5134-yمصطلحات موضوعية: Cyclopropanes, Male, Aminopyridines, Audiology, CIAS, Cognition, 0302 clinical medicine, Episodic memory, Original Investigation, Cross-Over Studies, fMRI, Brain, Middle Aged, ‘PDE4 inhibition’, Memory, Short-Term, medicine.anatomical_structure, Schizophrenia, Benzamides, Female, medicine.drug, Adult, medicine.medical_specialty, Memory, Episodic, Prefrontal Cortex, Placebo, behavioral disciplines and activities, ‘Cognitive enhancement’, 03 medical and health sciences, Double-Blind Method, Memory, medicine, Animals, Humans, Roflumilast, Pharmacology, Working memory, business.industry, medicine.disease, 030227 psychiatry, Dorsolateral prefrontal cortex, Phosphodiesterase 4 Inhibitors, PDE4, Verbal memory, Cognition Disorders, business, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Farah Yakub, Gez Lahu, Tolga Uz, Mitul A. Mehta, Steve C.R. Williams, Sukhi Shergill, James Gilleen, Judith Nottage, Sarah Kerins, Max Tsai, Lorena Valdearenas, Dominic Ffytche, Frank Ogrinc
المصدر: Journal of psychopharmacology (Oxford, England). 35(1)
مصطلحات موضوعية: Oncology, Adult, Cyclopropanes, Male, medicine.medical_specialty, Phosphodiesterase Type 4, Aminopyridines, Electroencephalography, law.invention, 03 medical and health sciences, 0302 clinical medicine, Cognition, Mental Processes, Quality of life, Randomized controlled trial, Double-Blind Method, law, Internal medicine, Medicine, Humans, Pharmacology (medical), Cognitive Dysfunction, Evoked Potentials, Roflumilast, Pharmacology, Psychiatric Status Rating Scales, Cross-Over Studies, medicine.diagnostic_test, business.industry, medicine.disease, 030227 psychiatry, Cyclic Nucleotide Phosphodiesterases, Type 4, Psychiatry and Mental health, Treatment Outcome, Schizophrenia, Benzamides, Female, Phosphodiesterase 4 Inhibitors, Drug Monitoring, business, 030217 neurology & neurosurgery, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bf23e8532241432f270a1bec2fc67f
https://pubmed.ncbi.nlm.nih.gov/32854568 -
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المؤلفون: Tong Zhu, Lev Gertsik, Ruishan Wu, Amit Desai, Lauren Benner, Gerard J. Marek, Tolga Uz
المصدر: Clinical Pharmacokinetics
مصطلحات موضوعية: Adult, Male, medicine.medical_treatment, Administration, Oral, Pharmacology, Placebo, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Cerebrospinal fluid, Pharmacokinetics, Double-Blind Method, medicine, Distribution (pharmacology), Humans, Pharmacology (medical), Dosing, Original Research Article, Antipsychotic, Randomized Controlled Trials as Topic, Clinical Trials, Phase I as Topic, Dose-Response Relationship, Drug, business.industry, Area under the curve, Middle Aged, medicine.disease, 030227 psychiatry, Psychotic Disorders, Schizophrenia, Area Under Curve, Dopamine Agonists, Benzimidazoles, Female, business, 030217 neurology & neurosurgery
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المؤلفون: Arjan Blokland, Anke Sambeth, Jos Prickaerts, Pim R. A. Heckman, Tolga Uz, Marlies van Duinen
المساهمون: Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, Section Psychopharmacology, RS: FPN NPPP II
المصدر: Psychopharmacology
Psychopharmacology, 235(1). Springerمصطلحات موضوعية: 0301 basic medicine, MECHANISM, Cyclopropanes, Male, Aminopyridines, Stimulation, Gating, Pharmacology, law.invention, 0302 clinical medicine, Randomized controlled trial, law, SCHIZOPHRENIA, PHOSPHODIESTERASE-4 INHIBITORS, Original Investigation, Sensory gating, Electroencephalography, Nausea, Effective dose (pharmacology), Clinical trial, medicine.anatomical_structure, Anesthesia, Benzamides, Evoked Potentials, Auditory, Female, medicine.drug, Adult, Adolescent, AUDITORY-EVOKED POTENTIALS, Vomiting, Sensory system, RATS, 03 medical and health sciences, Young Adult, Double-Blind Method, medicine, Journal Article, SCHIZOTYPAL PERSONALITY, Animals, Humans, Phosphodiesterase, Adverse effect, Roflumilast, RECEPTOR, Dose-Response Relationship, Drug, business.industry, P50, 030104 developmental biology, NEUROPHYSIOLOGICAL BIOMARKERS, COGNITION, Phosphodiesterase 4 Inhibitors, Phosphodiesterase inhibitor, business, 030217 neurology & neurosurgery